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Promising role of D-amino acids in irritable bowel syndrome

World Journal of Gastroenterology 2022年第31期28卷 4471-4474页

作者： Yuka Ikeda Kurumi Taniguchi haruka sawamura Ai Tsuji Satoru Matsuda Department of Food Science and Nutrition Nara Women's UniversityNara 630-8506Japan

Irritable bowel syndrome(IBS)is an important health care *** in the microbiota of the gut-brain axis may be linked to the pathophysiology of *** dietary intake could contribute to produce various metabolites including Damino acids by the fermentation by the gut microbiota.D-amino acids are the enantiomeric counterparts of L-amino acids,in general,which could play key roles in cellular physiological processes against various oxidative ***,the presence of D-amino acids has been shown to be linked to the protection of several organs in the *** particular,the gut microbiota could play significant roles in the stability of emotion via the action of D-amino ***,we would like to shed light on the roles of D-amino acids,which could be used for the treatment of IBS.

关键词： Irritable bowel syndrome D-amino acid Gut microbiota Colitis Probiotics Fecal microbiota transplantation

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Advantageous tactics with certain probiotics for the treatment of graft-versus-host-disease after hematopoietic stem cell transplantation

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World Journal of Hematology 2023年第2期10卷 15-24页

作者： Sayuri Yoshikawa Kurumi Taniguchi haruka sawamura Yuka Ikeda Ai Tsuji Satoru Matsuda Food Science and Nutrition Nara Women's UniversityNara 630-8506Japan

Hematopoietic stem cell transplantation(HSCT)becomes a standard form of cellular therapy for patients with malignant *** is the first-choice of immunotherapy,although HSCT can be associated with many complications such as graft-versus-host disease(GVHD)which is a major cause of morbidity and mortality after allogeneic *** has been shown that certain gut microbiota could exert protective and/or regenerative immunomodulatory effects by the production of short-chain fatty acids(SCFAs)such as butyrate in the experimental models of GVHD after allogeneic *** of gut commensal bacteria which can produce SCFAs may worsen dysbiosis,increasing the risk of *** of G-protein coupled receptors such as GPR41 seems to be upre-gulated in the presence of commensal bacteria,which might be associated with the biology of regulatory T cells(Tregs).Treg cells are a suppressive subset of CD4 positive T lymphocytes implicated in the prevention of GVHD after allogeneic ***,we discuss the current findings of the relationship between the modification of gut microbiota and the GVHD-related immunity,which suggested that tactics with certain probiotics for the beneficial symbiosis in gut-immune axis might lead to the elevation of safety in the allogeneic HSCT.

关键词： Gut microbiota Hematopoietic stem cell Reactive oxygen species Allogeneic hematopoietic stem cell transplantation Graft vs host disease Gut-immune axis©The Author(s)2023.Published by Baishideng Publishing Group Inc.All rights reserved.

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