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Cell Research 1990年第2期 197-206页

作者： harry KUBIN

NIH 3T3 cells, a mouse fibroblast cell line used as routine target cells for transfection experiments, undergo spontaneous transformation in our experiments after they form a confluent sheet in medium containing fetal bovine serum (FBS) or lower coneentration of calf serum (CS). The transformation takes the form of foci of multiplying cells among the surrounding cells which have stopped cell division. However, no focus of transformed cells could be seen in medium containing high concentration (10％) of CS. Further experiments indicated that the frequency of transformation is highly dependent on the concentration of serum and the transformation in CS is changeable when the cells are passaged in FBS. 3~H-thymidine autoradiography has been proved to be a sensitive measurement indicator for focus formation. Our results suggest that the high frequency of transformation and its dependence on confluency as well as on medium composition are characteristics of cell differentiation rather than mutation. The role of the NIH 3T3 cell line as a cancer-initiated cell population and its accelerated transformation by ras oncogene might be considered as a form of tumor promotion is discussed.

关键词： Cell transformation aberrant differentiation NIH 3T3 cells.

A review on molten sulfate salts induced hot corrosion

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Journal of Materials Science & Technology 2021年第31期90卷 243-254页

作者： Shanshan Hu harry Finkle Xingbo Liu Mechanical&Aerospace Engineering department Benjamin M.Statler College of Engineering&Mineral ResourcesWest Virginia UniversityMorgantownWV 26506-6106USA C.Eugene Bennett department of Chemistry West Virginia UniversityMorgantownWV 26506USA

Hot corrosion has been extensively observed in various high temperature applications,which might cause large economic *** deepen the insight and understanding of hot corrosion,herein,we provide a detailed discussion on hot corrosion induced by molten sulfate salt,in which Na_(2)SO_(4)is the main chemical *** hot corrosion is triggered and sustained by the negative solubility gradient of protective oxide from the oxide/salt interface to salt/gas *** this work,we reviewed several key factors,including temperature,gas composition,molten salt composition,alloy element and external stress,influencing the hot corrosion of alloy beneath the molten *** application of anti-corrosion coating seems to be the most effective and commercial mothed to mitigate hot ***,the progress of the development of effective coatings,e.g.,Ni-Cr coatings,aluminide coatings,silicide coatings and MCrAlY(X)coatings,has also been summarized.

关键词： Hot corrosion Molten sulfate salts Protective oxide layer Dissolution Anti-corrosion coatings

Synchronization of home departure and arrival times in dual earner households with children:Panel regression model of time gaps

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第5期6卷 504-513页

作者： Bilin Han harry Timmermans Urban Planning Group Eindhoven University of Technology

Organizing schedules and allocating time to different activities is always a challenge in dual-earner households,especially when they have *** may need to link their schedule to those of their children to allow them escorting their children to school or to take care or be with their children at *** paper reports the results of an analysis of the degree of synchronization of home departure and arrival times in dual earner households with children,where the degree of synchronization is defined as the gap between departure and arrival times of a parent and *** activity-travel diary data of different household members,a random parameters regression model is estimated to examine differences in time gaps in home departure and arrival times between parents and children as a function of gender,day of the week,age of the youngest child,and other socio-demographic *** results of the analysis provide insight into factors influencing the degree of synchronization and coordination of double activity-travel scheduling decisions in households with *** indicate that gender,number of children in the household,age of the youngest child,travel within or outside peak hours,day of the week,transport mode used for the work commute and household income level significantly affect time gaps,especially arrival time gaps.

关键词： Home departure and arrival times Synchronization Time gap Dual-earner households Random parameters panel regression model

Clinical,serological and genetic predictors of inflammatory bowel disease course

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World Journal of Gastroenterology 2012年第29期18卷 3806-3813页

作者： Laurent Beaugerie harry Sokol department of Gastroenterology AP-HPH pital Saint-Antoine F-75012 and UPMC University Paris 06F-75005 ParisFrance

