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World Journal of Orthopedics 2024年第3期15卷 257-265页

作者： Bryan Hamans Sheryl de Waard Sjoerd Kaarsemaker Esther R C janssen Inger N Sierevelt Gino M M J Kerkhoffs Daniël Haverkamp Department of Orthopaedic Surgery Xpert ClinicAmsterdam 1101EANetherlands Department of Orthopedic Surgery Amsterdam University Medical CenterAmsterdam 1105 AZNetherlands Esther R C janssen Department of Orthopaedic SurgeryViecuri Medisch CentrumVenlo 5912 BLNetherlands Centre for Orthopaedic Research Spaarne ZiekenhuisHoofddorp 2134 TMNetherlands Department of Orthopaedic Surgery and Sports Medicine Amsterdam UMC-Location AMCAmsterdam 1105 AZNetherlands Department of Orthopedic Surgery Xpert Orthopedic Surgery ClinicAmsterdam 1101 EANetherlands

BACKGROUND In recent years,there has been an increase in the number of total hip arthroplasty procedures in the younger patient *** active group has higher expectations of their prosthesis in comparison to the older population,and there is a greater physical demand for the *** femoral stems were in-troduced to retain proximal bone stock and joint biomechanics and became more common to implant in this specific ***,the long-term survival and functional outcomes of various short stems are still being investigated in different *** To determine the 5-year survival of the Optimys hip *** This was a prospective multicenter cohort study of 500 patients conducted in two hospitals in the *** patients received the Optimys short stem(Mathys ltd,Bettlach,Switzerland).The primary outcome measure was survival of the hip stem,with revision as the *** secondary outcome measurements included patient-reported outcome measures(PROMs).Kaplan-Meier analysis was used to calculate the 5-year survival ***-minus-log transformation was performed to calculate the 95%confidence interval(95%CI).Mixed model analyses were performed to assess the course of the PROMs during the 1st 2 years after *** were modeled separately for the 1st and 2nd years to calculate the yearly change in PROMs during both follow-up periods with accompanying 95%*** The mean age of the total 500 patients was 62.3 years(standard deviation:10.6)and 202 were male(40%).At a median follow-up of 5.5 years(interquartile range:4.5-6.7),7 patients were deceased and 6 revisions were registered,for infection(n=3),subsidence(n=2)and malposition(n=1).This resulted in an overall 5-year survival of 98.8%(95%CI:97.3-99.5).If infection was left out as reason for revision,a stem survival of 99.4%(95%CI:98.1-99.8)was *** questionnaires were completed by 471 patients(94%),317 patients(63%)completed the 1-year follow-up questionna

关键词： Total hip arthroplasty Femoral stem Short stem Optimys Survival 5-year survival Revision PROMs

一项在HBeAg阳性、慢性乙型肝炎(CHB)患者中比较磷丙替诺福韦(TAF)与富马酸替诺福韦二吡呋酯(TDF)的3期研究:96周时疗效和安全性结果

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一项在HBeAg阳性、慢性乙型肝炎(CHB)患者中比较磷丙替诺福韦(TAF...

Mid-term clinical outcomes of the uncemented Robert Mathys pressfit cup

第九届全国疑难及重症肝病大会

作者： Kosh Agarwal Scott Fung Wai Kay Seto Young Suk lim Ed Gane harry l.janssen Manoj Sharma Wan long Chuang Ho Bae Ki Tae Yoon John F.Flaherty Audrey lau Anuj Gaggar Vithika Suri Andrea Cathcart lanjia lin G Mani Subramanian Shalimar Norihiro Furusyo Maria Buti Henry l.Chan Kings College Hospital Department of Medicine University of Toronto Queen Mary Hospital Hong Kong Asan Medical Center Kaohsiung Medical University Hospital Pusan National University Yangsan Hospital All India Institute of Medical Sciences Kyushu Medical Center The Chinese University of Hong Kong

背景和目的:TAF是替诺福韦(TFV)的一种新型前体药,在血浆中比TDF更稳定,增强了TFV进入肝细胞的给药,且循环TFV水平降低。这项针对HBeAg阳性患者的随机双盲研究显示,之前在48周时,在HBV DNA小于29IU/ml的患者比例方面,TAF的疗效并不劣于T...

