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Synthesis, Mechanism of Formation and Insecticidal Activity of Novel Fluorinated Organophosphorus Compounds

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Chinese Journal of Chemistry 2002年第12期20卷 1598-1601,1464页

作者：吴军 HUDSON harry R. Department of Chemistry Zhejiang University Hangzhou Zhejiang 310027 China Division of Chemistry School of Biological and Applied Sciences University of North London London N7 8DB UK

The major products of the interaction between triethyl phosphite and 3-fluoropropanoyl chloride at room temperature are diethyl (E)-1-(3-fluoropropanoyloxy)-3-fluoroprop-1-enylphosphonate (3) and diethyl l-(diethoxyphosphoryl)-3-fluoropropyl phosphate (4). The compounds 3 and 4 were separated by chromatography, and structurally characterized by elemental analysis, NMR spectroscopy (1H, 13C, 19F and 31p) and mass spectrometry. possible reaction mechanisms are proposed. The major products 3 and 4 were tested for insecticidal activity. 3 gave 100% control of Musca domestica L. and phaedon cochledriae Fab. at a dose of 20 μg/per insect.

关键词： synthesis reaction mechanism insecticidal activity fluorinated organophosphonate

parentage analysis in Gabonese colonies of soil-feeding termites belonging to the Cubitermes sp. affinis subarquatus complex of species （Termitidae＂ Termitinae）

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Insect Science 2010年第2期17卷 84-90页

作者： Virginie Roy Lise Dupont Myriam harry Unite Mixte de Recherche 7618 Bioemco Universite Paris 12-Val de Mame 61 avenue du Gen6ral de Gaulle 94010 Creteil cedex Laboratoire Evolution Genomes et Speciation UPRg034 Centre National de la Recherche Scientifique 91198 Gif sur YvetteFrance

Cubitermes spp. are widely distributed soil-feeding termite species in sub- Saharan Africa which play a fundamental role in soil structure and fertility. A complex of at least four cryptic species （i.e., Cubitermes sp. affunis subarquatus complex of species） has been recently described using molecular markers. In order to investigate the breeding system of these species, five microsatellite markers were used to carry out parentage and re- latedness analyses in 15 Gabonese colonies. Monogamy was confirmed as the predominant reproductive organization in Cubitermes spp. （76% of the colonies）. Within 30% of these monogamous colonies, a high relatedness between reproductives was shown, suggesting that mating between related individuals occurs. However, Cubitermes colonies can deviate from monogamy. Indeed, parental contributions by at least two related reproductives of the same sex were revealed in four colonies and polyandry was demonstrated in two of them. Infiltration of reproductives in the colony is the most plausible explanation for such cases of polygamy in Cubitermes spp.

关键词： breeding system Cubitermes spp. microsatellite markers monogamy soil- feeding termites

Gut microbiome alters functions of mutant p53 to promote tumorigenesis

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Signal Transduction and Targeted Therapy 2020年第1期5卷 491-492页

作者： harry Cheuk Hay Lau Jun Yu Institute of Digestive Disease Department of Medicine and TherapeuticsState Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK Shenzhen Research InstituteThe Chinese University of Hong KongSha TinN.T.Hong Kong

In a recent study in Nature,Kadosh et al.1 established a landmark relationship between the gut microbiome and host epigenetics in intestinal *** demonstrated the substantial plasticity of mutant p53 in WNT-driven tumo... 详细信息

关键词： tumorigenesis involvement al

Lipid lowering in patients 75 years and older

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World Journal of Cardiology 2021年第10期13卷 526-532页

作者： Umidakhon Makhmudova p Christian Schulze harry R Davis Oliver Weingartner Klinik fur Innere Medizin I Universitatsklinikum JenaJena 07747Germany Synergy partners RD Solutions Synergy Partners RD SolutionsGaithersburgMD 20850United States

More than twenty years ago,knowledge about the importance of cholesterol absorption and the potential therapeutic effect of its inhibition led to the discovery and clinical application of the first and only cholesterol absorption inhibitor to date–*** then,ezetimibe has become a well-recognized player in lipid-lowering *** findings of IMpROVE-IT and EWTOpIA 75 imply that elderly patients over the age of 75 years in particular benefit from *** review summarizes the evidence,discusses the possible underlying pathophysiological mechanisms and calls for a change in future dyslipidemia guidelines.

关键词： Cholesterol Cholesterol absorption Cholesterol synthesis Ezetimibe Elderly

Trends in global semen parameter values

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Asian Journal of Andrology 2013年第2期15卷 169-173,I0004页

作者： harry Fisch Stephen R Braun Departments of Urology and Reproductive Medicine Weill Cornell Medical College New York PresbyterianHospital New York NY 10028 USA

Allegations for a worldwide decline in semen *** values have not withstood scientific scrutiny. Methodological flaws in an influential 1992 paper are summarized here, and studies that have been published since 1992 are reviewed. Of the 35 major studies of time trends in semen quality reviewed here, eight （a total of 18 109 men） suggest a decline in semen quality; 21 （112 386 men） show either no change or an increase in semen quality;, and six （26 007 men） show ambiguous or conflicting results. The cause （or causes） of the geographical and temporal variations in semen parameter values reported by these diverse studies deserve further investigation.

