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Case Report: Asymptomatic Osteosarcoma

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Case Reports in Clinical Medicine 2015年第12期4卷 369-375页

作者： Reiko Yamaguchi Seiichi Matsumoto Keisuke Ae Taisuke Tanizawa Tabu Gokita Keiko hayakawa Yuki Funauchi Munehisa Kito Hirotada Ishii Noriko Motoi Department of Orthopaedic Surgery Cancer Institute Hospital Tokyo Japan Ishii Orthopaedic Clinic Tokyo Japan Division of Pathology Cancer Institute Hospital Tokyo Japan

Osteosarcomas are primary malignant tumors that are characterized by the production of osteoid or immature bone. However they are the most common primary malignant tumor of bone in adolescents and young adults, the diagnosis of osteosarcoma is often delayed. It is because of the rarity of population, the variety of findings, nonspecific symptoms and so on. A 46-year-old male patient had left knee pain for 3 months without any symptoms in his right knee. At a nearby clinic, X-ray of his healthy side was taken by chance. The irregular bone formation was however seen in the metaphysis of the distal femur with spreading into the soft tissues. No abnormal findings were pointed out at his left side knee. A diagnosis of pleomorphic sarcoma was made by incisional biopsy. Pulmonary CT showed multiple nodules which were considered as multiple lung metastases. He was diagnosed as right femoral sarcoma, clinical stage IV (T1N0M1a) by TNM classification. He underwent preoperative chemotherapy, followed by limb-saving operation. No preoperative complaints were found in his left knee. Final diagnosis of surgically resected specimen was osteoblastic osteosarcoma which showed neoplastic osteoid formation within pleomorphic malignant cells. However, osteosarcomas occurred in adult populations are sometimes occurred as a secondary neoplasms, he had a history of diabetes but no other medical history, such as radiation therapy for a solid cancer, Paget’s disease, other benign bone lesions or inherited conditions. As far as our knowledge, we believe that this is a first case report of asymptomatic incidental osteosarcoma.

关键词： Incidental Osteosarcoma Asymptomatic Osteosarcoma De Novo Osteosarcoma

Development of simple HPLC/UV with a column-switching method for the determination of nicotine and cotinine in hair samples

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Health 2013年第4期5卷 687-694页

作者： Masayoshi Tsuji Yayoi Mori Hideyuki Kanda Teruna Ito Tomoo Hidaka Takeyasu Kakamu Tomohiro Kumagai Takehito hayakawa Yoneatsu Osaki Tetsuhito Fukushima Department of Epidemiology and Public Health School of Medicine Yokohama City University Yokohama Japan Department of Hygiene and Preventive Medicine School of Medicine Fukushima Medical University Fukushima Japan Division of Environmental and Preventive Medicine Department of Social Medicine Faculty of Medicine Tottori University Yonago Japan

Nicotine and cotinine in hair are good biomarkers for assessing long-term exposure to smoking. However, analytical devices such as GC/MS are associated with high cost and are not widely used. HPLC/UV is used widely in laboratories, but is unsuitable for measurement of minor constituents, except when using the column-switching method. Thus, we aimed to establish a simple, inexpensive and sensitive method based on HPLC/UV with column switching for measuring nicotine and cotinine in hair. First, we compared the presence and absence of a column selection unit. We then measured amounts of nicotine and cotinine in hair samples collected from the general population, and compared both the corresponding levels and the detection limits with those in previous studies. Finally, initial and running costs of HPLC/UV were compared with other analytical methods. As one of the results, the areas of nicotine and cotinine measured by HPLC/UV with column-switching method were 12.9 and 16.9 times greater, respectively, than those without the column-switching method. The amount of nicotine and cotinine in hair was significantly correlated to number of cigarettes smoked per day (r = 0.228, p = 0.040). In addition, the HPLC/UV method showed similar sensitivity and detection limit (nicotine, 0.10 ng/mg;cotinine, 0.08 ng/mg) as reported in previous studies. The cost of the HPLC/UV method is lower than that of other analytical methods. We were able to establish a low-cost method with good sensitivity for measuring nicotine and cotinine in hair. The HPLC/UV with a column-switching method will be useful as a first step in screening surveys in order to better understand the effects of smoking exposure.

关键词： HPLC/UV Column-Switching Method Nicotine Hair Cotinine

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渚滑川河口拦门沙演变特性

自然灾害学报 2007年第2期16卷 64-69页

作者：魏炳乾夏双喜早川博西安理工大学水电学院陕西西安710048 北见工业大学土木开发工学科

河口拦门沙的存在可导致径流流出不畅,并能引起一系列的河口生态及环境问题。特别是弯曲型河口,在波浪流、河川径流及弯道副流的共同作用下,拦门沙的形成及演变将更为复杂。通过对日本渚滑川河口多次实地调查资料的分析,揭示了渚滑川河... 详细信息

