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SBL-JP-0004:A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology Research 2025年第1期33卷 235-243页

作者： hassan M.OTIFI Department of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in GC progression,making them attractive targets for therapeutic ***:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 GC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by molecular docking scores and molecular dynamics *** interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target ***-JP-0004 displayed an half-maximal inhibitory concentration(IC_(50))value of 118.9 nM against JAK2 kinase and 200.9 nM against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-maximal growth inhibitory concentration(GI50)values of 250.8 and 516.3 nM,respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatment compared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 Molecular docking Molecular dynamics simulation

Nanosecond pulse and dual-wavelength Q-switched 1.5 μm fiber laser using MAX phase Cr_(2)TiAlC_(2) saturable absorber

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Optoelectronics Letters 2025年第1期21卷 7-12页

作者： Ahmed Shakir AL-HITI Hiba hassan Department of Electrical Engineering Faculty of EngineeringUniversity of AnbarAnbar 31001Iraq Department of Laser and Optoelectronics Engineering University of Technology-IraqBaghdadIraq

We demonstrated a new type of MAX phase material,chromium titanium aluminum carbide(Cr_(2)TiAlC_(2)) polymer film,to generate a passively Q-switched erbium-doped fiber laser(EDFL).The film thickness was measured to be around 45 μm,which was fabricated using the embedding method with polyvinyl alcohol(PVA) polymer as *** saturable absorber(SA) film demonstrates a dual-wavelength passively Q-switched EDFL which operates at 1 531 nm and 1 560.19 nm,*** Q-switching pulse duration could be varied from 2.46 μs to 770 ns,while the repetition rate varied from 92.76 kHz to 106.6 kHz with an increasing input pumping range from 154 mW to 300 *** maximum output power and pulse energy of 15.05 mW and 141.18 nJ were obtained at the maximum input power of 300 mW,respectively.

关键词： switched pulse fiber

Innovative dispersion techniques of graphene nanoplatelets(GNPs)through mechanical stirring and ultrasonication:Impact on morphological,mechanical,and thermal properties of epoxy nanocomposites

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Defence Technology(防务技术) 2025年第1期43卷 13-25页

作者： Vasi Uddin Siddiqui S.M.Sapuan Mohd Roshdi hassan Advanced Engineering Materials and Composites Research Centre(AEMC) Department of Mechanical and Manufacturing EngineeringUniversiti Putra MalaysiaUPM SerdangSelangor 43400Malaysia Department of Mechanical and Manufacturing Engineering Universiti Putra MalaysiaUPM SerdangSelangor 43400Malaysia

Graphene nanoplatelets(GNPs)have attracted tremendous interest due to their unique properties and bonding *** study focuses on the effect of GNP dispersion on the mechanical,thermal,and morphological behavior of GNP/epoxy *** study aims to understand how the dispersion of GNPs affects the properties of epoxy nanocomposite and to identify the best dispersion approach for improving mechanical performance.A solvent mixing technique that includes mechanical stirring and ultrasonication was used for producing the *** transform infrared spectroscopy was used to investigate the interaction between GNPs and the epoxy *** measurements of density and moisture content were used to confirm that GNPs were successfully incorporated into the *** findings showed that GNPs are successfully dispersed in the epoxy matrix by combining mechanical stirring and ultrasonication in a single step,producing well-dispersed nanocomposites with improved mechanical ***,the nanocomposites at a low GNP loading of 0.1 wt%,demonstrate superior mechanical strength,as shown by increased tensile properties,including improved Young's modulus(1.86 GPa),strength(57.31 MPa),and elongation at break(4.98).The nanocomposite with 0.25 wt%GNP loading performs better,according to the viscoelastic analysis and flexural properties(113.18 MPa).Except for the nanocomposite with a 0.5 wt%GNP loading,which has a higher thermal breakdown temperature,the thermal characteristics do not significantly *** effective dispersion of GNPs in the epoxy matrix and low agglomeration is confirmed by the morphological *** findings help with filler selection and identifying the best dispersion approach,which improves mechanical *** effective integration of GNPs and their interaction with the epoxy matrix provides the doorway for additional investigation and the development of sophisticated *** fiel

