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Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats

World Journal of Gastroenterology 2013年第34期19卷 5633-5644页

作者： Salim S Al-Rejaie hatem m abuohashish maher m Al-Enazi Abdullah H Al-Assaf mihir Y Parmar mohammed m Ahmed Department of Pharmacology andToxicology College of PharmacyKing Saud University Department of medical Laboratory Sciences College of Applied Medical SciencesSalman bin Abdulaziz University Department of Science and Nutrition College of Food and Agricultural SciencesKing Saud University

AIm:To evaluate the ameliorative effect of naringenin(NG)during ulcerative colitis(UC)in ***:Rats were treated with three different doses(25,50 and 100 mg/kg per day)of NG and a single dose of mesalazine(mES,300 mg/kg per day)for seven days prior to ulcerative colitis induction by4%acetic acid(AA).Twenty four hours after AA rectal administration,animals were scarified and the colonic tissues were *** mucus content was estimated using Alcian blue dye binding *** colon tissues,levels of total glutathione sulphadryls(T-GSH),non-protein sulphadryls(NP-SH)and thiobarbituric acid reactive substances(TBARS)were *** activities of the antioxidant enzymes,catalase(CAT)and superoxide dismutase(SOD)were *** of nucleic acids(DNA and RNA)and total protein were also estimated in colon *** levels of tumor necrosis factor-(TNF-),interleukin-1(IL-1),interleukin-6(IL-6),prostaglandin E2(PGE2)and nitric oxide(NO)were *** cross section of colitis tissue the histopathological changes were ***:Colonic mucus content was decreased in AA compared to controls(587.09±65.59 mg/kg vs941.78±68.41 mg/kg,Pministration markedly reduced T-GSH(5.25±0.37 nmol/L vs 3.04±0.24 nmol/L,Pmol/L vs 2.16±0.30 nmol/L,Pmg vs 3.04±0.2 U/mg,Pmg vs 1.77±0.18 U/mg,Pmol/L vs 59.90±16.34 nmol/L,Pmg vs 134.24±4.77 pg/mg,Pmg vs 422.19±31.47 pg/mg,Pmg vs 638.58±115.9 pg/mg,Pmg vs 541.74±58.34 pg/mg,Pmmol/g vs 101.90±10.73 mmol/g,Pmpared controls *** supplementation,significantly and dose dependently increased the colonic mucus *** elevated TBARS levels were significantly decreased(39.35±5.86nmol/L,P<0

关键词： Naringenin Ulcerative colitis Inflammatory bowel disease Oxidative stress

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A new technique of monsplasty as an adjunctive procedure in cases of abdominoplasty:A prospective clinical trial

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第3期6卷 124-129页

作者： Laila Ahmed Aboul Nasr Sherief Zamer Ahmed Fathy Elsayed mohamed hatem Elsahar Department of Plastic Surgery Faculty of Medicine Kasr Al-AinyCairo UniversityCairo11562Egypt

Background:No standard monsplasty technique has existed until *** various monsplasty methods have been described,they exhibit high complication rates with sparse postoperative *** that used pubic suspension techniques did not describe exact anatomical landmarks for the mons *** study aimed to improve the aesthetic and functional appearance of the pubic region with long-term results for all grades of pubic ptosis or bulging with abdominoplasty and provide exact anatomical points to anchor the mons to the rectus ***:This non-randomized prospective clinical trial included 30 patients with various degrees of abdominal wall laxity between December 2017 and September *** surgical procedure was performed for female patients with pendulous abdomen,pubic ptosis or bulging,body mass index≤35 kg/m^(2),and age 18–60 *** patients were followed for up to one year;patient satisfaction was assessed before and after surgery regarding aesthetic results and impact on outfits,hygiene,and sexual ***:The marginal homogeneity test revealed a statistically significant patient satisfaction rate regarding outfits,sexual function,hygiene,and *** postoperative complications,seroma(one case)was managed by aspiration,and one case of wound dehiscence was managed conservatively with ***:This study recommends a quick and reproducible monsplasty technique with a low complication rate,a technique that helps determine specific anatomical landmarks for anchoring the mons to the rectus *** this technique with abdominal contouring is advisable for optimal aesthetic results and maintained lymphatic drainage in the pubic region.

