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East Asian VLBI Network observations of active galactic nuclei jets:imaging with kaVA+Tianma+Nanshan

Research in Astronomy and Astrophysics 2021年第8期21卷 220-234页

作者： Yu-Zhu Cui kazuhiro Hada Motoki Kino Bong-Won Sohn Jongho Park Hyun-Wook Ro Satoko Sawada-Satoh Wu Jiang Lang Cui Mareki Honma Zhi-Qiang Shen Fumie Tazaki Tao An Ilje Cho Guang-Yao Zhao Xiao-Peng Cheng Kotaro Niinuma Kiyoaki Wajima Ying-kang Zhang Noriyuki kawaguchi Juan-Carlos Algaba Shoko Koyama Tomoya Hirota Yoshinori Yonekura Nobuyuki Sakai Bo Xia Yong-Bin Jiang Lin-Feng Yu Wei Gou Ju-Yeon Hwang Yong-Chen Jiang Yun-Xia Sun Dong-Kyu Jung Hyo-Ryoung Kim Jeong-Sook Kim Hideyuki Kobayashi Jee-Won lee Jeong-Ae lee Hua Zhang Guang-Hui Li Zhi-Qiang Xu Peng Li Jung-Hwan Oh Se-Jin Oh Chung-Sik Oh Tomoaki Oyama Duk-Gyoo Roh katsunori-M.Shibata Wen Guo Rong-Bing Zhao Wei-Ye Zhong Jin-Qing Wang Wen-Jun Yang Hao Yan Jae-Hwan Yeom Bin Li Xiao-Fei Li Jian-Ping Yuan Jian Dong Zhong Chen kazunori Akiyama Keiichi Asada Do-Young Byun Yoshiaki Hagiwara Jeffrey Hodgson Tae-Hyun Jung Kee-Tae Kim Sang-Sung lee Kunwoo Yi Qing-Hui Liu Xiang Liu Ru-Sen Lu Masanori Nakamura Sascha Trippe Na Wang Xue-Zheng Wang Bo Zhang Department of Astronomical Science The Graduate University for Advanced StudiesSOKENDAI2-21-1 OsawaMitakaTokyo 181-8588Japan Mizusawa VLBI Observatory National Astronomical Observatory of Japan2-12 HoshigaokaMizusawaOshuIwate 023-0861Japan Kogakuin University of Technology and Engineering Academic Support Center2665-1 NakanoHachiojiTokyo 192-0015Japan Korea Astronomy and Space Science Institute Yuseong-guDaejeon 34055Korea Department of Astronomy Yonsei University50 Yonsei-roSeodaemun-guSeoul 03722Korea Department of Astronomy and Space Science University of Science and Technology217 Gajeong-roDaejeonKorea Institute of Astronomy and Astrophysics Academia Sinica645 N Aohoku PIHiloHI 96720USA Graduate School of Sciences and Technology for Innovation Yamaguchi UniversityYoshida 1677-1YamaguchiYamaguchi 753-8512Japan Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China Institute of Astronomy The University of Tokyo2-21-1 OsawaMitakaTokyo 181-0015Japan Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomia s/nGranada E-18008Spain Department of Physics Faculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia Center for Astronomy Ibaraki University2-1-1 BunkyoMitoIbaraki 310-8512Japan Space Light Laboratory 77Yangjaedae-ro 86 roadGangdong-guSeoulKorea Massachusetts Institute of Technology Haystack Observatory 99 Millstone RoadWestfordMA 01886USA National Radio Astronomy Observatory 520 Edgemont RdCharlottesvilleVA 22903USA Toyo University 5-28-20 HakusanBunkyo-kuTokyo 112-8606Japan Department of Physics and Astronomy Seoul National UniversityGwanak-guSeoul 08826Korea Max Planck Institute for Radio Astronomy Auf dem hiigel 69Bonn 53121Germany SNU Astronomy Research Center Seoul National UniversityGwanak-guSeoul 08826Korea

