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Phase II study of novel orally PI3Kα/δinhibitor TQ-B3525 in relapsed and/or refractory follicular lymphoma

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2193-2201页

作者： Huaqing Wang Jifeng Feng Yanyan Liu Zhengzi Qian Da Gao Xuehong Ran Hui zhou Lihong Liu Binghua Wang Meiyun Fang hebing zhou Zhenqian Huang Shi Tao Zhuowen Chen Liping Su Hang Su Yu Yang Xiaobao Xie Huijing Wu Ping Sun Guoyu Hu Aibin Liang Zhiming Li Department of Oncology Tianjin Union Medical Center of Nankai UniversityTianjin 300121PR China The Institute of Translational Medicine Tianjin Union Medical Center of Nankai UniversityTianjin 300121PR China Department of Medical Oncology Jiangsu Cancer HospitalThe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009PR China Department of Medical Oncology Henan Cancer HospitalThe Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003PR China Department of Medical Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060PR China Department of Hematology The Affiliated Hospital of Inner Mongolia Medical College010050 HohhotPR China Department of Hematology Weifang People’s HospitalThe First Affiliated Hospital of Weifang Medical University261000 WeifangPR China Department of Lymphoma&Hematology Hunan Cancer HospitalThe Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University410013 ChangshaPR China Department of Hematology The Fourth Hospital of Hebei Medical University and Hebei Tumor Hospital050011 ShijiazhuangPR China Department of Lymphoma Weihai Central Hospital264400 WeihaiPR China Department of Hematology and Rheumatology The Affiliated Zhongshan Hospital of Dalian University116001 DalianPR China Department of Hematology Beijing Luhe Hospital101199 BeijingPR China Department of Hematology The First Affiliated Hospital of Guangzhou Medical University510120 GuangzhouPR China Department of Hematology The First Affiliated Hospital of Hainan Medical College570102 HaikouPR China Department of Hematology The First People’s Hospital of Foshan528000 FoshanPR China Department of Hematology Shanxi Cancer Hospital030013 TaiyuanPR China Department of Lymphoma Senior Department of HematologyThe Fifth Medical Center of Chinese PLA General Hospital100039 BeijingPR China Department of Lymphoma and Head and Neck Cancer Fujian Cancer Hospital350014 FuzhouPR China Department of Hematology The First People’s Hospit

This registration study assessed clinical outcomes of TQ-B3525,the dual phosphatidylinositol-3-kinase(PI3K)α/δinhibitor,in relapsed and/or refractory follicular lymphoma(R/R FL).This phase II study(*** *** March 27,2020)comprised run-in stage and stage 2.R/R FL patients after≥2 lines therapies received oral 20 mg TQ-B3525 once daily in a 28-day cycle until intolerable toxicity or disease *** endpoint was independent review committee(IRC)-assessed objective response rate(ORR).Based on results(ORR,88.0%;duration of response[DOR],11.8 months;progression-free survival[PFS],12.0 months)in 25 patients at run-in stage,second stage study was initiated and included 82 patients for efficacy/safety *** received prior-line(median,3)therapies,with 56.1%refractory to previous last therapies;73.2%experienced POD24 at *** stage 2,ORR was 86.6%(71/82;95%CI,77.3-93.1%),with 28(34.2%)complete *** control rate was 95.1%due to 7(8.5%)stable *** time to response was 1.8 *** 71 responders,median DOR was not reached;18-month DOR rate was 51.6%.with median follow-up of 13.3 months,median PFS was 18.5(95%CI,10.2-not estimable)*** overall survival(OS)was not reached by cutoff date;24-month OS rate was estimated as 86.1%.Response rates and survival data were consistent across all *** 3 or higher treatment-related adverse events were observed in 63(76.8%)cases,with neutropenia(22.0%),hyperglycemia(19.5%),and diarrhea(13.4%)being ***-B3525 showed favorable efficacy and safety for R/R FL patients after≥2 lines prior therapies.

