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Rheological Properties and MR Polishing Characteristics of Core Shell-Structured Silica-Coated CI Particles

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Journal of Iron and Steel Research International 2012年第S2期19卷 625-628页

作者： HONG Kwang-Pyo LEE Jung-Won CHOI Seung-bok KIM Gun-hee CHOI Hyoung-Jin CHO Myeong-Woo Department of Mechanical Engineering Inha University Korea Institute of Industrial Technology Department of Polymer Science and Engineering Inha University

Recently,ultra-precision polishing processes using smart materials such as magnetorheological(MR)fluids have been used for optics parts such as aspheric *** MR fluid applied in MR polishing is a phase controllable suspension comprising a mixture of CI particles and non-magnetic fluids such as mineral oil and *** fluids are a kind of smart material that can be controlled according to their flow properties such as viscosity and stiffness. Water-based MR fluids are easily oxidized if the fluids are exposed and this oxidation can bring irregular polishing results. Also,this phenomenon is one of several factors that reduce the life time of MR *** a previous work,CI particles were coated with a polymer or a composite for the improvement of dispersion stability and prevention of corrosion due to *** this study,the rheological properties such as viscosity and sedimentation of coated CI particles with silica were investigated with a rotational rheometer;MR polishing characteristics of BK7 glass were studied in order to investigate the surface *** wheel speed and magnetic field intensity were chosen as variables.

关键词： magnetorheological polishing silica viscosity surface roughness material removal

用多核固体核磁共振研究CsH_2PO_4和CsH_5(PO_4)_2的制备(英文)

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波谱学杂志 2010年第3期27卷 436-444页

作者： Seen Ae chae Young Eun LEE Oc hee HAN Sang Geul LEE 韩国基础科学研究院大丘中心忠南国立大学分析科学技术研究生院

探讨可能用作燃料电池固体酸电解质的化合物CsH2PO4(CDP)和CsH5(PO4)2(CPDP)的制备.CDP和CPDP混合物由摩尔比1:4的Cs2CO3:H3PO4水溶液结晶而成,而CDP和Cs2HPO4.1 .5 H2O( H-DCHP)混合物依其摩尔比1:2的水溶液制备.甲醇清洗能最有效地将... 详细信息

探讨可能用作燃料电池固体酸电解质的化合物CsH2PO4(CDP)和CsH5(PO4)2(CPDP)的制备.CDP和CPDP混合物由摩尔比1:4的Cs2CO3:H3PO4水溶液结晶而成,而CDP和Cs2HPO4.1 .5 H2O( H-DCHP)混合物依其摩尔比1:2的水溶液制备.甲醇清洗能最有效地将CDP从其混合物中分离出来.CDP、CPDP以及H-DCHP的33Cs和31P魔角旋转谱以及CPDP和H-DCHP的1H魔角旋转谱均为首次报道,对各化合物的谱峰做了指认.说明,透过确认合成的电解质以及合成过程所产生的副产物,多核固体核磁共振对于控制固体酸电解质合成的品质是一个非常有用的工具.

关键词：固体核磁共振固体酸电解质 CsH2PO4 CsH5(PO4)2 133Cs魔角旋转NMR 31P魔角旋转NMR 1H魔角旋转NMR

Epidermal growth factor upregulates Skp2/Cks1 and p27^(kip1) in human extrahepatic cholangiocarcinoma cells

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World Journal of Gastroenterology 2014年第3期20卷 755-773页

作者： Ja-yeon Kim Hong Joo Kim Jung Ho Park Dong Il Park Yong Kyun Cho Chong Il Sohn Woo Kyu Jeon Byung Ik Kim Dong Hoon Kim Seoung Wan chae Jin hee Sohn Kangbuk Samsung Medical Research Institute Sungkyunkwan University Kangbuk Samsung Hospital Department of Internal Medicine Sungkyunkwan University Kangbuk Samsung Hospital Department of Pathology Sungkyunkwan University Kangbuk Samsung Hospital

