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Biologic Agents in Behcet’s Disease:Our Experience and Review of the Literature

Open Journal of Rheumatology and Autoimmune Diseases 2015年第4期5卷 97-103页

作者： Nesibe Karahan Yesil hatice Sahin hatice Isik Zuhal Irnek Serpil Yazgan Adem Tok Yunus Emre Yandi Metin Isik Ismail Dogan Department of Rheumatology Ankara Research and Education Hospital Ankara Turkey Department of Internal Medicine Faculty of Medicine Bülent Ecevit University Zonguldak Turkey Department of Obstetrics and Gynecology Faculty of Medicine Bülent Ecevit University Zonguldak Turkey Department of Pediatric Disaease Faculty of Medicine Bülent Ecevit University Zonguldak Turkey Department of Ophtalmology Faculty of Medicine Bülent Ecevit University Zonguldak Turkey Department of Urology Faculty of Medicine Bülent Ecevit University Zonguldak Turkey Division of Biochemistry Department of Medical Services and Techniques Health Sciences Vocational School Bülent Ecevit University Zonguldak Turkey Division of Rheumatology Department of Internal Medicine Faculty of Medicine Bülent Ecevit University Zonguldak Turkey Division of Rheumatology Department of Internal Medicine Faculty of Medicine Hitit University &Ccedilorum Turkey

Behcet’s disease (BD) is a large vessel vasculitis with a wide range of clinical manifestations. Some of these manifestation may be life threatening and rapid suppression of the inflammation with effective immunosuppressive agent is crucial. There are traditional drugs with different response rates and all have efficacy on different manifestations of the disease. The most frightening manifestations of the disease are ocular, neurologic, intestinal and vascular types of involvement. Besides benign and easily treated manifestations there are also refractory cases with complicated involvement. The novel biologic agents have been used for these resistant patients and favorable response rates have been reported. In this review, we have shared our experience with biologic agents in BD and also reviewed the literature for the efficacy and safety for these novel agents for refractory patients.

关键词： Behcet’s Disease Novel Biologic Agents Refractory Patients

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A key problem and challenge for hepatology:Obesity-related metabolic liver diseases

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World Journal of Hepatology 2011年第6期3卷 142-146页

作者： Yasemin hatice Balaban Hacettepe University Medical Faculty Internal Medicine DepartmentGastroenterology UnitAnkara 06100Turkey

With the arrival of the new millennium,gastroenterologists have been faced with the problem of metabolic liver diseases associated with *** active role of the liver in metabolism and inflammation make it a key organ in the war against the rapidly-spreading worldwide epidemic of *** lives and much money could be saved if the work of hepatologists led to the development of effective diagnostic and therapeutic strategies against this growing leader of cirrhosis.

关键词： Metabolic liver diseases Steatohepatitis Obesity Insuline resistance Lipotoxicity Adiposopaty.

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Magnetic resonance imaging evaluation of head and neck involvement in IgG4-related disease

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Asian Pacific Journal of Tropical Medicine 2023年第6期16卷 276-283页

作者： Umur Anil Pehlivan Kamil Karaali hatice Deniz Ilhan Mehmet Soy Didem Arslan Omer Kaya Rabia Miray Kisla-Ekinci Burcak Cakir-Pekoz Ummuhan Cay Arbil Acikalin Ahmet Muhtesem Agildere Department of Radiology Başkent University Adana Dr.Turgut Noyan Application and Research CenterAdanaTurkey Department of Radiology Akdeniz University Faculty of MedicineAntalyaTurkey Department of Ophthalmology Akdeniz University Faculty of MedicineAntalyaTurkey Department of Internal Medicine and Rheumatology Bahçelievler Medical ParkAltınbaşUniversity Faculty of MedicineİstanbulTurkey Department of Internal Medicine and Rheumatology Çukurova University Faculty of MedicineAdanaTurkey Department of Radiology Çukurova University Faculty of MedicineAdanaTurkey Department of Pediatric Rheumatology Adana City Training and Research HospitalAdanaTurkey Department of Radiology Adana City Training and Research HospitalAdanaTurkey Department of Pediatric Infectious Disease Çukurova University Faculty of MedicineAdanaTurkey Department of Pathology Çukurova University Faculty of MedicineAdanaTurkey Department of Radiology Başkent University Faculty of MedicineAnkaraTurkey

