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Optoelectronics Letters 2024年第8期 460-471页

作者： LI Zhihan he wei LI Shaode Key Laboratory of the Ministry of Education for Optoelectronic Measurement Technology and Instrument Beijing Information Science and Technology University Beijing Laboratory of Optical Fiber Sensing and System Beijing Information Science and Technology University

Mid-infrared wavelength switchable and dual-wavelength random laser output has many potential applications. A polarization-maintaining random fiber Bragg grating(PMRFBG) array based on the photonic localization effect of longitudinal invariant transverse disorder in fiber structure is proposed, which can be used as random feedback of dual-wavelength and wavelength switchable output of random fiber laser(RFL). The random fiber Bragg grating(RFBG) array was designed on the panda-type polarization-maintaining fiber(PMF), and the two center wavelengths were 2 151.60 nm and 2 152.22 nm, respectively. The RFBG array was designed on the bow tie-type PMF, and the two center wavelengths were obtained, which were 2 153.08 nm and 2 153.96 nm, respectively. The RFBG array with a center wavelength of 2 139.27 nm was designed on single-mode fiber(SMF). The length of individual fiber Bragg grating(FBG) and PMRFBG, the refractive index modulation depth, the number of cascaded gratings, and the distance between gratings have different effects on the full width at half maximum(FWHM) and reflectance of the RFBG and PMRFBG array, but not on the central wavelength, as obtained by simulation using the transmission matrix method. The designed PMRFBG array provides theoretical support for the design of the feedback mechanism of RFL.

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γδT cells:Major advances in basic and clinical research in tumor immunotherapy

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Chinese Medical Journal 2024年第1期137卷 21-33页

作者： Yueqi Zhao Peng Dong wei he Jianmin Zhang Hui Chen Department of Immunology CAMS Key Laboratory for T Cell and ImmunotherapyState Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical SciencesChinese Academy of Medical Sciences and School of Basic MedicinePeking Union Medical CollegeBeijing 100005China Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy ChangzhouJiangsu 213000China Haihe Laboratory of Cell Ecosystem Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300020China

γδT cells are a kind of innate immune T cell.They have not attracted sufficient attention because they account for only a small proportion of all immune cells,and many basic factors related to these cells remain unclear.However,in recent years,with the rapid development of tumor immunotherapy,γδT cells have attracted increasing attention because of their ability to exert cytotoxic effects on most tumor cells without major histocompatibility complex(MHC)restriction.An increasing number of basic studies have focused on the development,antigen recognition,activation,and antitumor immune response ofγδT cells.Additionally,γδT cell-based immunotherapeutic strategies are being developed,and the number of clinical trials investigating such strategies is increasing.This review mainly summarizes the progress of basic research and the clinical application ofγδT cells in tumor immunotherapy to provide a theoretical basis for further the development ofγδT cell-based strategies in the future.

关键词： Gamma-delta T-cells T cell receptor CD1a Tumor immunotherapy Receptors,chimeric antigen Vδ1 cells αβT cells

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Numerical simulation of transient characteristics in a bulb turbine during the load rejection process

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Journal of Hydrodynamics 2024年第1期36卷 170-183页

作者： Yue Lu Yu-quan Zhang Zhong-wei he Yuan Zheng College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing210098China College of Energy and Electrical Engineering Hohai UniversityNanjing210098China Huadong Engineering Corporation Ltd. Hangzhou311122China

To evaluate the safety of the bulb tubular turbine,the dynamic hydraulic characteristics of a hydropower station system during the load rejection process are studied through numerical simulations and a prototype test.In the developed model,a dynamic grid technology(DGT)controls the closure of the guide vane and the blade,whilst the moment balance equation and the user-defined function(UDF)provide the runner’s rotation speed.The 3-D transient simulation method can well predict the rotation speed and mass flow curves in the state of load rejection.The simulation outcomes of the system performance are basically consistent with the measurement data of the prototype.As observed,the runner is subjected to the reversely increased torque and axial force,the system is in a braking phase,and the maximum speed peaks at 144.6%of the rated speed.Moreover,the internal flow of the runner is greatly affected by the closure of the guide vane,and the draft tube forms an eccentric spiral vortex rope.It breaks downstream,aggravating the instability of the draft tube.Overall,the transient characteristics span for the first five seconds,demonstrating the importance of establishing an efficient governing controller.The obtained results are useful for designing the turbine’s flow channel with a double regulating function and comprehending the turbine’s transient characteristics.

