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Pancreatic ductal adenocarcinoma: Risk factors, screening, and early detection

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World Journal of Gastroenterology 2014年第32期20卷 11182-11198页

作者： Andrew E Becker Yasmin G Hernandez harold Frucht Aimee L Lucas Henry D. Janowitz Division of Gastroenterology Icahn School of Medicine at Mount Sinai New York NY 10029 United States Division of Digestive and Liver Diseases Columbia University College New York NY 10032 United States

Pancreatic cancer is the fourth most common cause of cancer-related deaths in the United States, with over 38000 deaths in 2013. The opportunity to detect pancreatic cancer while it is still curable is dependent on our ability to identify and screen high-risk populations before their symptoms arise. Risk factors for developing pancreatic cancer include multiple genetic syndromes as well as modifiable risk factors. Genetic conditions include hereditary breast and ovarian cancer syndrome, Lynch Syndrome, familial adenomatous polyposis, Peutz-Jeghers Syndrome, familial atypical multiple mole melanoma syndrome, hereditary pancreatitis, cystic fibrosis, and ataxia-telangiectasia; having a genetic predisposition can raise the risk of developing pancreatic cancer up to 132-fold over the general population. Modifiable risk factors, which include tobacco exposure, alcohol use, chronic pancreatitis, diet, obesity, diabetes mellitus, as well as certain abdominal surgeries and infections, have also been shown to increase the risk of pancreatic cancer development. Several largevolume centers have initiated such screening protocols, and consensus-based guidelines for screening high-riskgroups have recently been published. The focus of this review will be both the genetic and modifiable risk factors implicated in pancreatic cancer, as well as a review of screening strategies and their diagnostic yields.

关键词： Pancreatic neoplasms Pancreas cancer screening Genetic predisposition to disease Hereditary breast and ovarian cancer syndrome Lynch syndrome Peutz-Jeghers BRCA PALB2 p16 Pancreatitis

Exploring the tectonostratigraphy of the Pakistan Himalaya with new detrital zircon geochronology and neodymium isotope data from the Kaghan Valley

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Geoscience Frontiers 2023年第6期14卷 117-132页

作者： W.Joel Schiffer Delores M.Robinson Shah Faisal harold H.Stowell Department of Geological Sciences and Center for Sedimentary Basin Studies University of AlabamaPO Box 870338TuscaloosaAL 35487USA National Centre of Excellence in Geology University of PeshawarPeshawar 25130Pakistan

In the central Himalaya,the Greater and Lesser Himalayan tectonostratigraphic zones can be distinguished from each other by combining detrital zircon U-Pb ages and whole-rock Nd isotopic *** the Hazara-Kashmir syntaxis of northern Pakistan,rock units in the Kaghan valley have been variously assigned to the Tethyan,Greater,and Lesser Himalayan *** determine which tectonostratigraphic zones are represented,we sampled across the Batal thrust in the northern Kaghan valley because this structure is identified in some research as the Main Central *** from the footwall yield Paleo-to Mesoproterozoic maximum depositional ages(-1.8-1.1 Ga)and an averageεNd(0)value *** from the hanging wall yield Neoproterozoic maximum depositional ages(~1000-600 Ma)andεNd(0)values *** contrasting detrital zircon ages show that the Batal thrust in the Kaghan valley is a major structural ***,these data lack the characteristic detrital zircon age spectra andεNd(0)values of Greater and Lesser Himalayan rocks north and south of the Main Central thrust in the central Himalaya,***,either the Batal thrust is not the Main Central thrust,or the Main Central thrust in the Kaghan valley cuts a different structural level and carries rock units not seen outside the Hazara-Kashmir syntaxis.