关键词： lymphoma assessed initiated

Revealing the critical effect of solid electrolyte interphase on the deposition and detriment of Co(Ⅱ) ions to graphite anode

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Journal of Energy Chemistry 2022年第6期31卷 389-396,I0011页

作者： Qiming Xie Jiawei Chen Lidan Xing Xianggui zhou Zekai Ma Binhong Wu Yilong Lin hebing zhou Weishan Li China National and Local Joint Engineering Research Center of MPTES in High Energy andSafety LIBs Engineering Research Center of MTEES(Ministry of Education)Research Center of BMET(Guangdong Province).Schoolof Chemistry.South China Normal University.Guangzhou 510006.Guangdong.China

"Dissolution,migration,and deposition"of transition metal ions (TMIs) result in capacity degradation of lithium-ion batteries (LIBs).Understanding such detrimental mechanism of TMIs is critical to the development of LIBs with long cycle *** most previous works,TMIs were directly introduced into the electrolyte to investigate such a detrimental *** these cases,the TMIs are deposited directly on the fresh anode ***,in the practical battery system,the TMIs are deposited on the anode covered with solid electrolyte interphase (SEI) *** the pre-presence of SEI film on anode surface influences the deposition and detriment of TMIs is *** this work,the deposition of Co element on graphite anode with and without SEI film were systematically *** results clearly show that,in comparison with that of fresh graphite (SEI-free),the presence of SEI film aggravates the deposition of Co ions due to the Li^(+)–Co^(2+) ion exchange between the SEI and Co^(2+)-containing electrolyte without the driving of the electric field,leading to faster capacity fading of graphite ***,how to regulate electrolytes and film-forming additives to design the components of SEI and prevent its exchange with TMIs,is a crucial way to inhibit the deposition and detriment of TMIs on graphite anode.

关键词： Lithium-ion batteries Transition metal ions Ion exchange Graphite anode SEI film

免疫表型在鉴别急性早幼粒细胞白血病与HLA-DR阴性急性髓系白血病中的应用

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临床检验杂志 2024年第4期42卷 272-276页

作者：郜伟峰单志娟周一平裴新蕊杨玉侯艳军周合冰首都医科大学附属北京潞河医院血液科北京101149

目的探讨免疫表型在急性早幼粒细胞白血病(APL)和HLA-DR阴性的急性髓系白血病(AML)之间的鉴别诊断中的价值。方法回顾性研究2014年至2024年间收治的42例APL患者和28例初治及复发的HLA-DR阴性AML患者。通过流式细胞免疫表型分析,比较两... 详细信息

目的探讨免疫表型在急性早幼粒细胞白血病(APL)和HLA-DR阴性的急性髓系白血病(AML)之间的鉴别诊断中的价值。方法回顾性研究2014年至2024年间收治的42例APL患者和28例初治及复发的HLA-DR阴性AML患者。通过流式细胞免疫表型分析,比较两组患者CD64、MPO、CD7、CD11c、CD9、CD123等抗原的阳性表达率。利用χ2检验进行统计学分析,并应用ROC曲线评估CD9和CD123的表达模式,以及CD64^(+)MPO^(+)CD7^(-)CD11c^(-)对APL的诊断价值。结果AML组患者的CD64、CD9、MPO阳性率显著低于APL组,而CD11c、CD7阳性率显著高于APL组,差异具有统计学意义(P<0.05)。CD64^(+)MPO^(+)CD7^(-)CD11c^(-)的综合抗原积分表达模式在鉴别诊断APL方面的ROC曲线下面积(AUC^(ROC))为0.859,敏感性为93.8%,特异性为75.0%,CD9/CD123的鉴别诊断APL的AUC^(ROC)为0.919,敏感性为83.3%,特异性为84.0%;而联合应用CD9/CD123和综合抗原积分的诊断模式,AUC^(ROC)为0.955,敏感性为83.3%,特异性为100%。结论CD9/CD123表达模式及CD64^(+)MPO^(+)CD7^(-)CD11c^(-)联合应用可作为鉴别诊断APL与HLA-DR阴性的AML的重要依据.

关键词：急性早幼粒细胞白血病 HLA-DR阴性急性髓系白血病流式细胞术 CD123 CD9

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DxH900血细胞分析仪性能及报警评价

标记免疫分析与临床 2024年第5期31卷 931-935页

作者：郜伟峰单志娟杨玉周一平裴新蕊侯艳军周合冰首都医科大学附属北京潞河医院血液科北京101149

目的评价DxH900血细胞分析仪性能及报警信息。方法参照《WS/T 406-2012临床血液学检验常规项目分析质量要求》,对DxH900血细胞分析仪进行性能验证;评价白细胞分类性能及异常细胞报警信息有效性。结果DxH900测定RBC、Hb和MCV的批内及批... 详细信息

