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THE EFFECT OF LESSER HIMALAYAN CALC-SILICATES ON THE ^(87)Sr/^(86)Sr OF THE BHOTE KOSI RIVER OF NEPAL—IMPLICATIONS FOR HIMALAYAN WEATHERING, THE MARINE ^(87)Sr/^(86)Sr RECORD AND GLOBAL CLIMATE

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地学前缘 2000年第S1期7卷 396-397页

作者： Lee Oliver 1,Nigel Harris 1, Nancy Dise 1,Mike Bickle 2[WT5,5”BX](1 Department of Earth Sciences, Open University, Milton Keynes MK7 6AA, UK 2 Department of Earth Sciences, Cambridge University, Cambridge cb2 3EQ, UK)

During the last 40Ma the marine 87 Sr/ 86 Sr record shows a rapid rise (from 0 7078 to 0 7092) [1] , a trend which has been linked to the Himalayan Orogeny [2] . Indeed, many Himalayan rivers, principally those of the Ganges\|Brahmaputra system, display high 87 Sr/ 86 Sr relative to [Sr] [3] . Theories concerning the cause of this radiogenic Sr enrichment are diverse, but our results suggest that Lesser Himalayan carbonate\|rich lithologies play a vital role [4,5] .The Bhote Kosi originates in Tibet at ca.5km elevation from Tibetan Sedimentary Series (TSS) bedrock, before traversing the High Himalayan Crystalline Series (HHCS) and Lesser Himalaya (LH) of eastern Nepal, joining the Indrawati (at ca.0 6km elevation) to form the Sun Kosi, part of the Ganges system. Carbonates, calc\|silicates and silicates have been identified from the TSS, HHCS and LH, and the Bhote Kosi provides an opportunity to study the influence of these upon fluvial chemistry. Interest is focused on the cause of a rapid rise in riverine Sr\|isotope ratios immediately downstream of the Main Central Thrust (MCT) and the role of carbonate\|rich lithologies exposed in this section. Similar lithologies are lacking in the catchment of a second Nepalese river system, the Lantang Khola—Trisuli, sampled during the same period, and used as a baseline indicator for the effect of LH carbonates on the dissolved load of the Bhote Kosi.

关键词： weathering strontium isotopes Himalayan rivers carbonates

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Construction,Characterization,and Chromosomal Mapping of a Fosmid Library of the White-Cheeked Gibbon (Nomascus leucogenys)

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Genomics,Proteomics & Bioinformatics 2007年第Z1期 207-215页

作者： Liping Chen1,2,Jianping Ye1,2,Yan Liu1,2,Jinghuan Wang1,Weiting Su1,Fengtang Yang1#,and Wenhui Nie1 1 Key Laboratory of Cellular and Molecular Evolution,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming 650223,China 2Graduate School of Chinese Academy of Sciences,Beijing 100039,China. #Current address: Wellcome Trust Sanger Institute,Hinxton,Cambridge cb10 1SA,UK.

Gibbons have experienced extensive karyotype rearrangements during evolution and represent an ideal model for studying the underlying molecular mechanism of evolutionary chromosomal rearrangements. It is anticipated that the cloning and sequence characterization of evolutionary chromosomal breakpoints will provide vital insights into the molecular force that has driven such a radical karyotype reshuffle in gibbons. We constructed and characterized a high-quality fosmid li-brary of the white-cheeked gibbon (Nomascus leucogenys) containing 192,000 non-redundant clones with an average insert size of 38 kb and 2.5-fold genome coverage. By end sequencing of 100 randomly selected fosmid clones,we generated 196 se-quence tags for the library. These end-sequenced fosmid clones were then mapped onto the chromosomes of the white-cheeked gibbon by fluorescence in situ hy-bridization,and no spurious chimeric clone was detected. BLAST search against the human genome showed a good correlation between the number of hit clones and the number of chromosomes,an indication of unbiased chromosomal distribu-tion of the fosmid library. The chromosomal distribution of the mapped clones is also consistent with the BLAST search result against human and white-cheeked gibbon genomes. The fosmid library and the mapped clones will serve as a valu-able resource for further studying gibbons' chromosomal rearrangements and the underlying molecular mechanism as well as for comparative genomic study in the lesser apes.

关键词： fosmid library white-cheeked gibbon chromosomal mapping fluorescence in situ hybridization

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老年人持续性血压控制与多发病进展的关系

中华高血压杂志 2020年第12期28卷 1204-1204页

作者：周卫(译) 袁源(摘) 叶鹏(审校) Bowling cb Sloane R Pieper C 不详

多发病医疗费用较高,死亡率也高,因此需要寻求能减缓其进程的干预措施。高血压是一种常见的慢性病,也是许多其他慢性病的危险因素,是一个理想的干预靶点。本研究旨在确定持续血压控制水平与多发病进展之间的关联。设计:本实验为回顾性... 详细信息

多发病医疗费用较高,死亡率也高,因此需要寻求能减缓其进程的干预措施。高血压是一种常见的慢性病,也是许多其他慢性病的危险因素,是一个理想的干预靶点。本研究旨在确定持续血压控制水平与多发病进展之间的关联。设计:本实验为回顾性队列研究。

关键词：回顾性队列研究血压控制危险因素医疗费用慢性病干预措施老年人持续性

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Stem cells as vehicles for the treatment of brain cancer