关键词： Abdominoplasty mons ptosis Pubic suspension Skin redundancy

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A Glassy Carbon Electrode modified with Cellulose Nanofibrils from Ammophila arenaria for the Sensitive Detection of L-Trytophan

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Journal of Sensor Technology 2024年第3期14卷 35-50页

作者： Sondes Bourigua Feriel Boussema Zayneb Jebali Houcine Barhoumi hatem majdoub Abderrazak maaref Nicole Jaffrezic-Renault Laboratory of Advanced materials and Interfaces Faculty of Sciences University of Monastir Monastir Tunisia Institute of Analytical Sciences University of Lyon Villeurbanne France

L-tryptophan is an essential amino acid for human health. Nanofibrillated cellulose (NFC) from marram grass (Ammophila arenaria) extracted from plants harvested in the center of Tunisia was used for the first time for the modification of a glassy carbon electrode (GCE), for the sensitive detection of L-tryptophan (Trp). After spectroscopic and morphological characterization of the extracted NFC, the GC electrode modification was monitored through cyclic voltammetry. The NFC-modified electrode exhibited good analytical performance in detecting Trp with a wide linear range between 7.5 × 10−4 mm and 10−2 mm, a detection limit of 0.2 µm, and a high sensitivity of 140.0 µA∙mm−1. Additionally, the NFC/GCE showed a good reproducibility, good selectivity versus other amino acids, uric acid, ascorbic acid, and good applicability to the detection of Trp in urine samples.

关键词： Nanofibrillated Cellulose Chitosan Chemically modified Glassy Carbon Electrode Electrochemical Detection L-Tryptophan

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Biochemical Liver Functions and molecular Identification of Fasciola hepatica from Experimentally Infected Rat model

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Open Journal of Animal Sciences 2024年第2期14卷 88-100页

作者： Omnia m. Kandil Emad B. Ata margarita P. Gabrashanska hatem A. Shalaby Tamer H. Abd El-Aziz Noha m. F. Hassan Soad m. Nasr mohamed A. Helal Ebtesam m. Al-Olayan Department of Parasitology & Animal Diseases Veterinary Research Institute National Research Centre Giza Egypt Institute of Experimental morphology Pathology and Anthropology with Museum Bulgarian Academy of Sciences Sofia Bulgaria Department of Zoology Collage of Science King Saud University Riyadh Saudi Arabia

The current study was performed to evaluate the liver function status as well as molecular characterization of the recovered worms in rats experimentally infected with F. hepatica. Sixteen male Wister rats aged 30 days were randomly allocated into two groups (n = 8). The first group was infected orally with 15 viable encysted metacercaria of F. hepatica per animal. The other group was kept non-infected (control group). At zero time (before infection), the 2nd, 4th, 6th, 8th, 10th, 12th and 14th weeks post-infection (WPI), blood and serum samples were collected via puncture of retro-orbital plexus of veins from each rat. Serum enzyme level (AST and ALT) and total protein were measured, and the serum protein profile was carried out using agarose gel electrophoresis. During the period of the experiment, serum ALT and AST activities and serum total globulins significantly increased while serum total proteins and albumin markedly decreased in the infected group. On the 14th WPI, the data of the electropherogram showed that globulin fractions (α1-, β- and γ-globulin) levels were significantly increased while α2-globulin was markedly decreased in the infected group. The molecular analysis confirmed the amplification of the ITS1, ITS2 and NDI genes of F. hepatica recovered from the infected liver of rats with amplicon sizes of 630, 510 and 560 bp, respectively. Sequencing of the amplified ITS gene resulted in the determination of 3 strains (PP108836, PP108837, and PP108838). Also, analysis of the ITS2 gene resulted in obtaining 3 isolates under the accession numbers (PP109065, PP109066, and PP109067). In conclusion, fasciolosis in the rat model is suitable for routine experimental infections and caused a pronounced liver dysfunction with discharging of the Fasciola eggs in the faeces and the development of adult stages in the bile ducts. Furthermore, molecular techniques are a sensitive