AIM:To evaluate the expression status of S-phase kinase-associated protein 2(Skp2)/cyclin-dependent kinases regulatory subunit 1(Cks1)and p27kip1,and assess the prognostic significance of Skp2/Cks1 expression with p27kip1in patients with extrahepatic ***:Seventy-six patients who underwent curative resection for histologically confirmed extrahepatic cholangiocarcinoma at our institution from December1994 to March 2008 were *** staining for Skp2,Cks1,p27kip1,and Ki67,along with other relevant molecular biologic experiments,were ***:By Cox regression analyses,advanced age(>65 years),advanced AJCC tumor stage,poorly differentiated histology,and higher immunostaining intensity of Skp2 were identified as independent prognostic factors in patients with extrahepatic *** epidermal growth factor(EGF,especially 0.1-10 ng/mL)significantly increased the proliferation indices by MTT assay and the mRNA levels of Skp2/Cks1 and p27kip1in SNU-1196,SNU-1079,and SNU-245 *** protein levels of Skp2/Cks1(from nuclear lysates)and p27kip1(from cytosolic lysate)were also significantly increased in these *** were significant reductions in the protein levels of Skp2/Cks1and p27kip1(from nuclear lysate)after the treatment of *** chromatin immunoprecipitation assay,we found that E2F1 transcription factor directly binds to the promoter site of ***:Higher immunostaining intensity of Skp2/Cks1 was an independent prognostic factor for patients with extrahepatic *** upregulates the mRNA and protein levels of Skp2/Cks1and p27kip1via the PI3K/Akt pathway and direct binding of E2F1 transcription factor with the Skp2 promoter.

关键词： S-phase kinase-associated protein 2 Cyclindependent kinases regulatory subunit 1 P27kip1 Cholangiocarcinoma E2F1 PI3K/Akt

CIM Model Extension for Intelligent DAS of Smart Power Grid in Korea

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Journal of Energy and Power Engineering 2012年第8期6卷 1328-1334页

作者： In-Yong Seo bok-Nam Ha Sang-Ok Kim Dong-Uk Heo hee-Joo Lee Smart Energy Lab KEPCO Research Institute Daejeon 305-760 Republic of Korea ANYGA TE Corporation Research Center Seoul 152- 742 Republic of Korea

The CIM （common information model） is an abstract information model that can be used to model an electrical network and various equipments used on the network. By using a common model, utilities and vendors can reduce their integration costs, which should allow more resources to be applied toward increased functionality for managing and optimizing the electrical system. As a part of smart grid, the SPG （smart power grid） was built on Jeju Island. The SPG consists of IDAS （intelligent distribution automation system）, substation automation system, intelligent transmission system, and active telemetrics system. To integrate these systems which have different operating systems and platforms CIM standard was used. But IDAS has many functions and advanced algorithms not defined in CIM. In this paper, the authors introduce how to develop and extend the CIM model for managing the IDAS.

关键词： Battery common information model distribution automation system smart grid.

A novel IRAK4/PIM1 inhibitor ameliorates rheumatoid arthritis and lymphoid malignancy by blocking the TLR/MYD88-mediated NF-κB pathway

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Acta Pharmaceutica Sinica B 2023年第3期13卷 1093-1109页

作者： Sae-Bom Yoon Hyowon Hong hee-Jong Lim Ji Hye Choi Yoon Pyo Choi Seong Wook Seo Hyuk Woo Lee Chong Hak chae Woo-Kyu Park Hyun Young Kim Daeyoung Jeong Tran Quang De Chang-Seon Myung heeyeong Cho Therapeutics&Biotechnology Division Korea Research Institute of Chemical TechnologyYuseong-guDaejeon 34114Republic of Korea Department of Pharmacology Chungnam National University College of PharmacyYuseong-guDaejeon 34134Republic of Korea Future Medicine Co. Ltd.Rm616 LH-Business Growth CenterSeongnamGyeonggido 13449Republic of Korea Department of Chemistry College of Natural SciencesCan Tho UniversityCan Tho city 9000Viet Nam