Objective:To evaluate the radiological features of IgG4-related disease(IgG4-RD)in the head and neck ***:In this radiology-based study,radiological features,clinical,laboratory,pathological findings,and prognosis of nine patients with head and neck involvement diagnosed with IgG4-RD were investigated ***:The median age of the patients was 38 years(range:2.5-79 years),and there were six males and three *** most common symptoms and clinical findings of the patients were eyelid and lacrimal gland swelling,painless exophthalmos,and *** most common site of involvement on MRI was the *** involvement was followed by branches of the trigeminal nerve,sinonasal cavity,cervical lymph nodes,and dural *** most common and remarkable imaging features were T2 hypointensity and diffuse homogeneous contrast ***:Head and neck involvement of the IgG4-RD,has specific imaging features that can help with ***,early diagnosis and better outcomes can be achieved with increasing awareness of these features of this relatively new pathology.

关键词： IgG4 Head and neck imaging Magnetic resonance imaging Orbit Perineural spreading

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Are Nutrition and Dietetics Students More Prone to Eating Disorders Related Attitudes and Comorbid Depression and Anxiety than Non-Dietetics Students?

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Food and Nutrition Sciences 2015年第14期6卷 1258-1266页

作者： Aliye Ozenoglu Gokce Unal Aydan Ercan hatice Kumcagiz Kamil Alakus Nutrition and Dietetics Department Samsun Health SchoolOndokuz Mayis UniversitySamsunTurkey Nutrition and Dietetics Department Faculty of Health ScienceBaskent UniversityAnkaraTurkey Counseling and Guidance Department Faculty of EducationOndokuz Mayis UniversitySamsunTurkey Statistics Department Faculty of Science and LiteratureOndokuz Mayis UniversitySamsunTurkey

It was aimed to investigate the eating attitudes and its relationships with anxiety and depression at Nutrition and Dietetics students. Students of Nutrition and Dietetics Departments were included in study group (n: 135) and non-medical students (n: 69) were in control group. Eating attitudes test (EAT-40), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) were applied to all students and some anthropometric measurements were taken. Body mass index (BMI) and percent of body fat were higher at students in study group than students in control group. There were no significant differences between groups with respect to EAT, BDI and BAI scores. But, BMI and body fat percentage in girls were significantly lower than boys. Both EAT and BDI scores were significantly higher in girls than boys but BAI scores did not differ significantly. It was concluded that students training on Nutrition and Dietetics might have obsessions related to body image. But results of this study revealed that especially young women were more susceptible to eating disorders and depression.

关键词： Eating Attitudes Anxiety Depression Dietetic Students

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土耳其的医学教育：从过去到未来

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复旦教育论坛 2009年第4期7卷 88-91页

作者： hatice Kurdak Derya Altintas Figen Doran 梅人朗(编译) 不详复旦大学公共卫生学院上海200032

本文从本科生医学教育、毕业后医学教育和继续医学教育的角度,论述了土耳其医学院校的历史和现状,医学教育的质量和专业风格,以及当前面临的问题和机遇。

关键词：土耳其本科生医学教育毕业后医学教育继续医学教育

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The relation between differential leukocyte count, neutrophil to lymphocyte ratio and the presence and severity of coronary artery disease

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Open Journal of Internal Medicine 2012年第3期2卷 163-169页

作者： hatice Selcuk Lale Dinc Mehmet Timur Selcuk Orhan Maden Ahmet Temizhan Cardiology Department Turkiye Yuksek Ihtisas Hospital Ankara Turkey