关键词： Pakistan Himalaya Tectonostratigraphy Main Central thrust Detrital zircon geochronology Neodymium isotopes

Treatment of hyperkalemic emergencies

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World Journal of Emergency Medicine 2022年第3期13卷 232-236页

作者： Yao Wu Yang-yang Fu Hua-dong Zhu Jun Xu Joseph harold Walline Emergency Department State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Centre for the Humanities and Medicine the University of Hong KongHong KongChina

Hyperkalemic emergency(HE)refers to life-threatening hyperkalemia consisting of a high serum potassium level with severe complications(e.g.,dysrhythmias,cardiac arrest,or myopathy).^([1])Hyperkalemic emergencies(HEs)a... 详细信息

关键词： cardiac potassium arrest

Optimization and Deployment of Memory-Intensive Operations in Deep Learning Model on Edge

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计算机科学 2023年第2期50卷 3-12页

作者： Peng XU Jianxin ZHAO Chi harold LIU Department of Computer Science and Technology Beijing Institute of TechnologyBeijing 100081China

As a large amount of data is increasingly generated from edge devices,such as smart homes,mobile phones,and wearable devices,it becomes crucial for many applications to deploy machine learning modes across edge *** execution speed of the deployed model is a key element to ensure service *** a highly heterogeneous edge deployment scenario,deep learning compiling is a novel approach that aims to solve this *** defines models using certain DSLs and generates efficient code implementations on different hardware ***,there are still two aspects that are not yet thoroughly investigated *** first is the optimization of memory-intensive operations,and the second problem is the heterogeneity of the deployment *** that end,in this work,we propose a system solution that optimizes memory-intensive operation,optimizes the subgraph distribution,and enables the compiling and deployment of DNN models on multiple *** evaluation results show the performance of our proposed system.

关键词： Memory optimization Deep compiler Computation optimization Model deployment Edge computing

Impact and Solutions of Seawater Heterogeneity on Wide-Angle Tomographic Inversion of Crustal Velocities in Deep Marine Environments—Numerical Studies

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Journal of Earth Science 2018年第6期29卷 1380-1389页

作者： Zhihui Zou Hua-Wei Zhou harold Gurrola Aifei Bian Zhonglai Huang Jianzhong Zhang College of Marine Geosciences Key Lab of Submarine Geosciences and Prospecting Techniques MOEOcean University of China Evaluation and Detection Technology Laboratory of Marine Mineral Resources Qingdao National Laboratory for Marine Science and Technology Department of Earth & Atmospheric Sciences University of Houston Department of Geosciences Texas Tech University Institute of Geophysics and Geomatics China University of Geosciences

The seawater column is typically taken as a homogeneous velocity layer in wide-angle crustal seismic surveys in marine environments. However, heterogeneities in salinity and temperature throughout the seawater layer result insignificant lateral variations in its seismic velocity, especially in deep marine environments. Failure to compensate for these velocity inhomogeneities will introduce significant artifacts in constructing crustal velocity models using seismic tomography. In this study, we conduct numerical experiments to investigate the impact of heterogeneous seismic velocities in seawater on tomographic inversion for crustal velocity models. Experiments that include lateral variation in seawater velocity demonstrated that the modeled crustal velocities were contaminated by artifacts from tomographic inversions when assuming a homogeneous water layer. To suppress such artifacts, we propose two strategies：（1） simultaneous inversion of water velocities and the crustal velocities;（2） layer-stripping inversion during which to first invert for seawater velocity and then correct the travel times before inverting for crustal velocities. The layer-stripping inversion significantly improves the modeling of variation in seawater velocity when preformed with seismic sensors deployed on the ocean bottom and in the water column. Such strategies improve crustal modeling via wide-angle seismic surveys in deep-marine environment.

关键词： deep water seismic tomography wide-angle seismic survey water heterogeneity OBS vertical cable

Atypical presentation of a ventricular papillary fibroelastoma

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Journal of Geriatric Cardiology 2017年第8期14卷 534-535页

作者： Julio Perez-Downes harold Dietzius Saif Ibrahim Vasant Jayasankar Leslie Oberst Department of Medicine University of Florida College of Medicine-Jacksonville USA Department of Cardiology Memorial tIospital USA Department of Cardiology University of Florida College of Medicine-Jacksonville USA Department of Cardiothoracic Surgery Memorial Hospital USA

Papillary fibroelastoma cardiac tumor. The most is the most common valvular common non-valvular site these minors present is the left ventricle, where they usually manifest as ischemic strokes or myocardial infarction. Although these tumors also have a risk of embolization into the peripheral system, reports of such events are exceedingly rare.

