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针刺手法操作行为的定量研究

中国针灸 2014年第3期34卷 247-251页

作者：李靖 lawrence Grierson Mary X Wu Ronny Breuer heather Carnahan 南京体育学院运动健康科学系江苏南京210014 南京市中西医结合医院治未病中心多伦多大学医学院威尔逊研究中心麦克马斯特大学家庭医学系大多伦多中医学院加拿大指压术针灸学校多伦多大学作业治疗系

目的:探索定量评估针刺手法操作行为的方法,并进一步分析专业针刺手法的行为特征。方法:根据针刺基本手法编制出《针刺基本手法操作行为量表》,经德尔菲法检验内容效度;2名独立评分人运用该量表评估针灸医师和初学者各12人的针刺手法操... 详细信息

目的:探索定量评估针刺手法操作行为的方法,并进一步分析专业针刺手法的行为特征。方法:根据针刺基本手法编制出《针刺基本手法操作行为量表》,经德尔菲法检验内容效度;2名独立评分人运用该量表评估针灸医师和初学者各12人的针刺手法操作行为,计算评判间信度,并比较这两组受试者操作行为总分及消毒、进针、行针及出针各步骤操作行为得分的差异。结果:该量表内容效度满意;评判间信度为0.768;且针灸医师组操作行为总分显著高于初学者组(13.80±1.05vs 11.03±2.14,P<0.01);医师进针及行针得分显著高于初学者(4.28±0.91vs 2.54±1.51,P<0.01;2.56±0.65vs 1.88±0.88,P<0.05);而消毒及出针得分与初学者无差异。结论:该量表可用于定量评估针刺手法操作行为,专业针刺手法的行为特征主要体现在能够完成难度较大且协调性精确性要求较高的进针及行针操作上。

关键词：针刺手法操作行为量表制定行为特征

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捻转针刺手法的运动学及动力学特征研究

针刺研究 2013年第5期38卷 415-419页

作者：李靖 lawrence Grierson Mary X Wu Ronny Breuer 周斌 heather Carnahan 南京体育学院运动健康科学系南京210014 南京市中西医结合医院南京210014 多伦多大学医学院威尔逊研究中心麦克马斯特大学家庭医学系大多伦多中医学院加拿大指压术针灸学校多伦多大学作业治疗系

目的:从运动学和动力学两个角度探索捻转手法的动作特征,从而为捻转手法操作的定量化提供依据。方法:运用高精度动作捕捉系统,精确测量捻转手法的幅度、频率、力量及操作时间等指标,比较12名针灸专家和12名初学者在仿真皮肤上10次操作... 详细信息

目的:从运动学和动力学两个角度探索捻转手法的动作特征,从而为捻转手法操作的定量化提供依据。方法:运用高精度动作捕捉系统,精确测量捻转手法的幅度、频率、力量及操作时间等指标,比较12名针灸专家和12名初学者在仿真皮肤上10次操作平补平泻捻转手法时上述数据的大小及离散程度的差异。结果:专家捻转频率离散系数显著低于初学者(P0.05)。结论:平补平泻捻转手法的技能水平并非体现在捻转的具体幅度、频率及力量上,其动作特征主要表现在动作稳定性和熟练程度两个方面;建议将捻转频率离散度和操作时间用于捻转手法的定量评估。

关键词：针刺手法技能运动学动力学定量分析

Mismatch repair enzyme expression in primary and castrate resistant prostate cancer

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Asian Journal of Urology 2016年第4期3卷 223-228页

作者： Belinda Nghiem Xiaotun Zhang Hung-Ming Lam lawrence DTrue Ilsa Coleman Celestia SHigano Peter SNelson Colin CPritchard Colm Morrissey Department of Urology University of WashingtonSeattleWAUSA State Key Laboratory of Quality Research in Chinese Medicine Macao Institute for Applied Research in Medicine and HealthMacao University of Science and TechnologyMacao(SAR)China Department of Pathology University of WashingtonSeattleWAUSA Divison of Human Biology Fred Hutchinson Cancer Research CenterSeattleWAUSA Department of Medicine University of WashingtonSeattleWAUSA Department of Laboratory Medicine University of WashingtonSeattleWAUSA

Objective:Although the utility of immunohistochemistry(IHC)for assessing mismatch repair(MMR)protein expression has been demonstrated in solid tumors including primary prostate cancer(PCa),its utility has not been assessed in castration-resistant PCa(CRPC).Methods:Tissue microarrays were constructed from 127 radical prostatectomies and 155 CRPC metastases from 50 ***(MLH1,MSH2,MSH6,and PMS2)expression was assessed by IHC and gene expression *** between MMR protein expression in PCa and CRPC and biochemical recurrence(BCR)or time from diagnosis to death respectively were ***:There was no correlation between levels of MMR protein and *** of MSH2 and MSH6 was the most pronounced at 15%and 22%in PCa and 17.8%and 16%in CRPC patients,***2 and MSH6 protein were absent in 9.4%and 8%of PCa and CRPC *** of individual MMR proteins did not correlate with BCR or time from diagnosis to *** absent MSH2/MSH6 in CRPC was associated with shorter time to death(pZ0.0006).Loss of MSH2 was verified at the gene expression *** finding correlated with microsatellite instability previously reported in this CRPC cohort.