关键词： Graphene nanoplatelets Epoxy Nanocomposites Mechanical properties Thermal properties Mechanical stirrer Sonication

Comparison of biomechanical indices measured by ocular response analyzer between children and elderly:a systematic review

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 154-159页

作者： hassan Hashemi Fereshteh Shokrollahzadeh Hadi Ostadimoghaddam abbasali Yekta Mehdi Khabazkhoob Noor Ophthalmology Research Center Noor Eye HospitalTehran ***Iran Rehabilitation Research Center Department of OptometrySchool of Rehabilitation SciencesIran University of Medical SciencesTehran ***Iran Refractive Errors Research Center Mashhad University of Medical SciencesMashhad ***Iran Department of Optometry School of Paramedical SciencesMashhad University of Medical SciencesMashhad ***Iran Department of Medical Surgical Nursing School of Nursing and MidwiferyShahid Beheshti University of Medical SciencesTehran ***Iran

Biomechanical study of the visual system by ocular response analyzer investigates the inter-structural biological relationships,mechanics,and function of the visual *** review aimed to investigate the changes in corneal biomechanical parameters with age and *** articles published in PubMed between 2000 and 2021 were investigated and critiqued,and valid scientific evidence was collected,reviewed and concluded according to the inclusion and exclusion *** studies showed that corneal biomechanical changes occur infrequently in children up to the age of 20y,and with increasing age and wider age range,there was a significant decrease in corneal biomechanical indices,especially corneal *** children and adults,most studies have shown that these biomechanical indicators,especially corneal resistance factor,were higher in *** hormonal changes may contribute to this finding,the role of axial length and other biometric indicators should not be *** axial length,the intraocular pressure,and the corneal thickness are other factors associated with biomechanical parameters that should be taken into account in clinical diagnosis and management especially for patients undergoing refractive surgery as well as keratoconus patients.

关键词： ocular response analyzer corneal biomechanics visual function children elderly

Bacteria and host: what does this mean for sepsis bottleneck?

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World Journal of Emergency Medicine 2025年第1期16卷 10-17页

作者： Azzah S Alharbi Raghad hassan Sanyi Esam I Azhar Department of Clinical Microbiology and Immunology Faculty of MedicineKing Abdulaziz UniversityJeddah 21362Saudi Arabia Special Infectious Agent Unit King Fahad Medical Research CenterKing Abdulaziz UniversityJeddah 21362Saudi Arabia College of Health and Medical Technology Middle Technical UniversityBaghdad 10047Iraq Department of Medical Laboratory Sciences Faculty of Applied Medical SciencesKing Abdulaziz UniversityJeddah 21362Saudi Arabia

BACKGROUND: Sepsis is a life-threatening inflammatory condition in which the invading pathogen avoids the host's defense mechanisms and continuously stimulates and damages host cells. Consequently, many immune responses initially triggered for protection become harmful because of the failure to restore homeostasis, resulting in ongoing hyperinflammation and immunosuppression. METHODS: A literature review was conducted to address bacterial sepsis, describe advances in understanding complex immunological reactions, critically assess diagnostic approaches, and emphasize the importance of studying bacterial bottlenecks in the detection and treatment of ***: Diagnosing sepsis via a single laboratory test is not feasible;therefore, multiple key biomarkers are typically monitored, with a focus on trends rather than absolute values. The immediate interpretation of sepsis-associated clinical signs and symptoms, along with the use of specific and sensitive laboratory tests, is crucial for the survival of patients in the early stages. However, long-term mortality associated with sepsis is now recognized, and alongside the progression of this condition, there is an in vivo selection of adapted ***: Bacterial sepsis remains a significant cause of mortality across all ages and societies. While substantial progress has been made in understanding the immunological mechanisms underlying the inflammatory response, there is growing recognition that the ongoing host-pathogen interactions, including the emergence of adapted virulent strains, shape both the acute and long-term outcomes in sepsis. This underscores the urgent need for novel high-throughput diagnostic methods and a shift toward more pre-emptive, rather than reactive, treatment strategies in sepsis care.

