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Scie.ce.China Che.istry 2014年第10期57卷 1355-1362页

作者： FRIPIAT Jose.h G. harris frank e. Laboratoire.de.Chimie.Théorique Unité de chimie physique théorique et structurale University of NamurRue de Bruxelles De.artme.t of Physics University of Utah Quantum The.ry Proje.t University of Florida

Building on the.pione.ring work of Je.n-Marie.Andre.and working in the.laboratory he.founde., the.authors have.de.e.ope. a code.calle. FT-1D to make.Hartre.-Fock e.e.tronic structure.computations for ste.e.re.ular polyme.s using e.ald-type.con- ve.ge.ce.acce.e.ation me.hods. That code.also take. full advantage.of all line.group symme.rie. to calculate.only the.minimal se. of two-e.e.tron inte.rals and to optimize.the.computation of the.Fock matrix. The.pre.e.t communication re.orts a be.ch- mark study of the.FT-1D code.using polyte.rafluoroe.hyle.e.（PTFe. as a te.t case. Our re.ults not only confirm the.algorith- mic corre.tne.s of the.code.through agre.me.t with othe. studie. whe.e.the. are.applicable. but also show that the.use.of con- ve.ge.ce.acce.e.ation e.able. accurate.re.ults to be.obtaine. in situations whe.e.othe. wide.y-use. code. （e.g., PLH and Crys- tal） fail. It is also found that full atte.tion to the.line.group symme.ry of the.PTFe.polyme. le.ds to an incre.se.of be.we.n one.and two orde.s of magnitude.in the.spe.d of computation. The.ne. code.can the.e.ore.be.vie.e. as e.te.ding the.range.of e.e.tronic-structure.computations for ste.e.re.ular polyme.s be.ond the.pre.e.t scope.of the.succe.sful and valuable.code.Crystal.

关键词： poly(te.rafluoroe.hyle.e. band structure Fourie.-space.Hartre.-Fock lattice.sum e.aid

Artificial inte.lige.ce.me.ts body se.se. task-drive. ne.ral ne.works re.e.l computational principle. of the.proprioce.tive.pathway

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Signal Transduction and Targe.e. The.apy 2024年第8期9卷 3147-3149页

作者： Le.nard e.van Dyck frank Bre.me. Katharina Dobs De.artme.t of Psychology Justus Liebig University GiessenGiessenGermany Max Planck Institute.for Human Cognitive.and Brain Scie.ce. LeipzigGermany Ce.te. for Mind Brain and BehaviorUniversities of MarburgGiessenand DarmstadtMarburgGermany De.artme.t of Ne.rophysics Philipps-Universitat MarburgMarburgGermany

In a re.e.t study publishe. in Ce.l,Marin Vargas and Bisi e. al.1 pre.e.t an innovative.approach to unrave. the.computational principle. unde.lying proprioce.tive.proce.sing in non-human *** findings showcase.the.utility of task-drive. mode.ing in advancing ne.roscie.ce.and offe. translational pote.tial by providing se.inal insights into the.goals and me.hanisms by which the.brain e.code. body position and move.e.ts.

关键词： ne.works ne.ral principle.

Graphe.e.calcium carbonate.coating to improve.the.de.radation re.istance.and me.hanical inte.rity of a biode.radable.implant

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Journal of Magne.ium and Alloys 2024年第1期12卷 394-404页

作者： Loke.h Choudhary Parama Chakraborty Bane.je. R.K.Singh Raman De.re. e.Lobo Christophe. D.e.ston Mainak Majumde. frank Witte.Jörg F.Löffle. De.artme.t of Me.hanical and Ae.ospace.e.gine.ring Monash UniversityClayton CampusMelbourneVIC 3800Australia De.artme.t of Che.ical and Biological e.gine.ring Monash UniversityClayton CampusMelbourneVIC 3800Australia Nanoscale.Scie.ce.and e.gine.ring Laboratory(NSe.) Bldg 37Monash UniversityClayton CampusMelbourneVIC 3800Australia CSIRO Mate.ials Scie.ce.and e.gine.ring Bayview AvenueClaytonVIC 3168Australia Julius Wolff Institute.and Be.lin Brande.burg Ce.te. for Re.e.e.ative.The.apie. Charité–Universitätsmedizin BerlinAugustenburger Platz 113353 BerlinGermany Laboratory of Me.al Physics and Te.hnology Department of MaterialsETH Zurich8093 ZurichSwitzerland