The East Asian Very Long Baseline Interferometry(VLBI) Network(EAVN) is a rapidly evolving international VLBI array that is currently promoted under joint efforts among China,Japan and *** aims at forming a joint VLBI Network by combining a large number of radio telescopes distributed over East Asian *** the combination of the Korean VLBI Network(KVN) and the VLBI Exploration of Radio Astrometry(VERA) into ka VA,further expansion with the joint array in East Asia is actively *** we report the first imaging results(at 22 and 43 GHz) of bright radio sources obtained with ka VA connected to Tianma 65-m and Nanshan 26-m Radio Telescopes in *** test the EAVN imaging performance for different sources,we observed four active galactic nuclei(AGN) having different brightness and *** a result,we confirmed that the Tianma 65-m Radio Telescope(TMRT) significantly enhances the overall array sensitivity,a factor of 4 improvement in baseline sensitivity and 2 in image dynamic range compared to the case of ka VA *** addition of the Nanshan 26-m Radio Telescope(NSRT) further doubled the east-west angular *** the resulting high-dynamic-range,high-resolution images with EAVN(ka VA+TMRT+NSRT),various fine-scale structures in our targets,such as the counter-jet in M87,a kink-like morphology of the 3 C 273 jet and the weak emission in other sources are successfully *** demonstrates the powerful capability of EAVN to study AGN jets and to achieve other science goals in *** expansion of EAVN will further enhance the angular resolution,detection sensitivity and frequency coverage of the network.

关键词： galaxies:active galaxies:jets instrumentation:interferometers radio continuum:galaxies

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Corticosterone suppresses dendritic maturation of immature neurons in hippocampus,which is counteracted by antidepressant treatment

Corticosterone suppresses dendritic maturation of immature n...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Benson WM LAU Suk-Yu YAU Tatia M.C.lee Yick-Pang ChinG Siu-Wa Tang Kwok-Fai SO Department of Anatomy Li Ka Shing Faculty of MedicineThe University of Hong Kong The State Key Laboratory of Brain and Cognitive Sciences The University of Hong Kong Research Centre of Heart BrainHormone and Healthy AgingFaculty of MedicineThe University of Hong Kong The State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongPokfulam Laboratory of Neuropsychology The University of Hong Kong Department of Anatomy Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulam Joint Laboratory for Brain function and Health(BFAH) Jinan University and The University of Hong Kong

＜正＞Objective Chronic corticosterone treatment was shown to suppress neurogenesis in hippocampus,while antidepressant treatment increases new hippocampal neuron *** previously showed that the suppressed neurogenesis in hippocampus could be attenuated by simultaneous selective serotonin reuptake inhibitor（SSRI） treatment. However,it is unknown whether the dendritic maturation of immature neurons is affected by these two classes of drugs. Method Sprague-Dawley rats were divided into four groups:（1）.corticosterone treatment,（2）.Paroxetine（a SSRI） treatment,（3）.co-treatment of corticosterone and paroxetine and（4）.control group with vehicle *** two weeks’ treatment,animals were killed and brain sections were immunostained with anti-doublecortin（DCX,an immature neuron marker） *** morphologies of immature neurons were analyzed by Sholl *** tissue was collected for brain-derived neurotrophic factor ELISA assay and DCX *** Compared to control group, immature neurons of corticosterone group showed a decreased dendritic *** contrast,paroxetine treatment increased the dendritic ***-treatment group showed dendritic complexity which is similar to control group. Hippocampal BDNF level is significantly decreased in corticosterone treatment group while co-treatment with paroxetine reversed the *** treatment also increased the expression level of DCX in *** Apart from neurogenesis,the present study shows that corticosterone and SSRI also affect dendritic growth of immature *** effect is associated with alternated hippocampal BDNF and DCX expression *** finding provides a new perspective on how stress hormone and antidepressant affect neuroplasticity,which may underlie the pathology of depressive and other psychiatric disorders.