关键词： Sepsis Bacteria Bottleneck Inflammation

Topographic factors associated with anterior chamber angle narrowing in patients with keratoconus

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 67-73页

作者： Hamed Soltan-Dehghan Abdollah Farzaneh hassan Hashemi Payam Nabovati Mehdi Khabazkhoob Rehabilitation Research Center Department of OptometrySchool of Rehabilitation SciencesIran University of Medical SciencesTehran ***Iran Noor Ophthalmology Research Center Noor Eye HospitalTehran ***Iran Department of Medical Surgical Nursing School of Nursing and MidwiferyShahid Beheshti University of Medical SciencesTehran ***Iran

AIM:To identify topographic determinants of the anterior chamber angle(ACA)in patients with keratoconus(KCN).METHODS:Four hundred and ten eyes of 294 patients with KCN were recruited for this ***,complete ocular examinations were performed for all patients,including visual acuity measurement,refraction,and slit-lamp ***,all participants underwent corneal imaging by the Oculus Pentacam ***:The mean age of the participants was 32.40±8.52y(15-60y)and 69.5%of them were *** mean ACA was 38.47°±5.75°(range:14.40°to 56.50°)in the whole sample,38.24°±6.00°in males,and 38.98°±5.11°in females(P=0.447).The mean ACA was significantly different among different groups of cone morphology,as patients with nipple cones showed the lowest mean ***,there were statistically significant differences in the mean ACA among different groups of cone locations,with patients having central cones exhibiting the lowest mean ACA(P<0.001).Anterior and posterior Q values were significantly,directly correlated with ACA(anterior Q:r=0.122,P=0.014,posterior Q:r=0.192,P<0.001).CONCLUSION:This study provides critical insights into the risk factors for ACA narrowing in KCN patients,which is essential for planning intraocular *** with nipple and central cones exhibited the most significant ACA ***,more negative Q-values are associated with increased ACA narrowing,highlighting the need for targeted diagnostic and therapeutic strategies.

关键词： keratoconus anterior chamber angle cone morphology cone location

MARIE:One-Stage Object Detection Mechanism for Real-Time Identifying of Firearms

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 279-298页

作者： Diana Abi-Nader hassan Harb Ali Jaber Ali Mansour Christophe Osswald Nour Mostafa Chamseddine Zaki Computer Science Department Faculty of SciencesLebanese UniversityBeirut146404Lebanon College of Engineering and Technology American University of the Middle EastEgaila54200Kuwait Lab-STICC CNRS UMR 6285ENSTA-BretagneBrest29200France

Security and safety remain paramount concerns for both governments and individuals *** today’s context,the frequency of crimes and terrorist attacks is alarmingly increasing,becoming increasingly intolerable to ***,there is a pressing need for swift identification of potential threats to preemptively alert law enforcement and security forces,thereby preventing potential attacks or violent *** advancements in big data analytics and deep learning have significantly enhanced the capabilities of computer vision in object detection,particularly in identifying *** paper introduces a novel automatic firearm detection surveillance system,utilizing a one-stage detection approach named MARIE(Mechanism for Realtime Identification of Firearms).MARIE incorporates the Single Shot Multibox Detector(SSD)model,which has been specifically optimized to balance the speed-accuracy trade-off critical in firearm detection *** SSD model was further refined by integrating MobileNetV2 and InceptionV2 architectures for superior feature extraction *** experimental results demonstrate that this modified SSD configuration provides highly satisfactory performance,surpassing existing methods trained on the same dataset in terms of the critical speedaccuracy *** these innovations,MARIE sets a new standard in surveillance technology,offering a robust solution to enhance public safety effectively.