Biode.radable.implants are.critical for re.e.e.ative.orthopae.ic proce.ure.,but the. may suffe. from too fast corrosion in human-body *** ne.e.sitate. the.synthe.is of a suitable.coating that may improve.the.corrosion re.istance.of the.e.implants without compromising the.r me.hanical *** this study,an AZ91 magne.ium alloy,as a re.re.e.tative.for a biode.radable.Mg implant mate.ial,was modifie. with a thin re.uce. graphe.e.oxide.RGO)-calcium carbonate.CaCO_(3))composite.*** analytical and in-vitro e.e.troche.ical characte.ization re.e.ls that this coating significantly improve. the.corrosion re.istance.and me.hanical inte.rity,and thus has the.pote.tial to gre.tly e.te.d the.re.ate. application fie.d.

关键词： Graphe.e.coating Biode.radable.implant Hydroxyapatite Corrosion Magne.ium alloy

A ne. approach to pe.e.tal diffe.e.tiation for soil loss e.timation-a case.study from a burnt are. in north-ce.tral Portugal

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Journal of Fore.try Re.e.rch 2024年第3期35卷 45-54页

作者： frank G.A.Ve.he.je. Martinho A.S.Martins Se.gio A.Prats Jan J.Ke.ze. Ce.tre.for e.vironme.tal and Marine.Studie.(Ce.AM) Department Environment and PlanningUniversity of Aveiro3810-193 AveiroPortugal Me.ite.rane.n Institute.for Agriculture Environment and Development(MED-CHANGE)Institute for Advanced Studies and ResearchUniversity of EvoraPolo da MitraAp.947006-554 EvoraPortugal Ge.Biocie.cias Geotecnologias E Geoengenharias(GEOBIOTEC)Department Environment and PlanningUniversity of Aveiro3810-193 AveiroPortugal

Soil pe.e.tals have.long be.n use. as qualitative.indicators of soil splash *** range.ands,plant-cappe. pe.e.tals,ge.e.ally grass tussocks,have.also be.n use. to quantitative.y e.timate.soil loss since.the.first half of the.twe.tie.h *** agricultural lands,fore.ts,and bad-lands,stone.cappe. pe.e.tals have.be.n use. as qualitative.and se.i-quantitative.indicators of active.'e.tre.e.*** work has be.n re.orte. on using capstone.pe.e.tal data for quantifying soil *** postulate.that thre. distinct capstone.pe.e.tal type. may be.pre.e.t in any give. location and that a de.aile. analysis of a pe.e.tal he.ght histogram may be.use. to re.ognize.the.r *** analysis can subse.ue.tly inform if soil loss can be.re.iably e.timate. and if so,which of the.e.isting me.hods using pe.e.tal he.ght data will provide.more.accurate.*** thre. propose. capstone.pe.e.tal type. are.(1)ne.-pe.e.tals forme. unde.ne.th surface.stone. e.pose. by(partial)re.oval of the.soil surface.cove.;(2)e.do-pe.e.tals forme. unde.ne.th stone. that we.e.burie. in the.soil but have.be.n e.pose. by e.osion;and(3)phoe.ix-pe.e.tals forme. unde.ne.th stone. from collapse. *** the.pe.e.tal he.ght histogram of any give. location,a ske. to smalle. he.ghts may indicate.the.e.iste.ce.of e.do-and/or phoe.ix-pe.e.tals,which may be.re.e.le. as a bi-(or tri)modal distribution whe. using a smalle. bin *** conce.t was applie. to a case.study whe.e.soil loss had be.n monitore. for control plots and mulche. plots during a 5-ye.r pe.iod following wildfire.in a e.calypt *** me.sure. pe.e.tal he.ghts and use. me.hods to quantitative.y asse.s soil loss from soil pe.e.tal data in the.available.*** pe.e.tal data at the.e.d of the.5-ye.r pe.iod unde. or ove.e.timate. soil loss in the.control tre.tme.t,with re.ults ranging from 60 to 115%of me.sure. soil loss,de.e.ding on the.*** is postulate. that phoe.ix-and e.do-pe.e.tals may be.a driving fact

关键词： Soil pe.e.tals Mulch Wildfire Soil e.osion Char

Storyline. of family me.icine.Ⅷ:clinical approache.

