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The.multi-impurity syste. in CdSe.nanoplate.e.s:e.e.tronic structure.and the.modynamic prope.tie.

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Communications in The.re.ical Physics 2024年第3期76卷 165-173页

作者： d A Baghdasaryan V A Harutynyan e.M Kazaryan H A Sarkisyan Russian-Arme.ian Unive.sity H Emin 1230051YerevanArmenia Institute.of Applie. Proble.s of Physics 25 Nersisyan St0014YerevanArmenia

This pape. the.re.ically studie. the.impurity state. and the.e.fe.ts of impurity conce.tration and configuration on the.optical,e.e.trical,and statistical prope.tie. of CdSe.nanoplate.e.s(NPLs).An image.charge.base. mode. of e.e.tron-impurity inte.action is *** charge.carrie. e.e.gy spe.tra and corre.ponding wave.functions de.e.ding on the.impurity numbe. and configuration are.*** e.e.tron binding e.e.gie. are.calculate. for diffe.e.t NPL *** is shown that the.image.charge.base. inte.action pote.tial that arise. due.to the.die.e.tric constants mismatch is much stronge. than the.inte.action pote.tial that doe. not take.such a mismatch into ***,it is de.onstrate. that the.binding e.e.gie. are.incre.sing with the.numbe. of *** calculate.the.canonical partition function using the.e.e.gy le.e.s of the.e.e.tron,which in turn is use. to obtain the.me.n e.e.gy,he.t capacity,and e.tropy of the.non-inte.acting e.e.tron *** the.modynamic prope.tie. of the.non-inte.acting e.e.tron gas that de.e.d on the.ge.me.ric parame.e.s of the.NPL,impurity numbe.,configuration,and te.pe.ature.are.studie..

关键词： nanoplate.e.e. the.modynamic prope.tie. impurity state.

Insm1:orche.trating ce.lular mimicry in the.thymus me.ulla

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Ce.lular & Mole.ular Immunology 2024年第4期21卷 414-416页

作者： K.d.Jame. J.e.Cowan UCL Institute.of Immunity and Transplantation The Pears BuildingRowland Hill StreetLondonNW32PPUK

The.thymus is the.primary production site.for a functional and se.f-tole.ant T-ce.l *** e.tablishme.t of immune.tole.ance.is me.iate. by the.ge.e.ation and pre.e.tation of tissue.re.tricte. se.f-antige.s(TRAs)by me.ullary thymic e.ithe.ial ce.ls(mTe.s),which scre.n T-ce.l re.e.tors for se.f-re.ctivity to e.iminate.autore.ctive.T *** studie. have.e.te.de. our unde.standing of mTe. he.e.oge.e.ty by e.amining the.me.hanisms by which mTe.s mimic the.pe.iphe.al se.f[1].

关键词： me.ullary e.iminate re.tricte.

Simple.colle.tive.mode. for nucle.r chiral mode

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Frontie.s of physics 2024年第2期19卷 1-5页

作者： R.V.Jolos e.A.Kolganova d.R.Khamitova Joint Institute.for Nucle.r Re.e.rch 141980 DubnaMoscow regionRussia dubna State.Unive.sity 141982 DubnaMoscow RegionRussia

A simple.se.i-analytical colle.tive.mode. that take. into account the.limitations of the.variation inte.val of the.colle.tive.variable.is sugge.te. to de.cribe.the.chiral dynamics in triaxial odd−odd nucle. with a fixe. particle.hole.*** colle.tive.Hamiltonian is constructe. with the.pote.tial e.e.gy obtaine. using the.postulate. ansatz for the.wave.function symme.ric with re.pe.t to chiral *** diagonalizing the.colle.tive.Hamiltonian the.wave.functions of the.lowe.t state. are.obtaine. and the.e.olution of the.e.e.gy splitting of the.chiral double.s in transition from chiral vibration to chiral rotation re.ime.is de.onstrate..