Patients with extensive or complicated Crohn's disease(CD) at diagnosis should be treated straightaway with immunosuppressive therapy according to the most recent *** patients with localized and uncomplicated CD at diagnosis,early use of immunosuppressive therapy is debated for preventing disease progression and limiting the disabling clinical *** this context,there is a need for predictors of benign or unfavourable subsequent clinical course,in order to avoid over-treating with risky drugs those patients who would have experienced spontaneous mid-term asymptomatic disease without progression towards irreversible intestinal *** diagnosis,an age below 40 years,the presence of perianal lesions and the need for treating the first flare with steroids have been consistently associated with an unfavourable subsequent 5-year or 10-year clinical *** positive predictive value of unfavourable course in patients with 2 or 3 predictors ranges between 0.75 and 0.95 in population-based and referral centre ***,the use of these predictors can be integrated into the elements that influence individual *** the CD postoperative context,keeping smoking and history of prior resection are the stron-gest predictors of disease symptomatic ***,these clinical predictors alone are not as reliable as severity of early postoperative endoscopic recurrence in clinical *** ulcerative colitis(UC),extensive colitis at diagnosis is associated with unfavourable clinical course in the first 5 to 10 years of the disease,and also with long-term colectomy and colorectal inflammation-associated colorectal *** patients with extensive UC at diagnosis,a rapid step-up strategy aiming to achieve sustained deep remission should therefore be *** the moment,no reliable serological or genetic predictor of inflammatory bowel disease clinical course has been identified.

关键词： Crohn's disease Ulcerative colitis Inflammatory bowel diseases Natural history Predictors Clinical practice

Early glaciological and Quaternary Geology cooperation

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Advances in Polar Science 2021年第4期32卷 275-280页

作者： harry ZILLIACUS university of Helsinki Faculty of Science Finland

The article depicts the author’s experiences of Glaciology and Quaternary Geology research between Finland and the People’s Republic of *** focus is on a visit to a glaciological station in Tianshan in *** climate is continental displaying warming-up and increased precipitation since the end of the 1980’*** data collected here is of utmost importance when analysing the future development of the *** associations to the historic Silk Roads are made having implications on the Belt and Road strategy launched by the *** to problems of sea and lake ice,Finland and the *** have found issues of mutual interest resulting in continuing cooperation in the Arctic and in ice-covered areas of *** forms of bilateral collaboration such as university education and training have evolved encompassing coming generations.

关键词： glaciers geomorphology Tianshan climate change the Belt and Road

Neurocomputing van der Pauw function for the measurement of a semiconductor's resistivity without use of the learning rate of weight vector regulation

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Journal of Semiconductors 2011年第12期32卷 32-39页

作者：李宏力孙以材王伟 harry Hutchinson Hebei university of Technology Tianjin Vocational Institute

Van der Pauw＇s function is often used in the measurement of a semiconductor＇s resistivity. However, it is difficult to obtain its value from voltage measurements because it has an implicit form. If it can be expressed as a polynomial, a semiconductor＇s resistivity can be obtained from such measurements. Normally, five orders of the abscissa can provide sufficient precision during the expression of any non-linear function. Therefore, the key is to determine the coefficients of the polynomial. By taking five coefficients as weights to construct a neuronetwork, neurocomputing has been used to solve this problem. Finally, the polynomial expression for van der Pauw＇s function is obtained.

关键词： measurement of the semiconductor's resistivity van der Pauw function reversal development neu-rocomputing polynomial match learning rate of weight vector regulation

THE PERIODIC harry-DYM EQUATION

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Chinese Annals of Mathematics 1987年第4期8卷 404-409页

作者：汪存启 department of Mathematics university of Science and Technology of China Hefei China.

The development of the inverse scattering transform（I.S.T）has made it possible tosolve certain physically significant nonlinear evolution equations with periodic *** and Tanaka have considered kdv equation;Ma and Ablowitz havediscussed the cubic Schrodinger *** this paper,following closely the analysis in[2,3]the author considers harry-Dym eqution（q2）t=-2rxxx（Ⅰ）where q（x,t）is periodic in x with period π for all time q（x,t）=q（x+π,t）,q（x,t）=r-1（x,t）>0

关键词： THE PERIODIC harry-DYM EQUATION

Helicobacter pylori serology in a birth cohort of New Zealanders from age 11 to 26

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World Journal of Gastroenterology 2005年第21期11卷 3273-3276页

作者： J.Paul Fawcett Gill O.Barbezat Richie Poulton Barry J.Milne harry H.X.xia Nicholas J.Talley School of Pharmacy university of Otago DunedinNew Zealand Dunedin School of medicine university of Otago DunedinNew Zealand Dunedin Multidisciplinary Health and Development Research Unit Dunedin School of medicine University of Otago Dunedin New Zealand department of medicine The university of Hong Kong Queen Mary Hospital Hong Kong China department of medicine the university of sydney Nepean HospitalNSW 2751Australia