关键词： corticosterone stress SSRI selective serotonin reuptake inhibitors neurogenesis doublecortin DCX hippocampus

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儿童4期神经母细胞瘤联合治疗的临床疗效观察

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中国当代儿科杂志 2022年第7期24卷 759-764页

作者：梁伟玲叶小帆钟共陈建军戴康临卓家良莫姝王博深李春雨蒋轩竹徐志渊周黎陈秀慧陈健良朱知梅李珮华陈志峰香港大学深圳医院儿科广东深圳518000 香港大学深圳医院神经外科广东深圳518000 香港大学深圳医院小儿外科广东深圳518000 香港大学玛丽医院儿童及青少年科学系中国香港香港儿童医院中国香港香港大学大学深圳医院放疗科广东深圳518000 香港大学深圳医院移植科广东深圳518000

目的观察4期神经母细胞瘤联合治疗的早期疗效,探讨提高生存率及改善生活质量的治疗方案。方法对2016年1月至2021年6月在香港大学深圳医院确诊的14例4期神经母细胞瘤患儿的临床资料、治疗及随访情况进行回顾性分析。结果14例患儿中位发... 详细信息

目的观察4期神经母细胞瘤联合治疗的早期疗效,探讨提高生存率及改善生活质量的治疗方案。方法对2016年1月至2021年6月在香港大学深圳医院确诊的14例4期神经母细胞瘤患儿的临床资料、治疗及随访情况进行回顾性分析。结果14例患儿中位发病年龄为3岁7.5个月。骨髓检查阳性9例,N-Myc基因扩增4例,神经元特异性烯醇化酶增高13例,尿香草扁桃酸增高7例。病理结果:分化型6例,未分化型1例,混合型1例,分化差型6例。N7方案化疗10例(含2例N7方案+三氧化二砷化疗患儿),Rapid COJEC方案化疗4例。手术13例;自体造血干细胞移植14例;放疗10例。Ch14.18/CHO免疫治疗8例,其中1例因在治疗过程中出现过敏性休克而停止免疫治疗;其余7例完成治疗,期间未观察到严重不良反应。完成免疫治疗患儿中1例复发后进行3次Lu177 Dotatate治疗,目前仍在化疗中。14例患儿中位随访时间为45个月。2年内复发4例,2年内总生存率100%;3年内复发4例,3年内无病存活7例。结论儿童4期神经母细胞瘤建议选择多学科联合方案治疗,使4期神经母细胞瘤患儿获得更好的生存及预后。

关键词：神经母细胞瘤自体造血干细胞移植 Ch14.18/CHO 儿童

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缺血性卒中后的院内医源性并发症和远期死亡率

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世界核心医学期刊文摘（神经病学分册） 2006年第3期2卷 56-57页

作者： Bae H.-J. Yoon D.-S. lee J. 高艳琼 Department of Preventive Medicine College of Medicine Korea University 126-305 5-ka Anam-dong Seongbuk-Gu Seoul South Korea

Background and Purpose-Inhospital medical complications account for a considerable portion of deaths during the early stage of stroke. However, relatively few studies have examined their long-term effects on mortality in stroke patients. Methods -We prospectively and consecutively collected data on 579 patients with acute ischemic stroke from November 1998 to February 2001. Mortality was confirmed using national death certificate data from 1999 to 2003. Results -During admission, one or more medical complications requiring intervention developed in 160 of these 579 patients (27.6%). For these 160 subjects, the 30-day, 90-day, 1-year, 2-year, 3-year, and 4-year mortalities were 16.3, 29.4, 46.9, 55. 6, 61.3, and 70.7%, whereas the mortality figures for those without such compli cations (n=419) were 1.4, 3.8, 8.8, 15.0, 19.1, and 22.4 (P < 0.001 with log-ra nk test). To eliminate the short-term effects of these complications and thus r eveal their long-term effects, we investigated differences in mortality versus the presence of inhospital complications at more than 30 days, 90 days, 1 year, 2 years, and 3 years after stroke, respectively. Cox’s proportional hazard regr ession analysis was applied at these times after stroke and showed that all haza rd ratios of medical complications in terms of mortality were statistically larg er than one, regardless of adjusting for effects of potential predictors on mort ality. Conclusions -Our study shows that stroke patient mortality is influenced by inhospital medical complications significantly up to the chronic stage. This finding suggests that the appropriate prevention and management of inhospital complications could improve shortterm and long-term prognoses after stroke.