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中国神经肿瘤杂志 2007年第1期5卷 58-58页

作者： Mapara KY Stevenson cb Thompson RC Ehtesham M Department of Neurological Surgery Vanderbilt University Medical Center Nashville TN 37232 USA

Stem cell therapy represents a promising new therapeutic modality for infiltrative gliomas. The promise of this emerging technology centers on the potent migratory tropism exhibited by stem cells for disseminated foci of intracranial pathologic findings. This important characteristic, which has been validated in a wide set of preclinical studies, forms a foundation for the use of transplanted stem cell populations as vehicles for the delivery of tumor-toxic molecules to sites of intracranial tumor. Nevertheless, although experimental models using this technique to target brain tumors have shown encouraging results,

关键词：脑瘤干细胞治疗载体

混合造血干细胞移植后输注供者淋巴细胞和白细胞介素2对急性髓性白血病疗效的影响

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中国组织工程研究与临床康复 2007年第24期11卷 4777-4780页

作者：王存邦白海欧英贤潘耀柱张茜葸瑞解放军兰州军区兰州总医院全军血液病中心甘肃省兰州市730050

目的:观察急性髓性白血病经混合造血干细胞移植后,应用供者淋巴细胞输注+白细胞介素2治疗的效果,并与移植后未经特殊治疗的效果进行比较。方法:①选取2000-01/2004-07解放军兰州军区兰州总医院全军血液病中心收治的19例急性髓性白血病患... 详细信息

目的:观察急性髓性白血病经混合造血干细胞移植后,应用供者淋巴细胞输注+白细胞介素2治疗的效果,并与移植后未经特殊治疗的效果进行比较。方法:①选取2000-01/2004-07解放军兰州军区兰州总医院全军血液病中心收治的19例急性髓性白血病患者,实验经医院伦理委员会批准,患者均知情同意。随机数字表法分为两组:观察组8例,年龄17～40岁,M2a 4例,M4 1例,M5a 3例;对照组11例,年龄19～39岁,M2a 2例,M3a 2例,M4 3例,M5a 4例。②两组患者采用化疗联合重组人粒细胞集落刺激因子的方法动员自体外周血造血干细胞,采集后液氮中保存5d备用。③术前采用直线加速器对患者全身及肺部照射,预处理完毕后实施混合造血干细胞移植。首先回输自体单个核细胞中位数为4×108/kg,CD34+细胞中位数为6.2×106/kg,粒-巨噬祖细胞集落形成单位中位数为5.8×104/kg。间隔1～6h后,采集人类白细胞抗原半相合异体骨髓,按回输自体单个核细胞数的1/6～1/10输注给患者。④两组患者移植期间均住无菌层流病房,给予相应并发症的防治及支持治疗。在粒细胞降至0时注射重组人粒细胞集落刺激因子150μg/12h,促进造血恢复。观察组给予供者淋巴细胞输注+白细胞介素2治疗,每次采集的供者淋巴细胞中,CD3+淋巴细胞中位数为1.43×108/kg,CD4+细胞中位数为0.97×108/kg,CD8+细胞中位数为0.41×108/kg,中位治疗次数4(1～7)次,回输后即开始应用100wu/d重组人白细胞介素2,共10d。对照组混合造血干细胞移植后未给予特殊治疗。结果:19例急性髓性白血病患者均进入结果分析。①造血恢复:两组患者均获得造血重建,术后4～9d粒细胞均降至0,12～17d粒细胞达0.5×109L-1,16～21d白细胞达4.0×108 L-1,19～23 d血小板达20×108 L-1。16～21 d骨髓检查示恢复期骨髓象。②术后并发症:两组患者不同程度地出现口腔溃疡,随着造血恢复,7～10d溃疡消失。观察组1例患者出现出血性膀胱炎,两组各2例患者出现发热。无肝静脉闭塞病和移植物抗宿主病发生。③嵌合体形成:观察组中1例M4患者形成嵌合体,对照组中2例M4患者与1例M5患者形成嵌合体,嵌合体持续存在3～12个月。④供者淋巴细胞输注+白细胞介素2疗效:观察组中有1例M2a患者在接受2次特殊治疗后7个月复发死亡;1例M2a患者接受2次特殊治疗后1年出现骨髓增生异常综合征,脑出血死亡,1例M5a患者应用特殊治疗1次后出现不明原因高热、抽搐,死于癫痫持续状态,其余5例患者随访2年均健康存活,长期生存率为62.5%(5/8)。对照组有2例M2a患者、2例M4患者、1例M5患者于移植后1～7个月复发死亡,1例M3患者于移植后25d死于脑出血,其余2例M3患者、2例M4患者、1例M5患者随访2年均健康存活,长期生存率为45.4%(5/11)。结论:混合造血干细胞移植后应用供者淋巴细胞输注+白细胞介素2治疗,急性髓性白血病患者均获得造血重建且无移植物抗宿主病发生,其长期生存率有效提高。

关键词：供者淋巴细胞输注白细胞介素2 急性髓性白血病混合造血干细胞移植

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A NOVEL APPROACH TO THE PROBLEM OF PARTITIONING HIGHLY INTEGRATED VLSI SYSTEMS

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A NOVEL APPROACH TO THE PROBLEM OF PARTITIONING HIGHLY INTEG...