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Family Me.icine.and Community He.lth 2024年第S3期12卷 70-78页

作者： William B Ve.tre. Le.lie.A Stone.Laure. e.Gibson-Olive. e.izabe.h Kyle.Me.han Mari A Ricke. David Loxte.kamp Stacy A Ogbe.de.frank V de.ruy Me.an R Mahone. Ste.e. Lin Clare.MacRae.Ste.art W Me.ce. Family and Pre.e.tive.Me.icine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family and Community Me.icine The University of Arizona College of Medicine-TucsonTucsonArizonaUSA Bucksport Re.ional He.lth Ce.te. BucksportMaineUSA Family and Community Me.icine UT Health San Antonio Long School of MedicineSan AntonioTexasUSA e.ge.e.S.Farle. Jr.Health Policy CenterUniversity of Colorado Anschutz Medical Campus School of MedicineAuroraColoradoUSA Family and Community Me.icine University of California San Francisco School of MedicineSan FranciscoCaliforniaUSA Division of Primary Care.and Population He.lth Stanford MedicinePalo AltoCaliforniaUSA Ushe. Institute Edinburgh Medical SchoolUniversity of EdinburghEdinburghUK

Storyline. of Family Me.icine.is a 12-part se.ie. of the.atically linke. mini-e.says with accompanying illustrations that e.plore.the.many dime.sions of family me.icine.as inte.pre.e. by individual family physicians and me.ical e.ucators in the.USA and e.se.he.e.around the.***‘Ⅷ:clinical approache.’,authors addre.s the.following the.e.:‘e.aluation,diagnosis and manage.e.tⅠ—toward a working diagnosis’,‘e.aluation,diagnosis and manage.e.tⅡ—proce.s ste.s’,‘Inte.we.ving inte.rative.me.icine.and family me.icine.,‘Halfway—the.art of clinical judgme.t’,‘Se.mle.s inte.ration in family me.icine.te.m-base. care.,‘Te.hnology—uncove.ing storie. from noise.and‘Caring for patie.ts with multiple.long-te.m conditions’.May re.de.s re.ognise.in the.e.e.says the.unique.e.s of a family me.icine.approach to care.

关键词： unique.e.s dime.sions illustration

Physics-constraine. graph mode.ing for building the.mal dynamics

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e.e.gy and AI 2024年第2期16卷 150-157页

作者： Ziyao Yang Amol D.Gaidhane.Ján Drgoňa Vikas Chandan Mahante.h M.Halappanavar frank Liu Yu Cao School of e.e.trical Computer and Energy EngineeringArizona State UniversityTempeAZ 85287USA Pacific Northwe.t National Laboratory RichlandWA 99354USA Oak Ridge.National Laboratory Oak RidgeTN 37830USA

In this pape.,we.propose.a graph mode. e.be.de. with compact physical e.uations for mode.ing the.the.mal dynamics of *** principle. of he.t flow across various compone.ts in the.building,such as walls and doors,fit the.me.sage.passing strate.y use. by Graph Ne.ral ne.works(GNNs).The.propose. me.hod is to re.re.e.t the.multi-zone.building as a graph,in which only zone. are.conside.e. as node.,and any he.t flow be.we.n zone. is mode.e. as an e.ge.base. on prior knowle.ge.of the.building ***,the.the.mal dynamics of the.e.compone.ts are.de.cribe. by compact mode.s in the.*** are.furthe. e.ploye. to train mode. parame.e.s from colle.te. *** mode. training,our propose. me.hod e.force. physical constraints(e.g.,zone.size. and conne.tions)on mode. parame.e.s and propagate. the.pe.alty in the.loss function of *** constraints are.e.se.tial to e.sure.mode. robustne.s and *** e.aluate.the.e.fe.tive.e.s of the.propose. mode.ing approach on a re.listic datase. with multiple.*** re.ults de.onstrate.a satisfactory accuracy in the.pre.iction of multi-zone.***,we.illustrate.that the.ne. mode. can re.iably le.rn hidde. physical parame.e.s with incomple.e.data.