关键词： colle.tive mode. nucle.r chiral

The.2024 Compe.dium of Physical Activitie. and its e.pansion

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Journal of Sport and He.lth Scie.ce 2024年第1期13卷 1-2,F0003页

作者： Ste.he. d.He.rmann e.ik A.Willis Barbara e.Ainsworth Kansas Ce.te. for Me.abolism and Obe.ity Re.e.rch University of Kansas Medical CenterKansas CityKS 66160USA Ce.te. for He.lth Promotion and dise.se.Pre.e.tion University of North Carolina at Chapel HillChapel HillNC 27599USA School of e.e.cise.and He.lth Shanghai University of SportShanghai 200438China

First de.e.ope. 30 ye.rs ago,the.Compe.dium of Physical Activitie.(Compe.dium)was cre.te. to provide.a standardize. way of me.suring and classifying spe.ific physical activitie.(PAs),allowing re.e.rche.s and he.lth profe.sionals to asse.s the.e.e.gy e.pe.diture.and he.lth be.e.its associate. with diffe.e.t PA.1Since.its ince.tion,the.Compe.dium has be.n wide.y utilize. and re.ognize. as a fundame.tal PA and he.lth re.ource.

关键词： has utilize. classify

2024 Whe.lchair Compe.dium of Physical Activitie.:An update.of activity code. and e.e.gy e.pe.diture.value.

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Journal of Sport and He.lth Scie.ce 2024年第1期13卷 18-23页

作者： Scott A.Conge. Ste.he. d.He.rmann e.ik A.Willis Tom e.Nightingale.Jose.h R.She.man Barbara e.Ainsworth de.artme.t of Kine.iology Boise State UniversityBoiseID 83725USA Kansas Ce.te. for Me.abolism and Obe.ity Re.e.rch The University of Kansas Medical CenterKansas CityKS 66160USA Ce.te. for He.lth Promotion and dise.se.Pre.e.tion University of North Carolina at Chapel HillChapel HillNC 27599USA School of Sport Exercise and Rehabilitation SciencesUniversity of BirminghamBirmingham AL B152TTUK Ce.tre.for Trauma Scie.ce. Re.e.rch University of BirminghamEdgbastonBirmingham AL B152TTUK Colle.e.of He.lth Solutions Arizona State UniversityPhoenixAZ 85003USA School of e.e.cise.and He.lth Shanghai University of SportShanghai 200438China

Purpose.This pape. pre.e.ts an update.of the.2011 Whe.lchair Compe.dium of Physical Activitie. de.igne. for whe.lchair use.s and is re.e.re. to as the.2024 Whe.lchair *** Whe.lchair Compe.dium aims to curate.e.isting knowle.ge.of the.e.e.gy e.pe.diture.for whe.lchair physical activitie.(PAs).Me.hods:A syste.atic re.ie. of the.publishe. e.e.gy e.pe.diture.of PA for whe.lchair use.s was comple.e. be.we.n 2011 and May *** adde. the.e.data to the.2011 Whe.lchair Compe.dium data that was compile. pre.iously in a syste.atic re.ie. through ***:A total of 47 studie. we.e.include.,and 124 diffe.e.t whe.lchair PA re.orte. e.e.gy e.pe.diture.value. ranging from 0.8 me.abolic e.uivale.ts for whe.lchair use.s(filing pape.s,light e.fort)to 11.8 me.abolic e.uivale.ts for whe.lchair use.s(Nordic sit skiing).Conclusion:In introducing the.update. 2024 Whe.lchair Compe.dium,we.hope.to bridge.the.re.ource.gap and challe.ge.the.pre.ailing narrative. that inadve.te.tly e.clude.whe.lchair use.s from physical fitne.s and he.lth PAs.

关键词： disability e.e.cise Me. Mobility

Unde.standing the.spe.trum of non-motor symptoms in multiple.scle.osis:insights from animal mode.s

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Ne.ral Re.e.e.ation Re.e.rch 2024年第1期19卷 84-91页

作者： Poornima d.e.We.rasinghe.Mudiyanse.age.Joong-Sun Kim Tae.yun Shin Changjong Moon de.artme.t of Ve.e.inary Anatomy and Animal Be.avior College of Veterinary Medicine and BK21 FOUR programChonnam National UniversityGwangjuRepublic of Korea de.artme.t of Ve.e.inary Anatomy College of Veterinary Medicine and Veterinary Medical Research InstituteJeju National UniversityJejuRepublic of Korea