Objectives: Total leukocyte count, a marker of inflammation has long been reported to be related with coronary artery disease (CAD). Recently, differenttial leukocyte count and elevated neutrophil to lymphocyte ratio (N/L) has been shown to indicate an increased long-term risk of mortality in patients with stable CAD, myocardial infarction and undergoing cardiovascular surgery. Thses studies offer incremental prognostic value to total leukocyte count. We sought to determine the relationship between the leukocyte subtypes and N/L ratio and the presence and extent of CAD. Study design: The study consisted of 107 patients [70 (65.4%) men, 37 (34.6%) women, mean age 59.5 ± 10.6 years] referred to coronary angiography with suspected CAD. The subjects were classified into two groups according to the presence of significant CAD and the extent of CAD was determined by the Gensini method. Results: The lymphocyte count was found to be lower (2031 ± 741 cells/μL vs 2392 ± 611 cells/μL, p: 0.010) and the N/L ratio was found to be higher in patients with CAD (2.86 ± 1.57 vs 2.04 ± 1.01, p p: 0.005]. Conclusion: Our findings reveal that N/L ratio, a simple marker which can be derived from a routine complete blood count test was significantly and independently related to presence and severity of coronary atherosclerosis.

关键词： Leukocyte Neutrophil Lymphocyte Coronary Artery Disease Lymphocyte Ratio

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Histopathological comparison of topical therapy modalities for acute radiation proctitis in an experimental rat model

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World Journal of Gastroenterology 2006年第30期12卷 4879-4883页

作者： Cagatay Korkut Oktar Asoglu Murat Aksoy Yersu Kapran hatice Bilge Nese Kiremit-Korkut Mesut Parlak Bilge Hospital Istanbul Turkey Department of General Surgery Istanbul Medical Faculty Istanbul University Turkey Department of Pathology Istanbul Medical Faculty Istanbul University Institute for Oncology Istanbul University Turkey Institute for Experimental Medical Research Istanbul Faculty of Medicine Istanbul University Turkey

AIM： To evaluate the prevalent topical therapeutic modalities available for the treatment of acute radiation proctitis compared to formalin. METHODS： A total of 120 rats were used. Four groups （n = 30） were analyzed with one group for each of the following applied therapy modalities： control, mesalazine, formalin, betamethasone, and misoprostol. A single fraction of 17.5 Gy was delivered to each rat. The rats in control group rats were given saline, and the rats in the other three groups received appropriate enemas twice a day beginning on the first day after the irradiation until the day of euthanasia. On d 5, 10, and 15, ten rats from each group were euthanized and a pathologist who was unaware of treatment assignment examined the rectums using a scoring system. RESULTS： The histopathologic scores for surface epithelium, glands （crypts） and lamina propria stroma of the rectums reached their maximum level on d 10. The control and formalin groups had the highest and mesalazine had the lowest, respectively on d 10. On the 15^th d, mesalazine, betamethasone, and misoprostol had the lowest scores of betamethasone. CONCLUSION： Mesalazine, betamethasone, and misoprostol are the best topical agents for radiation proctitis and formalin has an inflammatory effect and should not be used.

关键词： Acute radiation proctitis Mesalazine Formalin Betamethasone Misoprostol

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Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager

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Light(Science & Applications) 2017年第1期6卷 159-167页

作者： Filiz Yesilkoy Roland A Terborg Josselin Pello Alexander A Belushkin Yasaman Jahani Valerio Pruneri hatice Altug Institute of BioEngineering École Polytechnique Fédérale de LausanneCH-1015 LausanneSwitzerland ICFO-Institut de Ciències Fotòniques The Barcelona Institute of Science and Technology08860 Castelldefels(Barcelona)Spain ICREA-InstitucióCatalana de Recerca i Estudis Avançats 08010 BarcelonaSpain

Nanophotonics,and more specifically plasmonics,provides a rich toolbox for biomolecular sensing,since the engineered metasurfaces can enhance light–matter interactions to unprecedented *** far,biosensing associated with high-quality factor plasmonic resonances has almost exclusively relied on detection of spectral shifts and their associated intensity ***,the phase response of the plasmonic resonances have rarely been exploited,mainly because this requires a more sophisticated optical *** we present a new phase-sensitive platform for high-throughput and label-free biosensing enhanced by *** employs specifically designed Au nanohole arrays and a large field-of-view interferometric lens-free imaging reader operating in a collinear optical path *** unique combination allows the detection of atomically thin(angstrom-level)topographical features over large areas,enabling simultaneous reading of thousands of microarray *** the plasmonic chips are fabricated using scalable techniques and the imaging reader is built with low-cost off-the-shelf consumer electronic and optical components,the proposed platform is ideal for point-of-care ultrasensitive biomarker detection from small sample *** research opens new horizons for on-site disease diagnostics and remote health monitoring.

