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Liver cirrhosis and diabetes:Risk factors,pathophysiology,clinical implications and management

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World Journal of Gastroenterology 2009年第3期15卷 280-288页

作者： Diego Garcia-Compean Joel Omar Jaquez-Quintana Jose Alberto Gonzalez-Gonzalez hector maldonado-garza Department of Gastroenterology Faculty of MedicineUniversity HospitalAve Madero y GonzalitosCol Mitras CentroMonterrey 64700Mexico

About 30% of patients with cirrhosis have diabetes mellitus(DM).Nowadays,it is a matter for debate whether type 2 DM in the absence of obesity and hypertriglyceridemia may be a risk factor for chronic liver ***,which develops as a complication of cirrhosis,is known as "hepatogenous diabetes".Insulin resistance in muscular and adipose tissues and hyperinsulinemia seem to be the pathophysiologic bases of diabetes in liver *** impaired response of the islet β-cells of the pancreas and hepatic insulin resistance are also contributory ***-alcoholic fatty liver disease,alcoholic cirrhosis,chronic hepatitis C(CHC) and hemochromatosis are more frequently associated with *** resistance increases the failure of the response to treatment in patients with CHC and enhances progression of *** in cirrhotic patients may be *** diabetes is clinically different from that of type 2 DM,since it is less frequently associated with microangiopathy and patients more frequently suffer complications of *** increases the mortality of cirrhotic *** of the diabetes is complex due to liver damage and hepatotoxicity of oral hypoglycemic *** manuscript will review evidence that exists in relation to:type 2 DM alone or as part of the metabolic syndrome in the development of liver disease;factors involved in the genesis of hepatogenous diabetes;the impact of DM on the clinical outcome of liver disease;the management of DM in cirrhotic patients and the role of DM as a risk factor for the occurrence and exacerbation of hepatocellular carcinoma.

关键词： Insulin resistance Type 2 diabetes mellitus Liver cirrhosis Hepatocellular carcinoma Chronic hepatitis C

Direct pre-differentiation of rat mesenchymal stem cells into dopaminergic cells

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Stem Cell Discovery 2013年第2期3卷 133-138页

作者： Judith Zavala-Arcos Maria Teresa Gonzalez-garza Janet Gutierrez-Alcala hector R. Martinez Jorge E. Moreno-Cuevas Servicio de Terapia Celular School of Medine and Health CITES Tecnológico de Monterrey Monterrey México

The use of stem cells has been proposed as an alternative treatment for certain neurodegenerative disorders. It has also been suggested that in the pre-differentiated state, stem cells might provide a better therapeutic option than cells that are undifferentiated or fully differentiated. The purpose of this study was to develop a protocol aimed at reducing the incubation time required to induce the conversion of rat mesenchymal stem cells into immature dopaminergic neurons. Stem cells obtained from rat bone marrow were incubated in a control or induction media for 2-24 h. Cells incubated for 24 h in induction medium demonstrated an increase on the levels of the neuronal protein markers nestin, glial fibrillary acid protein, and β-tubulin III, as well as increases in the expression of Pax3, EN1, Thy1.1, and GEF10 genes. This manuscript presents evidence that adult mesenchymal cells are capable to respond, in a short time period, to a neuroinduction medium, and give raise to pre-differentiated neuron like cells representing an alternative for Parkinson disease cell therapy transplantation.

关键词： Cell Differentiation Dopamine Producing Cells Neuro-Differentiation Parkinson’s Disease Stem Cells

Spectrally resolved Hong-Ou-Mandel interferometry for quantum-optical coherence tomography

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Photonics Research 2020年第6期8卷 1023-1034页

作者： PABLO YEPIZ-GRACIANO ALI MICHEL ANGULO MARTINEZ DORILIAN LOPEZ-MAGO hector CRUZ-RAMIREZ ALFRED B.U'REN Instituto de Ciencias Nucleares Universidad Naciona/Autonoma de MexicoApdo.Postal 70-543Ciudad de Mexico 04510Mexico Tecnologico de Monterrey Escuela de Ingenieria y CienciasAve.Eugenio Garza Sada 2501MonterreyN.L.64849Mexico

