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Nanoscopic Tip Sensors Fabricated by Gas Phase Etching of Optical Glass Fibers

Photonic Sensors 2012年第4期2卷 331-339页

作者： Jorg BIERLICH Jens KOBELKE David BRAND Konstantin KIRSCH Jan DELLITH hartmut bartelt IPHT Institute of Photonic Technology Albert-Einstein-Sir. 9 07745 Jena Germany EAH University of Applied Sciences Carl-Zeiss-Promenade 2 07745 Jena Germany

Silica-based fiber tips are used in a variety of spectroscopic, micro- or nano-scopic optical sensor applications and photonic micro-devices. The miniaturization of optical sensor systems and the technical implementation using optical fibers can provide new sensor designs with improved properties and functionality for new applications. The selective-etching of specifically doped silica fibers is a promising method in order to form complex photonic micro structures at the end or within fibers such as tips and cavities in various shapes useful for the all-fiber sensor and imaging applications. In the present study, we investigated the preparation of geometrically predefined, nanoscaled fiber tips by taking advantage of the dopant concentration profiles of highly doped step-index fibers. For this purpose, a gas phase etching process using hydrofluoric acid （HF） vapor was applied. The shaping of the fiber tips was based on very different etching rates as a result of the doping characteristics of specific optical fibers. Technological studies on the influence of the etching gas atmosphere on the temporal tip shaping and the final geometry were performed using undoped and doped silica fibers. The influence of the doping characteristics was investigated in phosphorus-, germanium-, fluorine- and boron-doped glass fibers. Narrow exposed as well as protected internal fiber tips in various shapes and tip radiuses down to less than 15 nm were achieved and characterized geometrically and topologically. For investigations into surface plasmon resonance effects, the fiber tips were coated with nanometer-sized silver layers by means of vapour deposition and finally subjected to an annealing treatment.

关键词： Optical fiber tips nanoprobes gas phase etching doping tip shaping metal coating

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Fiber Bragg Gratings in Small-Core Ge-Doped Photonic Crystal Fibers

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Journal of Electronic Science and Technology of China 2008年第4期6卷 429-433页

作者： Yiping Wang hartmut bartelt Wolfgang Ecke Reinhardt Willsch Jens Kobelke Michael Kautz Sven Brueckner Mantled Rothhardt Institute of Photonic Technology Albert-Einstein-Str.9 07745 Jcna Germany and State Key Lab of Advanced OpticalCommunication Systems and Networks Shanghai Jiaotong UniversityShanghai 200240 China Institute of Photonic Technology Albert-Einstein-Str. 9 07745 Jena Germany.

This paper reports fiber Bragg gratings （FBGs） inscribed in a small-core Ge-doped photonic crystal fibers with a UV laser and a Talbot interferometer. The responses of such FBGs to temper- ature, strain, bending, and transverse-loading were systematically investigated. The Bragg wavelength of the FBGs shifts toward longer wavelengths with increasing temperature, tensile strain, and transverse-loading. The bending and transverse- loading properties of the FBGs are sensitive to the fiber orientations.

关键词： Fiber Bragg gratings photonic crystal fibers optical fiber sensors.

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Interdigitated terahertz metamaterial sensors:design with the dielectric perturbation theory

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Photonics Research 2024年第6期12卷 1115-1128页

作者： LEI CAO FANQI MENG ESRAÖZDEMIR YANNIK LOTH MERLE RICHTER ANNA KATHARINA WIGGER MAIRA BEATRIZ PÉREZ SOSA ALAA JABBAR JUMAAH SHIHAB AL-DAFFAIE PETER HARING BOLÍVAR hartmut G.ROSKOS State Key Laboratory of Advanced Electromagnetic Technology Huazhong University of Science and TechnologyWuhan 430074China Physikalisches Institut Johann Wolfgang Goethe-UniversitätFrankfurt am MainGermany University of Siegen Institute for High Frequency and Quantum ElectronicsSiegenGermany Department of Electrical Engineering Eindhoven University of Technology5612 AE EindhovenThe Netherlands