关键词：缺血性卒中内医远期效应秩和检验数据确认死亡证明慢性阶段上均

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韩国原发性结肠淋巴瘤状况:一项kaSID(韩国肠病研究协会)研究

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世界核心医学期刊文摘（胃肠病学分册） 2006年第4期2卷 10-11页

作者： Kim Y.-H lee J.H Yang S.K. J.C. Rhee 纪泛扑 Department of Medicine Samsung Medical Center 50 Irwon-Dong Kangnam-ku Seoul 135-710 South KoreaDr.

Although almost all primary colorectal lymphomas are of B-cell lineage in Western countries, primary colorectal T-cell lymphomas are not uncommon in the East. The aim of this study was to review the clinical characteristics and treatment outcomes of primary colorectal lymphomas, with special emphasis on the differences between T-cell and B-cell lymphomas. Ninety-five cases of primary colorectal lymphomas that satisfied Dawson‘s criteria were identified from the clinical databases of 13 university hospitals in Korea. The mean age at the time of presentation was 51.1 years and the male : female ratio was 64 ∶31. The clinical information, including endoscopic and histological characteristics, was retrospectively analyzed. Of the primary colorectal lymphomas, 78 cases (82.1%) were of B-lineage and 17 cases (17.9%) were of T-cell lineage. Patients with T-cell lymphomas presented at a younger age than patients with B-cell lymphomas (42.8 vs 52.9 years, respectively; P = 0.016). The most common presenting symptom was abdominal pain (87.1%) for B-cell lymphomas, whereas hematochezia or night fe ver was more common for T-cell lymphomas (52.9%and 35.3%, respectively). The most common endoscopic type was fungating mass (54.0%) for B-cell lymphomas and ulcerative/ ulcero-infiltrative lesions (80.0%) for T-cell lymphomas. Intussusception was more common in B-cell lymphomas than in T-cell lymphomas(30.8%vs 5.9%, respectively; P = 0.035), but perforation was more common in T-cell lymphomas than in B-cell lymphomas (23.5%vs 3.8%, respectively; P = 0.005). The prognosis was significantly worse for T-cell lymphomas than for B-cell lymphomas (P = 0.002). Primary colorectal T-cell lymphomas are characterized by multifocal ulcerative lesions in relatively young patients , a high rate of hematochezia, fever, or perforation, and a poor prognosis even for cases of localized disease.

关键词：结肠淋巴瘤 kaSID 研究协会结肠直肠淋巴瘤患者淋巴瘤病组织学特征发病年龄病灶局限溃

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多形性胶质母细胞瘤中NTRK1融合基因

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临床与实验病理学杂志 2015年第2期31卷 123-123页

作者： Kim J lee Y Cho H J 姜春婷许春伟张博中国人民解放军307医院病理科北京100071

多形性胶质母细胞瘤（ GBM）是脑肿瘤中最具有侵袭性肿瘤,目前仍然无任何靶向治疗后生存获益报道。最近研究表明实体肿瘤中融合基因通常扮演驱动基因的角色和药物干预的潜在靶点。在调查GBM潜在的融合基因时,该团队通过癌症基因图谱（ T... 详细信息

多形性胶质母细胞瘤（ GBM）是脑肿瘤中最具有侵袭性肿瘤,目前仍然无任何靶向治疗后生存获益报道。最近研究表明实体肿瘤中融合基因通常扮演驱动基因的角色和药物干预的潜在靶点。在调查GBM潜在的融合基因时,该团队通过癌症基因图谱（ TCGA）对162例GBM患者进行RNA测序分析发现神经营养酪氨酸激酶受体1型（NTRK1,编码Tr-ka）的3′外显子和神经组织中高表达的NFASC、BCAN的5′外显子基因融合。该基因融合后保留NTRK1框架中的跨膜和激酶结构域。 NTRK1是神经生长因子（ NGF）促生存信号传导的介质,也是一种在人类癌症中发现被普遍改变的已知致癌基因。虽然 GBM 中广泛缺乏 NTRK1表达,融合阳性GBM中表达丰度较高的融合基因并提高NTRK1通路活性。在NIH3T3细胞株中通过慢病毒转染NFASC-NTRK1融合基因能够增强体外增殖,软琼脂中集落形成以及小鼠肿瘤形成表明融合促进 GBM 的启动或融合阳性 GBM 的维护,因此NTRK1融合基因可能是一个合理的药物靶标。