关键词： Mismatch repair Castration resistant prostate cancer MLH1 MSH2 MSH6 PMS2

Determinants of nurse faculty intention to remain employed

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Open Journal of Nursing 2012年第3期2卷 254-261页

作者： Ann E. Tourangeau heather Thomson Margaret Saari Kimberley Widger Era Mae Ferron Kathleen MacMillan lawrence S. Bloomberg Faculty of Nursing University of Toronto Toronto Canada School of Health Sciences Humber College Toronto Canada

Shortage of nurses is a major concern across healthcare systems. One contributing factor that has received little attention is the shortage of adequately prepared nurse faculty. The nurse shortage will be exacerbated if the supply of adequately prepared nurse faculty is insufficient. Little is known about the factors that influence nurse faculty to remain employed. Focus groups were conducted in 2011 with nurse faculty from both colleges and universities in Ontario, Canada. Six focus groups including 37 participants were held with different groups of nurse faculty in geographically diverse areas of the province. Focus group transcripts were reviewed by five members of the research team using thematic analysis strategies to identify factors related to nurse faculty intention to remain employed. Nurse faculty members’ intention to remain employed was influenced by factors that fell into four thematic categories: personal characteristics, work environment and organizational support, job content, and external characteristics. Each thematic category includes several factors reported to influence nurse faculty intention to remain employed. The “Determinants of Nurse Faculty Intention to Remain Employed” Model is hypothesized. Strategies to address modifiable factors and support non-modifiable factors are suggested to promote retention of nurse faculty. Additional research is needed to test the hypothesized model of nurse faculty intention to remain employed.

关键词： Nurse Faculty Retention Work Environment Organizational Support Theory Development Focus Groups Nursing Workforce

Understanding the effects of radiative preheat and self-emission from shock heating on equation of state measurement at 100s of Mbar using spherically converging shock waves in a NIF hohlraum

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Matter and Radiation at Extremes 2020年第1期5卷 16-22页

作者： Joseph Nilsen Andrea L.Kritcher Madison EMartin Robert E.Tipton heather D.Whitley Damian C.Swift Tilo Doppner Benjamin L.Bachmann Amy E.Lazicki Natalie B.Kostinski Brian R.Maddox Gilbert W.Collins Siegfried H.Glenzer Roger W.Falcone lawrence Livermore National Laboratory LivermoreCalifornia 94551USA University of Rochester RochesterNew York 14627USA SLAC National Accelerator Menlo ParkCalifornia 94025USA University of California Berkeley BerkeleyCalifornia 94720USA

Over the last six years many experiments have been done at the National Ignition Facility to measure the Hugoniot of materials,such asCHplastic at extreme pressures,up to 800 ***“Gbar”design employs a strong spherically converging shock launched through a solid ball of material using a hohlraum radiation *** shock front conditions are characterized using x-ray *** this paper we examine the role of radiation in heating the unshocked material in front of the shock to understand the impact it has on equation of state measurements and how it drives the measured data off the theoretical Hugoniot *** particular,the two main sources of radiation heating are the preheating of the unshocked material by the high-energy kilo-electron-volt x-rays in the hohlraum and the heating of the material in front of the shock,as the shocked material becomes hot enough to radiate *** our model,we estimate that preheating can reach 4 eV in unshocked material,and that radiation heating can begin to drive data off the Hugoniot significantly,as pressures reach above 400 Mb.

关键词： spherical equation radiative

2019年全球、地区和国家5岁以下儿童呼吸道合胞病毒引发急性下呼吸道感染疾病负担研究的系统分析

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中国病毒病杂志 2023年第2期13卷 81-95页

作者： You Li Xin Wang Dianna M.Blau Mauricio T.Caballero Daniel R.Feikin Christopher J.Gill Shabir A.Madhi Saad B.Omer Eric A.F Simoes Harry Campbell Ana Bermejo Pariente Darmaa Bardach Quique Bassat Jean-Sebastien Casalegno Giorgi Chakhunashvili Nigel Crawford Daria Danilenko Lien Anh Ha Do Marcela Echavarria Angela Gentile Aubree Gordon Terho Heikkinen QSue Huang Sophie Jullien Anand Krishnan Eduardo Luis Lopez Josko Markic Ainara Mira-Iglesias Hannah CMoore Jocelyn Moyes lawrence Mwananyanda DJames Nokes Faseeha Noordeen Evangeline Obodai Nandhini Palani Candice Romero Vahid Salimi Ashish Satav Euri Seo Zakhar Shchomak Rosalyn Singleton Kirill Stolyarov Sonia K Stoszek Anne von Gottberg Danielle Wurzel Lay-Myint Yoshida Chee Fu Yung heather J Zar Harish Nair 张甜甜从兵兵邓舒予不详南京医科大学公共卫生学院江苏南京211166