Designing terahertz sensors for highly sensitive detection of nanoscale thin films and a few biomolecules poses a substantial challenge but is crucial for unlocking their full potential in scientific research and advanced *** work presents a strategy for optimizing metamaterial sensors in detecting small quantities of dielectric *** amount of frequency shift depends on intrinsic properties(electric field distribution,Q-factor,and mode volume)of the bare cavity as well as the overlap volume of its high-electric-field zone(s)and the *** by the simplified dielectric perturbation theory,interdigitated electric split-ring resonators(ID-eSRRs)are devised to significantly enhance the detection sensitivity compared with eSRRs without interdigitated ***-eSRR’s fin-gers redistribute the electric field,creating strongly localized enhancements,which boost analyte *** periodic change of the inherent antiphase electric field reduces radiation loss,leading to a higher *** with ID-eSRR sensors operating at around 300 GHz demonstrate a remarkable 33.5 GHz frequency shift upon depositing a 150 nm SiO_(2)layer as an analyte simulant,with a figure of merit improvement of over 50 times compared with structures without interdigitated *** rational design offers a promising avenue for highly sensitive detection of thin films and trace biomolecules.

关键词： dielectric perturbation theory

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High-throughput screening of novel TFEB agonists in protecting against acetaminopheninduced liver injury in mice

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Acta Pharmaceutica Sinica B 2024年第1期14卷 190-206页

作者： Xiaojuan Chao Mengwei Niu Shaogui Wang Xiaowen Ma Xiao Yang Hua Sun Xujia Hu Hua Wang Li Zhang Ruili Huang Menghang Xia Andrea Ballabio hartmut Jaeschke Hong-Min Ni Wen-Xing Ding Department of Pharmacology Toxicology and TherapeuticsUniversity of Kansas Medical CenterKansas CityKS 66160USA NMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Oncology the First Affiliated Hospital of Anhui Medical UniversityAnhui Medical UniversityHefei 230032China National Center for Advancing Translational Sciences National Institutes of HealthBethesdaMD 20892USA Telethon Institute of Genetics and Medicine TIGEMPozzuoliNaples 80131Italy Medical Genetics Department of Translational MedicineFederico II UniversityNaples 80131Italy Department of Molecular and Human Genetics Baylor College of MedicineHoustonTX 77030USA Department of Internal Medicine Division of GastroenterologyHepatology&MotilityUniversity of Kansas Medical CenterKansas CityKS 66160USA

Macroautophagy(referred to as autophagy hereafter)is a major intracellular lysosomal degradation pathway that is responsible for the degradation of misfolded/damaged proteins and *** studies showed that autophagy protects against acetaminophen(APAP)-induced injury(AILI)via selective removal of damaged mitochondria and APAP protein *** lysosome is a critical organelle sitting at the end stage of autophagy for autophagic degradation via fusion with *** the present study,we showed that transcription factor EB(TFEB),a master transcription factor for lysosomal biogenesis,was impaired by APAP resulting in decreased lysosomal biogenesis in mouse *** loss-of and gain-of function of hepatic TFEB exacerbated or protected against AILI,***,overexpression of TFEB increased clearance of APAP protein adducts and mitochondria biogenesis as well as SQSTM1/p62-dependent non-canonical nuclear factor erythroid 2-related factor 2(NRF2)activation to protect against *** also performed an unbiased cell-based imaging high-throughput chemical screening on TFEB and identified a group of TFEB *** these agonists,salinomycin,an anticoccidial and antibacterial agent,activated TFEB and protected against AILI in *** conclusion,genetic and pharmacological activating TFEB may be a promising approach for protecting against AILI.

