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Functional phenotypes of CCR5 on CD4+ T cells of relevance to its genetic and epigenetic associations with HIV infection

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Cellular & Molecular Immunology 2020年第7期17卷 680-681页

作者： Dusanka S.Skundric harley y.tse Paul C.Montgomery Department of Biochemistry Microbiology and ImmunologyWayne State UniversitySchool of MedicineDetroitMIUSA

The article by Kulkarni et *** a description of some genetic and epigenetic interactions that determine the functional phenotypes of the chemokine receptor CCR5,which is critical to human immunodeficiency virus type 1(HIV-1)infection.1 Significant advances in the genetic regulation of human diseases have been made through the use of genome-wide association studies(GWASs)over the past several *** daunting task of elucidating the cellular pathways that are critical to human disease regulation remains for many disease-associated coding genetic variants.

关键词： CCR5 epigenetic al.

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Geochronology and trace element geochemistry of zircon,monazite and garnet from the garnetite and/or associated other high-grade rocks:Implications for Palaeoproterozoic tectonothermal evolution of the Khondalite Belt,North China Craton

Geochronology and trace element geochemistry of zircon,monaz...

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中国科学院地质与地球物理研究所2013年度（第13届）学术年会

作者： Shujuan Jiao Jinghui Guo Simon L.harley Peng Peng State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of Sciences

It is well documented that the Khondalite Belt of the North China Craton formed by the collision of the yinshan and Ordos Blocks during ca.1.95 Ga,but the onset of the post-collisional exhumation stage has not been well *** garnetite and garnet-bearing quartz-rich lens that are regarded as residue-melt phases occur occasionally in the foliated metasedimentary rocks in the Jining terrane of the Khondalite *** are free of regional gneissosity,and may be generated during the post-collisional exhumation *** U-Pb dating,monazite chemical dating and trace element analyses of zircon,monazite and garnet have been carried out on the garnetites and associated other high-grade metamorphic *** geochronological results reveal a major age group of ca.1890 Ma from the zircon grains/overgrowths and inclusion-type monazites within the garnet poikiloblasts in the *** trace elements analyses show that zircon hosted in the mantle of the garnet poikiloblasts in the garnetite contains the highest HREE and y contents,whereas zircon hosted in the garnet rims shows higher HREE and y contents than matrix zircon ***-type monazite in the garnetite shows higher La/Sm ratio than matrix monazite *** garnet poikiloblasts in the garnetite exhibit bell-shaped HREE and y zoning profiles attributed to Rayleigh fractionation during their *** to garnet poikiloblasts, coronal garnet shows higher Gro,Cr and Li contents,but lower X,Sm,HREE,Zn and Zr contents and weaker Eu negative anomalies,reflecting their different formation *** on evidences from microstructural analyses,REE concentrations and patterns,HREE partition coefficients and the Tiin -zircon thermometer,it is proposed that most of the zircon grains/overgrowths in the garnetite formed coevally with garnet ***,ca.1890 Ma represents the timing of garnet poikiloblast growth during the partial melting of the *** garnet or Zn-ric

关键词： Khondalite Belt Monazite chemical dating North China Craton Trace element geochemistry Zircon U-Pb dating

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冠状动脉手术复查患者中无症状性颈部血管杂音对颈动脉疾病的预测价值

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世界核心医学期刊文摘（心脏病学分册） 2006年第5期2卷 39-39页

作者： Sonecha T.N Delis K.T Henein M.y. 雷聪 Cardiovascular Clinic London Medical Centre 144 Harley Street London W1G 7LD United Kingdom

Objective: To investigate the predictive value of asymptomatic cervical bruit for detecting internal carotid artery disease in consecutive patients undergoing coronary artery bypass grafting(CABG). Design: A prospective cohort study. Setting: Tertiary referral university hospitals. Patients: 153 consecutive patients(mean age 57 years) undergoing CABG, without previous history of cerebrovascularevents. Interventions: Patients underwent detailed pre-operative work-up, including coronary angiography and carotid artery duplex scanning. Internal carotid artery diameter stenosis was graded as A: normal; B: 80- 99% and E=complete occlusion. Results: 72 patients(47.1% )(95% CI: 39% , 55% ) had no evidence of internal carotid artery stenosis; 81(52.9% )(95% CI: 44.9% , 60.9% ) had varying grades of disease, unilateral or bilateral. Cervical bruit was detected in 12 / 153 patients(7.8% )(95% CI: 3.5% , 12.1% ) of whom all but one(0.7% ) had varying grades of internal carotid artery disease; of these, 4 patients had bilateral cervical bruit(2.6% )(95% CI: 0.06% , 5.2% ). The sensitivity, specificity, positive and negative predictive values and overall accuracy of cervical bruit for detection of ≥ 50% internal carotid artery stenosis were 23.5% , 95.8% , 25% , 95.5% and 91.8% , respectively. The relative risk of ≥ 50% stenosis ipsilateral to cervical bruit in 306 sides was 5.58(95% CI: 2.0, 15.0) and the odds ratio 7.1(95% CI: 2.0, 25.0). Conclusions: Asymptomatic cervical bruit proved a highly specific clinical sign for detection of internal carotid artery stenosis, whether haemodynamically significant(≥ 50% ) or otherwise, in patients undergoing myocardial revascularisation. This was matched by a high negative predictive value and overall accuracy for flow limiting atheroma(≥ 50% stenosis). yet, steering carotid investigations on the basis of cervical bruit alone would result in ≥ 80% internal carotid artery stenosis remaining undete

关键词：颈动脉疾病颈部血管杂音预测价值无症状性冠状动脉手术患者颈内动脉狭窄冠状动脉搭桥术前瞻性队列研究复查

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