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Comparison of pre-treatment and post-treatment use of selenium in retinal ischemia reperfusion injury

International Journal of Ophthalmology(English edition) 2015年第2期8卷 263-268页

作者： Alper Yazici hasan aksit Esin Sogutlu Sari Arzu Yay Haydar Ali Erken Dilek aksit Harun Cakmak Kamil Seyrek Sitki Samet Ermis Department of Ophthalmology Faculty of MedicineBalikesir University Department of Biochemistry Faculty of VeterinaryBalikesir University Department of Histology and Embryology Faculty of Medicine Erciyes University Department of Physiology Faculty of Medicine Balikesir University Department of Pharmacology Faculty of VeterinaryBalikesir University Department of Ophthalmology Faculty of Medicine Adnan Menderes University Department of Biochemistry Faculty of Medicine Balikesir University

AIM: To investigate the effects of selenium in rat retinal ischemia reperfusion(IR) model and compare pretreatment and post-treatment ***: Selenium pre-treatment group(n =8) was treated with intraperitoneal(i.p.) selenium 0.5 mg/kg for7 d and terminated 24 h after the IR injury. Selenium posttreatment group( n = 8) was treated with i. p. selenium0.5 mg/kg for 7d after the IR injury with termination at the end of the 7d period. Sham group(n =8) received *** injections identical to the selenium volume for 7d with termination 24 h after the IR injury. Control group(n =8) received no intervention. Main outcome measures were retina superoxide dismutase(SOD), glutathione(GSH),total antioxidant status(TAS), malondialdehyde(MDA),DNA fragmentation levels, and immunohistological apoptosis ***: Compared to the Sham group, selenium pre-treatment had a statistical difference in all parameters except SOD. Post-treatment selenium also resulted in statistical differences in all parameters except the MDA levels. When comparing selenium groups, the pre-treatment selenium group had a statistically higher success in reduction of markers of cell damage such as MDA and DNA fragmentation. In contrast, the post-selenium treatment group had resulted in statisticallyhigher levels of GSH. Histologically both selenium groups succeeded to limit retinal thickening and apoptosis. Pre-treatment use was statistically more successful in decreasing apoptosis in ganglion cell layer compared to post-treatment ***: Selenium was successful in retinal protection in IR injuries. Pre-treatment efficacy was superior in terms of prevention of tissue damage and apoptosis.

关键词： retina selenium ischemia-reperfusion apoptosis pre-treatment post-treatment oxidative stress

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