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Use of platelet lysate for bone regeneration-are we ready for clinical translation?

World Journal of Stem Cells 2016年第2期8卷 47-55页

作者： Ala Altaie heather owston Elena Jones Leeds Institute of Rheumatic and Musculoskeletal Medicine University of LeedsSt.James's University Hospital

Current techniques to improve bone regeneration following trauma or tumour resection involve the use of autograft bone or its substitutes supplemented with osteoinductive growth factors and/or osteogenic cells such as mesenchymal stem cells(MSCs).Although MSCs are most commonly grown in media containing fetal calf serum,human platelet lysate(PL) offers an effective *** marrow- derived MSCs grown in PLcontaining media display faster proliferation whilst maintaining good osteogenic differentiation *** pre-clinical investigations using PL-expanded MSCs seeded onto osteoconductive scaffolds indicate good potential of such constructs to repair bone in *** an alternative approach,nude PL-coated scaffolds without seeded MSCs have been proposed as novel regenerative medicine *** though methods to coat scaffolds with PL vary,in vitro studies suggest that PL allows for MSC adhesion,migration and differentiation inside these *** new bone formation and vascularisation in comparison to uncoated scaffolds have also been observed in *** review outlines the state-of-the-art research in the field of PL for ex vivo MSC expansion and in vivo bone *** minimise inconsistency between the studies,further work is required towards standardisation of PL preparation in terms of the starting material,platelet concentration,leukocyte depletion,and the method of platelet *** quality control procedures and its "potency" assessment are urgently needed,which could include measurements of key growth and attachment factors important for MSC maintenance and ***,different PL formulations could be tailor-made for specific bone repair *** measures would undoubtedly speed up clinical translation of PL-based treatments for bone regeneration.

关键词： Mesenchymal stem cells Platelet lysate Bone regeneration

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