关键词： Autophagy DILI Drug screening Hepatotoxicity Lysosome Mitochondria Mitophagy NRF2

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Convergent Data-Driven Regularizations for CT Reconstruction

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1342-1368页

作者： Samira Kabri Alexander Auras Danilo Riccio Harmut Bauermeister Martin Benning Michael Moeller Martin Burger Helmholtz Imaging Deutsches Elektronen-Synchrotron DESYNotkestr.8522607 HamburgGermany Institute for Vision and Graphics University of SiegenAdolf-Reichwein-StraBe 2a57076 SiegenGermany School of Mathematical Sciences Queen Mary University of LondonMile End RoadLondon E14NSUK The Alan Turing Institute British Library96 Euston RdLondon NW12DBUK Fachbereich Mathematik Universitat HamburgBundesstrasse 5520146 HamburgGermany

The reconstruction of images from their corresponding noisy Radon transform is a typical example of an ill-posed linear inverse problem as arising in the application of computerized tomography(CT).As the(naive)solution does not depend on the measured data continuously,regularization is needed to reestablish a continuous *** this work,we investigate simple,but yet still provably convergent approaches to learning linear regularization methods from *** specifically,we analyze two approaches:one generic linear regularization that learns how to manipulate the singular values of the linear operator in an extension of our previous work,and one tailored approach in the Fourier domain that is specific to *** prove that such approaches become convergent regularization methods as well as the fact that the reconstructions they provide are typically much smoother than the training data they were trained ***,we compare the spectral as well as the Fourier-based approaches for CT-reconstruction numerically,discuss their advantages and disadvantages and investigate the effect of discretization errors at differentresolutions.

关键词： Inverse problems Regularization Computerized tomography(CT) Machine learning

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Fire up the pyre:inosine thermogenic signaling for obesity therapy

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Signal Transduction and Targeted Therapy 2022年第12期7卷 4255-4256页

作者： Nienke Willemsen Stefan Kotschi Alexander bartelt Institute for Cardiovascular Prevention(IPEK) Ludwig-Maximilians-UniversityMunichGermany Institute for Diabetes and Cancer(IDC) Helmholtz Center MunichGerman Research Center for Environmental HealthNeuherbergGermany German Center for Cardiovascular Research Partner Site Munich Heart AllianceLMU HospitalMunichGermany Department of Molecular Metabolism&SabriÜlker Center for Metabolic Research Harvard T.H.Chan School of Public HealthBostonMAUSA

In a recent study published in Nature,Niemann et *** have discovered a metabolite signaling pathway that could pave the way to new weight loss drugs1(Fig.1).Obesity and its comorbidities are a major threat to public h... 详细信息

关键词： sine weight drugs

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A Reverse Dynamical Investigation of the Catastrophic Wood-Snow Avalanche of 18 January 2017 at Rigopiano, Gran Sasso National Park, Italy

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International Journal of Disaster Risk Science 2021年第1期12卷 40-55页

作者： Barbara Frigo Perry bartelt Bernardino Chiaia Igor Chiambretti Margherita Maggioni Department of Structural Building and Geotechnical Engineering-DISEGPolitecnico di Torino10129 TurinItaly WSL Institute for Snow and Avalanche Research SLF 7260 Davos DorfSwitzerland Associazione Interregionale di Coordinamento e documentazione per i problemi inerenti alla Neve e alle Valanghe–AINEVA 38122 TrentoItaly Dipartimento di Scienze Agrarie Universita`di TorinoForestali e Alimentari–DISAFA10095 GrugliascoTOItaly Centro Interdipartimentale sui Rischi Naturali in Ambiente Montano e Collinare–NatRisk 10095 GrugliascoTOItaly

On 18 January 2017 a catastrophic avalanche destroyed the Rigopiano Gran Sasso Resort&Wellness(Rigopiano Hotel)in the Gran Sasso National Park in Italy,with 40 people trapped and a death toll of *** article describes the location of the disaster and the general meteorological scenario,with field investigations to provide insight on the avalanche dynamics and its interaction with the hotel *** data gathered in situ suggest that the avalanche was a fluidized dry snow avalanche,which entrained a sligthtly warmer snow cover along the path and reached extremely long runout distances with braking effect from mountain *** avalanche that reached the Rigopiano area was a‘‘wood-snow’’avalanche—a mixture of snow and uprooted and crushed trees,rocks,and other *** were no direct eyewitnesses at the event,and a quick post-event survey used a numerical model to analyze the dynamics of the event to estimate the pressure,velocity,and direction of the natural flow and the causes for the destruction of the *** the magnitude and the damage caused by the event,the avalanche was at a high to very high intensity scale.

