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Role of targeted neuromodulation in the treatment of congenital unilateral lower lip palsy:A clinical case report

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第3期6卷 139-141页

作者： Hafiz Saqib Sikandar Ali hassan Ameer Hamza Department of Plastic Surgery Gujranwala Medical College Teaching HospitalGujranwalaPunjab52200Pakistan Department of Burns and Plastic Surgery Queen Elizabeth HospitalUniversity of Birmingham TrustsBirminghamB152GWUnited Kingdom Department of Oral and Maxillofacial Surgery Liaquat University of Medical and Health SciencesJamshoro76090Pakistan

Congenital unilateral lower lip palsy(CULLP),or congenital hypoplasia of the depressor anguli oris muscle,also known as asymmetric crying facies,is a rare condition that results in asymmetry of the lower lip during smiling,laughing,and *** the etiology is unknown,weakness of the depressor labii inferioris(DLI)muscle is implicated as a contributing ***,no well-established treatment options are *** case report describes an 18-year-old male patient diagnosed with *** examination revealed a symmetric face at rest,but asymmetry when smiling and opening the *** the administration of lidocaine into the affected DLI muscle,the patient’s smile and lower lip symmetry were immediately restored without any adverse ***,administration of botulinum toxin for neuromodulation of the DLI muscle led to a significant improvement in symmetry and oral function within 2 weeks,which was sustained at 1 month and 3 months *** adverse effects were reported,and both patients and families expressed high satisfaction with the *** case highlights the potential use of neuromodulation as a minimally invasive and effective treatment for CULLP.

关键词： Facial paralysis Botulinum toxin Chemodenervation Asymmetric smile Congenital unilateral lower lip palsy Asymmetric crying facies

In silico identification of antiviral compounds for the treatment of chikungunya virus infection:qsar modelling and md simulation analysis

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Medicine in Novel Technology and Devices 2024年第2期22卷 102-114页

作者： Hayder M Abdulhamza Muthanna S.Farhan Sara.S hassan Hany Aqeel Al-Hussainy Amjad Ibrahim Oriabi Department of Pharmacy Kut University CollegeAlkutWasit52001Iraq Department of Pharmaceutical Chemistry College of PharmacyUniversity of BaghdadBaghdadIraq Al-Manara College for Medical Sciences Department of PharmacyIraq Department of Pharmacy Hilla University CollegeBabylonIraq Dr Hany Akeel Institute Iraqi Medical Research CenterBaghdad10001Iraq

Chikungunya virus(CHIKV),transmitted by arthropods,has gained global recognition for its impact on public *** has expanded globally,including Africa,Asia,and the Indian subcontinent,and has a helicase protein in its genome that is crucial for its ***,the study targeted the helicase protein of CHIKV with 745 antiviral compounds using an ML-based QSAR model and molecular *** binders(5279172,78161839,6474310,and 5330286)were selected for MD simulation based on the control(Silvestrol).All compounds had the highest binding scores,with 78161839 showing the most consistent RMSD and the least conformational variation,indicating high *** also showed the lowest binding free energy(ΔG¼31.31 kcal/mol),indicating energetically favourable *** and Fel also depicted the stable complex confirmation of the protein and 78161839 complex during the 100 ns ***,this study aimed to identify helicase function antiviral binders that could be experimentally tested for treating CHIKV.

关键词： Chikungunya virus Machine learning based QSAR Molecular dynamic solution Helicase

A Framework for Driver DrowsinessMonitoring Using a Convolutional Neural Network and the Internet of Things

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Intelligent Automation & Soft Computing 2024年第2期39卷 157-174页

作者： Muhamad Irsan Rosilah hassan Anwar hassan Ibrahim Mohamad Khatim Hasan Meng Chun Lam Wan Mohd Hirwani Wan Hussain School of Computing Telkom UniversityBandung40257Indonesia Faculty of Information Science and Technology Universiti Kebangsaan MalaysiaBangi43600Malaysia Department of electrical Engineering College of EngineeringQassim UniversityAl-Gassim51411Saudi Arabia Graduated School of Business Universiti Kebangsaan MalaysiaBangi43600Malaysia

