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Long-Term and Immediate Impacts of Health Emergency and Disaster Risk Management(Health-EDRM) Education Interventions in a Rural Chinese Earthquake-Prone Transitional Village

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International Journal of Disaster Risk Science 2018年第3期9卷 319-330页

作者： Emily Ying Yang Chan Janice Ying-en Ho Zhe Huang Jean Hee Kim Holly Ching Yu Lam Phoebe Pui Wun Chung Carol ka Po Wong Sida Liu Sharon Chow Collaborating Centre for Oxford University and CUHK for Disaster and Medical Humanitarian Response (CCOUC) The Chinese University of Hong Kong Nuffield Department of Medicine University of Oxford The Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong Franois-Xavier Bagnoud Center for Health & Human Rights Harvard University Integrated Research on Disaster Risk (IRDR) International Centre of Excellence–CCOUC (ICoE-CCOUC) Wu Zhi Qiao (Bridge to China) Charitable Foundation

Ma'an Qiao Village, a Dai and Yi ethnic minority-based community in Sichuan Province, China sustained complete infrastructure devastation during the 2008 Panzhihua earthquake. Health emergency and disaster risk management(Health-EDRM) education intervention programs were implemented in 2010 and 2011. This serial cross-sectional survey study aimed to examine the immediate and long-term impacts of the Health-EDRM interventions in this remote rural community. The findings demonstrate knowledge improvement in areas of water and sanitation, food and nutrition, and disaster preparedness immediately after the Health-EDRM education interventions. Temporal stability of knowledge retention was observed in household hygiene and waste management and smoking beliefs in 2018, 7 years after the *** important findings include knowledge uptake pattern differences of oral rehydration solution(ORS) between earthquake-prone and flood-prone communities. Usage of Internet and mobile technology for accessing disaster-related information was found to be independent of gender and income. Overall, this study demonstrated the knowledge improvement through Health-EDRM education interventions in a remote rural community. Promoting behavioral changes through interventions to raise awareness has the potential to reduce health risks in transitional post-disaster settings. Future programs should aim to identify evidence-based practices and explore how technology can support Health-EDRM education among vulnerable subgroups.

关键词： Earthquake Transitional community Disaster preparedness kit Disaster risk reduction Health emergency and disaster risk management Rural China Sichuan

飞行阻隔器获取罕见甲虫标本的效能及在生物多样性调查中应用潜力的评价——以香港采集为例

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环境昆虫学报 2022年第5期44卷 1113-1123页

作者：陈炎栋杨海东梁敏轩张嘉康李英铭贺旭黄正中白明中国科学院动物研究所动物进化与系统学院重点实验室北京100101 香港特别行政区政府渔农自然护理署香港特别行政区999077

本研究在2017-2019年期间利用新型大型飞行阻隔器在香港地区8个样地(八仙岭、西贡、城门、马鞍山、大帽山、大榄、地塘仔、石壁)开展了甲虫采集,整理鉴定出11科15种罕见甲虫,其中包括中国新纪录属种3个,香港地区新纪录科1个,香港地区新... 详细信息

本研究在2017-2019年期间利用新型大型飞行阻隔器在香港地区8个样地(八仙岭、西贡、城门、马鞍山、大帽山、大榄、地塘仔、石壁)开展了甲虫采集,整理鉴定出11科15种罕见甲虫,其中包括中国新纪录属种3个,香港地区新纪录科1个,香港地区新纪录属7个,香港地区新纪录种5个。在此基础上,对飞行阻隔器在获取罕见甲虫标本方面的效能进行了评价,并给出了飞行阻隔器未来的改造建议与方向,探讨了飞行阻隔器在生物多样性调查中的应用潜力。

关键词：飞行阻隔器香港生物多样性鞘翅目新纪录

TURMERIC-COULD IT BE A MULTI-TARGETED HERB FOR COLORECTAL CANCER ADJUVANT THERAPY?

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World Journal of Traditional Chinese Medicine 2015年第4期1卷 74-75页

作者： Grace GL Yue hin-Fai Kwok Julia KM lee Lei Jiang Si Gao Carmen KM Chan Eric CW Wong Kwok-Pui Fung Ping-Chung Leung Zhong Zuo Clara BS Lau Institute of Chinese Medicine State Key Laboratory of Phytochemistry and Plant Resources in West China (CUHK) School of Biomedical Sciences School of Pharmacy The Chinese University of Hong Kong

Turmeric is a medicinal herb in Asia and as dietary supplement in western *** major active component,*** good reputation for chemopreventive effects in different ***,poor oral bioavailability of curcumin hinders the w... 详细信息

关键词： TURMERIC-COULD IT BE A MULTI-TARGETED HERB FOR COLORECTAL CANCER ADJUVANT THERAPY

Mechanistic study on the effect of cytokine-induced cardiogenesis in embryonic stem cells

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Mechanistic study on the effect of cytokine-induced cardioge...