关键词： Avalanche flow velocity Avalanche impact pressure Forensic field investigation Italy Rigopiano disaster Wood-snow avalanche

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Quenchants for Induction Hardening for the Automotive Industry, Choice and Maintenance

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材料热处理学报 2004年第5期25卷 514-518页

作者： hartmut Beitz Thorsten Beitz PETROFER CHEMIE Headquarters Hildesheim GermanyPETROFER CHEMIE Department of Heat Treatment Hildesheim Germany

The different types of quenchants for induction hardening - mainly for shower quenching - but also for immersion will be described in regard to their properties, film-formation, remaining residues, how to handle these etc.. Furtheron the maintenance of such quench fluids will be desribed in detail regarding concentration control, control of growth of micro-organism, contamination and maintenance.

关键词：感应淬火淬火剂绝缘薄膜热处理

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Designing a Security Architecture for a P2P Video Conference System

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China Communications 2008年第2期5卷 49-58页

作者： hartmut Koeni Department of Computer Science Brandenburg University of Technology Cottbus

More and more modern group oriented collaborativeapplications use the peer-to-peer(P2P)paradigm tobe independent of expensive infrastructures as theyare,for instance,provided for audio and video conferencesby H.323 *** collaborativeP2P solutions require appropriate mechanismsto protect group privacy and data integrity.A centralizedclient/server based video conference system canbe well shielded in a standard manner,whilst thereare no off-the-shelf approaches to secure a P2P videoconference up to *** paper addresses this issueand presents a flexible security *** BRAVIS system[4]as an example it shows howthe architecture can be embedded into a P2P videoconferencing system.

关键词： Peer-to-peer (P2P) security architecture video conference

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CO_(2)Plume Geothermal(CPG)Systems for Combined Heat and Power Production:an Evaluation of Various Plant Configurations

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Journal of Thermal Science 2022年第5期31卷 1266-1278页

作者： SCHIFFLECHNER Christopher WIELAND Christoph SPLIETHOFF hartmut Chair of Energy Systems TUM School of Engineering and DesignTechnical University of Munich85747 GarchingGermany

CO_(2) Plume Geothermal(CPG)systems are a promising concept for utilising petrothermal resources in the context of a future carbon capture utilisation and sequestration *** geothermal energy has a tremendous worldwide potential for decarbonising both the power and heating *** paper investigates three potential CPG configurations for combined heating and power generation(CHP).The present work examines scenarios with reservoir depths of 4 km and 5 km,as well as required district heating system(DHS)supply temperatures of 70℃ and 90℃.The results reveal that a two-staged serial CHP concept eventuates in the highest achievable net power *** a thermosiphon system,the relative net power reduction by the CHP option compared with a sole power generation system is significantly lower than for a pumped *** net power reduction for pumped systems lies between 62.6%and 22.9%.For a thermosiphon system with a depth of 5 km and a required DHS supply temperature of 70℃,the achievable net power by the most beneficial CHP option is even 9.2%higher than for sole power generation *** second law efficiency for the sole power generation concepts are in a range between 33.0%and 43.0%.The second law efficiency can increase up to 63.0%in the case of a CHP ***,the combined heat and power generation can significantly increase the overall second law efficiency of a CPG *** evaluation of the achievable revenues demonstrates that a CHP application might improve the economic performance of both thermosiphon and pumped CPG ***,the minimum heat revenue required for compensating the power reduction increases with higher electricity *** summary,the results of this work provide valuable insights for the potential development of CPG systems for CHP applications and their economic feasibility.

关键词： deep geothermal energy combined heat and power generation CO_(2)plume geothermal systems petrothermal resources carbon capture utilisation and storage

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