关键词： Firearm and gun detection single shot multi-box detector deep learning one-stage detector MobileNet inception convolutional neural network

Review of Techniques for Integrating Security in Software Development Lifecycle

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Computers, Materials & Continua 2025年第1期82卷 139-172页

作者： hassan Saeed Imran Shafi Jamil Ahmad Adnan Ahmed Khan Tahir Khurshaid Imran Ashraf College of Electrical and Mechanical Engineering National University of Sciences and Technology(NUST)Rawalpindi46604Pakistan Department of Computer Science Abasyn University Islamabad CampusIslamabad45510Pakistan Military College of Signals National University of Sciences and Technology(NUST)Rawalpindi46600Pakistan Department of Electrical Engineering Yeungnam UniversityGyeongsan38541Republic of Korea Department of Information and Communication Engineering Yeungnam UniversityGyeongsan38541Republic of Korea

Software-related security aspects are a growing and legitimate concern,especially with 5G data available just at our *** conduct research in this field,periodic comparative analysis is needed with the new techniques coming up *** purpose of this study is to review the recent developments in the field of security integration in the software development lifecycle(SDLC)by analyzing the articles published in the last two decades and to propose a way *** review follows Kitchenham’s review *** review has been divided into three main stages including planning,execution,and *** the selected 100 articles,it becomes evident that need of a collaborative approach is necessary for addressing critical software security risks(CSSRs)through effective risk management/estimation *** risks using a numeric scale enables a comprehensive understanding of their severity,facilitating focused resource allocation and mitigation *** a comprehensive understanding of potential vulnerabilities and proactive mitigation efforts facilitated by protection poker,organizations can prioritize resources effectively to ensure the successful outcome of projects and initiatives in today’s dynamic threat *** review reveals that threat analysis and security testing are needed to develop automated tools for the *** estimation of effort required to prioritize potential security risks is a big challenge in software *** accuracy of effort estimation can be further improved by exploring new techniques,particularly those involving deep *** is also imperative to validate these effort estimation methods to ensure all potential security threats are *** challenge is selecting the right model for each specific security *** achieve a comprehensive evaluation,researchers should use well-known benchmark checklists.

关键词： Software development lifecycle systematic literature review critical software security risks national institute of standards and technology DevSecOps open web application security project McGraw’s touch points

Geospatial analysis of neotectonics in the Jebel Gustar Mountain,northeastern Algeria

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Journal of Mountain Science 2025年第2期22卷 391-403页

作者： TAIB hassan HADJI Riheb ZIGHMI Karim HAMED Younes GENTILUCCI Matteo BEDRI Khaoula Department of Geological Sciences Faculty of Earth SciencesGeography and Regional PlanningUniversitéFrères Mentouri-Constantine 1 BP325 Route d’Ain El Bey 25017ConstantineAlgeria Laboratory of Applied Research in Engineering Geology GeotechnicsWater Sciences and EnvironmentFerhat Abbas UniversitySetif 19137Algeria Department of Earth Sciences Institute of Architecture and Earth SciencesFerhat Abbas UniversitySetif 19137Algeria International Association of Water Resources in the Southern Mediterranean Basin Gafsa 2112Tunisia Department of Earth Sciences Faculty of Sciencesuniversity of GafsaCampus Universitaire Sidi Ahmed Zarroug–2112GafsaTunisia School of Science and Technology Geology DivisionUniversity of CamerinoVia Gentile III da Varano762032 Camerino MCItaly Mining Engineering Laboratory National Polytechnic School of Algiers10 Rue des Frères OUDEKEl Harrach 16200 AlgiersAlgeria

This research investigates dynamic earth processes within the South Setifian allochthonous ensemble,providing insights into landscape evolution and seismotectonic activity within the Tellian mountain *** on the Jebel Gustar and Kef Lahmar area,which includes 14 sub-basins,this research uses a DEM-based technique to assess Holocene activities,lineament characteristics,and stream *** geomorphic indices are used to assess relative active tectonics:the stream lengthgradient index(SL),drainage basin asymmetry(AF),valley-floor width to valley height ratio(VF),drainage basin shape(BS),and mountain front sinuosity(SMF).A weighted overlay of these five indices produces the Index of Relative Active Tectonics(IRAT)*** findings reveal significant neotectonic activity in the study area,supported by profound basement *** research highlights the morpho-structural processes and neotectonics activity in the Jebel Gustar,providing a framework for investigating the evolution of this ***,it enhances comprehension of the interactions between the alpine range's internal zones in Eastern Algeria and the Atlasic *** study proposes a systematic approach to evaluate the tectonic and geomorphological dynamics of the South Setif region.

关键词： Active tectonics Crustal deformation Holocene activities Geomorphic indices Neotectonic dynamics