背景和目的:TAF是替诺福韦(TFV)的一种新型前体药,在血浆中比TDF更稳定,增强了TFV进入肝细胞的给药,且循环TFV水平降低。这项针对HBeAg阳性患者的随机双盲研究显示,之前在48周时,在HBV DNA小于29IU/ml的患者比例方面,TAF的疗效并不劣于TDF,且骨骼和肾脏影响改善。本文摘展示了96周治疗后的结果。

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World Journal of Clinical Cases 2024年第19期12卷 3684-3691页

作者： Kishan Ritek Ramsodit Inger N Sierevelt Esther R C janssen Sjoerd Kaarsemaker Daniël Haverkamp Department of Orthopedic Surgery Xpert Clinics AmsterdamAmsterdam 1101EANorth-HollandNetherlands Department of Orthopedic Spaarne Gasthuis AcademyHoofddorp 2134 TMNetherlands Department of Orthopaedic Surgery Viecuri Medical CentreVenlo 5912 BLNetherlands Department of Orthopaedic Surgery Viecuri Medisch CentrumVenlo 5912 BLNetherlands

BACKGROUND The use of uncemented cups during total hip arthroplasty(THA)has gained popularity in recent *** Robert Mathys(RM)pressfit cup,an uncemented monoblock implant is expected to preserve bone density due to its composition and external surface,while reducing backside wear with its monoblock *** factors should lead to a high survival rate of the *** To evaluate the mid-term survival and functional outcome of the RM Pressfit cup in a large study *** Between 2011 and 2020,we included 1324 patients receiving a primary THA using the RM pressfit *** clinical follow-up was performed at 2 years postoperatively with the Dutch arthroplasty register used to assess implant status *** for acetabular failure and reason for revision were reported to evaluate implant survival,while the hip disability and osteoarthritis outcome score(HOOS)scores were used to assess functional *** The mean age at surgery was 64.9 *** mean follow-up was 4.6 *** the 1324 THAs performed,13 needed cup revisions within 5 years after index THA:5 due to aseptic loosening,6 due to infection,2 due to dislocation and 2 due to other *** resulted in a 5-year cup survival of 98.8%(95%CI:98.1-99.5).Nine of the cup revisions occurred within the first year after index *** scores increased significantly in all domains during the first year and levelled out during the second *** In the present study,the RM pressfit cup demonstrated excellent clinical outcomes at mid-term follow-up;however,future studies are needed to assess the long-term outcomes of this acetabular implant.

关键词： Total hip arthroplasty Uncemented RM pressfit cup Hip osteoarthritis Cup revision Pressfit Aseptic loosening

Public health importance of light intensity physical activity

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Journal of Sport and Health Science 2024年第5期13卷 674-675页

作者： Robert Ross Ian janssen Mark S.Tremblay School of Kinesiology and Health Studies Queen’s UniversityKingstonON K7L 3N6Canada School of Medicine Division of Endocrinology and MetabolismQueen’s UniversityKingstonON K7L 3N6Canada Healthy Active living and Obesity Research Group Children’s Hospital of Eastern Ontario Research InstituteOttawaON K1H 8L1Canada Department of Pediatrics University of OttawaOttawaON K1H 8L1Canada

*** intensity physical activity(PA)benefits health PA guidelines worldwide recommend that adults accumulate 150 min of moderate intensity or 75 min of vigorous intensity PA(moderate-to-vigorous PA(MVPA))weekly to achieve health benefits.1-3 Absent from these guidelines are recommendations for light intensity PA(lPA,e.g.,walking at a leisurely pace of 3 km/h or less,equivalent to 1.5-2.9 metabolic equivalents).

