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Developmental Effects of Malathion Exposure on Recognition Memory and Spatial Learning in Males Wistar Rats

Journal of Behavioral and Brain Science 2013年第3期3卷 331-340页

作者： Pacome Kouadio N’Go Fatima-Zahra Azzaoui Porlo Rigobert Soro Majda samih Ahmed Omar Touhami Ahami mohamed Najimi Fatiha Chigr Unit of Clinics and Cognitives Neurosciences Laboratory of Biology and HealthDepartment of BiologyFaculty of SciencesUniversity Ibn TofailKenitraMorocco Laboratory of Physiology Animal Department of BiologyFaculty of Sciences and TechnologyUniversity Sultan Moulay SlimaneBeni MellalMorocco

Most cognitive effects of Organophosphate Pesticides (OP) are induced after exposure to parathion, chlorpyrifos and diazinon, which the usage has been restricted because of overt signs of their toxicities. In this study, we investigate whether developmental exposure to Malathion could impair spatial learning and recognition memory in male rats. Animals exposed by intragastric route, from in utero to young adult stage, to incremental doses of Malathion dissolved in corn oil;100, 200 and 300 mg/kg of body weight, and one control group are given corn oil. Then, cognitive and behaveioral abilities are assessed using Barnes maze and object recognition memory task. Malathion administration at 300 mg/kg is toxic to pregnant dams, and pups are stillborns. Rats exposed to 200 mg/kg make a significant working memory error, and require more time to find an escape box during the initial training phase of Barnes maze. However, fewer errors are made in rats exposed to 100 mg/kg. For reversal learning task, the high dose group shows great deficits in spatial strategy to locate the new position of the box. With respect to recognition task, both dose 100 and 200 mg/kg impair significant short-term (2 h after habituation phase) object recognition memory, but long-term (24 h after habituation phase) recognition memory is intact in high dose group. The current study also reveals that all treatments induce high significant neocortex acetylcholinesterase (AChE) activity inhibition, but 100 mg/kg dose is not sufficient to disrupt great hippocampal activity alteration. These results suggest that developmental exposure to Malathion, despite low toxicity described, may induce late-emerging spatial learning and recognition memorialterations. Moreover, Cortical and hippocampal area that support strongly these behaviors remain sensitive to incremental doses of Malathion.

关键词： AChE Developmental Neurotoxicity Malathion Organophosphate Pesticide Recognition Memory Spatial Learning

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Rationales and uncertainties for aspirin use in COVID-19:a narrative review

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Family Medicine and Community Health 2021年第2期9卷 15-23页

作者： hazem A Sayed Ahmed Eric Merrell Mansoura Ismail Anwar I Joudeh Jeffrey B Riley Ahmed Shawkat Hanan Habeb Edward Darling Reda A Goweda mohamed H Shehata Hossam Amin Gary F Nieman Hani Aiash Department of Family Medicine Suez Canal University Faculty of MedicineIsmailiaEgypt Department of Medicine State University of New York Upstate Medical UniversitySyracuseNew YorkUSA Department of Internal Medicine The University of JordanAmmanJordan Department of Cardiovascular Perfusion State University of New York Upstate Medical UniversitySyracuseNew YorkUSA Department of Critical Care State University of New York Upstate Medical UniversitySyracuseNew YorkUSA Egypt Ministry of Health and Population CairoEgypt Department of Community Medicine Umm Al-Qura University College of MedicineMakkahSaudi Arabia Department of Family and Community Medicine Arabian Gulf University College of Medicine and Medical ScienceManamaBahrain Department of Critical Care New York Medical CollegeValhallaNew YorkUSA Department of Surgery State University of New York Upstate Medical UniversitySyracuseNew YorkUSA

Objectives To review the pathophysiology of COVID-19 disease,potential aspirin targets on this pathogenesis and the potential role of aspirin in patients with *** Narrative *** The online databases PubMed,OVID Medline and Cochrane Library were searched using relevant headlines from 1 January 2016 to 1 January *** guidelines from relevant societies,journals and forums were also assessed for *** Not *** A review of the selected literature revealed that clinical deterioration in COVID-19 is attributed to the interplay between endothelial dysfunction,coagulopathy and dysregulated *** has anti-inflammatory effects,antiplatelet aggregation,anticoagulant properties as well as pleiotropic effects on endothelial *** the COVID-19 pandemic,low-dose aspirin is used effectively in secondary prevention of atherosclerotic cardiovascular disease,prevention of venous thromboembolism after total hip or knee replacement,prevention of pre-eclampsia and postdischarge treatment for multisystem inflammatory syndrome in *** low-dose aspirin therapy may reduce the risk of intensive care unit admission and mechanical ventilation in hospitalised patients with COVID-19,whereas aspirin association with mortality is still *** The authors recommend a low-dose aspirin regimen for primary prevention of arterial thromboembolism in patients aged 40-70 years who are at high atherosclerotic cardiovascular disease risk,or an intermediate risk with a risk-enhancer and have a low risk of ***’s protective roles in COVID-19 associated with acute lung injury,vascular thrombosis without previous cardiovascular disease and mortality need further randomised controlled trials to establish causal conclusions.

关键词： prevention aspirin mortality

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Multi-objective Optimization for Target Tracking in Quantized Sensor Networks

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通讯和计算机（中英文版） 2012年第10期9卷 1195-1205页

作者： Majdi Mansouri Faicel Hnaien hazem Nounou mohamed Nounou Hichem Snoussi Cedric Richard College of Engineering-Electrical and Computer Engineering Texas A &M University Doha 3874 Qatar ICD/LOSI University of Technology of Troyes Troyes l O000 France ICD/LM2S University of Technology of Troyes 10000 Troyes France Laboratoire FIZEA U UMR CNRS 6525 Nice Sophia Antipolis University 06000 Nice France

This work presents a multi-objective algorithm for jointly selecting the appropriate group of candidate sensors and optimizing the quantization for target tracking in WSN (wireless sensor networks). The authors focus on a more challenging problem of how to effectively utilize quantized sensor measurement for target tracking in sensor networks by considering sensors selection problem. Firstly, The authors jointly optimize the quantization level and the group of candidate sensors selection in order to provide the required data of the target and to balance the energy dissipation in the WSN. Then, The authors estimate the target position using QVF (quantized variational filtering) algorithm. The quantization optimization and the sensor selection are based on MO (multi-objective) that defines the main parameters that may influence the relevance of the participation in cooperation for target tracking. This selection is also based on the transmitting power between one sensor and the CH (cluster head). The best sensors selection and quantization optimization are designed to reduce the communication cost and the estimation error, which leads to a significant reduction of energy consumption and an accurate target tracking. The computation of these criteria is based on the target position predictive distribution provided by the QVF algorithm. The simulation results show that the proposed method outperforms the quantized variational filtering algorithm under sensing range constraint and the binary variational filtering algorithm.

关键词：无线传感器网络多目标优化目标跟踪量化滤波算法目标位置估计误差选择问题

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