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Etiopathogenesis of primary biliary cirrhosis

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World Journal of Gastroenterology 2008年第21期14卷 3328-3337页

作者： Ana Lleo Pietro Invernizzi Ian R Mackay harry Prince Ren-Qian Zhong M Eric Gershwin Division of Internal Medicine and Liver Unit San Paolo Hospital School of Medicine University of Milan Milan 20142 Italy Division of Rheumatology Allergy and Clinical Immunology University of California at Davis Davis CA 95616 United States Department of Biochemistry & Molecular Biology Monash University Clayton Victoria 3800 Australia Focus Diagnostics 5785 Corporate Avenue Cypress CA 90630 United States Laboratory Diagnostics of Changzheng Hospital Second Military Medical University and Clinical Immunology Center of PLA Shanghai 200003 China

Primary biliary cirrhosis(PBC) is an autoimmune disease of the liver characterized by progressive bile duct destruction eventually leading to cirrhosis and liver *** serological hallmark of the disease is the presence of circulating antimitochondrial antibodies(AMA).these reflect the presence of autoreactive t and B cells to the culprit antigens,the E2 subunits of mitochondrial 2-oxo-acid dehydrogenase enzymes,chiefly pyruvate dehydrogenase(PDC-E2).the disease results from a combination of genetic and environmental risk *** predisposition is indicated by the higher familial incidence of the disease particularly among siblings and the high concordance rate among monozygotic *** triggering events appear crucial to disrupt a pre-existing unstable immune tolerance of genetic origin allowing,after a long latency,the emergence of clinical *** mimetopes of the vulnerable epitope of the PDC-E2 autoantigen can be derived from microbes that utilize the PDC enzyme or,alternatively,environmental xenobiotics/chemical compounds that modify the structure of native proteins to make them immunogenic.A further alternative as a source of antigen is PDC-E2 derived from apoptotic *** the effector phase the biliary ductular cell,by reason of itsproclivity to express the antigen PDC-E2 in the course of apoptosis,undergoes a multilineage immune attack comprised of CD4+ and CD8+ t cells and *** this article,we critically review the available evidence on etiopathogenesis of PBC and present interpretations of complex data,new developments and theories,and nominate directions for future research.

关键词： Autoantibodies Autoreactive t cells 2-oxoacid dehydrogenase Biliary epithelial cells Primary biliary cirrhosis

A MODIFIED HEAt CONDUCtION MODEL

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Chinese Journal of Mechanical Engineering 1995年第3期8卷 175-186页

作者： harry Gingold Dinesh Gera(Department of Mathematics)( Department of Mechanical &Aerospace Engineering)West Virginia University(Morgantown WV 26506 U.S.A)

the purpose of this paper is to devise a new model of heat conduction for a body which istotally insulated at its boundary. the essence of the new model is modification of the Fourier law insuch a way that the resulting heat conduction problem will be fonnulated as an initial value problemwith a nonstandard partial differential equation. the values of normal derivatives of the heat fiuxto various orders for all tmies (t> 0) will be detemined by the governing partial differential equa-tion and the values of normal derivatives of fluxes at the initial time (t=0). We study the properitesof this model and demonstrate its validity for a simple onedimensional case of a thin bar insulatedat both ends.

关键词： Heatconduction Model

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Intrahepatic CD8^+ lymphocyte trapping during tolerance induction using mushroom derived formulations:A possible role for liver in tolerance induction

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World Journal of Gastroenterology 2008年第24期14卷 3872-3878页

作者： Mony Shuvy tiberiu Hershcovici Lidya Zolotarov Yaron Ilan Cristina LulI-Noguera harry Wichers Ofer Danay Dan Levanon Liver Unit Department of Medicine Hadassah HebrewUniversity Medical Center Jerusalem IL-91120 Israel WageningenUniversity and Research Center Wageningen 6706 KN TheNetherlands Migal Kiryat Shmone 11016Israel