关键词： intensity light benefits

病毒性肝炎:乙型肝炎和丁型肝炎-临床(治疗、新化合物、耐药性) 一项在HBeAg阴性、慢性乙型肝炎(CHB)患者中比较磷丙替诺福韦(TAF)与富马酸替诺福韦二吡呋酯(TDF)的3期研究:96周时疗效和安全性结果

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病毒性肝炎:乙型肝炎和丁型肝炎-临床(治疗、新化合物、耐药性) ...

Telaprevir/boceprevir era: From bench to bed and back

第九届全国疑难及重症肝病大会

作者： Maurizia Brunetto Young Suk lim Ed Gane Wai Kay Seto Marina Osipenko Sang Hoon Ahn harry l.janssen Akash Shukla Wan long Chuang Huy Trinh Mustafa K.Celen John F.Flaherty Audrey H.lau Anuj Gaggar Vithika Suri Neeru Bhardwaj Kyungpil Kim G Mani Subramanian Calvin Pan Namiki Izumi Patrick Marcellin Henry Chan Maria Buti University Hospital of Pisa Asan Medical Centre Erasmus Medical Center

背景和目的:TAF是替诺福韦(TFV)的一种新型前体药,在血浆中比TDF更稳定,增强了TFV进入肝细胞的给药,且循环TFV水平降低。这项在HBeAg阴性患者中比较TAF与TDF的随机双盲研究显示,之前在48周时,在HBV DNA小于29IU/ml的患者比例方面,TAF的...

背景和目的:TAF是替诺福韦(TFV)的一种新型前体药,在血浆中比TDF更稳定,增强了TFV进入肝细胞的给药,且循环TFV水平降低。这项在HBeAg阴性患者中比较TAF与TDF的随机双盲研究显示,之前在48周时,在HBV DNA小于29IU/ml的患者比例方面,TAF的疗效并不劣于TDF,且骨骼和肾脏影响改善。本文摘展示了96周治疗后的结果。方法:425例患者被随机分配到接受TAF 25mg QD(n=285)或TDF 300mg QD(n=140),且治疗144

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World Journal of Gastroenterology 2012年第43期18卷 6183-6188页

作者： Maikel P Peppelenbosch harry lA janssen Robert J de Knegt Department of Gastroenterology and Hepatology Erasmus MC-University Medical Center 3015 CE Rotterdam The Netherlands

Hepatitis C virus (HCV) infects approximately 200 million people worldwide. Interferon-based therapies have dominated over the past two decades. However, the overall response rates remain suboptimal. Thanks to the tremendous effort from both academia and industry, two serine protease inhibitors telaprevir and boceprevir for treating chronic hepatitis C have finally reached the clinic. Although these compounds are only approved for combination use with interferon and ribavirin in genotype 1 HCV infected chronic patients, the management of HCV patients however is now evolving incredibly. Here, we overviewed a series of landmark studies, regarding the clinical development of telaprevir and boceprevir. We discussed the mechanism-of-action of telaprevir/boceprevir and their potential application in HCV-positive liver transplantation patients. We further emphasized some emerging concerns with perspective of further development in this field.

关键词： Telaprevir Boceprevir Mechanism-of-action Clinical efficacy liver transplantation patient Interferon Ribavirin

Propulsive matrix of a helical flagellum

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Chinese Physics B 2014年第11期23卷 51-56页

作者：张何朋刘斌 Bruce Rodenborn harry l.Swinney Department of Physics and Astronomy and Institute of Natural Sciences School of Natural Sciences University of California Department of Physics and Center for Nonlinear Dynamics University of Texas at Austin

We study the propulsion matrix of bacterial flagella numerically using slender body theory and the regularized Stokeslet method in a biologically relevant parameter regime. All three independent elements of the matrix are measured by computing propulsive force and torque generated by a rotating flagellum, and the drag force on a translating flagellum. Nu- merical results are compared with the predictions of resistive force theory, which is often used to interpret micro-organism propulsion. Neglecting hydrodynamic interactions between different parts of a flagellum in resistive force theory leads to both qualitative and quantitative discrepancies between the theoretical prediction of resistive force theory and the numerical results. We improve the original theory by empirically incorporating the effects of hydrodynamic interactions and propose new expressions for propulsive matrix elements that are accurate over the parameter regime explored.

