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片仔癀通过调节小鼠的肠道菌群和代谢物抑制非酒精性脂肪性肝炎

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Engineering 2024年第4期35卷 257-269页

作者： Xianyi Zeng Xiang Zhang Hao Su Hongyan Gou harry Cheuk-Hay Lau Xiaoxu Hu Ziheng Huang Yan Li Jun Yu Shenzhen Research Institute The Chinese University of Hong KongShenzhen 518057China Department of Medicine and Therapeutics Institute of Digestive DiseaseState Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong 999077China

Non-alcoholic steatohepatitis(NASH)is a severe form of non-alcoholic fatty liver disease without effective *** traditional Chinese medicine formulation pien Tze Huang(pTH)can suppress inflammatory ***,we evaluate the effects of pTH on the evolution of NASH and its underlying *** found that pTH prevented the development of steatohepatitis induced by various dietary models,including a high-fat high-cholesterol(HFHC)diet,choline-deficient high-fat diet(CD-HFD),and methionine-and choline-deficient(MCD)diet,along with significant suppression of liver injury,hepatic triglyceride,and lipid ***,ten days of pTH treatment after the onset of NASH significantly ameliorated MCD diet-induced steatosis and liver injury in *** the metagenomic sequencing of stool samples,we found that pTH administration restored the gut microbiota with enrichment of probiotics including Lactobacillus acidophilus(***),Lactobacillus plantarum,Lactococcus lactis,and Bacillus *** enriched *** prevented MCD diet-induced *** addition,pTH restored the gut barrier function in mice with steatohepatitis,as evidenced by reduced intestinal permeability,decreased serum lipopolysaccharides(LpS)level,and increased epithelial tightjunction protein E-cadherin *** metabolomic analysis via liquid chromatography-mass spectrometry profiling identified the alteration in the metabolism of bile acids in the portal vein of pTHtreated *** further confirmed that an intact gut microbiota is necessary for pTH to exhibit antisteatohepatitis *** conclusion,pTH protects against steatohepatitis development by modulating the gut microbiota and *** is a potential promising prophylactic and therapeutic option for patients with NASH.

关键词： pien Tze Huang Non-alcoholic steatohepatitis Gut barrier function Gut microbiota

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全胜夺冠

财新周刊 2024年第29期 14-15页

作者： harry Langer(图) 视觉中国

当地时间2024年7月14日,德国柏林,2024年男足欧洲杯决赛,西班牙队2比1击败英格兰队夺冠,西班牙队球员卡瓦哈尔高举德劳内杯与队友庆祝。本届赛事中,西班牙队七战全胜,先是以头名身份从“死亡之组”中出线,随后在八分之一决赛中轻取格鲁... 详细信息

当地时间2024年7月14日,德国柏林,2024年男足欧洲杯决赛,西班牙队2比1击败英格兰队夺冠,西班牙队球员卡瓦哈尔高举德劳内杯与队友庆祝。本届赛事中,西班牙队七战全胜,先是以头名身份从“死亡之组”中出线,随后在八分之一决赛中轻取格鲁吉亚队,并接连淘汰夺冠热门德国队和法国队闯入决赛。

关键词：西班牙队英格兰队德国队法国队欧洲杯格鲁吉亚男足赛事

将WHO《心理健康差距干预指南》应用于中国全科医学服务:一项德尔菲研究

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中国全科医学 2024年第1期27卷 15-26页

作者： Kendall Searle Grant Blashki Ritsuko Kakuma 杨辉吕淑荣李宝琪肖莹莹 harry Minas VIC 3010 Global and Cultural Mental Health Unit Centre for Mental HealthSchool of Population and Global HealthUniversity of MelbourneParkvilleAustralia VIC 3010 Nossal Institute for Global Health University of MelbourneMelbourneAustralia WC1E 7HTE London School of Hygiene and Tropical Medicine LondonEnglandUK VIC 3168 Monash Institute for Health and Clinical Education School of Primary Health CareMonash UniversityNotting HillAustralia 中国科学院大学深圳医院(光明) 广东省深圳市518107

背景中国全科医生越来越期望能够识别和预防抑郁障碍,但其接受的心理健康培训有限,社区卫生服务中心(CHCs)也缺乏针对抑郁障碍的诊断和服务规范。WHO《心理健康差距干预指南》第2版(mhGAp-IG.v2)是为非心理健康专业人员提供的决策支持工... 详细信息