关键词： interferometric imaging label-free plasmonic biosensors lens-free imaging phase interrogation point-of-care devices protein microarray detection

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Assessment of the Patient Movement for Lesion during Myocardial Perfusion SPECT Imaging by Cardiac Phantom

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World Journal of Nuclear Science and Technology 2015年第2期5卷 129-139页

作者： Eser Erim Turkan Ertay Ismail Evren Mine Eren Cengiz Tasci hatice Durak Department of Medical Physics Institute of Health Sciences Dokuz Eylul University Izmir Turkey Department of Nuclear Medicine School of Medicine Dokuz Eylul University Izmir Turkey Gama Nuclear Medicine Center Gaziantep Turkey

Movement of the patient during myocardial perfusion SPECT leads to some artifacts that make the interpretation difficult. In this study, myocardial perfusion imaging protocol was performed on a cardiac phantom and SPECT was performed by simulating patient movements. A lesion model with dimensions of 1.2 × 2 × 2 cm was created on the inferoseptal wall of the cardiac phantom. Imaging was done in circular orbits in 64 × 64 matrix and step and shoot mode. First set of images taken with no movement was referred as the reference image. During imaging, patient movement was simulated by moving the phantom in ±X and ±Y directions between the frames starting from 8th frame to 16th frame. At the end of imaging, Bull’s eye maps of images with movement were com-pared with Bull’s eye maps of reference images. Bull’s eye maps were evaluated by an experienced nuclear medicine physician. Shifting patient’s movement in all directions by ±1 and ±2 cm, dis-placed the localization of the lesion mildly and this did not hamper the evaluation. However, movements of ±3 or ±4 cm resulted in artifacts which in turn caused partial or no visualization of the lesion. In motion corrected images, the lesion could be evaluated in ±1 and ±2 cm movements while lesion could not be evaluated in ±3 and ±4 cm movements. As a result, movement greater than ±3 cm causes significant image artifacts and this should be considered as a potential source of error in myocardial perfusion studies.

关键词： SPECT Myocardial Perfusion Scintigraphy Cardiac Phantom

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Rational Usage of Disease Modifying Anti-Rheumatic Drugs with the Guidance of EULAR and ACR Suggestions

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Open Journal of Rheumatology and Autoimmune Diseases 2015年第4期5卷 104-112页

作者： Zuhal Ornek Metin Isik Nesibe Karahan Yesil Ismail Dogan hatice Sahin Ali Erdem Baki Department of Pediatrics Faculty of MedicineBülent Ecevit UniversityZonguldakTurkey Division of Rheumatology Department of Internal MedicineFaculty of MedicineBülent Ecevit UniversityZonguldakTurkey Department of Rheumatology Ankara Education and Research HospitalAnkaraTurkey Division of Rheumatology Department of Internal MedicineFaculty of MedicineCorum Hitit UniversityCorumTurkey Department of Internal Medicine Faculty of MedicineBülent Ecevit UniversityZonguldakTurkey Department of Physical Medicine and Rheabilitation Faculty of MedicineBülent Ecevit UniversityZonguldakTurkey

Disease modifying anti-rheumatic agents are the cornerstone in management of Rheumatoid Arthritis and when used correctly they are life-saving. As the number of the agents increases, detailed guidelines become more and more important for clinicians to set safe and effective regimens. Herein, we combined the EULAR and ACR recommendations for clinicians and also pointed some important facts peculiar to our country.

关键词： DMARD Rational EULAR ACR

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