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Sec-Auditor:A Blockchain-Based Data Auditing Solution for Ensuring Integrity and Semantic Correctness

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Computers, Materials & Continua 2024年第8期80卷 2121-2137页

作者： Guodong Han hecheng li College of Computer Qinghai Normal UniversityXining810008China

Currently,there is a growing trend among users to store their data in the ***,the cloud is vulnerable to persistent data corruption risks arising from equipment failures and hacker ***,when users perform file operations,the semantic integrity of the data can be *** both data integrity and semantic correctness has become a critical issue that requires *** introduce a pioneering solution called Sec-Auditor,the first of its kind with the ability to verify data integrity and semantic correctness simultaneously,while maintaining a constant communication cost independent of the audited data ***-Auditor also supports public auditing,enabling anyone with access to public information to conduct data *** feature makes Sec-Auditor highly adaptable to open data environments,such as the *** Sec-Auditor,users are assigned specific rules that are utilized to verify the accuracy of data ***,users are given the flexibility to update their own rules as *** conduct in-depth analyses of the correctness and security of *** also compare several important security attributes with existing schemes,demonstrating the superior properties of *** results demonstrate that even for time-consuming file upload operations,our solution is more efficient than the comparison one.

关键词： Provable data possession public auditing cloud storage data integrity semantic correctness

Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials

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Signal Transduction and Targeted Therapy 2022年第11期7卷 4090-4117页

作者： Zhenyi Niu Runsen Jin Yan Zhang hecheng li Department of Thoracic Surgery Ruijin HospitalShanghai Jiao Tong University School of Medicine197 Ruijin 2nd RoadShanghaiChina Department of Immunology and Microbiology Shanghai Jiao Tong University School of Medicine280 South Chongqing RoadShanghaiChina

Lung cancer is the leading cause of cancer-related death across the *** lung adenocarcinoma,patients with lung squamous cell carcinoma(LSCC)have not benefitted from targeted *** immunotherapy has significantly improved cancer patients’outcomes,the relatively low response rate and severe adverse events hinder the clinical application of this promising treatment in ***,it is of vital importance to have a better understanding of the mechanisms underlying the pathogenesis of LSCC as well as the inner connection among different signaling pathways,which will surely provide opportunities for more effective therapeutic interventions for *** this review,new insights were given about classical signaling pathways which have been proved in other cancer types but not in LSCC,including PI3K signaling pathway,VEGF/VEGFR signaling,and CDK4/6 *** signaling pathways which may have therapeutic potentials in LSCC were also discussed,including the FGFR1 pathway,EGFR pathway,and KEAP1/NRF2 ***,chromosome 3q,which harbors two key squamous differentiation markers SOX2 and TP63 is discussed as well as its related potential therapeutic *** also provided some progress of LSCC in epigenetic therapies and immune checkpoints blockade(ICB)***,we outlined some combination strategies of ICB therapies and other targeted ***,prospects and challenges were given related to the exploration and application of novel therapeutic strategies for LSCC.

关键词： therapies squamous targeted

Group Decision-Making Method with Incomplete Intuitionistic Fuzzy Preference Relations Based on a Generalized Multiplicative Consistent Concept

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Computer Modeling in Engineering & Sciences 2022年第9期132卷 881-907页

作者： Xiaoyun Lu Jiuying Dong hecheng li Shuping Wan School of Computer Science Qinghai Normal UniversityXining810008China School of Science Shanghai Institute of TechnologyShanghai201418China School of Statistics Jiangxi University of Finance and EconomicsNanchang330013China School of Information Technology Jiangxi University of Finance and EconomicsNanchang330013China

Based on the analyses of existing preference group decision-making(PGDM)methods with intuitionistic fuzzy preference relations(IFPRs),we present a new PGDM framework with incomplete IFPRs.A generalized multiplicative consistent for IFPRs is defined,and a mathematical programming model is constructed to supplement the missing values in incomplete ***,in this study,another mathematical programming model is constructed to improve the consistency level of unacceptably multiplicative consistent *** group decisionmaking(GDM)with incomplete IFPRs,three reliable sources influencing the weights of experts are ***,a method for determining the weights of experts is developed by simultaneously considering three reliable ***,a targeted consensus process(CPR)is developed in this study with reference to the actual situation of the consensus level of each ***,in response to the proposed multiplicative consistency definition,a novel method for determining the optimal priority weights of alternatives is ***,based on the above theory,a novel GDM method with incomplete IFPRs is developed,and the comparative and sensitivity analysis results demonstrate the utility and superiority of this work.