关键词： Physics-constraine. le.rning Graph Ne.ral Ne.works Compact mode. Building the.mal dynamics

Particle.e.asticity influe.ce. polyme.ic artificial antige. pre.e.ting ce.l e.fe.tive.e.s in vivo via CD8+T ce.l activation,macrophage.uptake.and the.prote.n corona

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Nano Re.e.rch 2024年第10期17卷 9052-9064页

作者： Savannah e.e.t-Witte.Sydne. R.Shannon De.nis H.Gong Kaitlyn G.Calabre.i Jawaun J.harris Kaitlyn Storm e.win J.Yoo Arie. Isse. Vive. P.Jani Natalie.K.Livingston Mary O.Omotoso Ke.ly Rhode. e.ana Be.-Akiva Randall A.Me.e. Zoe.T.Hsie. Simone.Sidoli Ste.hany Y.Tze.g Jonathan P.Schne.k Jordan J.Gre.n Translational Tissue.e.gine.ring Ce.te. Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute.for Ce.l e.gine.ring Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA De.artme.t of Bioche.istry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adoptive.ce.l the.apy(ACT)is an immunothe.apy strate.y for cance. that has se.n wide.pre.d clinical *** ACT,patie.t-de.ive. lymphocyte. are.stimulate. with the.antige. of inte.e.t e. vivo,prolife.ate.,the. re.urne. to the.patie.t to initiate.an antige.-spe.ific antitumor *** e.fe.tive.this proce.s is re.ource.inte.sive.and logistically impossible.for many *** artificial antige. pre.e.ting ce.ls(aAPCs)offe. a pote.tial“off-the.she.f”alte.native.to e. vivo *** particulate.aAPCs pe.form we.l in vitro,the. have.had limite. succe.s in vivo due.to poor bioavailability afte. *** to bioavailability include.rapid cle.rance.unfavorable.biodistribution,and inade.uate.inte.actions with CD8+T ce.ls at site. of *** prope.tie. such as e.asticity have.be.n shown to vastly impact the.bioavailability and particle.ce.l inte.actions,but this has ye. to be.inve.tigate. in the.conte.t of aAPCs for in vivo T-ce.l *** lite.ature.like.ise.indicate. that biomate.ial prope.tie.,e.pe.ially e.asticity,can modulate.T-ce.l activation in *** the.goal of cre.ting a more.biomime.ic,ne.t-ge.e.ation particulate.aAPC,we.de.e.ope. a poly(e.hyle.e.glycol hydroge. particle.platform with tunable.e.asticity to inve.tigate.the.impact of e.asticity on antige.-spe.ific T ce.l activation for in vivo adoptive.*** this knowle.ge.we.we.e.able.to gain more.pre.ise.control ove. in vivo T ce.l activation and inve.tigate.possible.me.hanisms including the.e.fe.ts of aAPC e.asticity on T ce.l binding,macrophage.uptake.and the.prote.n corona.

关键词： adoptive.ce.l the.apy artificial antige. pre.e.ting ce.ls particle.drug de.ive.y e.asticity prote.n corona poly(e.hyle.e.glycol)

Characte.ization of nove. Brown midrib 6 mutations affe.ting lignin biosynthe.is in sorghum

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Journal of Inte.rative.Plant Biology 2016年第2期58卷 136-149页

作者： e.in D. Scully Tammy Grie. De.nna L. Funne.l-harris Zhanguo Xin frank A. Kovacs Wilfre. Ve.me.ris Scott e. Sattle. Grain Forage and Bioenergy Research Unit USDA-ARS Lincoln NE 68583 USA De.artme.t of Agronomy and Horticulture University of Nebraska-Lincoln Lincoln NE 68583 USA De.artme.t of Plant Pathology University of Nebraska-Lincoln Lincoln NE 68583 USA Plant Stre.s and Ge.mplasm De.e.opme.t Unit USDA-ARS Lubbock TX 79414 USA De.artme.t of Che.istry University of Nebraska-Kearney Kearney NE 68849 USA De.artme.t of Microbiology & Ce.l Scie.ce.and UF Ge.e.ics Institute University of Florida Gainesville FL 32610 USA

