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Status and prospects for symmetric organic redox flow batteries

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journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn j.W.So Konstantin Feinberg Marina Manoraj jenny cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

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立体定向伽玛刀放射外科治疗癫痫的短期观察

中华神经外科杂志 1996年第6期12卷 376-377页

作者： c.j黄 c.j金釜山大学医学院亚洲医疗中心神经外科

立体定向伽玛刀放射外科治疗癫痫的短期观察Ｃ．Ｊ黄Ｃ．Ｊ金放射外科成功治疗局灶性癫痫已有报道。立体定向放射外科治疗ＡＶＭ或低恶性度脑肿瘤同时能减少相关的癫痫发作（１，２）。推测放射外科治疗癫痫基于非突触机制（３）。一项... 详细信息

立体定向伽玛刀放射外科治疗癫痫的短期观察Ｃ．Ｊ黄Ｃ．Ｊ金放射外科成功治疗局灶性癫痫已有报道。立体定向放射外科治疗ＡＶＭ或低恶性度脑肿瘤同时能减少相关的癫痫发作（１，２）。推测放射外科治疗癫痫基于非突触机制（３）。一项猫的早期实验研究显示，受照射后脑电...

关键词：癫痫伽玛刀放射外科手术

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Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi juan Pablo de Rivero Vaccari jennifer c.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang j.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric critical care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

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Experimental Investigation on Attenuation of Emission with Optimized LPG jet Induction in a Dual Fuel Diesel Engine and Prediction by ANN Model

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Experimental Investigation on Attenuation of Emission with O...

Elements of the p block 1

2011 2nd International conference on Advances in Energy Engineering(IcAEE)

作者： Thomas Renald c.j Somasundaram P Department of Aeronautical Engineering Sri Ramakrishna Engineering College Department of Mechanical Engineering KS Rangasamy College of Technology

Environment pollution due to vehicles exhaust emission is still a severe crisis and an international concern has been raised for its control and ***,man-kind is experiencing an epidemic of illnesses made worse by air pollution mainly because of increased number of automotive *** main problem faced by most of the vehicles today is the emission of NO which can be controlled by different ways such as exhaust gas recirculation,using alternate fuels,turbo charging,and different mode of *** the other hand,diesel engines are the most trustworthy power sources in the *** to inflexible emission norms and rapid depletion of petroleum resources,there has been a continuous exertion to use alternative *** researches are being carried out to reduce emission rates and these researches would be explored till reducing the exhaust emission upto zero *** such a way,the present investigation explores with a series of experiments towards effective combustion of air,LPG and diesel mixture without encompassing major modification in the engine ***,LPG jet is inducted through air inlet to accomplish homogeneous mixture then it is allowed into the combustion chamber of cI *** major parameters of the LPG jet injector are optimised through cFD technique by utilizing a commercial cFD *** in the performance of the engine and emission levels with the influences of the jet parameters are observed and analysed *** optimized jet parameters obtained through cFD technique and the experimental results achieved from the dual fuelled cI engine show considerable improvement in the engine performance and significant reduction in cO,cO,Hc and NO emission besides the normal engine performance and emission levels of diesel fuel induction Eventually,an artificial neural network(ANN) model is developed for predicting the emission levels based on the jet parameters,applying load and%of LPG induction by

关键词： Dual fuel cI engine LPG jet injection homogeneous air-fuel mixture jet parameters cFD approach reduction of emission engine performance ANN model

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Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

丛书名： The molecular world book 9

2002年

作者： c.j Harding D.A. johnson R. janes

来源：畅想之星图书光盘版（南... 评论

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journal of Energy chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua jo jonggeol Na j.jay Liu Young-ju Kim Wangyun Won Department of chemical and Biological Engineering Korea University Department of chemical Engineering (Integrated process) Kyung Hee University Department of chemical Engineering and Materials Science Ewha Womans University Department of chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy c, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LcAs）.Strategy A was found to be the most favorable both economically（USRDScHARDOLLAR3,402/ton） and environmentally（-26.9 kg cO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery carbon mitigation climate change Global warming Lignin utilization Bioeconomy