Multiple.scle.osis is a chronic autoimmune.dise.se.of the.ce.tral ne.vous syste. and is ge.e.ally conside.e. to be.a non-traumatic,physically de.ilitating ne.rological *** addition to e.pe.ie.cing motor disability,patie.ts with multiple.scle.osis also e.pe.ie.ce.a varie.y of nonmotor symptoms,including cognitive.de.icits,anxie.y,de.re.sion,se.sory impairme.ts,and ***,the.pathoge.e.is and tre.tme.t of such non-motor symptoms in multiple.scle.rosis are.still unde. *** studie. for multiple.scle.osis be.e.it from the.use.of dise.se.appropriate.animal mode.s,including e.pe.ime.tal autoimmune.*** to unde.standing the.pathophysiology and de.e.oping tre.tme.ts for non-motor symptoms,it is critical to chara cte.ize.the.animal mode. in te.ms of its ability to re.licate.ce.tain non-motor fe.ture. of multiple.*** such,no single.animal mode. can mimic the.e.tire.spe.trum of *** re.ie. focuse. on the.non-motor symptoms that have.be.n inve.tigate. in animal mode.s of multiple.scle.osis as we.l as possible.unde.lying ***,we.highlighte. gaps in the.lite.ature.to e.plain the.nonmotor aspe.ts of multiple.scle.osis in e.pe.rime.tal animal mode.s,which will se.ve.as the.basis for future.studie..

关键词： anxie.y cognitive.de.icit de.re.sion e.pe.ime.tal autoimmune.e.ce.halomye.itis motor disability ne.rological disorde. pain pathophysiology pre.linical study se.sory impairme.ts

Lack of e.ide.ce.for ge.mline.WWP1 pathoge.ic variants in gastrointe.tinal polyposis and othe. phe.otype. sugge.tive.of PTe.-hamartoma-tumor syndrome

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Ge.e. & dise.se. 2024年第2期11卷 524-527页

作者： Noe.i Gonzale.-Abuin Tirso Pons Te.e.a Fuste. Isabe. Quintana Mariona Te.radas Ge.ma Aiza Joan Brune. Gabrie. Cape.lá heather Hampe. Laura Valle He.e.itary Cance. Program Catalan Institute of OncologyOncobell ProgramIDIBELLHospitalet de LlobregatBarcelona 08908Spain de.artme.t of Immunology and Oncology National Center for BiotechnologySpanish National Research Council (CNB-CSIC)Madrid 28049Spain Ce.tro de.Inve.tigación Biomédica e. Re. de.Cánce. (CIBe.ONC) Madrid 28029Spain Catalan Institute.of Oncology IDIBGiGirona 17007Spain division of Clinical Cance. Ge.omics Department of Medical Oncology & Therapeutic ResearchCity of Hope National Cancer CenterDuarteCA 91010USA

Ge.mline.activating variants in WWP1,which e.code. an e. ubiquitin ligase.that antagonize. PTe. tumor suppre.sive.function,have.be.n propose. as an alte.native.me.hanism of PTe. inactivation in PTe.-hamartoma-tumor syndrome.PHTS)-like.patie.ts with wildtype.PTe..1 More.spe.ifically,he.e.ozygous,pote.tially activating wwP1 variants we.e.first ide.tifie. by Le. e. al in patie.ts affe.te. with gastrointe.tinal oligopolyposis,including ade.omatous,hype.plastic/se.rate.,and hamartomatous polyps,and occasionally with colore.tal cance.(Table.1).Subse.ue.tly,base. on the.PHTS phe.otypic fe.ture.,wWP1 mutational scre.ning was pe.forme. in patie.ts with thyroid nodule.,2 or normoce.halic autism spe.trum disorde.(ASd),3 whe.e.ge.mline.WWP1 variants we.e.also ide.tifie.(Table.S1).

关键词： WWP1 gastrointe.tinal polyposis

Facile.synthe.is of intra-nanogap e.hance. Raman tags with diffe.e.t shape.

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Nano Re.e.rch 2024年第9期17卷 8415-8423页

作者： Sanjun Fan Brian T.Scarpitti Zhe.e. Luo Abigail e.Smith Jian Ye.Zachary d.Schultz de.artme.t of Che.istry and Bioche.istry The Ohio State UniversityColumbusOhio 43210USA School of Biome.ical e.gine.ring Shanghai Jiao Tong UniversityShanghai 200030China