背景中国全科医生越来越期望能够识别和预防抑郁障碍,但其接受的心理健康培训有限,社区卫生服务中心(CHCs)也缺乏针对抑郁障碍的诊断和服务规范。WHO《心理健康差距干预指南》第2版(mhGAp-IG.v2)是为非心理健康专业人员提供的决策支持工具,可用于评估、管理、随访精神障碍、神经疾病及物质使用障碍患者。鉴于mhGAp-IG.v2的通用性,其在中国的应用应根据抑郁障碍在不同文化下的差异性和中国心理健康系统特点进行调整。方法开展两轮基于网络的德尔菲(Delphi)调查。邀请来自深圳市的全科医生小组对mhGAp-IG.v2中涉及抑郁障碍的199条表述进行五分制的赞同程度打分,即“如要把该表述用在深圳市,是否赞同调整其内容和结构”。如果>80%的全科医生“有些/肯定赞同”调整某表述,则视为全科医生对调整该表述达成共识;如果>80%的全科医生“有些/肯定不赞同”调整某表述,则视为全科医生对不调整该表述达成共识。结果全科医生对79%的表述达成了需要调整的共识,平均得分为4.26分,即全科医生“有些赞同”对mh GAp-IG.v2中涉及抑郁障碍的相关表述进行调整。具体调整建议包括:抑郁评估方法应考虑更广泛的抑郁症状,并考虑病情的发展阶段;增加抑郁筛查工具的使用指南;明确全科医生的作用,以及家庭参与和跨部门服务的转诊途径;药物治疗建议应与中国用药规范保持一致;指南所有章节要强调预防自杀;情境化健康教育;强调“以人为本”的服务方法。全科医生认为,应维持mhGAp-IG.v2中对经历抑郁发作的双相障碍患者的诊断和治疗建议。结论对mhGAp-IG.v2抑郁部分的调整研究反映出对指南的评估应考虑文化和国情背景,包括中国特色的初级卫生保健系统、健康优先领域、治疗可得性,以及多样化的社会心理教育需要。调整后的mhGAp-IG.v2可以给中国全科医学教育和全科医疗服务提供参考,也可以为其他国家的非精神病学专业人员开展心理健康服务提供有益借鉴。

关键词：抑郁障碍心理健康差距干预指南德尔菲调整概念化初级保健跨部门服务世界卫生组织中国深圳

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象鸟,澳大利亚的巨型丑小鸭

中学生英语 2024年第15期 23-25页

作者： harry pettit 王怡霖(选译) 不详

世界上最大的鸟有一头牛那么重,它5万年前生活在澳大利亚。不会飞的史氏雷啸鸟用两条后腿缓慢前行。它是一个灭绝的生物群mihirungs(原住民语“巨鸟”的意思)中最大的一个,这个生物群的名字来源于土著人对巨型鸟的称呼。

关键词：生物群澳大利亚土著人原住民丑小鸭巨型鸟

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比利时国家铁路改进客运车辆的策略

国外铁道机车与动车 2024年第3期 10-11页

作者： [比]harry Hondius 韩丽(译) 孟娜(校) 不详

比利时国家铁路客运运营商(SNCB)于2023年初启动了一项单流制电动车组的采购计划,并期望在2030年左右完成该项目,届时SNCB将对其客运车队进行简化。

关键词： SNCB M7双层列车 AM30动车组

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无弹性物质参与的密封是未来的趋势

流程工业 2024年第4期 14-17页

作者： harry Jost Anja Quattelbaum Matthias Dörr NEUMO GmbH+Co.KG

即将实施的pFAS(全氟和多氟烷基化合物)禁令以及更严格的TA Luft(空气清洁技术标准)排放限值,是当前困扰着化工和生命科学行业从业者的两大热门话题。这使得管道连接如何能够实现安全密封并符合法规要求成为焦点问题。本文描述了制药、... 详细信息

即将实施的pFAS(全氟和多氟烷基化合物)禁令以及更严格的TA Luft(空气清洁技术标准)排放限值,是当前困扰着化工和生命科学行业从业者的两大热门话题。这使得管道连接如何能够实现安全密封并符合法规要求成为焦点问题。本文描述了制药、生物科技、食品和化工及氢能领域在这样的政策环境下所面临的问题,并给出了解决方案。此外,本文还特别介绍了不含弹性密封材料的管道连接件,并强调了无弹性物质参与的密封是未来的趋势。