In this paper,we revisit the well-known Hong_Ou-Mandel(HOM)effect in which two photons,which meet at a beamsplitter,can interfere destructively,leading to null in coincidence *** a standard HOM measurement,the coincidence counts across the two output ports of the beamsplitter are monitored as the temporal delay be-tween the two photons prior to the beamsplitter is varied,resulting in the well-known HOM *** show,both theoretically and experimentally,that by leaving the delay fixed at a particular value while relying on spectrally resolved coincidence photon counting,we can reconstruct the HOM dip,which would have been obtained through a standard delay-scanning,non-spectrally resolved HOM *** show that our numerical reconstruction procedure exhibits a novel dispersion cancellation effect,to all *** discuss how our present work can lead to a drastic reduction in the time required to acquire a HOM interferogram,and specifically discuss how this could be of particular importance for the implementation of fficient quantum optical coherence tomog-raphy devices.

关键词： resolved coincidence quantum

Evaluation of Native Strains of Isaria fumosorosea （Wize） Against Anastrepha ludens （Loew）（Diptera： Tephritidae）

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Journal of Life Sciences 2012年第8期6卷 957-960页

作者： Fatima Lizeth Gandarilla-Pacheco hector Daniel Nava-Gonzalez Katiushka Arevalo-Nifio Luis JesusGalan-Wong Myriam Elias-Santos Isela Quintero-Zapata Instituto de Biotecnologla Facultad de Ciencias Biol6gicas Universidad Aut6noma de Nuevo Le6n San Nicolas de los GarzaN.L. 66450 Mdxico

We evaluated the pathogenicity of six strains 1. fumosorosea to determine their potential as biological control agents of A. ludens by performing bioassays under laboratory conditions （25 ± 2 ℃, 60± 5% R.H and 12：12 h L： D） exposing larvae and pupae to a concentration of 1 × 10^8 conidia per milliliter using three different methods： direct spraying, spray of soil and submerged for both instars. The results showed that direct spraying method Pfr-612 strain showed the highest mortality （47%） in pupae while for larvae was strain HIB-27 to 46%. Regarding spray of soil Pfr-612 strain showed the highest percentage of mortality for pupae and larvae with 45 and 57% mortality, respectively. Finally, for the submerged method in pupae HIB-27 strain showed 62% mortality whereas in larvae HIB-32 strain showed 46%. These results indicate that A. ludens is susceptible in at least two instars to L fumosorosea and make this fungus a promising agent for control of the Mexican fruit fly.

关键词： A. ludens biological control entomopathogenic fungi L fumosorosea.

Panda X-III： Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers

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Science China(Physics,Mechanics & Astronomy) 2017年第6期60卷 8-47页

作者： Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan NPAC and Department of Physics and Astronomy Shanghai Jiao Tong University Shanghai Laboratory for Particle Physics and Cosmology Shanghai 200240 China College of Physical Science and Technology Central China Normal University Wuhan 430079 China China Institute of Atomic Energy Beijing 102413 China School of Physics Peking University Beijing 100871 China School of Physics and Key Laboratory of Particle Physics and Particle Irradiation (MOE) Shandong University Jinan 250100 China School of Physics and Engineering Sun Yat-Sen University Guangzhou 510275 China Department of Modern Physics University of Science and Technology of China Hefei 230026 China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of China Hefei 230026 China University ofZaragoza C/P Cerbuna 12 50009 Zaragoza Spain IRFU CEA Universite Paris-Saclay F-91191 Gif-sur-Yvette France Department of Physics University of Maryland College Park MD 20742 USA Nuclear Science Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA Center for Excellence in High Energy Physics and Astrophysics Suranaree University of Technology Nakhon Ratchasima 30000 Thailand

Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation *** X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 *** pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the *** signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial *** detector will be immersed in a large water tank to ensure～5 m of water shielding in all *** second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds.

关键词： neutrinoless double beta decay lepton number violation underground experiment TPC Micromegas