关键词： Fasciola hepatica Liver Functions Serum Enzymes Serum Protein Electrophoresis molecular Characterization

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Prevelance of Bovine Cysticercosis in Egypt and the Cysticidal Effect of Two Extracts Obtained from Balanites aegyptiaca and moringa oleifera on mice model Affected with T. saginata Cysticerci

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Open Journal of Animal Sciences 2024年第2期14卷 39-55页

作者： Omnia m. Kandil Noha m. F. Hassan Doaa Sedky hatem A. Shalaby Heba m. Ashry Nadia m. T. Abu El Ezz Sahar m. Kandeel mohamed S. Abdelfattah L. Ying Ebtesam m. Al-Olayan Parasitology and Animal Diseases Department Veterinary Research Institute National Research Centre Dokki Cairo Egypt Chemistry of Natural Compounds Department Pharmaceutical and Drugs Industries Research Institute National Research Centre Dokki Cairo Egypt Chemistry Department Faculty of Science Helwan University Cairo Egypt State Key Laboratory of Plateau Ecology and Agriculture Qinghai University Xining China College of Agriculture and Animal Husbandry Qinghai University Xining China Department of Zoology Collage of Science King Saud University Riyadh Saudi Arabia

The aim of the present study was to determine the prevalence of bovine cysticercosis in both cattle and buffloas, in Egypt and to assess the cysticidal efficacy of Balanites aegyptiaca fruits (B. aegyptiaca) and moringa oleifera seeds (m. oleifera) extracts in experimentally infected mice. The study detected the level of tumor necrosis factor (TNF-α) to monitor the immune and inflammatory responses of experimentally infected mice. Through meat inspection, a total number of 2125 male bovine, 2 to 5 years old, (1125 cattle and 1000 buffloes) were examined under the authority of Albsatine and Alwaraq official abattoirs in Cairo Governorate, Egypt covering the period extended from march 2022 to April 2023. The overall prevalence of the disease among bovine was 7.8% (6.31% of cattle and 9.5% of buffloes). Besides, B. aegyptiaca and m. oleifera extracts showed cysticidal activity in experimentally infected mice. A decrease in the numbers of cysticerci was found in all treated mice groups, and up to 88% reduction was achieved in the B. aegyptiaca-treated group;higher than that was recorded in both m. oleifera (72.23%) and albendazole-treated ones (80.56%). Postmortem findings proved that m. oleifera and B. aegyptiaca reduced cysticerci numbers comparable to a commercial anthelmintic. The study showed a significant decrease (P 0.001) in TNF-α levels after treatment with Balanites and moringa extracts, compared with the untreated control and the albendazole-treated groups.

关键词： Prevalence Balanites aegyptiaca moringa oleifera mice T. saginata Cysticerci

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Throughput Enhancement for NOmA Systems Using Intelligent Reflecting Surfaces

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Computers, materials & Continua 2022年第12期73卷 5233-5244页

作者： Raed Alhamad hatem Boujemaa Information Technology Department Saudi Electronic UniversityRiaydhSaudi Arabia UCAR-SUPCOm-COSIm Ariana2083Tunisia

In this article,we optimize the powers associated to Non Orthogonal multiple Access(NOmA)users,sensing and harvesting duration for Cognitive Radio Networks(CRN).The secondary source harvests energy from node A ***,it senses the channel to detect primary ***,the secondary source transmits a signal that is reflected by Intelligent Reflecting Surfaces(IRS)so that all reflections have a zero phase at any user.A set Ii of reflectors are associated to user *** use ofm=mi=512,256,128,64,32,16,8 reflectors per user offers 45,42,39,36,33,30,27 dB gain *** absence of *** also suggest the use of IRS in energy *** use P=8 reflectors for energy harvesting and m=mi=8 reflectors per user for data communications offers 7 and 38 dB gain *** IRSm=mi=8 and the absence of *** use of P=16 reflectors for energy harvesting and m=mi=8 reflectors per user for data communications offers 9 and 42 dB gain *** IRS m=mi=8 and the absence of IRS.