目的评价DxH900血细胞分析仪性能及报警信息。方法参照《WS/T 406-2012临床血液学检验常规项目分析质量要求》,对DxH900血细胞分析仪进行性能验证;评价白细胞分类性能及异常细胞报警信息有效性。结果DxH900测定RBC、Hb和MCV的批内及批间精密度(CV)均≤1.0%,WBC和PLT的批内CV≤2.0%,批间CV≤1.6%。WBC、RBC、Hb和MCV准确度偏差≤5.4%,PLT的偏差≤14%。WBC、RBC、Hb和PLT的携带污染率≤0.45%,以上4项在临床标本覆盖浓度范围内,斜率在1±0.03以内,且R^(2)>0.99;以显微镜镜检为“金标准”,白细胞分类与显微镜镜检结果相比,中性粒细胞、淋巴细胞和嗜酸粒细胞的相关性较好(r分别为0.913、0.897和0.728,P<0.01),其次为单核细胞及嗜碱性粒细胞(r分别为0.586,0.588,P<0.01);发现异型淋巴细胞及淋巴增殖性疾病的灵敏度达100%,阴性预测值100%;当WBC≥4.0×10^(9)/L时,原始细胞报警灵敏度达100%,阴性预测值100%。结论DxH900血细胞分析仪各项性能良好,符合WS/T406-2012文件要求,适用于临床标本检测,尤其适用于血液系统疾病的筛查。

关键词： DxH900血细胞分析仪性能评价白细胞分类

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人细小病毒B19感染4例报道并文献复习

标记免疫分析与临床 2024年第4期31卷 781-784页

作者：郜伟峰单志娟周一平裴新蕊侯艳军杨玉张越周合冰首都医科大学附属北京潞河医院血液科北京101149

人类细小病毒B19感染可诱发免疫功能低下的患者发生传染性红斑、关节痛、贫血和其他血细胞减少。本文报告4例由骨髓细胞涂片检查发现,并通过PCR方法确诊的人类细小病毒B19感染病例。

关键词：细小病毒B19 贫血骨髓细胞形态核内包涵体

Treatment patterns and a prognostic scoring system for elderly acute myeloid leukemia patients:a retrospective multicenter cohort study in China

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Cancer Biology & Medicine 2022年第6期19卷 871-883页

作者： Chunli Zhang Wei Wan Shuai Zhang Jingwen Wang Ru Feng Jiangtao Li Junyue Chai hebing zhou Liru Wang Yuping Zhong Xiaodong Mo Mengzhu Shen Hongmei Jing Hui Liu Department of Hematology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Department of Hematology Peking University Third HospitalBeijing 100191China Department of Hematology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Hematology Beijing No.6 HospitalBeijing 100007China Department of Hematology Beijing Luhe HospitalCapital Medical UniversityBeijing 101100China Department of Hematology Fuxing HospitalCapital Medical UniversityBeijing 100038China Department of Hematology Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100043China Peking University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044China

Objective:Acute myeloid leukemia(AML)is primarily a malignant disorder affecting the *** aimed to compare the outcomes of different treatment patterns in elderly AML patients and to propose a prognostic scoring system that could predict survival and aid therapeutic ***:Patients aged≥60 years who had been diagnosed with AML at 7 hospitals in China were enrolled(n=228).Treatment patterns included standard chemotherapy,low intensity therapy,and best supportive care(BSC).Results:The early mortality rates were 31%,6.8%,and 6.3%for the BSC,low intensity therapy,and standard chemotherapy groups,*** complete remission rate of the standard chemotherapy group was higher than that of the low intensity therapy *** median overall survival(OS)was 561 days and 222 days for the standard chemotherapy and low intensity therapy groups,respectively,and were both longer than that of the BSC group(86 days).Based on multivariate analyses,we defined a prognostic scoring system that enabled classification of patients into 3 risk groups,in an attempt to predict the OS of patients receiving chemotherapies and low intensity *** and intermediate risk patients benefited more from standard chemotherapies than from low intensity ***,the median OS was comparable between standard chemotherapies and low intensity therapies in high risk ***:Our prognostic scoring system could predict survival and help select appropriate therapies for elderly AML *** chemotherapy is important for elderly AML patients,particularly for those categorized into low and intermediate risk groups.

关键词： Acute myeloid leukemia chemotherapy comorbidity elderly geriatric assessment

Highly stabilized and lowly polarized Li anodes using a hybrid surface film with inner Li–Zn nucleation sites and outer LiF-rich protection texture

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Science China Materials 2022年第7期65卷 1779-1788页

作者： Dehui Zhang Zihao Li Huirong Wang Wenguang Zhang Yanxia Che Xiaoyan Lin Shumian Ding Xiaoming Wei hebing zhou Weishan Li School of Chemistry South China Normal UniversityGuangzhou 510006China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China National and Local Joint Engineering Research Center of MPTES in High Energy and Safety LIBs Engineering Research Center of MTEES(Ministry of Education)and Key Lab of ETESPG(GHEI)South China Normal UniversityGuangzhou 510006China