关键词：多形性胶质母细胞瘤融合基因酪氨酸激酶神经生长因子 NIH3T3 基因融合 GBM 侵袭性肿瘤

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Medical,behavioural and social preconception and interconception risk factors among pregnancy planning and recently pregnant Canadian women

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Family Medicine and Community Health 2022年第3期10卷 7-19页

作者： Cindy-lee Dennis Alessandra Prioreschi Hilary K Brown Sarah Brennenstuhl Rhonda C Bell Stephanie Atkinson Dragana Misita Flavia Marini Sarah Carsley Nilusha Jiwani-Ebrahim Catherine Birken Lawrence S.Bloomberg Faculty of Nursing University of TorontoTorontoOntarioCanada St Michael's Hospital Li ka Shing Knowledge Institute TorontoOntarioCanada SAMRC/Wits Developmental Pathways for Health Research Unit Department of Paediatrics and Child HealthFaculty of Health SciencesUniversity of the WitwatersrandJohannesburg-BraamfonteinGautengSouth Africa Dalla Lana School of Public Health University of TorontoTorontoOntarioCanada Department of Health&Society University of TorontoTorontoOntarioCanada Department of Agricultural Food and Nutritional SciencesUniversity of AlbertaEdmontonAlbertaCanada Paediatrics McMaster UniversityHamiltonOntarioCanada Public Health Ontario TorontoOntarioCanada York Region Public Health VaughanOntarioCanada Paediatric Medicine The Hospital for Sick ChildrenTorontoOntarioCanada Faculty of Medicine University of TorontoTorontoOntarioCanada

Objectives The objective of this study is to describe the clustering of medical,behavioural and social preconception and interconception health risk factors and determine demographic factors associated with these risk clusters among Canadian *** Cross-sectional data were collected via an online questionnaire assessing a range of preconception risk *** of each risk factor and the total number of risk factors present was *** logistic regression models determined which demographic factors were associated with having greater than the mean number of risk *** factor analysis determined how risk factors clustered,and Spearman’s r determined how demographic characteristics related to risk factors within each *** *** Participants were recruited via advertisements on public health websites,social media,parenting webpages and referrals from ongoing studies or existing research *** were eligible to participate if they could read and understand English,were able to access a telephone or the internet,and were either planning a first pregnancy(preconception)or had≥1 child in the past 5 years and were thus in the interconception *** Most women(n=1080)were 34 or older,and were in the interconception period(98%).Most reported risks in only one of the 12 possible risk factor categories(55%),but women reported on average 4 risks *** risks were a history of caesarean section(33.1%),miscarriage(27.2%)and high birth weight(13.5%).Just over 40%had fair or poor eating habits,and nearly half were not getting enough physical ***-quarters had a body mass index indicating overweight or *** without a postsecondary degree(OR 2.35;95%CI 1.74 to 3.17)and single women(OR 2.22,95%CI 1.25 to 3.96)had over twice the odds of having more risk *** with two children or more had 60%lower odds of having more risk factors(OR 0.68,95%CI 0.52 to 0.86).Low educatio

关键词： Canada behaviour conception

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Analysis of inborn errors of metabolism： disease spectrum for expanded newborn screening in Hong Kong

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Chinese Medical Journal 2011年第7期124卷 983-989页

作者： Han-Chih Hencher lee Chloe Miu Mak Ching-Wan Lam Yuet-Ping Yuen, Angel On-Kei Chan Chi-Chung Shek Tak-Shing Siu Chi-Kong Lai Chor-Kwan Ching Wai-Kwan Siu Sammy Pak-Lam Chen Chun-Yiu Law Morris Hok-Leung Tai Sidney Tam Albert Yan-Wo Chan Chemical Pathology Laboratory Department of Pathology Princess Margaret Hospital Hong Kong SAR China Division of Clinical Biochemistry Queen Mary Hospital Hong Kong SAR China Department of Pathology Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong SAR China Chemical Pathology Laboratory Department of Pathology Queen Elizabeth Hospital Hong Kong SAR China

Background Data of classical inborn errors of metabolism （IEM） of amino acids, organic acids and fatty acid oxidation are largely lacking in Hong Kong, where mass spectrometry-based expanded newborn screening for IEM has not been initiated. The current study aimed to evaluate the approximate incidence, spectrum and other characteristics of classical IEM in Hong Kong, which would be important in developing an expanded newborn screening program for the local area.