关键词： Bulb tubular turbine load rejection numerical simulation dynamic grid prototype test

Precision tuning of highly efficient Pt-based ternary alloys on nitrogen-doped multi-wall carbon nanotubes for methanol oxidation reaction

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Journal of Energy Chemistry 2024年第1期88卷 242-251,I0006页

作者： Xingqun Zheng Zhengcheng Wang Qian Zhou Qingmei Wang wei he Shun Lu College of Safety Engineering Chongqing University of Science&TechnologyChongqing 401331China College of Chemistry and Chemical Engineering Chongqing UniversityChongqing 400044China School of Chemistry and Chemical Engineering Guizhou UniversityGuizhou 550025GuiyangChina Department of Chemistry University of Rhode IslandKingston 02881Rhode IslandUnited States Chongqing Institute of Green and Intelligent Technology Chinese Academy of SciencesChongqing 400714China

The electrochemical methanol oxidation is a crucial reaction in the conversion of renewable energy.To enable the widespread adoption of direct methanol fuel cells(DMFCs),it is essential to create and engineer catalysts that are both highly effective and robust for conducting the methanol oxidation reaction(MOR).In this work,trimetallic PtCoRu electrocatalysts on nitrogen-doped carbon and multi-wall carbon nanotubes(PtCoRu@NC/MWCNTs)were prepared through a two-pot synthetic strategy.The acceleration of CO oxidation to CO_(2) and the blocking of CO reduction on adjacent Pt active sites were attributed to the crucial role played by cobalt atoms in the as-prepared electrocatalysts.The precise control of Co atoms loading was achieved through precursor stoichiometry.Various physicochemical techniques were employed to analyze the morphology,element composition,and electronic state of the catalyst.Electrochemical investigations and theoretical calculations confirmed that the Pt_(1)Co_(3)Ru_(1)@NC/MWCNTs exhibit excellent electrocatalytic performance and durability for the process of MOR.The enhanced MOR activity can be attributed to the synergistic effect between the multiple elements resulting from precisely controlled Co loading content on surface of the electrocatalyst,which facilitates efficient charge transfer.This interaction between the multiple components also modifies the electronic structures of active sites,thereby promoting the conversion of intermediates and accelerating the MOR process.Thus,achieving precise control over Co loading in PtCoRu@NC/MWCNTs would enable the development of high-performance catalysts for DMFCs.

关键词： Ternary alloys Electrocatalysts Methanol oxidation reaction Electron transfer Theoretical calculations

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A strategy to synthesize phosphorus-containing nickel phyllosilicate whiskers to enhance the flame retardancy of epoxy composites with excellent mechanical and dry-friction properties

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Frontiers of Chemical Science and Engineering 2024年第3期18卷 39-50页

作者： Shibin Nie Zongquan Zhao Yuxuan Xu wei he Wenli Zhai Jinian Yang School of Public Security and Emergency Management Anhui University of Science and TechnologyHefei231131China School of Safety Science and Engineering Anhui University of Science and TechnologyHuainan232001China School of Materials Science and Engineering Anhui University of Science and TechnologyHuainan232001China Institute of Energy Hefei Comprehensive National Science CenterHefei230000China

To enhance the fire safety and wear resistance of epoxy,phosphorus-containing nickel phyllosilicate whiskers(FP-NiPS)were synthesized using a facile hydrothermal technology,with 9,10-dihydro-9-oxa-10-phosphaphenanthrene as the organic modifier.The impacts of FP-NiPS on the thermal stability,flame retardancy,and mechanical and tribological properties of EP composites were explored.The findings demonstrated that 5 wt%FP-NiPS elevated the limiting oxygen index of the EP composite from 23.8%to 28.4%,achieving a V-0 rating during vertical burning tests.FP-NiPS could enhance the thermal stability of epoxy resin(EP)and facilitate the development of a dense and continuous carbon layer,thereby significantly improving the fire safety of the EP composites.The FP-NiPS led to an 8.2%increase in the tensile strength and a 38.8%increase in the elastic modulus of the EP composite,showing outstanding mechanical properties.Furthermore,FP-NiPS showed remarkable potential in enhancing the wear resistance of EP.The wear rate of 1 wt%FP-NiPS is 2.34×10^(−5) mm^(3)·N^(−1)·m^(−1),a decrease of 66.7%compared to EP.This work provides a novel promising modification method to enhance the fire safety,mechanical and wear resistance properties of EP.