河口拦门沙的存在可导致径流流出不畅,并能引起一系列的河口生态及环境问题。特别是弯曲型河口,在波浪流、河川径流及弯道副流的共同作用下,拦门沙的形成及演变将更为复杂。通过对日本渚滑川河口多次实地调查资料的分析,揭示了渚滑川河口拦门沙的演变特性。结果表明:渚滑川河口修筑防波堤后,在东北方向的海洋入射波作用下,拦门沙由河口右岸发育并向左岸逐渐延伸扩展,其河水流动也相应由右岸偏向左岸一侧;不论河口有无拦门沙,3次洪水在右岸的最大冲深均稳定在-6m高程,且河床横剖面的形状基本不变,即汛期时该河口河床形状已达平衡状态。

关键词：渚滑川河口拦门沙演变

Comparative Analyses of Stomatal Size and Density among Ecotypes of <i>Aster hispidus</i>(Asteraceae)

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American Journal of Plant Sciences 2013年第3期4卷 524-527页

作者： Yoshimasa Kumekawa Haruki Miyata Kyohei Ohga Hiroshi hayakawa Jun Yokoyama Katsura Ito Shin-ichi Tebayashi Ryo Arakawa Tatsuya Fukuda Faculty of Science Yamagata University Yamagata Japan. Graduate School of Integrated Arts and Sciences Kochi University Kochi Japan

To determine the size and the density of stomata among different environments, we conducted anatomical analyses using Aster hispidus var. hispidus (open field), As. hispidus var. leptocladus (serpentine soil), and As. hispidus var. insularis (coastal). The stomatal size was not significantly different among these ecotypes but the density of stomata in the serpentine and coastal ecotypes was significantly lower than that of As. hispidus var. hispidus, which suggests that these ecotypes have experienced selection that reduced the density of stomata for adaptation to the dry conditions of serpentine and coastal areas.

关键词： Aster hispidus Costal Ecotype Density Guard Cell Serpentine Size

On the Precursory Abnormal Animal Behavior and Electromagnetic Effects for the Kobe Earthquake (M~6) on April 12, 2013

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Open Journal of Earthquake Research 2016年第3期5卷 165-171页

作者： Masashi hayakawa Hiroyuki Yamauchi Nobuyo Ohtani Mitsuaki Ohta Susumu Tosa Tomokazu Asano Alexander Schekotov Jun Izutsu Stelios M. Potirakis Konstantinos Eftaxias hayakawa Institute of Seismo Electromagnetics Co. Ltd. UEC (University of Electro-Communications) Incubation Center Chofu Japan UEC Advanced Wireless & Communications Research Center Chofu Japan Department of Animal Science and Biotechnology Azabu University Sagamihara Japan Department of Human and Animal-Plant Relationships Tokyo University of Agriculture Atsugi Japan Kagawa Prefecture Livestock Experiment Station Kida Japan Institute of Physics of the Earth Russian Academy of Sciences Moscow Russia Department of Electronic Engineering Chubu University Kasugai Japan Department of Electronics Engineering Piraeus University of Applied Sciences (TEI of Piraeus) Athens Greece Department of Physics University of Athens Athens Greece

After the 2011 Tohoku earthquake (EQ), there have been numerous aftershocks in the eastern and Pacific Ocean of Japan, but EQs are still rare in the western part of Japan. In this situation a relatively large (magnitude (M) ~6) EQ happened on April 12 (UT), 2013 at a place close to the former 1995 Kobe EQ (M~7), so we have tried to find whether there existed any precursors to this EQ, especially abnormal animal behavior (milk yield of cows), observed at Kagawa, Shikoku, near the EQ epicenter. The milk yield of cows has been continuously monitored at Kagawa, and it is found that the milk yield exhibited an abnormal depletion about 10 days before the EQ. This behavior has been extensively compared with the former electromagnetic precursors (ULF radiation, ionos-pheric perturbation). This leads to the discussion on the sensory mechanism of unusual behavior of mild yield of cows, and it may be suggested that ULF radiation among different electromagnetic precursors is a mostly likely driver, at least, for this EQ.

关键词： Abnormal Animal Behavior Earthquakes Milk Yield of Cows ULF Radiation Sensory Mechanism of Animals

日本香川地区荷斯坦牛乳与娟姗牛乳营养成分的比较

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中国食品卫生杂志 2015年第6期27卷 652-657页

作者：王任 Shigeru hayakawa 周明昊罗金文浙江省食品药品检验研究院浙江杭州310052 香川大学农学部

目的比较日本香川地区荷斯坦和娟姗牛乳中乳清蛋白的总蛋白质含量,乳过氧化物酶(LPO)和乳铁蛋白的一些基本性质。方法以荷斯坦和娟姗牛乳为对象,经酸沉淀除酪蛋白后,通过离心,SP-Sepharose离子交换层析分离纯化得到乳过氧化物酶和乳铁蛋... 详细信息