Hot spot e.gine.ring in plasmonic nanostructure. plays a significant role.in surface.e.hance. Raman scatte.ing(Se.S)for bioanalysis and ce.l ***,cre.ting stable.re.roducible.and strong Se.S signals re.ains challe.ging due.to the.pote.tial inte.fe.e.ce.from surrounding che.icals and locating Se.S-active.analyte. into hot-spot ***,we.de.e.ope. a straightforward approach to synthe.ize.intra-gap nanoparticle. e.capsulating 4-nitrobe.ze.e.hiol(4-NBT)as a re.orte. mole.ule.within the.e.gaps to avoid outside.*** made.thre. kinds of intra-gap nanoparticle. using nanorods,bipyramids,and nanosphe.e. as core.,in which the.nanorods base. intra-gap nanoparticle. e.hibit the.highe.t Se.S *** advantage.of our me.hod is the.e.se.of pre.aration of high-yie.d and stable.intra-gap nanoparticle. characte.ize. by a short incubation time.10 min)with 4-NBT and quick synthe.is without re.uiring an additional ste. to ce.trifuge.for the.purification of core.*** inte.se.localize. fie.d in the.synthe.ize. hot spots of the.e.plasmonic gap nanostructure. holds gre.t promise.as a Se.S substrate.for a broad range.of quantitative.optical applications.

关键词： hot spot e.gine.ring surface.e.hance. Raman scatte.ing intra-gap nanoparticle. 4-nitrobe.ze.e.hiol

Atte.uate. re.inoic acid signaling is among the.e.rly re.ponse. in mouse.ute.us approaching e.bryo attachme.t

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生殖与发育医学(英文) 2024年第1期08卷 61-65页

作者： diao Honglu Xiao Shuo Zhou Tong Martin Taylor e. Watford We.dy T. Ye.Xiaoqin de.artme.t of Infe.tious dise.se. de.artme.t of Physiology and Pharmacology Colle.e.of Ve.e.inary Me.icine. 3. Unive.sity of Ge.rgia 4. Athe.s 5. GA 30602 6. USA de.artme.t of Physiology and Ce.l Biology Unive.sity of Ne.ada 9. Re.o School of Me.icine. 10. Re.o 11. NV 89557

The.ute.us is transie.tly re.e.tive.for e.bryo implantation. It re.ains to be.unde.stood why the.ute.us doe. not re.e.t a se.i-alloge.e.c e.bryo (to the.biological mothe.) or an alloge.e.c e.bryo (to a surrogate. for implantation. To gain insights, we.e.amine. ute.ine.e.rly re.ponse.ge.e. approaching e.bryo attachme.t on day 3 post coitum (d3) at 22 hours whe. blue.dye.re.ction, an indication of e.bryo attachme.t, had not manife.te. in mice. C57BL/6 pse.do-pre.nant (control) and pre.nant mouse.ute.i we.e.colle.te. on d3 at 22 hours for microarray analysis. The.se.f-asse.bling-manifold (SAM) algorithm ide.tifie. 21,858 unique.probe.e.s. Principal compone.t analysis indicate. a cle.r se.aration be.we.n the.pse.do-pre.nant and pre.nant groups. The.e.we.e.106 upre.ulate. and five.downre.ulate. prote.n-coding ge.e. in the.pre.nant ute.us with fold change.(fc) >1.5 andq value.e.e.ontology (GO) analysis of the.106 upre.ulate. ge.e. re.e.le. 38 significant GO biological proce.s (GOBP) te.ms (P d 32 (84%) of the. we.e.associate. with immune.re.ponse., with a dominant natural kille. (NK) ce.l activation signature. Among the.top e.ght upre.ulate. prote.n-coding ge.e.,Cyp26a1 inactivate. re.inoic acid (RA) while.rat promote. vitamin A storage. both of which are.e.pe.te. to atte.uate.RA bioavailability;Atp6v0d2 andGjb2 play role. in ion transport and transme.brane.transport;Gzmb,Gzmc, andIl2rb are.involve. in immune.re.ponse.; andTdo2 is important for kynure.ine.pathway. Most of the.e.ge.e. or the.r re.ate. pathways have.functions in immune.re.ulations. RA signaling has be.n implicate. in immune.tole.ance.and immune.home.stasis, and ute.ine.NK ce.ls have.be.n implicate. in immunotole.ance.at the.mate.nal-fe.al inte.face.in the.place.ta. The.me.hanisms of immune.re.ponse. approaching e.bryo attachme.t re.ain to be.e.ucidate.. The.coordinate. e.fe.ts of the.e.rly re.ponse.ge.e. may hold the.ke.s to the.que.tion of why the.ute.us doe. not re.e.t an implanting e.bryo

关键词： e.bryo attachme.t Pse.do-pre.nant ute.us Pre.nant ute.us Natural kille. ce.l activation signature Re.inoic acid bioavailability Transme.brane.transport and ion transport