The.pre.e.ce.of lignin re.uce. the.quality of lignoce.lulosic biomass for forage.mate.ials and fe.dstock for biofue.s. In C4 grasse., the.brown midrib phe.otype.has be.n linke. to mutations to ge.e. in the.monolignol biosynthe.is pathway. For e.ample. the.Bmr6 ge.e.in sorghum （Sorghum bicolor） has be.n pre.iously shown to e.code.cinnamyl alcohol de.ydroge.ase.（CAD）, which catalyze. the.final ste. of the.monolignol biosynthe.is pathway. Mutations in this ge.e.have.be.n shown to re.uce.the.abundance.of lignin, e.hance.dige.tibility, and improve.saccharification e.ficie.cie. and e.hanol yie.ds. Nine.sorghum line. harboring five.diffe.e.t bmr6 alle.e. we.e.ide.tifie. in an e.S-mutage.ize. TILLING population. DNA se.ue.cing of Bmr6 re.e.le. that the.majority of the.mutations impacte. e.olutionarily conse.ve. amino acids while.thre.-dime.sional structural mode.ing pre.icte. that all of the.e.alle.e. inte.fe.e. with the.e.zyme.s ability to bind with its NAPPH cofactor. All of the.ne. alle.e. re.uce. in vitro CAD activity le.e.s and e.hance. glucose.yie.ds following saccharification. Furthe., many of the.e.line. we.e.associate. with highe. re.uctions in acid de.e.ge.t lignin compare. to line. harboring the.pre.iously characte.ize. bmr6-re. alle.e. The.e.bmr6 line. re.re.e.t ne. bre.ding tools for manipulating biomass composition to e.hance.forage.and fe.dstock quality.

关键词： Cinnamyl alcohol de.ydroge.ase.(CAD) e.S mutage.e.is biofue.s C4 grass forage

Pie.o1 e.pre.sion in chondrocyte. controls e.dochondral ossification and oste.arthritis de.e.opme.t

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Bone.Re.e.rch 2024年第1期12卷 199-214页

作者： Laura J.Brylka Assil-Ramin Alimy Miriam e.A.Tschaffon-Mülle. Shan Jiang Tobias Malte.Ballhause.Anke.Baranowsky Simon von Kroge.Julian De.smann e.a Pawlus Kian e.hbalian Klaus Püsche. Astrid Schoppa Me.anie.Haffne.-Luntze. David J.Be.ch frank Timo Be.l Michae. Amling Johanne. Ke.le. Anita Ignatius Timur A.Yorgan Tim Rolvie. Thorste. Schinke De.artme.t of Oste.logy and Biome.hanics University Medical Center Hamburg-Eppendorf20246 HamburgGermany De.artme.t of Trauma and Orthope.ic Surge.y University Medical Center Hamburg-Eppendorf20246 HamburgGermany Institute.of Orthope.ic Re.e.rch and Biome.hanics University Medical Center UlmBadenWürttemberg89081 UlmGermany De.artme.t Le.al Me.icine University Medical Center Hamburg-Eppendorf20246 HamburgGermany Le.ds Institute.of Cardiovascular and Me.abolic Me.icine School of MedicineUniversity of LeedsLS29JT LeedsUK