背景呼吸道合胞病毒(respiratory syncytial virus,RSV)是引起婴幼儿急性下呼吸道感染最常见的病原体。此前估计,2015年全球60月龄以下儿童共发生3 310万次RSV相关急性下呼吸道感染,导致118 200人死亡。此后,几项社区监测研究获得了对RS... 详细信息

背景呼吸道合胞病毒(respiratory syncytial virus,RSV)是引起婴幼儿急性下呼吸道感染最常见的病原体。此前估计,2015年全球60月龄以下儿童共发生3 310万次RSV相关急性下呼吸道感染,导致118 200人死亡。此后,几项社区监测研究获得了对RSV相关社区死亡的更精确估计。本文旨在更新2019年全球、地区和国家层面60月龄以下儿童RSV相关急性下呼吸道感染的发病率和死亡率,重点关注总体死亡率和在研RSV免疫制剂针对的更窄的婴儿年龄组。方法检索获得MEDLINE、Embase、Global Health、CINAHL、Web of Science、LILACS、OpenGrey、中国知网、万方和维普数据库2017—2020年发表文献中的新数据,并纳入RSV GEN合作者提供的未发表数据,以扩展全球RSV疾病负担数据集。纳入的研究符合以下条件:报告了社区中或需要住院治疗的60月龄以下儿童RSV原发性急性下呼吸道感染的数据;报告了至少连续12个月的数据,但院内病死率或RSV季节性定义明确的地区除外;报告了RSV相关急性下呼吸道感染的发病率、住院率、院内病死率或急性下呼吸道感染住院的RSV阳性比例。如果病例定义不明或应用不一致、RSV感染未经实验室确认或仅基于血清学检测、报告的急性下呼吸道感染病例少于50例,则排除该研究。本研究应用广义线性混合效应模型(generalized linear mixed-effects model,GLMM)估计了2019年全球和地区(按国家发展状况和世界银行收入分类)RSV相关急性下呼吸道感染的发病率、住院率和院内病死率;通过基于危险因素的模型估计了国家层面RSV相关急性下呼吸道感染的发病率;通过GLMM开发了新模型,纳入最新的RSV社区死亡率数据,用于估计RSV的总体死亡率。本综述已在PROSPERO注册(CRD42021252400)。结果除了先前综述中纳入的317项研究外,还纳入了113项符合条件的新研究以及51项未发表的研究,共计481项研究。据估计,2019年全球60月龄以下儿童中,共发生3 300万(置信区间为2 540万~4 460万)次RSV相关急性下呼吸道感染,导致360万(290万~460万)例住院、26 300(15 100~49 100)例院内死亡以及101 400(84 500~125 200)例可归因于RSV的总死亡数。在0~6个月的婴儿中,共发生660万(460万~970万)次RSV相关急性下呼吸道感染,导致140万(100万~200万)例住院、13 300(6 800~28 100)例院内死亡以及45 700(38 400~55 900)例可归因于RSV的总死亡数。60月龄以下和28 d~6月龄儿童的死亡中分别有2.0%(置信区间为1.6%~2.4%)和3.6%(3.0%~4.4%)归因于RSV。在各年龄组中,95%以上的RSV相关急性下呼吸道感染事件和97%以上的可归因于RSV的死亡事件都发生在中低收入国家。结论 RSV显著增加了全球60月龄以下儿童的发病和死亡负担,尤其是在出生后前6个月和中低收入国家。本研究强调了全球RSV疾病的总体死亡率负担,60月龄以下儿童中,每50例死亡就有1例可归因于RSV;28 d至6个月大的婴儿中,每28例死亡就有1例可归因于RSV。每1例RSV相关急性下呼吸道感染院内死亡,对应社区中约3例可归因于RSV的死亡。对6月龄内婴儿提供保护的RSV被动免疫计划有望对减轻RSV疾病负担,但实施计划时,仍需要更多数据来了解RSV疾病负担高峰可能向大龄转移的影响。

关键词：呼吸道合胞病毒下呼吸道感染儿童疾病负担住院发病率死亡率病死率模型估计系统分析