AIM: to determine the immunomodulatory effect of Shiitake (a mushroom extract),we tested its effect on liver-mediated immune regulation in a model of immune-mediated colitis. MEtHODS: Four groups of mice were studied. Colitis was induced by intracolonic instillation of tNBS in groups A and B. Groups A and C were treated daily with Shiitake extract,while groups B and D received bovine serum albumin. Mice were evaluated for development of macroscopic and microscopic. the immune effects of Shiitake were determined by FACS analysis of intra-hepatic and intrasplenic lymphocytes and IFN-γ ELISPOt assay. RESULtS: Administration of Shiitake resulted in marked alleviation of colitis,manifested by signifi cant improvement in the macroscopic and microscopic scores,and by reduction in IFN-γ-producing colonies in group A,compared to group B mice (1.5 pfu/mL vs 3.7 pfu/mL,respectively). this beneficial effect was associated with a significant increase in the intra-hepatic CD8+ lymphocyte trapping,demonstratedby an increased intrasplenic/intrahepatic CD4/CD8 lymphocyte ratio. these effects were accompanied by a 17% increase in the number of intrahepatic natural killer t (NKt) cells. A similar effect was observed when Shiitake was administered to animals without disease induction. CONCLUSION: Shiitake extract affected liver-mediated immune regulation by altering the NKt lymphocyte distribution and increasing intrahepatic CD8+ t lymphocyte trapping,thereby leading to alleviation of immune-mediated colitis.

关键词： Mushrooms Colitis Immune modulation Shiitake Natural killer t cell

A NEW MEtHOD tO CALCULAtE INDOOR NAtURAL LIGHtING BY IMPROVING “ LUMEN MODELS”

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A NEW METHOD TO CALCULATE INDOOR NATURAL LIGHTING BY IMPROVI...

2007世界太阳能大会：太阳能与人类居住

作者： Fakra Ali Hamada harry Boyer Eddy Lafosse Philippe Lauret Laboratoire de Physique du Btiment et des Systèmes Faculté des Sciences de l’Homme et de l’Environnement 117 rue du général Ailleret 97430 Tampon Université de La Réunion (France)

Many researches were undertaken in order to set up models which enable to calculate indoor daylighting [1-3].there are three of type’s method to calculate the daylight luminance through windows and large openings inside the *** others,‘simplified methods’ (Lumen method,Split Flux System method,etc...),‘numerical simulation method’ (Radiosity,Ray tracing,etc...) and finally ‘experimental method’ (scale model,building experimental,etc...) are described in *** put some specific interest in the ‘simplified methods’ because they are easy to use and don’t need a lot of inputs for *** big disadvantage for most of these models is these models depend on restricted *** example,if we considered " Split Flux System method", we see that the models can be used only to overcast *** example,the " lumen method" applied for any skies,but the models gives only five values in the *** they can only work under precise and limited *** this present paper,we purpose to see how we can circumvent these difficulties by improving the "Lumen Model".Indeed,we will to introduce the notion of " Equivalent Deep" (E) into the " Lumen method".this " Equivalent Deep" will calculate any values and any types of skies instead of the original " Lumen method";that only calculate five values.

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中压低温空气分离流程

杭氧科技 1996年第3期 47-51页

作者： harry Cheung 美国联碳工业气体公司

本文侧重氩的提取。介绍了新型的 M—Plant 空气分离循环,使氩提取率提高5%,能耗低10%,结构紧凑。并与传统的 t—Plant 空气分离循环作了比较(t—Plant 循环通用性好,操作灵活)。在氩是主要产品时,最好选用 M—Plant循环,在氧是主要产品... 详细信息

本文侧重氩的提取。介绍了新型的 M—Plant 空气分离循环,使氩提取率提高5%,能耗低10%,结构紧凑。并与传统的 t—Plant 空气分离循环作了比较(t—Plant 循环通用性好,操作灵活)。在氩是主要产品时,最好选用 M—Plant循环,在氧是主要产品时,最好选用 t—Plant 循环。图2表2。

关键词：精馏提氩低温技术空气分离中压流程设备循环大型低压设备循环

A study of the effects of 3,5-diiodo-L-thyronine in the tail suspension and forced swim models of depression

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translational Neuroscience and Clinics 2016年第2期2卷 96-107页

作者： Nataliia Markova Anton Chernopiatko Aslan Kubatiev Sergey Bachurin harry M.W.Steinbusch tatyana Strekalova Laboratory of Biomolecular screening Institute of Physiologically Active Compounds Russian Academy of Sciences Laboratory of Cognitive dysfunctions Federal State Budgetary Scientific Institution "Institute of General Pathology and Pathophysiology" Department of Neuroscience School for Mental Health and Neuroscience Maastricht University Section of Neuropharmacology Research