Interleukin-1 receptor-associated kinase 4(IRAK4)is a pivotal enzyme in the Toll-like receptor(TLR)/MYD88 dependent signaling pathway,which is highly activated in rheumatoid arthritis tissues and activated B cell-like diffuse large B-cell lymphoma(ABC-DLBCL).Inflammatory responses followed by IRAK4 activation promote B-cell proliferation and aggressiveness of ***,proviral integration site for Moloney murine leukemia virus 1(PIM1)functions as an anti-apoptotic kinase in propagation of ABC-DLBCL with ibrutinib *** developed a dual IRAK4/PIM1 inhibitor KIC-0101 that potently suppresses the NF-κB pathway and proinflammatory cytokine induction in vitro and in *** rheumatoid arthritis mouse models,treatment with KIC-0101 significantly ameliorated cartilage damage and ***-0101 inhibited the nuclear translocation of NF-κB and activation of JAK/STAT pathway in *** addition,KIC-0101 exhibited an anti-tumor effect on ibrutinib-resistant cells by synergistic dual suppression of TLR/MYD88-mediated NF-κB pathway and PIM1 *** results suggest that KIC-0101 is a promising drug candidate for autoimmune diseases and ibrutinib-resistant B-cell lymphomas.

关键词： Drug discovery IRAK4 PIM1 NF-κB pathway Rheumatoid arthritis ABC-DLBCL Ibrutinib resistance Dual inhibitor

Therapeutic potential of Gastrodia elata Blume for the treatment of Alzheimer's disease

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Neural Regeneration Research 2013年第12期8卷 1061-1070页

作者： Guang-Biao Huang Tong Zhao Sushma Shrestha Muna Hong-Mei Jin Jong-Il Park Kyu-Sik Jo Bo-hee Lee Soo-Wan chae Sun-Young Kim Soo-Hyun Park Eun-Ock Park Eun-Kyung Choi Young-Chul Chung Department of Psychiatry Chonbuk National University Medical SchoolJeonju 561-756 Republic of Korea Muju Chunma Native Local Industrial Center Muju 568-844 Republic of Korea Clinical Trial Center for Functional Foods Chonbuk National University HospitalJeonju 561-756 Republic of Korea Department of Pharmacology Chonbuk National University Medical SchoolJeonju 561-756 Republic of Korea

Several studies have demonstrated that the Chinese herb Gastrodia elata Blume can protect against amyloid beta-peptide （Ap）-induced cell death. To investigate the possible therapeutic effects of Gastrodia elata Blume on Alzheimer＇s disease, we established a rat model of AIzheimer＇s disease by injecting A325-35 into bilateral hippocampi. These rats were intragastrically administered 500 or 1 000 mg/kg Gastrodia elata Blume per day for 52 consecutive days. Morris water maze tests showed that Gastrodia elata Blume treatment significantly improved the spatial memory of Alzheimer＇s disease rats. Congo red staining revealed that Gastrodia elata Blume significantly reduced the number of amyloid deposits in the hippocampus of these rats. Western blot analysis showed that choline acetyltransferase expression in the medial septum and hippocampus was significantly increased by the treatment of Gastrodia elata Blume, while EIIman method showed significant decrease in the activity of acetylcholinesterase in all three regions （prefrontal cortex, medial septum and hippocampus）. These findings suggest that long-term administration of Gastrodia elata Blume has therapeutic potential for Alzheimer＇s disease.

关键词： neural regeneration neuroprotective effect Traditional Chinese medicine Gastrodia elata Blume Alzheimer's disease Morris water maze test choline acetyltransferase acetylcholinesterase grants-supported paper neuroregeneration

Electrochemically metal-doped reduced graphene oxide films:Properties and applications

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Journal of Materials Science & Technology 2020年第5期40卷 72-80页

作者： Myung-Sic chae Tae Ho Lee Kyung Rock Son Tae Hoon Park Kyo Seon Hwang Tae Geun Kim School of Electrical Engineering Korea UniversityAnam-ro 145Seongbuk-guSeoul 02841South Korea Department of Clinical Pharmacology and Therapeutics College of MedicineKyung Hee UniversitySeoul 02447South Korea