目的比较日本香川地区荷斯坦和娟姗牛乳中乳清蛋白的总蛋白质含量,乳过氧化物酶(LPO)和乳铁蛋白的一些基本性质。方法以荷斯坦和娟姗牛乳为对象,经酸沉淀除酪蛋白后,通过离心,SP-Sepharose离子交换层析分离纯化得到乳过氧化物酶和乳铁蛋白,利用考马斯亮蓝定量、SDS-PAGE定性、ABTS检测乳过氧化物酶活性、最后通过基质辅助激光解吸电离飞行时间质谱(MALDI-TOF-MS)确认分子量。结果娟姗牛乳中乳清蛋白的总蛋白质和乳过氧化物酶含量均高于荷斯坦中乳清蛋白中的总蛋白质和乳过氧化物酶含量。娟姗乳清蛋白中的乳过氧化物酶活性(0.870 5 U/ml)高于荷斯坦乳清蛋白中的乳过氧化物酶活性(0.758 9 U/ml)。娟姗乳清蛋白中的乳过氧化物酶和乳铁蛋白分子量分别为786 48.154和831 23.538 k Da,荷斯坦乳清蛋白中的乳过氧化物酶和乳铁蛋白分子量分别为777 64.841和827 65.494 k Da。结论对于乳酪行业,当考虑养殖奶牛品种生产乳酪同时又想最大限度利用需要处理的乳清蛋白和乳铁蛋白的时候,相比于荷斯坦奶牛,娟姗奶牛是更好的选择。

关键词：乳过氧化物酶乳铁蛋白乳清蛋白十二烷基磺酸钠聚丙烯酰胺凝胶电泳基质辅助激光解吸电离飞行时间质谱酶活性日本香川荷斯坦奶牛娟姗奶牛牛乳

A case of toxic epidermal necrolysis complicated by severe liver damage and hemophagocytic syndrome of unknown pathogenesis

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A case of toxic epidermal necrolysis complicated by severe l...

Crystal Growth, Thermal, Mechanical and Optical Properties of a New Organic Nonlinear Optical Material: Ethyl P-Dimethylamino Benzoate (EDMAB)

The Second Eastern Asia Dermatology Congress(EADC2012)

作者： Toshifumi Yamaoka Hiroaki Azukizawa Atsushi Tanemura Hiroyuki Murota Tomoya Hirose Koichi hayakawa Takeshi Shimazu Naoki Wada Eiichi Morii Ichiro Katayama Department of Dermatology Course of Integrated MedicineOsaka University Graduate School of Medicine Department of Traumatology and Acute Critical Medicine Osaka University Graduate School of Medicine Department of Pathology Osaka University Graduate School of Medicine

＜正＞A 76-year-old Japanese woman who had received Etodolac for cervical spondylosis over the previous 2 weeks, developed a cough and a sore throat associated with common cold in the previous 10 *** consulted out-patient clinic of other hospital and admitted with the findings of severe liver *** was found to have confluent targetoid

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Journal of Minerals and Materials Characterization and Engineering 2011年第1期10卷 1-11页

作者： V. Natarajan J. Kalyana Sundar P. Selvarajan M. Arivanandhan K. Sankaranarayanand S. Natarajan Y. hayakawa Department of Physics Aditanar College of Arts and Science Tiruchendur India Research Institute of Electronics Shizuoka University Johoku 3-5-1 Hamamatsu Japan. School of Physics Alagappa University Karaikudi-630003 India. School of Physics Madurai Kamaraj University Madurai-625021 India.

An organic material, namely, ethyl p-dimethylamino benzoate was crystallized for the first time by solution growth technique using pure and mixed solvents. Growth kinetics and morphology changes with solvents were investigated based on solute –solvent interactions of pure and mixed solvents. An appropriate mixed solvent for high quality crystals with well-defined morphology is reported. The absence of solvent molecules and the presence of various functional groups of the grown sample were qualitatively confirmed by FTIR spectroscopic studies. Thermal properties of the grown sample were analyzed by TG and DTA analysis. Mechanical properties of the EDMAB crystal were investigated by micro hardness studies. Moreover, the grown crystal shows high transparency in the visible and near IR regions. The material shows relatively high SHG efficiency than that of KDP.

关键词： Organic compounds Crystal growth - Optical properties

在交流电压和冲击电压条件下逆变器供电的电动机线圈局部放电特性

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国外大电机 2006年第2期 35-38页

作者： Naoki hayakawa[日] 阎康（译）杨笑石（校）

由于普通由逆变器供电的电动车辆和混合车辆的电动机运行在低电压下，一般来说它们的绝缘性能对于绝缘的基本设计来说并不重要。但为了得到更好的性能，逆变器供电的电动机运行电压不断提高，例如，为了获得大功率输出和紧凑型结构，要... 详细信息

由于普通由逆变器供电的电动车辆和混合车辆的电动机运行在低电压下，一般来说它们的绝缘性能对于绝缘的基本设计来说并不重要。但为了得到更好的性能，逆变器供电的电动机运行电压不断提高，例如，为了获得大功率输出和紧凑型结构，要求合理的电气绝缘性能设计。尤其是逆变器供电的电动机利用电力电子装置，例如具有高速开关性能的IGBT，于是该电动机承受陡波前的瞬态冲击电压，如图1所示。

关键词：电动机双股绞合线局部放电起始电压周期冲击电压交流电压