关键词： nickel phyllosilicate epoxy resin flame retardant wear resistance mechanical property

Fast and Accurate Predictor-Corrector Methods Using Feedback-Accelerated Picard Iteration for Strongly Nonlinear Problems

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1263-1294页

作者： Xuechuan Wang wei he Haoyang Feng Satya N.Atluri School of Astronautics Northwestern Polytechnical UniversityXi’an710072China Department of Mechanical Engineering Texas Tech UniversityLubbock79409USA

Although predictor-corrector methods have been extensively applied,they might not meet the requirements of practical applications and engineering tasks,particularly when high accuracy and efficiency are necessary.A novel class of correctors based on feedback-accelerated Picard iteration(FAPI)is proposed to further enhance computational performance.With optimal feedback terms that do not require inversion of matrices,significantly faster convergence speed and higher numerical accuracy are achieved by these correctors compared with their counterparts;however,the computational complexities are comparably low.These advantages enable nonlinear engineering problems to be solved quickly and accurately,even with rough initial guesses from elementary predictors.The proposed method offers flexibility,enabling the use of the generated correctors for either bulk processing of collocation nodes in a domain or successive corrections of a single node in a finite difference approach.In our method,the functional formulas of FAPI are discretized into numerical forms using the collocation approach.These collocated iteration formulas can directly solve nonlinear problems,but they may require significant computational resources because of the manipulation of high-dimensionalmatrices.To address this,the collocated iteration formulas are further converted into finite difference forms,enabling the design of lightweight predictor-corrector algorithms for real-time computation.The generality of the proposed method is illustrated by deriving new correctors for three commonly employed finite-difference approaches:the modified Euler approach,the Adams-Bashforth-Moulton approach,and the implicit Runge-Kutta approach.Subsequently,the updated approaches are tested in solving strongly nonlinear problems,including the Matthieu equation,the Duffing equation,and the low-earth-orbit tracking problem.The numerical findings confirm the computational accuracy and efficiency of the derived predictor-corrector algorithms.

关键词： Predictor-corrector method feedback-accelerated Picard iteration nonlinear dynamical system real-time computation

Manipulating the Phase Transition Behavior of Dual Temperature-Responsive Block Copolymers by Adjusting Composition and Sequence

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Chinese Journal of Polymer Science 2024年第2期42卷 176-187,I0006页

作者： Zhi Zou Xiang Xu Hai-Tao Zhao Jian-Nan Cheng wei-wei he Li-Fen Zhang Zhen-Ping Cheng Suzhou key Laboratory of Macromolecular Design and Precision Synthesis Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationState and Local Joint Engineering Laboratory for Novel Functional Polymeric MaterialsCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou215123China State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of JiangsuSoochow UniversitySuzhou215123China

Temperature-responsive polymers have garnered significant attention due to their ability to respond to external stimuli.In this work,dual temperature-responsive block copolymers are synthesized via reversible addition-fragmentation chain transfer polymerization(RAFT)polymerization utilizing zwitterionic monomer methacryloyl ethyl sulfobetaine(SBMA) and N-isopropyl acrylamide(NIPAAm) as monomers.The thermal responsive behaviors can be easily modulated by incorporating additional hydrophobic monomer benzyl acrylate(BN) or hydrophilic monomer acrylic acid(AA),adjusting concentration or pH,or varying the degree of polymerization of the block chain segments.The cloud points of the copolymers are determined by UV-Vis spectrophotometry,and these copolymers exhibit both controlled upper and lower critical solu bility temperatures(LCST and UCST) in aqueous solution.This study analyzes and summarizes the influencing factors of dual temperature responsive block copolymers by exploring the effects of various conditions on the phase transition temperature of temperature-sensitive polymers to explore the relationship between their properties and environment and structure to make them more selective in terms of temperature application range and regulation laws.It is very interesting that the introduction of poly-acrylic acid(PAA) segments in the middle of di-block copolymer PSBMA_(55)-b-PNIPAAm_(80) to form PSBMA_(55)-b-PAA_(x)-b-PNIPAAm_(80) results in a reversal of temperature-responsive behaviors from 'U'(LCST UCST) type,while the copolymer PSBMA_(55)-b-P(NIPAAm_(80)-co-AA_(x)) not.This work provides a clue for tuning the phase transition behavior of polymers for manufacture of extreme smart materials.