One of the major causes of road accidents is sleepy *** accidents typically result in fatalities and financial losses and disadvantage other road *** studies have been conducted to identify the driver’s sleepiness and integrate it into a warning *** studies have examined how the mouth and eyelids ***,this limits the system’s ability to identify drowsiness ***,this study designed an Accident Detection Framework(RPK)that could be used to reduce road accidents due to sleepiness and detect the location of *** drowsiness detectionmodel used three facial parameters:Yawning,closed eyes(blinking),and an upright head *** model used a Convolutional Neural Network(CNN)consisting of two *** initial phase involves video processing and facial landmark coordinate *** second phase involves developing the extraction of frame-based features using normalization *** these phases used OpenCV and *** dataset contained 5017 images with 874 open eyes images,850 closed eyes images,723 open-mouth images,725 closed-mouth images,761 sleepy-head images,and 1084 non-sleepy head *** dataset of 5017 images was divided into the training set with 4505 images and the testing set with 512 images,with a ratio of 90:*** results showed that the RPK design could detect sleepiness by using deep learning techniques with high accuracy on all three parameters;namely 98%for eye blinking,96%for mouth yawning,and 97%for head ***,the test results have provided an overview of how the developed RPK prototype can accurately identify drowsy *** findings will have a significant impact on the improvement of road users’safety and mobility.

关键词： Drowsy drivers convolutional neural network openCV microprocessor face detection

Perspectives and Experiences of Education Stakeholders: A Quantitative Study on the Adoption of Artificial Intelligence in Executive Training Using Structural Equation Modeling

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Intelligent Information Management 2024年第2期16卷 104-120页

作者： el Mostafa Atoubi Rachid Jahidi Regional Center for Education and Training Professions (CRMEF) Casablanca Morocco ENCG Settat Hassan 1st University Settat Morocco

The recent increase in the use of artificial intelligence has led to fundamental changes in the development of training and teaching methods for executive education. However, the success of artificial intelligence in regional centers for teaching and training professions will depend on the acceptance of this technology by young executive trainees. This article discusses the potential benefits of adopting AI in executive training institutions in Morocco, specifically focusing on CRMEF Casablanca Settat. Based on the Unified Theory of Acceptance and Use of Technology (UTAUT) (Venkatesh et al., 2003), this study proposes a model to identify the factors influencing the acceptance of artificial intelligence in regional centers for teaching professions and training in Morocco. To achieve this, a structural equation modeling approach was used to quantitatively describe the impact of each factor on AI adoption, utilizing data collected from 173 young executive trainees. The results indicate that perceived ease of use, perceived usefulness, trainer influence, and personal innovativeness influence the intention to use artificial intelligence. Our research provides managers of CRMEFs with a set of practical recommendations to enhance the implementation conditions of an artificial intelligence system. It aims to understand which factors should be considered in designing an artificial intelligence system within regional centers for teaching professions and training (CRMEFs).

关键词： Artificial Intelligence Technology Acceptance Intention to Use UTAUT Model Personal Innovativeness of Young Executive Trainees

Regional constrained control problem for a class of semilinear distributed systems

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Control Theory and Technology 2018年第3期16卷 221-231页

作者： el hassan ZERRIK Nihale el BOUKHARI MACS team Faculty of Sciences Moulay Ismail University Meknes Morocco

The aim of this paper is to investigate a regional constrained optimal control problem for a class of semi[inear distributed systems, which are linear in the control but nonlinear in the state. For a quadratic cost functional and a closed convex set of admissible controls, the existence of an optimal control is proven, and then this is characterized for three cases of constraints. A useful algorithm is developed, and the approach is illustrated through simulations for a heat equation.