关键词： biochemical genetics chemical pathology expanded newborn screening Hong Kong," inborn errorsof metabolism tandem mass spectrometry

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糖尿病心脏microRNA的表达及与心律失常发生的关系

糖尿病心脏microRNA的表达及与心律失常发生的关系

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中华医学会心电生理和起搏分会第十次全国学术年会

作者：凌天佑 Xiao-Li Wang Tin-Wah Lau Win-Kuang Shen 吴立群 Hon-Chi lee 上海交通大学医学院附属瑞金医院心脏内科 The Department of Internal Medicine Division of Cardiovascular DiseasesMayo ClinicRochesterMinnesota 55905USA

目的糖尿病,在全球有着相当高的发病率与死亡率,且呈逐年上升趋势。研究提示,糖尿病患者心脏性猝死、心房颤动(房颤)等事件的发生率较正常人群升高。microRNA(miRNA)对于基因的表达,有着重要的调节作用,并具有潜在的治疗价值。本研究通...

目的糖尿病,在全球有着相当高的发病率与死亡率,且呈逐年上升趋势。研究提示,糖尿病患者心脏性猝死、心房颤动(房颤)等事件的发生率较正常人群升高。microRNA(miRNA)对于基因的表达,有着重要的调节作用,并具有潜在的治疗价值。本研究通过糖尿病心脏组织miRNA的变化,从分子生物学角度分析糖尿病心脏病变、心律失常发生率上升的机制,具有重要的基础与临床意义。方法 6周雄性小鼠8只,分为糖尿病组与对照组各4只,糖尿病组小鼠予以注射STZ诱导糖尿病,血糖>300mg/dL8周后,取糖尿病组与对照组小鼠心脏,分离心房、心室组织,提取RNA,进行miRNA array分析,以real-time PCR验证array的数据结果,并通过生物信息软件分析心律失常可能相关的靶基因及通路。结果与对照组相比,糖尿病组心房组织miR-411-star、miR-322、miR-200b、miR-10b,心室组织miR-764-5p、miR-200c、miR-770-5p、miR-29b-star显著增高(Pka、Na、Ca通道如KCNN4、KCNK10、SCN3B、SCN5A、CACNB1、CACNA1C等,以及与TGFβ、细胞外基质等结构重构相关的可能靶基因如SMAD7,SMAD5,MMP16等;通路分析亦提示,变化的miRNA与细胞间粘附连接、缝隙连接、MAPK信号通路、Wnt信号通路、VEGF信号通路、Ubiquitin介导的蛋白水解、钙信号通路、氧化磷酸化等可能相关。这些靶基因与通路涉及细胞增殖、凋亡、连接、离子通道等,与心肌组织结构重构与电重构相关。结论糖尿病引起的miRNA变化,可能参与调控心肌组织结构重构与电重构,并进一步引起房性与室性心律失常的发生。

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1100kV GIS用断路器的设计

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高压电器 2007年第3期43卷 189-191,193页

作者：金麟吉李二赫郑智均权奇永宋元杓金德秀韩国晓星(株)

介绍了所研制的1 100 kV、50 ka GIS用断路器的技术规范、基本结构及合闸电阻的合理布置;利用商用Maxwell2D,3D软件及专用的程序,对断路器灭弧室的电场分布情况进行了分析,对合闸电阻的热容量进行了计算,并做了相关的试验验证,证明该型... 详细信息

介绍了所研制的1 100 kV、50 ka GIS用断路器的技术规范、基本结构及合闸电阻的合理布置;利用商用Maxwell2D,3D软件及专用的程序,对断路器灭弧室的电场分布情况进行了分析,对合闸电阻的热容量进行了计算,并做了相关的试验验证,证明该型断路器的开断性能良好,其所配用的合闸电阻的热容量满足使用要求。

关键词： 1100 kV GIS用断路器电场分布合闸电阻热容量计算

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