关键词： CRN NOmA spectrum sensing energy harvesting throughput maximization

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Impact of different nano additives on performance, combustion, emissions and exergetic analysis of a diesel engine using waste cooking oil biodiesel

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Propulsion and Power Research 2022年第2期11卷 209-223页

作者： m.S.Gad mostafa m.Abdel Aziz hatem Kayed mechanical Engineering Department Faculty of EngineeringFayoum UniversityEgypt mechanical Engineering Department Institute of Aviation Engineering and TechnologyGizaEgypt mechanical Power Engineering Department Faculty of EngineeringCairo University12613Egypt

Biodiesel is derived from waste cooking oil (WCO) by transesterification. methylester was prepared by mixing diesel and biodiesel oils as 20% by volume. Nano particles asTiO2, Al2O3 and CNTs were blended with biodiesel blend at different concentrations of 25,50, and 100 mg/l to enhance the physicochemical fuel characteristics to obtain clean and effi-cient combustion performance. An experimental setup was incorporated into a diesel engine toinvestigate the influence of these nano-materials on engine performance, exergy analysis, combustion characteristics and emissions using WCO biodiesel-diesel mixture. Enriching methylester mixture with 100 ppm titanium, alumina and CNTs (B20T100, B20A100 andB20C100) increased the thermal efficiency by 4%, 6% and 11.5%, respectively compared toB20. Biodiesel blending with nano additives B20T100, B20A100 and B20C100 decreasedthe emissions of CO (11%, 24% and 30%, respectively), HC (8%, 17% and 25%, respectively)and smoke (10%, 13% and 19%, respectively) compared to B20. However, the noticeable increase of NOx was estimated by 5%, 12% and 27% for B20T100, B20A100 and B20C100,respectively. Finally, the results showed the rise in peak cylinder pressure by 5%, 9% and 11% and increase in heat release rate by 4%, 8% and 13% for B20T100, B20A100 andB20C100, respectively. The fuel exergy of B20T100, B20A100 and B20C100 are lower thanbiodiesel blend B20 by 6.5%, 16% and 23% but the exergetic efficiency are increased by 7%,19% and 30% at full load about B20.

关键词： Waste cooking oil(WCO) Nano additives Engine performance Exergy Combustion characteristics Emissions

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Performance,emissions and exergy analyses of adding CNTs to various biodiesel feedstocks

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Propulsion and Power Research 2022年第4期11卷 511-526页

Extraction of biodiesel from waste cooking oil,jatropha,and corn oils is done by *** and biodiesel were blended at 20%volume ratio to make methyl *** doses of 25,50,and 100 mg/l,carbon nanotubes(CNTs)was mixed with biodiesel *** objective of the present research is to examine experimentally a diesel engine performance,combustion characteristics,exergy and emissions analyses with inclusion of nano additive to various methyl ester *** ester blend is enriched with CNTs as JB20C100,WB20C100 and CB20C100 where the improvements in thermal efficiency are raised about biodiesel mixture by 9%,13%and 15%,*** of 100 ppm of CNTs to biodiesel blends achieves the greatest reductions in CO(14%,22%and 30%),HC(16%,20%and 25%),and smoke emissions(15%,19%and 23%)for JB20C100,WB20C100 and CB20C100,*** comparing with B20,blending 100 ppm CNTs with JB20,CB20,and WB20 obtained the highest increases in cylinder pressure of 3%,5%,and 10%,as well as the highest increases in heat release of 4%,7%,and 11%,*** downside of CNTs addition achieves a rise in NOx emissions by 10%,17%,and 22%for JB20C100,WB20C100,and CB20C100,*** efficiency increases by 8%,19%,and 24%for B20T100,B20A100,and B20C100,*** index improvements achieve 1.5%,5%and 6.5%,for B20T100,B20A100,and B20C100,***20 with CNTs of 100 ppm is highly recommended for improving engine performance,combustion,and exergy characteristics with considerable emissions reduction.