关键词： Semilinear distributed systems regional optimal control constraints heat equation

Aryl hydrocarbon receptor dynamics in esophageal squamous cell carcinoma:From immune modulation to therapeutic opportunities

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World Journal of Experimental Medicine 2024年第3期14卷 48-56页

作者： Mina Rahmati hassan Moghtaderi Saeed Mohammadi Ahmed Al-Harrasi Biotechnology Research Center Pasteur Institute of IranTehran ***TehranIran Natural and Medical Sciences Research Center University of NizwaNizwa 616Ad DakhiliyahOman

Esophageal squamous cell carcinoma(ESCC)is a substantial global health *** escape mechanisms are important in ESCC progression,enabling cancer cells to escape the surveillance of the host immune *** key player in this process is the Aryl Hydrocarbon Receptor(AhR),which influences multiple cellular processes,including proliferation,differentiation,metabolism,and immune *** AhR signaling participates in ESCC development by stimulating carcinogenesis,epithelial-mesenchymal transition,and immune *** AhR signaling is a potential therapeutic approach for ESCC,with AhR ligands showing efficacy in preclinical ***,modification of AhR ligands and combination therapies present new opportunities for therapeutic *** review aims to address the knowledge gap related to the role of AhR signaling in ESCC pathogenesis and immune escape.

关键词： Esophageal squamous cell carcinoma Aryl hydrocarbon receptor Immune escape Tumor microenvironment Immunosuppression Therapeutic targeting

Effect of Dietary Components on the Shear Bond Strength of Orthodontics Brackets after Thermal Aging

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Open Journal of Stomatology 2024年第6期14卷 309-315页

作者： Philip Punzalan Tanya Al Talib Anthony Fusco Neamat hassan Abubakr School of Dental Medicine University of Nevada Las Vegas Nevada USA

Introduction: The stability of orthodontic brackets throughout orthodontic treatment plays a critical role in the treatment’s effectiveness. The present in vitro study was designed to assess the impact of various dietary components on the performance of orthodontic brackets. Methods: Metal orthodontic brackets were bonded to 66 extracted anterior teeth divided into groups based on the solution type: Milk, Gatorade, Cold Coffee, and a control group using water. Each group consisted of 20 teeth except for the control group, which included six teeth. The bracketed teeth were submerged in their respective solutions for 15 minutes three times daily at different intervals to mimic an in vivo environment and were stored in artificial saliva at room temperature (23?C). The specimens underwent artificial aging through 10,000 cycles of thermocycling (representing one clinical year) between 5?C and 55?C. Shade measurements were taken using a VITA Easy Shade device, capturing the classic shade and L*, a*, and b* values. Delta E values were calculated immediately post-bonding and after 7 days, 1 month, 1, and 2 clinical years. The shear bond strength of each bracket was measured using an ultra-tester machine. Results: After two clinical years, significant differences in ΔE color values were observed across all groups, with the most substantial change noted in teeth immersed in cold coffee. Brackets submerged in milk demonstrated lower shear bond strength than other solutions, whereas the control group exhibited the highest shear bond strength (P = 0.01). Conclusion: The study indicates that dietary components significantly influence tooth color stability and the shear bond strength of orthodontic brackets, underscoring the importance of considering these factors in orthodontic treatment planning.

关键词： Shear Bond Orthodontic Brackets Color Stability Thermal Aging

Practical approach to linear endoscopic ultrasound examination of the gallbladder

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World Journal of Radiology 2024年第6期16卷 184-195页

作者： Hussein hassan Okasha Eyad Gadour hassan Atalla Omar AbdAllah Abdel-Hameed Reem Ezzat Ahmed elsayed Alzamzamy elsayed Ghoneem Rasha Ahmad Matar Zeinab hassan Bogdan Miutescu Ayman Qawasmi Katarzyna M Pawlak Ahmed elmeligui Department of Internal Medicine Division of Gastroenterology and HepatologyKasr Al-Aini School of MedicineCairo UniversityCairo 11562Egypt Department of Gastroenterology and Hepatology King Abdulaziz Hospital-National GuardAhsa 31982Saudi Arabia Department of Medicine School of MedicineZamzam University CollegeKhartoum 11113Sudan Department of Internal Medicine Hepatology and Gastroenterology UnitFaculty of MedicineMansoura UniversityMansoura 35516Egypt Department of Internal Medicine Faculty of MedicineAssiut UniversityAssiut 71511Egypt Department of Gastroenterology and Heptology Maadi Armed Forces Medical ComplexMilitary Medical AcademyCairo 11728Egypt Department of Gastroenterology and Advance Endoscopy Sultant Qaboos Comprehensive Cancer Care and Research CentreMuscat 0961Oman Department of Internal Medicine Stockport Hospitals NHS Foundation TrustManchester SK27JEUnited Kingdom Department of Gastroenterology and Hepatology Victor Babes University of Medicine and PharmacyTimisoara 300041Romania Advanced Regional Research Centre in Gastroenterology and Hepatology Victor Babes University of Medicine and PharmacyTimisoara 30041Romania Department of Gastroenterology Al-Makassed Islamic Charitable Society HospitalCairo 11124Egypt Division of Gastroenterology St.Michael’s HospitalUniversity of TorontoToronto M5B 1W8Canada Department of Gastroenterology Southend University HospitalEssex SS26XTUnited Kingdom