The fine control of doping levels in graphene materials such as reduced graphene oxide(RGO)is important to properly manipulate their ambipolar transport characteristics for various device ***,conventional doping methods involve complex chemical reactions,large-scale doping processes,and poor ***,a simple and controllable electrochemical doping treatment(EDT),performed via the conductive channels created at the RGO surface by the application of an electric field,is introduced to tailor the electrical properties of RGO films.X-ray photoelectron spectroscopy and Raman spectroscopy measurements are performed to detect the presence of Ni atoms in RGO films after the EDT(EDT-RGO).Then,EDT-RGO field-effect transistors(FETs)are fabricated with different doping areas(0 to 100%fractional area)on the RGO active channel to investigate the effect and selective-area doping capability of the *** to p-type doping compensation by the intercalated Ni atoms,the electron mobility of the EDT-RGO FET decreases from 1.40 to 0.12 cm2 V-1s-1 compared with that of the undoped RGO-FET,leading to the conversion from ambipolar to unipolar p-type transfer characteristics.

关键词： Reduced graphene oxide Electrochemical doping treatment Electrical breakdown process Field-effect transistor

Inhibitory Effect of Epigallocatechin-3-gallate on Angiotensin Ⅱ-Induced Expression of Adhesion Molecules in Vascular Endothelial Cells.

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Inhibitory Effect of Epigallocatechin-3-gallate on Angiotens...

Effect of Silane Coupling Agent on the Flexural Property of Glass Fiber Reinforced Composite Film

第十五届国际药理学大会

作者： hee-Yul Ahn Yeon Jeong chae Seok hee Yun Hun Sik Kim Hao Jia Chan Hyung Kim Department of Pharmacology College of MedicineChungbuk National University Cheongju South Korea Department of Pharmacology College of MedicineChungbuk National University Cheongju South Korea Department of Pharmacology College of MedicineChungbuk National University Cheongju South Korea Department of Pharmacology College of MedicineChungbuk National University Cheongju South Korea Department of Pharmacology College of MedicineChungbuk National University Cheongju South Korea Department of Pharmacology College of MedicineChungbuk National University Cheongju South Korea

＜正＞ Attachment of leukocytes to the vascular endothelium and the subsequent migration of cells into the vessel wall are early events in atherogenesis. Expression of endothelial adhesion molecules play an important role in this process. In the present study, we tested the effect of Epigllocatechin-3-gallate （ EGCG） on proatherogenic agent, angiotensin Ⅱ （Ang Ⅱ）-induced expression of adhesion molecules in vascular endothelial cells. We showed that EGCG inhibits Ang Li-stimulated VCAM-1 and ICAM-1 expression in HUVECs. Inhibition of Ang Ⅱ-in-duced adhesion molecules expression was manifested already on the transcriptional level. EGCG pretreatment inhibited Ang Ⅱ-stimulated activation of p38 MAPK and ERK 1/2. while EGCG did not exert any significant changes in activation of c-Jun N-terminal kinase （JNK）. In addition, a specific p38 MAPK inhibitor, SB202190 or ERK 1/2 inhibitor, PD98059, suppressed Ang Ⅱ-stimulated VCAM-1 and ICAM-1 expression. Conclusion: These results suggest that EGCG inhibits Ang Ⅱ-induced adhesion molecules expression, which is regulated by p38 MAPK and ERK 1/2 signaling pathways

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Journal of Materials Science and Chemical Engineering 2014年第10期2卷 38-42页

作者： Hye-Hyun Kim Si-Young Kim Dae-hee Kim chae-Young Oh Nam-Ju Jo Department of Polymer Science & Engineering Pusan National University Busan Korea

Transparent glass fiber reinforced composites films ware fabricated by UV light induced chemical crosslinking of composite materials consisting of glass fiber and UV curable resin in film state. In order to apply film to flexible device, excellent flexural property is required, then the delamination should not occurred between glass fiber and UV curable resin when film is bent. To minimize delamination and improve the interfacial adhesion at interface between glass fiber and UV curable resin, the γ-aminopropyl triethoxy silane and γ-glycid oxypropyl trimethoxy silane were applied for the surface treatment of glass fibers. Silanization of glass fiber surface was checked by scanning electron microscopy and the degree of delamination of composite film was confirmed through the bending test, ASTEM290-96a, used by haze meter.

关键词： Glass Fiber Silane UV Curable Resin Composite Flexural Property Haze