A new osteogenic protein isolated from Dioscorea opposita Thunb accelerates bone defect healing through the mTOR signaling axis

第八届海峡两岸心血管科学研讨会

作者： Sau Kwan Law Cecilia Sze-lee Leung Chi Lok Tse ka Long Yau Christina Fung-Ping Leung Suk Ying Tsang School of Life Sciences the Chinese University of Hong Kong School of Biomedical Sciences the Chinese University of Hong Kong

＜正＞Embryonic stem cells（ESCs） can self - renew and are pluripotent,meaning that they can proliferate indefinitely in culture while maintaining the ability to differentiate into all cell types,including the cardiomyocytes. During myocardial infarction,significant number of cardiomyocytes is *** can be a potential source of cardiomyocytes for cell replacement *** myocardial infarction,proinflammatory cytokines, including interleukin 1 -beta（IL-1 β ）,interleukin 6（IL-6）,interleukin 10（IL - 10） and interleukin 18（IL- 18） are *** aims of the present study were to investigate the effects of these cytokines on the cardiac differentiation of ESCs,and the mechanisms underlying their effects on cardiac differentiation. The changes of intracellular reactive oxygen species（ROS） level upon cytokine treatment in differentiating embryoid bodies（EBs） were examined by confocal ***-1 β ,IL - 10 and IL - 18 were found to increase the intracellular ROS level in differentiating *** western blotting,ROS were found to enhance cardiac differentiation by increasing the expression of cardiac transcription factors（TFs）,consistent with previous *** addition,ROS was also found to post-translationally modify and activate the cardiac TFs. ROS was found to increase the expression of active phosphorylated TFs while decrease the expression of inactive phosphorylated *** present results showed that some proinflammatory cytokines increased ROS generation in differentiating EBs while ROS increased cardiac differentiation by both increasing the expression and activity of cardiac *** studies would be required to investigate if these cytokines increase cardiac differentiation through increasing ROS.

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Bioactive Materials 2023年第9期27卷 429-446页

作者： John Akrofi Kubi Augustine Suurinobah Brah Kenneth Man Chee Cheung Yin Lau lee kai-Fai lee Stephen Cho Wing Sze Wei Qiao Kelvin Wai-Kwok Yeung Department of Orthopaedics and Traumatology Li Ka Shing Faculty of MedicineThe University of Hong Kong(HKU)Hong Kong S.A.R.PR China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma HKU-Shenzhen HospitalShenzhen518053PR China Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineHKU21 Sassoon RoadHong Kong S.A.RPR China Shenzhen Key Laboratory of Fertility Regulation Reproductive Medicine CenterHKU-Shenzhen HospitalShenzhenPR China Department of Biology Faculty of ScienceHong Kong Baptist UniversityKowloon TongHong Kong S.A.RPR China Golden Meditech Center for NeuroRegeneration Sciences Hong Kong Baptist UniversityKowloon TongHong Kong S.A.RPR China Applied Oral Sciences and Community Dental Care Faculty of DentistryHong Kong S.A.RPR China

Delayed bone defect repairs lead to severe health and socioeconomic impacts on patients. Hence, there are increasing demands for medical interventions to promote bone defect healing. Recombinant proteins such as BMP-2 have been recognized as one of the powerful osteogenic substances that promote mesenchymal stem cells (MSCs) to osteoblast differentiation and are widely applied clinically for bone defect repairs. However, recent reports show that BMP-2 treatment has been associated with clinical adverse side effects such as ectopic bone formation, osteolysis and stimulation of inflammation. Here, we have identified one new osteogenic protein, named ‘HKUOT-S2’ protein, from Dioscorea opposita Thunb. Using the bone defect model, we have shown that the HKUOT-S2 protein can accelerate bone defect repair by activating the mTOR signaling axis of MSCs-derived osteoblasts and increasing osteoblastic biomineralization. The HKUOT-S2 protein can also modulate the transcriptomic changes of macrophages, stem cells, and osteoblasts, thereby enhancing the crosstalk between the polarized macrophages and MSCs-osteoblast differentiation to facilitate osteogenesis. Furthermore, this protein had no toxic effects in vivo. We have also identified HKUOT-S2 peptide sequence TKSSLPGQTK as a functional osteogenic unit that can promote osteoblast differentiation in vitro. The HKUOT-S2 protein with robust osteogenic activity could be a potential alternative osteoanabolic agent for promoting osteogenesis and bone defect repairs. We believe that the HKUOT-S2 protein may potentially be applied clinically as a new class of osteogenic agent for bone defect healing.