关键词： Temperature responsive polymers High critical solubility temperature(UCST) Low critical solubility temperature(LCST) Block copolymers

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Vector field path following for a micro flapping-wing robot

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Science China(Information Sciences) 2024年第6期67卷 442-444页

作者： Haifeng HUANG Yingte LIU Tao NIU Chang WANG Yao ZOU wei he School of Intelligence Science and Technology University of Science and Technology Beijing Institute of Artificial Intelligence University of Science and Technology Beijing Key Laboratory of Intelligent Bionic Unmanned Systems Ministry of EducationUniversity of Science and Technology Beijing

Flapping-wing robots mimic the flight patterns of natural flying creatures,granting them natural camouflage.They hold promising applications in the military reconnaissance,urban surveillance,and various other fields[1–3].However,the current limitations in size often restrict the suitability of existing bird-like flapping-wing robots,

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Multifunctional nanoparticle-mediated combining therapy for human diseases

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Signal Transduction and Targeted Therapy 2024年第2期9卷 343-375页

作者： Xiaotong Li Xiuju Peng Makhloufi Zoulikha George Frimpong Boafo Kosheli Thapa Magar Yanmin Ju wei he School of Pharmacy China Pharmaceutical UniversityNanjing 2111198PR China Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013PR China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China

Combining existing drug therapy is essential in developing new therapeutic agents in disease prevention and treatment.In preclinical investigations,combined effect of certain known drugs has been well established in treating extensive human diseases.Attributed to synergistic effects by targeting various disease pathways and advantages,such as reduced administration dose,decreased toxicity,and alleviated drug resistance,combinatorial treatment is now being pursued by delivering therapeutic agents to combat major clinical illnesses,such as cancer,atherosclerosis,pulmonary hypertension,myocarditis,rheumatoid arthritis,inflammatory bowel disease,metabolic disorders and neurodegenerative diseases.Combinatorial therapy involves combining or co-delivering two or more drugs for treating a specific disease.Nanoparticle(NP)-mediated drug delivery systems,i.e.,liposomal NPs,polymeric NPs and nanocrystals,are of great interest in combinatorial therapy for a wide range of disorders due to targeted drug delivery,extended drug release,and higher drug stability to avoid rapid clearance at infected areas.This review summarizes various targets of diseases,preclinical or clinically approved drug combinations and the development of multifunctional NPs for combining therapy and emphasizes combinatorial therapeutic strategies based on drug delivery for treating severe clinical diseases.Ultimately,we discuss the challenging of developing NP-codelivery and translation and provide potential approaches to address the limitations.This review offers a comprehensive overview for recent cutting-edge and challenging in developing NP-mediated combination therapy for human diseases.

关键词： drugs diseases prevention

Visible-Light-Driven Four-Component Radical Relay Aminocarbonylation of Unactivated Alkenes

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Chinese Journal of Chemistry 2024年第9期42卷 990-996页

作者： Bin Lu Feng-Shuo Bao Zi-wei he Wen-Jing Xiao Jia-Rong Chen Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction College of ChemistryCentralChina Normal University152 LuoyuRoadWuhanHubei 430079China Wuhan Institute of Photochemistry and Technology 7North Bingang RoadWuhanHubei 430083China Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province Gannan Normal UniversityGanzhouJiangxi 341000China

Catalytic four-component radical carbonylation of unactivated alkenes has recently been recognized as a robust protocol for rapid construction of various structurally diverse carbonyl compounds.Given the significance of fluorine-containing groups,this reaction class has been extensively applied to assembly of a variety of perfluoroalkyl carboxylic acid derivatives by transition metal catalysis.herein,we report a visible-light-driven radical relay 1,2-perfluoroalkylation aminocarbonylation of unactivated alkenes using CO gas as carbonyl source and 4CzIPN as organic photocatalyst.A wide range of alkenes and amines were well tolerated,providing the valuableβ-perfluoroalkylated amides with generally good yields and high chemoselectivity.

关键词： Visible light Photoredox catalysis Radical aminocarbonylation Multicomponent reaction Carbon monoxide Unactivated alkenes AmidesIReactionmechanisms