关键词： Fibroelastoma Ischemia Myocardium Neoplasm Thrombosis

Native Langage and School: A Case Study on Ethnic College Students’ Language Practices and Their Acadmic Experience at Northeast Normal University

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Native Langage and School: A Case Study on Ethnic College St...

作者： harold Mauricio Carre（?）o Parada 东北师范大学

学位级别：硕士

Ethnic minority students are enrolled in formal education everyday around the world. This study explores the influence of the environment upon the participants’native language use. The concept of practice describes the use of the language in this study;it also surveys the role of native languages in connection with the academic performance. In addition, it inquires about the advantanges and the challenges of studying in a second language for Chinese ethnic minority students in Northeast Normal University. A pilot study was used to test the questions for this study. A bilingual questionnaire in English and Chinese and an interview-focus group were used to collect data;All the information was tape recorded to save the information. The gathering and analysis were guided for three research questions that attempt to show the language used in the university, the role of the native language in the participants field of study and the experience of use a second language as medium of instruction. The findings show that the native language plays an important role in the studies of the participants and it is a mark of identity for them. The study wants to contribute to the literature about ethnic minority students in China and other countries.

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Context-free Grammars for Triangular Arrays

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Acta Mathematica Sinica,English Series 2015年第3期31卷 445-455页

作者： Robert X.J.HAO Larry X.W.WANG harold R.L.YANG Center for Combinatorics LPMC-TJKLC Nankai University

We consider context-free grammars of the form G = {f → f^b1＋b2＋1g^a1＋a2, g → f^b1 g^a1＋1},where ai and bi are integers sub ject to certain positivity conditions. Such a grammar G gives rise to triangular arrays {T（n, k）}0≤k≤n satisfying a three-term recurrence relation. Many combinatorial sequences can be generated in this way. Let Tn （x） =∑k=0^n T（n, k）x^k. Based on the differential operator with respect to G, we define a sequence of linear operators Pn such that Tn＋1（x） = Pn（Tn（x））. Applying the characterization of real stability preserving linear operators on the multivariate polynomials due to Borcea and Br？ndén, we obtain a necessary and sufficient condition for the operator Pn to be real stability preserving for any n. As a consequence, we are led to a sufficient condition for the real-rootedness of the polynomials defined by certain triangular arrays, obtained by Wang and ***, as special cases we obtain grammars that lead to identities involving the Whitney numbers and the Bessel numbers.

关键词： Context-free grammar stable polynomials real-rootedness Bessel numbers Whitneynumbers

Coagulase-negative Staphylococci in Conjunctivitis and Blepharitis

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眼科学报 1993年第3期9卷 129-135页

作者： Yue-Kong Au harold GJensen James Rowsey Mark Reynolds Department of Ophthalmology Louisiana State UniversityShreveportLouisianaUSA Dean McGee Eye Institute Oklahoma CityOklahomaUSA

Coagulase-negative staphylococcus(C-NS)are regarded as normal flora of the lids and *** ability of these organisms to cause conjunctivitis and blepharitis can be overlooked or *** elucidate the role of individual C-NS species in these eye diseases we compared Staphylococcus *** from the conjunctiva and lids of 50 healthy volunteers with 248 strains of Staphylococcus isolated from patients with staphylococcal conjunctivitis or *** was the most frequent species isolated from the conjunctiva and lids of both *** was isolated only from infected *** individual C-NS species was found to be significantly associated with eye disease,but the colony count of C-NS after isolation was a useful indicator of conjunctivitis and *** ability of Staphylococcus to ferment mannitol or mannose was associated with isolates only from infected patients.

关键词： Staphylococcus aureus coagulase-negative Staphylococcus Staphylococcus epidermidis conjunctivitis blepharitis