关键词： Dioscorea spp protein Mesenchymal stem cells(MSCs) Osteoblast differentiation Bone mineral density(BMD) Bone defect repair mTOR signaling pathway

Rock magnetic property of gravity core CSH1 from the northern Okinawa Trough and the effect of early diagenesis

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Acta Oceanologica Sinica 2007年第5期26卷 54-65页

作者： GE Shulan SHI Xuefa WU Yonghua lee Tehquei XIONG Yingqian SAITO Yoshiki Marine Sedimentation and Environmental Geology Key Laboratory of State Oceanic Administration First Institute of Oceanography State Oceanic Administration Qingdao 266061 China Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China Institute of Earth Sciences Taipei China Geology Survey of Japan Tsukuba 306 - 8567 Japan

Detailed rock magnetic investigations were undertaken at 2 -4 cm interval for the gravity core CSHI （with a length of 17.36 m） from the northern Okinawa Trough. Time-scale of the core was constructed by two characteristic tephras and foraminferal assemblages, indicating an age of 50 ka for the bottom of the core. Except for three tephras and abrupt decrease in surface, there are little changes in all kinds of rock magnetic parameters that can be correlated to the climate change for the last 50 ka. Different from the common sediments, most S-ratios （S equals the negative ratio of IRM-0.3T to SIRM, which is an indicator of low coercivity content） of the sediments are smaller than 0. 9, which implies a substantial amount of magnetic minerals with high coercivity. The existence of iron sulphide （ greigite or pyrrhotite） is revealed by representative susceptibility - temperature curves showing 200 350 ℃ Curie temperature in addition to 580 ℃ of magnetite, and also by awful smell during heating and dark heating products. Both the occurrence of authigenic iron sulphide and quick decrease of magnetic parameters near the surface clearly show that sediments from Core CSHI have undergone early diagenesis. The featureless magnetic changes of the whole core except for three tephras mean that the post-depositonal alteration is so strong that most original signals have been destroyed. For the same reason, the organic matter in sediment and sulphate in pore water must have been consumed along with dissolution, precipitation of iron and manganese happening sequencially during the redox reaction series. Great caution must be taken when using these altered chemical parameters for the interpretation of climatic changes.

关键词： northern Okinawa Trough gravity core of CSHI rock magnetic property characteristic tephra early diagenesis

基于ka波段分布式MEMS移相器芯片微封装研究(英文)

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仪器仪表学报 2007年第1期28卷 23-28页

作者：贺训军吴群朱淮城 lee Jongchul 哈尔滨工业大学电子与信息技术研究院哈尔滨理工大学应用科学学院哈尔滨 150080 中国毫米波毫米波/亚毫米波末制导技术国防科技重点实验室韩国光云大学无线电科学与工程系

本文提出一种适用于ka波段分布式MEMS移相器的新型封装结构——具有垂直互连线的薄硅作为分布式MEMS移相器衬底,并用芯片微封装方法对移相器进行封装。采用CST模拟软件研究封装结构对移相器射频性能影响,模拟结构表明:当封装结构衬底厚... 详细信息

本文提出一种适用于ka波段分布式MEMS移相器的新型封装结构——具有垂直互连线的薄硅作为分布式MEMS移相器衬底,并用芯片微封装方法对移相器进行封装。采用CST模拟软件研究封装结构对移相器射频性能影响,模拟结构表明:当封装结构衬底厚度、垂直互连线半径和空腔高度分别为450μm、50μm和80μm时,ka波段分布式MEMS移相器的插入损耗小于0．55 dB,回波损耗优于12 dB,相移量具有很好的线性关系,说明该新型封装结构非常适合RF MEMS器件低成本批量封装。

关键词： ka波段 MEMS移相器芯片微封装薄衬底垂直互连线

香港及珠三角地区MODIS高分辨率气溶胶光学厚度的反演

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环境科学学报 2009年第7期29卷 1372-1380页

作者：黄文声李真李权镐李占清郭嘉熙香港理工大学土地测量及地理资讯学系中国香港美国马里兰大学地球系统科学综合研究中心帕克分校美国

为了有效解决地区性和城市范围内的气溶胶分布并反演陆地上气溶胶的性质,一种针对中分辨率成像光谱辐射计(MODIS)的气溶胶反演新算法应运而生.本文首先通过改良的最小反射率技术(MRT)来确定季节性的地表反射率和利用瑞利通道辐射率中解... 详细信息