AIM: To determine seroprevalence of Helicobacter pylori (Hpylori)in the Dunedin Multidisciplinary Health and Development Study (DMHDS) at age 26 in order to investigate seroconversion and seroreversion from age 11 to 26 and the association of seropositivity with risk factors for H pylori infection. METHODS: Participants in the DMHDS at age 26 and retrospectively at age 21 were tested for H pylori antibodies using two commercially available ELISA ***, socioeconomic status (SES), smoking,educational attainment and employment at age 26 were tested for association with H pylori seropositivity. RESULTS: At ages 21 and 26,seroprevalence of H pylori using one or other kit was 4.2% (n=795) and 6.3% (n=871) respectively, Seroreversion rate was lower than seroconversion rate (0.11% vs 0.53% per person-year) in contrast to the period from age 11 to 21 when seroreversion rate exceeded seroconversion rate (0.35% vs 0.11% per person-year). Serology in those tested at ages 11, 21, and 26 remained unchanged in 93.6% of the sample. Seroprevalence at age 26 was lower among those with a secondary school qualification (P=0.042) but was not associated with gender, SES, smoking or employment status. CONCLUSION: H pylori seroprevalence in a New Zealand birth cohort remains low between ages 11 and 26. H pylori infection remains stable from childhood to adulthood although seroreversion seems to be more common in the adolescent years than in young adults.

关键词： H pylori Seroprevalence Cohort

上海安亭新镇经验:规划结构中的文化和空间适应与转化

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China City Planning Review 2024年第1期33卷 22-33页

作者：哈利·邓·哈托格鲍莉珂梁毅方 TU Delft the Netherlands Tongji university ShanghaiP.R.China 不详 Amsterdam university of Applied Sciences Amsterdamthe Netherlands

this paper we study planned and unplanned adjustment processes in master-planned communities and new towns by a first wave of residents,in which changes in lifestyles play a central *** can unplanned transitions be stimulated and play a role in making a new town more attractive,sustainable,adjustable,and fexible in use?We apply this to the case of Anting New Town in *** focus on both personal and collective adjustments and appropriation in housing,commercial,as well as public *** explore methods of doing visual research by observation,in line with methods by Venturi and *** adding economic and socio-cultural drivers and institutional frameworks,which allow these alterations to happen,conclusions are made about the possible sustainability,adjustability,and flexibility of these planned *** analyze adjustments from different perspectives on the themes of urbanity and identity:architectural-morphological,②functional-economical,and *** different approaches to studying the planned and unplanned city,we explain how the urbanity and identity of Anting have changed in various *** of building structures and urban spaces is a key element in this process of *** is the outcome of a wider process of economicand socio-culturalchange.

关键词： adaptability appropriation identity master-planned communities new towns open city personalization public space

Environmental factors affecting degradation of perfluorooctanoic acid(PFOA) by In2O3 nanoparticles

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Journal of Environmental Sciences 2020年第7期32卷 48-56页

作者： Weilan Zhang harry Efstathiadis Lingyun Li Yanna Liang department of Environmental and Sustainable Engineering University at AlbanySUNYAlbanyNY 12222USA department of Nanoengineering SUNY Polytechnic InstituteAlbanyNY 12203USA New York State department of Health Division of Environmental Health SciencesWadsworth CenterAlbanyNY 12237USA

Nanophotocatalysts have shown great potential for degrading poly-and perfluorinated substances(PFAS).In light of the fact that most of these catalysts were studied in pure water,this study was designed to elucidate effects from common environmental factors on decomposing and defluorinating perfluorooctanoic acid(PFOA)by In2O3 *** from this work demonstrated that among the seven parameters,pH,sulfate,chloride,H2O2,In2O3 dose,NOM and O2,the first four had statistically significant negative effects on PFOA *** PFOA is a strong acid,the best condition leading to the highest PFOA removal was identified for two pH *** pH was between 4 and 8,the optimal condition was:pH=4.2;sulfate=5.00 mg/L;chloride=20.43 mg/L;H2O2=0 mmol/*** this condition,PFOA decomposition and defluorination were 55.22 and 23.56%,*** pH was between 2 and 6,the optimal condition was:pH=2;sulfate=5.00 mg/L;chloride=27.31 mg/L;H2O2=0 mmol/*** this condition,the modeled PFOA decomposition was 97.59%with a defluorination of approximately 100%.These predicted results were all confirmed by experimental ***,In2O3 nanoparticles can be used for degrading PFOA in aqueous *** approach works best when the target contaminated water contains low concentrations of NOM,sulfate and chloride and at a low pH.

关键词： Perfluorooctanoic acid(PFOA) Nanophotocatalyst Degradation Defluorination Optimization