Objectives: Recent findings have further highlighted the role of the thyroid system in the pathophysiology of depression and revealed new physiologically relevant elements of the thyroid system. Our previous study showed an antidepressant-like effect of 3,5-diiodo-L-thyronine(t2), which was previously considered to be a physiologically inactive molecule, in mice. Here, we aimed to investigate the antidepressant-like effects of t2 further. Methods: We studied the effects of bolus injections of t2 to C57Bl6 J mice at doses of 0.25 or 0.75 mg/kg with the tail suspension and forced swim models. the effects of the higher dose were investigated in CD1 mice in the forced swim test. Potential behavioral effects of these treatments were also studied using the novel cage and dark-light box ***: A reduction of depressive-like behavior was found in mice treated with 0.75 mg/kg of t2 in the tail suspension test, but not in the forced swim test. Locomotion and anxiety variables were unaltered following treatment with t2. there were no significant changes after bolus administration of 0.25 mg/kg t2 in either test for depressive-like behavior. thus, bolus injection of t2 at the dose 0.75 mg/kg can induce antidepressant-like effects without affecting other behaviors. Conclusions: A discrepant result in the forced swim test may be due to its different sensitivity to t2 compared with the tail suspension paradigm. Furthermore, the development of procedural modifications of this model can be useful in its application in pre-clinical studies.

关键词： forced swim test tail suspension test depression animal models thyroid hormones

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Water-Energy-Food Nexus： Comparative Scenarios and Public Policy Perspectives from Some Latin American Countries Regarding Biogas from Agriculture and Livestock

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Journal of Agricultural Science and technology(A) 2015年第6期5卷 408-427页

作者： Janaina Camile Pasqual Claudia Cecilia Lardizabal Gricelda Herrera harry Alberto Bollmann Estela de Oliveira Nunes International Center of Renewable Energies/Biogas and International Center of Hydroinformatics (Itaipu Binacional) PontificalCatholic University of Parandt (PUCPR) CAPES Fellowship Curitiba Parana 80030180 Brazil Integrated Watershed Management Biology Department National Autonomous University of Honduras San Pedro Sula Cortes21103 Honduras Faculty of Social Sciences and Humanistic (FCSH) Research and Projects Applied on Earth Sciences Center (CIPA T) EscuelaSuperior Polit~cnica del Litoral (ESPOL) Guayaquil 09-01-5863 Ecuador Urban Management Program Pontifical Catholic University of Parana (P UCPR) Curitiba Paran6 80215-901 Brazil Brazilian Corporation of Agricultural Research (EMBRAPA Soybean) Londrina Parana 86001-970 Brazil

Latin American and the Caribbean countries have one of the world＇s largest sources of renewable energy. Nonetheless, it estimated that nearly three-quarters of their energy consumption relies on the use of fossil fuels, with most of the countries being net importers, ultimately imposing a marked economic and political dependence on those energy commodities. therefore, the opportunity lies in a higher utilization of various renewable energy resources, which contribute to the country＇s energy security while promoting significant environmental benefits. this manuscript aimed to provide a comparative analysis of current energy scenarios of six Latin American countries （Mexico, Honduras, Nicaragua, Brazil, Chile and Ecuador） to evaluate their policies, programs and strategies implemented in the search for greater participation of renewable energy, with a special attention to biogas. Given the importance of the water-energy-food nexus that could foment the use of renewable energies under conditions of water scarcity, a qualitative data comparison was accomplished, considering biogas production potential, biogas projects and CO2 emissions.

关键词： Water and energy nexus biogas CO2 emissions public policy.

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荷兰铁路铰接式Sprinter电动车组

国外铁道车辆 2006年第3期43卷 17-18页

作者： harry Hondius 心竹

介绍了荷兰铰接式Sprinter电动车组的结构特点及技术参数,并与t型、V型和SM90型电动车组进行了比较。

关键词：电动车组结构比较荷兰

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Indoleamine 2,3-dioxygenase as biomarkers for classification of macrophages and to study immunomodulatingactivity of dietary fibers

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Indoleamine 2,3-dioxygenase as biomarkers for classification...