关键词：连接件密封交叉污染

Climate change and plague history in Europe

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Science China Earth Sciences 2018年第2期61卷 163-177页

作者： Ricci p.H.YUE harry F.LEE The Department of Geography The University of Hong Kong International Center for China Development Studies The University of Hong Kong

previous research that reported the linkage between climate change and plague activity primarily refers to the immediate effect of short-term climatic variation. Yet, decades of discussion about the climate-plague association cannot determine the precise role of climate in shaping plague dynamics. One reason for this discrepancy originates from the narrow selection of spatio-temporal settings for comprehensive analysis of the correlation, leading to a limited consideration of the complexity of possible *** analyzing a 414-year long record of plague outbreak in pre-industrial Europe and the corresponding climatic data in multi-scale,we find little evidence to support climate-plague correlation in(1) both climatic variations and large-scale climatic phenomena,(2)both country scale and continental scale,(3) annual to inter-annual scale, and(4) both linear and non-linear analytic approaches. The null-result should not be viewed as a general rejection of other recent findings related to climate-plague association; nevertheless,it suggests that a wider consideration of scales, sensitivity checks and consideration of contexts should be included in explaining and predicting plague transmission under contemporary global climate conditions.

关键词： plague Climate change Scale pre-industrial period Europe

A robust WENO scheme for nonlinear waves in a moving reference frame

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Journal of Hydrodynamics 2016年第3期28卷 482-488页

作者： Stavros KONTOS harry B.BINGHAM Ole LINDBERG Allan p.ENGSIG-KARUp Department of Mechanical Engineering Technical University of DenmarkDenmark Department of Applied Mathematics and Computer Science Technical University of DenmarkDenmark

For robust nonlinear wave simulation in a moving reference frame, we recast the free surface problem in Hamilton-Jacobi form and propose a Weighted Essentially Non-Oscillatory （WENO） scheme to automatically handle the upwinding of the convective term. A new automatic procedure for deriving the linear WENO weights based on a Taylor series expansion is introduced. A simplified smoothness indicator is proposed and is shown to perform well. The scheme is combined with high-order explicit Runge-Kutta time integration and a dissipative Lax-Friedrichs-type flux to solve for nonlinear wave propagation in a moving frame of reference. The WENO scheme is robust and less dissipative than the equivalent order upwind-biased finite difference scheme for all ratios of frame of reference to wave propagation speed tested. This provides the basis for solving general nonlinear wave-structure interaction problems at forward speed.

关键词： nonlinear waves Weighted Essentially Non-Oscillatory (WENO) finite difference

Numerical modelling of resonance mechanisms in jointed rocks using transfer functions

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第5期15卷 1076-1089页

作者： harry Holmes Chrysothemis paraskevopoulou Mark Hildyard Krishna Neaupane David p.Connolly School of Earth and Environment University of LeedsLeedsLS29JTUK AECOM Ltd. ChesterfieldS417SLUK

Resonance effects in parallel jointed rocks subject to stress waves are investigated using transfer functions,derived from signals generated through numerical *** is important for a range of engineering situations as it identifies the frequency of waves which will be favourably *** different numerical methods are used for this study,adopting the finite difference method and the combined discrete element-finite difference *** numerical models are validated by replicating results from previous *** two methods are found to behave similarly and show the same resonance effects;one operating at low frequency and the other operating at relatively high *** resonance effects are interpreted in terms of simple physical systems and analytical equations are derived to predict the resonant frequencies of complex rock *** frequency resonance is shown to be generated by a system synonymous with masses between springs,described as spring resonance,with an equal number of resonant frequencies as the number of *** frequency resonance is generated through superposition of multiple reflected waves developing standing waves within intact blocks,described as superposition *** resonance through superposition has previously been identified,resonance based on masses between springs has not been previously identified in jointed *** findings of this study have implications for future analysis of multiple jointed rock masses,showing that a wave travelling through such materials can induce other modes of propagation of waves,*** resonance.

关键词： Resonance Jointed rocks Finite difference method Discrete element Transfer functions Wave propagation