关键词： Intuitionistic fuzzy preference relations multiplicative consistency consensus optimization model group decision-making

Molecular heterogeneity of anti-PD-1/PD-L1 immunotherapy efficacy is correlated with tumor immune microenvironment in East Asian patients with non-small cell lung cancer

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Cancer Biology & Medicine 2020年第3期17卷 768-781页

作者： Runsen Jin Chengming liu Sufei Zheng Xinfeng Wang Xiaoli Feng hecheng li Nan Sun Jie He Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Thoracic Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective:The aim of this study was to investigate how the tumor immune microenvironment differs regarding tumor genomics,as well as its impact on prognoses and responses to immunotherapy in East Asian patients with non-small cell lung cancer(NSCLC).Methods:We performed an integrated analysis using publicly available data to identify associations between anti-programmed death 1(PD-1)/programmed death-ligand 1(PD-L1)immunotherapy efficacy and classic driver oncogene mutations in East Asian NSCLC *** pooled and clinical cohort analyses were used to correlate driver oncogene mutation status and tumor microenvironment based on PD-L1 and CD8+tumor-infiltrating lymphocytes(TILs).Immune infiltrating patterns were also established for genomic NSCLC subgroups using the CIBERSORT ***:Based on East Asian NSCLC patients,TIDE analyses revealed that for anti-PD-1/PD-L1 immunotherapy,epidermal growth factor receptor(EGFR)-mutant and anaplastic lymphoma kinase(ALK)-rearranged tumors yielded inferior responses;however,although Kirsten rat sarcoma viral oncogene homolog(KRAS)-mutant tumors responded better,the difference was not statistically significant(EGFR:P=0.037;ALK:Plinical cohort analyses demonstrated tumor immune microenvironment heterogeneities correlated with oncogenic *** results showed remarkably higher PD-L1-and TIL-positive KRAS-mutant tumors,suggesting KRAS mutations may drive an inflammatory phenotype with adaptive immune ***,the EGFR-mutant or ALK-rearranged groups showed a remarkably higher proportion of PD-L1-/TIL-tumors,suggesting an uninflamed phenotype with immunological ***,similar to triple wild-type NSCLC tumors,EGFR L858R-mutant tumors positively correlated with an inflammatory phenotype,suggesting responsiveness to anti-PD-1/PD-L1 immunotherapy(P<0.05).Furthermore,the CIBERSORT algorithm results revealed that EGFR-mutant and ALK-rearranged tumors were characterize

关键词： NSCLC East Asian oncogene mutations PD-1/PD-L1 inhibitors immune microenvironment

Pluralistic Efficiency-Equity Tradeoffs in Locating Public Services

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Journal of Systems Science and Information 2014年第2期2卷 130-143页

作者： Lei FANG hecheng li Nankai University Department of Mathematics Qinghai Normal University Business School

Aside from efficiency, equity is a particularly salient objective in siting public *** this paper, we develop and test a bicriteria mixed integer program that trades off the efficiency and equity measures between an individual and the group. Individual efficiency is measured by data envelopment analysis(DEA) while individual equity is modeled by a center location model. On the other hand, group efficiency is measured by the median location model, while group equity is measured by the Gini coefficient. Available computational results suggest that the multicriteria model provides a promising approach to locate public services in a pluralistic society, when the individual rights are often weighed against common good.

关键词： efficiency data envelopment analysis equity median center

Treatmentsforresectableesophageal cancer:from traditional systemic therapy to immunotherapy

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Chinese Medical Journal 2022年第18期135卷 2143-2156页

作者： Yan Yan Xijia Feng Chengqiang li Toni Leru hecheng li Shanghai Jjao Tong University School of Medicine Shanghai 200025China Department of Thoracic Surgery Rujin Hospital Afliated to Shanghai Jjao Tong University School of MedicineShanghai 200025China Department of Thoracic Surgery University Hospital GasthuisbergUniversity of LeuvenLeuven 3000Belgium

Esophageal cancer(EC)has a high incidence and poor *** two major histological types,squamous cell carcinoma and adenocarcinoma,differ in their epidemiology and treatment *** with locally advanced EC benefit from multimodal therapy concepts including neoadjuvant chemotherapy,neoadjuvant chemoradiotherapy,and perioperative ***,immunotherapy for the solid tumor is a hot *** with adjuvant immune checkpoint inhibitors(ICIs)is the first immunotherapy for resectable EC listed in the latest National Comprehensive Cancer Network Guidelines for the Esophageal and Esophagogastric Junction *** clinical trials have established ICIs for three treatment models of resectable *** short-term results demonstrated ideal efficacy and tolerable toxicity,though some concerns *** review summarizes the novel data on the ICIs for resectable EC and lists the registered related clinical ***,this review can provide a reference for ongoing research on the treatment options for resectable EC.