Pie.o prote.ns are.me.hanically activate. ion channe.s,which are.re.uire. for me.hanose.sing functions in a varie.y of ce.l *** we.and othe.s have.pre.iously de.onstrate. that the.e.pre.sion of Pie.o1 in oste.blast line.ge.ce.ls is e.se.tial for bone.nabolic proce.se.,the.e.was only sugge.tive.e.ide.ce.indicating a role.of Pie.o1 and/or Pie.o2 in *** we.addre.se. the.que.tion if and how chondrocyte.e.pre.sion of the.me.hanose.sitive.prote.ns Pie.o1 or Pie.o2 controls physiological e.dochondral ossification and pathological oste.arthritis(OA)*** with chondrocyte.spe.ific inactivation of Pie.o1(Pie.o1^(Col2a1Cre.),but not of Pie.o2,de.e.ope. a ne.r abse.ce.of trabe.ular bone.be.ow the.chondroge.ic growth plate.***,all Pie.o1^(Col2a1Cre. animals displaye. multiple.fracture. of rib bone. at 7 days of age.which we.e.locate. close.to the.growth *** ske.e.al growth was only mildly affe.te. in the.e.mice.OA pathologie. we.e.marke.ly le.s pronounce. compare. to litte.mate.controls at 60 we.ks of ***,whe. OA was induce. by ante.ior cruciate.ligame.t transe.tion,only the.chondrocyte.inactivation of Pie.o1,not of Pie.o2,re.ulte. in atte.uate. articular cartilage.***,oste.phyte.formation and maturation we.e.also re.uce. in Pie.o1^(Col2a1Cre. *** furthe. obse.ve. incre.se. Pie.o1 prote.n abundance.in cartilaginous zone. of human ***,we.ide.tifie. Ptgs2 and Ccn2 as pote.tially re.e.ant Pie.o1 downstre.m ge.e. in ***,our data do not only de.onstrate.that Pie.o1 is a critical re.ulator of physiological and pathological e.dochondral ossification proce.se.,but also sugge.t that Pie.o1 antagonists may be.e.tablishe. as a nove. approach to limit oste.phyte.formation in OA.

关键词： Pie.o1 marke.ly ossification

Control of Rhyzope.tha dominica in store. rough rice.through a combination of diatomace.us e.rth and varie.al re.istance

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Inse.t Scie.ce 2008年第5期15卷 455-460页

作者： Yaowaluk Chanbang frank H. Arthur Ge.ald e. Wilde.Jame. e. Throne Chiang Mai Unive.sity Chiang Mai Thailand USDA-ARS Grain Marke.ing and Production Re.e.rch Ce.te. Manhattan KS USA De.artme.t of e.tomology Kansas State University Manhattan KS USA

Adults ofRhyzope.tha dominica （F.）, the.le.se. grain bore., we.e.e.pose. on four varie.ie. of rough rice.with Dobie.indice. of susce.tibility of 1.1 to 1.1 （low）, and four varie.ie. with Dobie.indice. of susce.tibility of 3.4 to 3.8 （high）. The.varie.ie. with low and high Dobie.indice. we.e.classifie. as re.istant and susce.tible. re.pe.tive.y, to R. dominica. The.purpose.of the.study was to e.aluate.control of R. dominica through the.use.of diatomace.us e.rth （De. in combination with rice.varie.ie. that we.e.e.the. susce.tible.or re.istant to R. dominica. The.rice.was tre.te. with varying rate. of the.comme.cial De.Inse.to, up to a maximum of 1 000 mg De.kg of rice. Adult mortality at e.ch application rate.of De.was ge.e.ally gre.te. on thre. of four re.istant varie.ie. compare. to thre. of four susce.tible.varie.ie.. Proge.y production from the.pare.tal ge.e.ation e.pose. on the.rice.was also gre.te. in 3 of the.4 re.istant varie.ie. compare. to 3 of the.4 susce.tible.varie.ie. at De.rate. of 500 mg/kg or more. Proge.y production in rice.tre.te. with a maximum rate.of 1 000 mg/kg De.range. from 7-44 adults on the.re.istant varie.ie. compare. to 75-155 adults on the.susce.tible.varie.ie.. At De.rate. of 500, 750, and 1 000 mg/kg, the.pe.ce.tage.of inse.t-damage. ke.ne.s （IDK） was also gre.te. in 3/4 re.istant varie.ie. than in the.susce.tible.varie.ie.. Re.ults show combining the.use.of De.with varie.al re.istance.of rough rice.to R. dominica could be.use. to limit populations of this inse.t in store. rice.and he.p pre.e.t e.onomic damage.

关键词： diatomace.us e.rth De host plant re.istance inte.rate. control rice