关键词： low-Reynolds-number flows micro-organism dynamics bacterial swimming

New therapeutic opportunities for Hepatitis C based on small RNA

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World Journal of Gastroenterology 2007年第33期13卷 4431-4436页

作者： Qiu-wei Pan Scot D Henry Bob J Scholte Hugo W Tilanus harry lA janssen luc JW van der laan Departments of Gastroenterology & Hepatology and Surgery Erasmus MC-University Medical Centre Rotterdam The Netherlands Department of Surgery Erasmus MC-University Medical Centre Rotterdam The Netherlands Department of Cell Biology Erasmus MC- University Medical Centre Rotterdam The Netherlands Department of Gastroenterology & Hepatology Erasmus MC-University Medical Centre Rotterdam The Netherlands

Hepatitis C virus （HCV） infection is one of the major causes of chronic liver disease, including cirrhosis and liver cancer and is therefore, the most common indication for liver transplantation. Conventional antiviral drugs such as pegylated interferon-alpha, taken in combination with ribavirin, represent a milestone in the therapy of this disease. However, due to different viral and host factors, clinical success can be achieved only in approximately half of patients, making urgent the requirement of exploiting alternative approaches for HCV therapy. Fortunately, recent advances in the understanding of HCV viral replication and host cell interactions have opened new possibilities for therapeutic intervention. The most recent technologies, such as small interference RNA mediated gene-silencing, antisense oligonucleotides （ASO）, or viral vector based gene delivery systems, have paved the way to develop novel therapeutic modalities for HCV. In this review, we outline the application of these technologies in the context of HCV therapy. In particular, we will focus on the newly defined role of cellular microRNA （miR-222） in viral replication and discuss its potential for HCV molecular therapy.

关键词： Hepatitis C virus therapy miR-122 RNAi Antisense oligonucleotides Viral vectors

The omnivorous predator Macrolophus pygmaeus,a good candidate for the control of both greenhouse whitefly and poinsettia thrips on gerbera plants

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Insect Science 2020年第3期27卷 510-518页

作者： Ada leman Barbara l.Ingegno luciana Tavella Arne janssen Gerben J.Messelink Wageningen University&Research Business Unit Greenhouse HorticultureBleiswijkthe Netherlands Dipartimento di Scienze Agrarie Forestall e Alimentari(DISAFA)ULF Entomologia Generate e ApplicataUniversity of TorinoGrugliasco(TO)Italy IBED Department of Evolutionary and Population BiologyUniversity of AmsterdamAmsterdamthe Netherlands

The poinsettia thrips Echinothrips americanus Morgan is a relatively new pest that has spread rapidly worldwide and causes serious damage in both vegetable and ornamental *** this study,we investigated if and how effective this pest can be controlled in gerbera by the omnivorous predator Macrolophus pygmaeus(Rambur).Because herbivores on plants can interact through a shared predator,we also investigated how poinsettia thrips control is affected by the presence of the greenhouse whitefly Trialeurodes vaporariorum(Westwood),a pest that commonly coexists with *** in *** laboratory studies,we found that the predator *** fed on both pests when offered *** tests showed a clear preference of the predators for plants infested by whiteflies but not by *** a greenhouse experiment,densities of both pests on single gerbera plants were reduced to very low levels by the predator,either with both pests present together or ***,predator‐mediated effects between whiteflies and thrips played only a minor *** plant feeding of the shared predator probably reduced the dependence of predator survival and reproduction on the densities of the two pests,thereby weakening potential predator‐mediated ***,*** is a good candidate for biological control of both pests in ***,further research is needed to investigate pest control at larger scales,when the pests can occur on different plants.

关键词： apparent competition biological control Echinothrips americanus pest interactions prey preference Trialeurodes vaporariorum