关键词： Esophageal cancer Immune checkpoint inhibitor Immunotherapy

An Evolutionary Algorithm Based on a New Decomposition Scheme for Nonlinear Bilevel Programming Problems

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International Journal of Communications, Network and System Sciences 2010年第1期3卷 87-93页

作者： hecheng li Yuping WANG 不详

In this paper, we focus on a class of nonlinear bilevel programming problems where the follower’s objective is a function of the linear expression of all variables, and the follower’s constraint functions are convex with respect to the follower’s variables. First, based on the features of the follower’s problem, we give a new decomposition scheme by which the follower’s optimal solution can be obtained easily. Then, to solve efficiently this class of problems by using evolutionary algorithm, novel evolutionary operators are designed by considering the best individuals and the diversity of individuals in the populations. Finally, based on these techniques, a new evolutionary algorithm is proposed. The numerical results on 20 test problems illustrate that the proposed algorithm is efficient and stable.

关键词： Nonlinear Bilevel Programming Decomposition Scheme Evolutionary Algorithm Optimal Solutions

符码:想象的公共表象——以维科、阿伦特为中心论心性#1#秩序的融合是如何可能的

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文艺理论研究 2017年第4期37卷 151-160页

作者：李河成陕西师范大学哲学与政府管理学院哲学博士后科研流动站

作为想象的公共表象,符码可以为心性—秩序、个人—社会的融合提供一种分析范例。维科的民政神学,通过"想象性的类概念"和"以己度物的比喻",阐释了人类共同意识的起源,展现了诗性智慧对于共同体的心体意义。这对主体性哲学分化表象与存... 详细信息

作为想象的公共表象,符码可以为心性—秩序、个人—社会的融合提供一种分析范例。维科的民政神学,通过"想象性的类概念"和"以己度物的比喻",阐释了人类共同意识的起源,展现了诗性智慧对于共同体的心体意义。这对主体性哲学分化表象与存在的趋向具有批判性意义;阿伦特关于"范例"的观念通过特殊表象的交互共通而将具体与普遍相连接,从而达致可公度性的效力。这提供了理解想象机制如何由审美感通(心体)走向社会共通的路径。想象符码"亲在—绽现(Dasein-ekstasis)"的存在样态不同于说教、规训的知识论策略在于:符码历史生发于"共同意识"和"公共交往",植根于对个体生命的提升以及与他者的融通,借以展现了审美共通感的公共哲学意义。

关键词：想象符码公共表象是其应是审美共通感心性秩序

Development and characterization of urethral stricture model in rabbits

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Journal of Medical Colleges of PLA(China) 2010年第6期25卷 351-358页

作者： Fu Delai Wang Ziming Chong Tie li hecheng Zhang Huibo Zhang Peng Gan Weimin Department of Urology Second Affiliated Hospital School of Medicine Xi 'an Jiaotong University Xi 'an 710004 China Department of Urology Affiliated Hospital of Shaanxi Traditional Chinese Medical College Xianyang 712000 China

Objective： To establish an experimental model of urethral stricture in rabbits. Methods： A total of 21 adult male New Zealand rabbits were included into group. After intravenous anesthesia, urethroscopy was performed with a pediatric resectoscope （F13）. Fifteen animals were randomly selected as the study group. A lcm-long circumferential electrocoagulation of the bulbar urethra was performed to these animals until ulceration of the mucosa. The remaining 6 animals underwent video urethroscopy without electrocoagulation, serving as controls. On the 30th day, retrograde urethrogram and urethroscopy were performed to evaluate urethral stricture formation, histological examinations （HE and Sirius Red staining） were done to assess urethral pathological change. Results： Two rabbits in study group died and no death occurred in controls. Based on urethrogram and urethroscopy, no rabbits in control group developed urethral stricture, while significant stricture formation was observed in every case of the study group. Histological examination showed a normal urethra in control cases, while at stricture site of the study group extensive fibrosis of muscle and submucous tis High collagen expression in fibrosis tissue was assayed sue by was observed with a large number of fibroblasts infiltration Sirius Red staining. Conclusion： A lcm-long endoscopic electrocoagulation can successfully induce urethral stricture formation in rabbit models. This method offers an ideal animal model for the fundamental and clinical study of urethral stricture

关键词： Urethral stricture Animal model Rabbits