为了有效解决地区性和城市范围内的气溶胶分布并反演陆地上气溶胶的性质,一种针对中分辨率成像光谱辐射计(MODIS)的气溶胶反演新算法应运而生.本文首先通过改良的最小反射率技术(MRT)来确定季节性的地表反射率和利用瑞利通道辐射率中解析出大气上气溶胶的反射率来估计气溶胶的反射系数.结果表明,MRT地表反射率的图像和MODIS地表反射系数的产品(MOD09)有很好的契合度,两者的相关系数高达0.9.此外,考虑到不同气溶胶的光学性质和太阳观测组合对计算辐射传输的影响,本研究还制定了全面广泛的差算表(LUT).由此产生的卫星500m分辨率的气溶胶光学厚度(AOT)和香港太阳光度计(AERONET)及MicrotopsII观测资料的相关系数r分别为0.96和0.87(相伴概率值p<0.0001).该研究证明了城区高分辨率气溶胶反演的可行性,还能帮助研究气溶胶的分布和城区大气瞬态污染的影响.此外,MODIS500m分辨率的气溶胶光学厚度图像还可用于研究跨境气溶胶,使定位珠江三角洲区域污染源变得可行.

关键词： MODIS 气溶胶表观反射率香港

Targeting papain-like protease for broad-spectrum coronavirus inhibition

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Protein & Cell 2022年第12期13卷 940-953页

作者： Shuofeng Yuan Xiaopan Gao kaiming Tang Jian-Piao Cai Menglong Hu Peng Luo Lei Wen Zi-Wei Ye Cuiting Luo Jessica Oi-Ling Tsang Chris Chun-Yiu Chan Yaoqiang Huang Jianli Cao Ronghui Liang Zhenzhi Qin Bo Qin Feifei Yin hin Chu Dong-Yan Jin Ren Sun Jasper Fuk-Woo Chan Sheng Cui Kwok-Yung Yuen State Key Laboratory of Emerging Infectious Diseases Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong SARChina Department of Microbiology Li Ka ShingFaculty of MedicineThe University of Hong KongPokfulamHong Kong SARChina NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong SARChina Department of Molecular and Medical Pharmacology David Geffen School of MedicineUniversity of California Los AngelesLos AngelesCAUSA Key Laboratory of Tropical Translational Medicine of Ministry of Education Hainan Medical UniversityHaikou 571199China Academician Workstation of Hainan Province Hainan Medical UniversityHaikou 571199China Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases The University of Hong KongPokfulamHong Kong Special Administrative RegionChina Guangzhou Laboratory Guangzhou 510320China Department of Clinical Microbiology and Infection Control The University of Hong Kong-Shenzhen HospitalShenzhen 518053China

The emergence of SARS-CoV-2 variants of concern and repeated outbreaks of coronavirus epidemics in the past two decades emphasize the need for next-generation pan-coronaviral *** the multi-functional papain-like protease(PLpro)domain of the viral nsp3 holds ***,none of the known coronavirus PLpro inhibitors has been shown to be in vivo ***,we screened a structurally diverse library of 50,080 compounds for potential coronavirus PLpro inhibitors and identified a noncovalent lead inhibitor F0213 that has broad-spectrum anti-coronaviral activity,including against the Sarbecoviruses(SARSCoV-1 and SARS-CoV-2),Merbecovirus(MERS-CoV),as well as the Alphacoronavirus(hCoV-229E and hCoVOC43).Importantly,F0213 confers protection in both SARS-CoV-2-infected hamsters and MERS-CoV-infected human DPP4-knockin mice.F0213 possesses a dual therapeutic functionality that suppresses coronavirus replication via blocking viral polyprotein cleavage,as well as promoting antiviral immunity by antagonizing the PLpro deubiquitinase *** the significant difference of substrate recognition,mode of inhibition studies suggest that F0213 is a competitive inhibitor against SARS2-PLpro via binding with the 157K amino acid residue,whereas an allosteric inhibitor of MERSPLpro interacting with its 271E *** proof-ofconcept findings demonstrated that PLpro is a valid target for the development of broad-spectrum anticoronavirus *** orally administered F0213 may serve as a promising lead compound for combating the ongoing COVID-19 pandemic and future coronavirus outbreaks.

关键词： protease inhibitor coronavirus Nsp3 antiviral