Lithium(Li)metal is the most promising anode for improving the energy density of currently commercialized Li-ion ***,its practical application is limited due to its high reactivity to electrolytes,which induces severe electrolyte decomposition and Li-dendrite *** are usually constructed on Li anode to address the above ***,it is a big challenge to balance the stability and plating/stripping overpotential of Li *** this work,we report a novel strategy for constructing a highly stable and lowly polarized surface film on Li anode.A chemically and structurally unique film is formed by simply dropping a zinc trifluoromethanesulfonate[Zn(OTF)_(2)]and fluoroethylene carbonate(FEC)-containing solution onto Li *** unique film consists of inner nucleation sites and outer protection textures,mainly containing Li–Zn alloy and LiF/polymer,*** former results from the preferential reduction of Zn(OTF)_(2),providing nucleation sites with low polarization for Li plating/*** contrast,the latter arises from the subsequent reduction of FEC,providing protection for the underneath Li–Zn alloy and Li metal and ensuring the stability of Li *** Li anode with such a unique surface film exhibits excellent cycling stability and low plating/stripping overpotentials,which have been demonstrated using Li//Li symmetric and Li//LiFePO_(4)full cells.

关键词： Li anode cycling stability plating/stripping overpotential surface film

Insight into the interaction between Ni-rich LiNi0.8Co0.1Mn0.1O2 cathode and BF4--introducing electrolyte at 4.5V high voltage

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Journal of Energy Chemistry 2019年第12期28卷 235-243页

作者： Guangyuan Lan hebing zhou Lidan Xing Jiawei Chen Zifei Li Rude Guo Yanxia Che Weishan Li National and Local Joint Engineering Research Center of MPTES in High Energy and Safety LIBs Engineering Research Center of MTEES (Ministry of Education) Research Center of BMET (Guangdong Province) Key Laboratory of ETESPG (GHEI) School of Chemistry and Environment South China Normal University

Owing to the high specific capacity and high voltage,Ni-rich(LiNi0.8Co0.1Mn0.1O2,LNCM811)cathode has been considered as one of the most promising candidate cathode materials for next generation lithium ion batteries,whereas severe capacity fading greatly hinders its practical ***,the compatibility of Ni-rich materials with LiBF4-containing electrolyte has not yet been ***,1 M LiPF6-based electrolyte with introducing 2 M LiBF4 is proposed to dramatically improve the cyclic stability of high voltage LNCM811/Li *** of high concentrated LiBF4 improves the moisture stability of electrolyte,which hinders the generation of harmful by-product HF,resulting in improved interfacial stability of *** plating/stripping reaction of Li/Li symmetric cell confirms that the enhanced cyclic stability is ascribed to the improved interfacial stability of LNCM811 instead of lithium *** and composition characterization results reveal that LiBF4 participates in the CEI film-forming reaction,resulting in suppressed oxidation of electrolyte and interfacial structural destruction of LNCM811.

关键词： LiNi0.8Co0.1Mn0.1O2 4.5 V high voltage Interfacial stability LiBF4 co-salt CEI film

“双一流”背景下高校学科资源配置的策略选择与反思——基于三所大学的案例研究

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教育发展研究 2022年第17期42卷 26-33页

作者：周合兵毕宇龙陈先哲华南师范大学现代国家与大学治理研究中心华南师范大学教育科学学院华南师范大学高等教育研究所广州510631

学科资源配置一直是高校治理和建设发展过程中的经典课题和棘手难题,我国推行“双一流”建设以后高校学科资源配置策略更是发生明显变化。文章对三所不同层次大学的案例研究发现:各校基于阶段性发展目标,学科资源配置分别遵循发展目标... 详细信息

学科资源配置一直是高校治理和建设发展过程中的经典课题和棘手难题,我国推行“双一流”建设以后高校学科资源配置策略更是发生明显变化。文章对三所不同层次大学的案例研究发现:各校基于阶段性发展目标,学科资源配置分别遵循发展目标导向、效益优先导向和优先发展导向,并大体上都达成了自身的战略目标,但也存在学科资源配置失衡、学科资源配置监管失位和学科生态建设失效等隐患。建议从多个层面优化高校学科资源配置及学科建设:一是高校在配置学科资源时应因校制宜,分类施策;二是学科应因势利导注重特色发展,汇聚优质资源形成比较竞争优势;三是应警惕高等教育优绩主义对学科生态建设的冲击,优化学科资源配置机制和生态体系。

关键词： “:双一流”建设学科建设资源配置策略选择