The gallbladder(GB)is a susceptible organ,prone to various pathologies that can be identified using different imaging *** ultrasound(TUS)is typically the initial diagnostic method due to its numerous well-established ***,in cases of uncertainty or when a definitive diagnosis cannot be established,computed tomography(CT)or magnetic resonance imaging may be employed to provide more detailed ***,CT scans may sometimes offer inadequate spatial resolution,which can limit the differentiation of GB lesions,particularly when smaller yet clinically relevant abnormalities are ***,endoscopic ultrasound(EUS)provides higher frequency compared to TUS,superior spatial resolution,and the option for contrast-enhanced harmonic imaging,enabling a more comprehensive ***,EUS can serve as a supplementary tool when conventional imaging methods are *** review will describe the standard EUS examination of the GB,focusing on its endosonographic characteristics in various GB path-ologies.

关键词： Endoscopic ultrasound Linear endoscopic ultrasound Gallbladder anatomy Gallbladder pathologies Therapeutic endoscopic ultrasound

FlowBreakdown of Hybrid Nanofluid on a Rigid Surface with Power Law Fluid as Lubricated Layers

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1485-1499页

作者： Mirza Naveed Jahangeer Baig NadeemSalamat Sohail Nadeem NaeemUllah Mohamed Bechir Ben Hamida hassan Ali Ghazwani Sayed M.eldin A.S.Al-Shafay Instituite of Mathematics Khwaja Fareed University of Engineering and Information TechnologyRahim yar Khan64200Pakistan Department of Mathematics Quaid-I-Azam UniversityIslamabad44000Pakistan Department of Mathematics Wenzhou UniversityWenzhou325035China College of Engineering Department of Mechanical EngineeringImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11564Saudi Arabia Research Laboratory of Ionized Backgrounds and Reagents Studies(EMIR) Preparatory Institute for Engineering Studies of Monastir(IPEIM)University of MonastirMonastir5060Tunisia Higher School of Sciences and Technology of Hammam Sousse Department of PhysicsJazan82511Kingdom of Saudia Arabia Department of Mechanical Engineering Faculty of engineeringJazan UniversityP.O.Box 45124JazanKingdom of Saudia Arabia Center of Research Faculty of EngineeringFuture University in EgyptNew Cairo11835Egypt Department of Mechanical Engineering College of EngineeringPrince Sattam bin Abdulaziz UniversityAlkharj16436Saudi Arabia

Thiswork investigates an oblique stagnation point flowof hybrid nanofluid over a rigid surface with power lawfluidas lubricated layers. Copper (Cu) and Silver (Ag) solid particles are used as hybrid particles acting in water H2O asa base fluid. The mathematical formulation of flow configuration is presented in terms of differential systemthat isnonlinear in nature. The thermal aspects of the flow field are also investigated by assuming the surface is a heatedsurface with a constant temperature T. Numerical solutions to the governing mathematical model are calculatedby the RK45 algorithm. The results based on the numerical solution against various flow and thermal controllingparameters are presented in terms of line graphs. The specific results depict that the heat flux increases over thelubricated-indexed parameter.

关键词： Oblique stagnation point flow hybrid nanofluid lubricated layer magnetohydrodynamics