关键词： pAST 20 YEARS SpERM COUNTS FERTILE MEN GENERAL-pOpULATION UNITED-STATES LAST DECADE NO EVIDENCE DANISH MEN YOUNG MEN QUALITY

Meta-analysis of ground movements associated with deep excavations using a data mining approach

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第2期11卷 409-416页

作者： harry Holmes Emilio Garcia-Taengua Raul Fuentes AECOM Ltd. University of Leeds

This paper presents a rigorous statistical approach to identify the controlling factors in the development of ground movements associated with deep excavations. It also gives the most suitable definition of support stiffness from many suggested definitions in the literature. The study is based on a newly compiled database from 389 case studies of propped and anchored excavations. Data mining techniques(e.g. principal component analysis and multi-linear regression) were used to identify significant relationships between the parameters under study and to quantify the global trends in the database. The study shows that the main factors controlling the ground movements are those related to ground conditions, confirming the conclusions of previous empirical studies. It is also shown that the definition of Addenbrooke et al.(1994) is the most suitable expression of support stiffness, therefore providing conclusive evidence for its future use.

关键词： Geomechanics Slope stability Special soil Unsaturated soil

propulsive matrix of a helical flagellum

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Chinese physics B 2014年第11期23卷 51-56页

作者：张何朋刘斌 Bruce Rodenborn harry L.Swinney Department of physics and Astronomy and Institute of Natural Sciences School of Natural Sciences University of California Department of physics and Center for Nonlinear Dynamics University of Texas at Austin

We study the propulsion matrix of bacterial flagella numerically using slender body theory and the regularized Stokeslet method in a biologically relevant parameter regime. All three independent elements of the matrix are measured by computing propulsive force and torque generated by a rotating flagellum, and the drag force on a translating flagellum. Nu- merical results are compared with the predictions of resistive force theory, which is often used to interpret micro-organism propulsion. Neglecting hydrodynamic interactions between different parts of a flagellum in resistive force theory leads to both qualitative and quantitative discrepancies between the theoretical prediction of resistive force theory and the numerical results. We improve the original theory by empirically incorporating the effects of hydrodynamic interactions and propose new expressions for propulsive matrix elements that are accurate over the parameter regime explored.

关键词： low-Reynolds-number flows micro-organism dynamics bacterial swimming

LONG TERM pERFORMANCE OF STEROID-ELUTING LEAD IN DUAL CHAMBER pACING

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Chinese Medical Sciences Journal 1997年第2期12卷 118-120页

作者：华伟 harry Mond Clinical Electrophysiology Lab Fu Wai Hospital CAMS & PUMC Beijing 100037 Department of Cardiology The Royal Melbourne HospitalVIC 3050Australia

The atrial pacing lead is believed having higher stimulation thresholds and long-term complication rates than ventricular lead, this being one of the factors limiting the use of dual chamber pacing. A prospective study was undertaken to evaluate both atrial and ventricular bipolar lined steroid-eluting leads in long-term dual chamber pacing. There are 81 pairs of leads (Medtronic Capsure Sp) used in 81 patients. Bipolar atrial and ventricular stimulation thresholds were measured immediately post implantation and 1,3, 6,12,18 and 24 months. All leads demonstrated low mean stimulation thresholds during the follow-up and more than 94 % of leads could be paced chronically in the atrium and ventricle at 2.5 volts. In conclusion, atrial and ventricular steroid-eluting leads gave excellent stimulation thresholds allowing low energy long-term dual chamber pacing.

关键词： steroid elution dual chamber pacing

Differentiations of geographic distribution and subsistence strategies between Tibetan and other major ethnic groups are determined by the physical environment in Hehuang Valley

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Science China Earth Sciences 2019年第2期62卷 412-422页

作者： Xin JIA harry F.LEE Mengchun CUI Guoquan CHENG Yang ZHAO Hong DING Ricci p.H.YUE Huayu LU School of Geographic and Oceanographic Sciences Nanjing University College of Earth and Environmental Sciences Lanzhou University Needham Research Institute Department of Geography and Resource Management The Chinese University of Hong Kong School of Marxism Taiyuan University of Technology Department of Geography and International Center for China Development Studies The University of Hong Kong

The people of the Tibetan plateau have received extensive attention from scholars because of their unique adaptability to the low temperature and anoxic environments. However, the Tibetan communities and their habitats in the low-altitude regions of the plateau have rarely been studied in a scientific manner. Based on the extraction of geographic information of 197 towns in the Hehuang Valley and on variance analysis, this study examines the habitats and subsistence strategies of the Tibetans and other major ethnic groups in the low-latitude region of the Tibetan plateau. Our statistical results show that the annual average temperature of Tibetan habitats in the Hehuang Valley is relatively high. The relatively warm environment of the valley allows the Tibetans in that area to cultivate wheat and barley and raise cattle and sheep—a subsistence strategy significantly different from that of other Tibetans in the high-altitude regions in the Tibetan plateau. In addition, the Tibetan communities in the Hehuang Valley include similar agri-pastoral ethnic groups (including Hui and Salar), both of which adopt similar subsistence strategies. The agricultural ethnic groups (Han and Tu) live in a relatively cool and humid environment facilitating agricultural production, while the agri-pastoral ethnic groups (Tibetan, Hui, and Salar) inhabit relatively warm and arid environment in the valley. Due to the lack of agricultural activities, agri-pastoral groups must also engage in animal husbandry to supplement their diet. In the Ando Tibetan region, the subsistence strategies of the ethnic groups are closely related to their physical *** ethnic groups communicate among themselves, integrate, and influence each other, resulting in a diversified culture. This study proves that the habitat variation at a regional scale corresponds significantly to the variation of subsistence strategies. Our findings may further refine knowledge about the human-environmental relationsh

关键词： Tibetan plateau Ethnic group Ethnic geography Hehuang Valley Ando Tibetan region