关键词： Biodiesel Carbon nanotubes(CNTs) Engine performance Exergy Combustion characteristics Emissions

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Performance Evaluation and Effectiveness of the Reverberation Room

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Sound & Vibration 2021年第1期55卷 43-55页

作者： mohamed Abd-Elbasseer hatem Kh mohamed Acoustics Laboratory National Institute of Standards(NIS)GizaEgypt

This research presents a thorough evaluation of the reverberation room at Acoustics Laboratory in National Institute of Standards(NIS)according to the related international *** evaluation aims at examining the room performance and exploring its effectiveness in the frequency range from 125 Hz to 10000 Hz according to the international standard *** room,which was designed and built several years ago,is an irregular rectangular shape free from *** volume is about 158.84 m^(3),which meets the requirement of the ISO 354 standard Lmaxmodal density showed adequate modes that give acceptable uniformity starting comfortably from frequency of 125 *** room has a reverberation time that is suitable for its size over the frequency range of *** room sound absorption surface area and its sound absorption coefficient satisfy the criteria given in ISO 3741 and ISO *** is an accepted diffuse sound field inside the room due to the standard deviation of measured sound level,which is less than 1.5 dB over all the frequency *** only exception was 125 Hz which may be due to a lack of diffusivity of the sound field at this *** evaluation proves that the NIS reverberation room is in full agreement with the international standards,which in turns qualifies the room to host measurements inside without concerns.

关键词： Reverberation room cut-off frequency sound absorption spatial uniformity modal counts

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Experimental and Numerical Investigation on High-Pressure Centrifugal Pumps:Ultimate Pressure Formulation,Fatigue Life Assessment and Topological Optimization of Discharge Section

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Computer modeling in Engineering & Sciences 2023年第12期137卷 2845-2865页

作者： Abdourahamane Salifou Adam hatem mrad Haykel marouani Yasser Fouad School of Engineering University of Québec in Abitibi-Témiscamingue(UQAT)Rouyn-NorandaQuébecJ9X 5E4Canada National Engineering School of monastir LGMUniversity of MonastirMonastir5019Tunisia Department of Applied mechanical Engineering College of Applied EngineeringMuzahimiyah BranchKing Saud UniversityRiyadh11421Saudi Arabia

A high percentage of failure in pump elements originates from *** study focuses on the discharge section behavior,made of ductile iron,under dynamic *** experimental protocol is established to collect the strain under pressurization and depressurization tests at specific *** experimental results are used to formulate the ultimate pressure expression function of the strain and the lateral surface of the discharge section and to validate finite element ***-Safe is then used to assess the fatigue life cycle using different types of fatigue criteria(Coffin-manson,morrow,Goodman,and Soderberg).When the pressure is under 3000 PSI,pumps have an unlimited service life of 107 cycles,regardless of the ***,for a pressure of 3555 PSI,only the morrow criterion denotes a significant decrease in fatigue life cycles,as it considers the average *** topological optimization is then applied to the most critical pump model(with the lowest fatigue life cycle)to increase its fatigue *** the solid isotropic material with a penalization approach,the Abaqus Topology Optimizationmodule is *** goal is to reduce the strain energy density while keeping the volume within *** to the findings,a 5%volume reduction causes the strain energy density to decrease from 1.06 to 0.66106 J/m^(3).According to morrow,the fatigue life cycle at 3,555 PSI is 782,425 longer than the initial 309,742 cycles.

关键词： Centrifugal pump ultimate pressure fatigue life topological optimization

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