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Assessment of colistin resistance in Gram negative bacteria from clinical samples in resource-limited settings

Asian Pacific Journal of Tropical Medicine 2022年第8期15卷 367-373,I0011-I0013页

作者： Shubham Chauhan Narinder Kaur Adesh K.Saini Jyoti Chauhan harit kumar Department of Microbiology Maharishi Markandeshwar Institute of Medical Sciences and ResearchMaharishi Markandeshwar(Deemed to be)UniversityMullanaAmbalaIndia Department of Biotechnology Maharishi Markandeshwar Engineering CollegeMaharishi Markandeshwar(Deemed to be)UniversityMullanaAmbalaIndia

Objective:To find a proper method to assess colistin resistance in multidrug resistant Gram negative bacteria(MDR-GNB)on a routine basis in resource limited ***:Clinical samples were ***-GNB were identified and were examined for colistin resistance by colistin broth elution method,colistin agar method,and colistin disk elution screening *** microdilution method was used the gold ***:A total of 10235 clinical samples were processed,in which 857(8.4%)MDR-GNB were *** very significant errors,categorical agreement,major errors,positive predictive values,negative predictive values,specificity and sensitivity of all the phenotypic methods were 5.5%,0%,94.4%,100%,99.6%,100%and 94.4%,respectively for the detection of colistin *** colistin elution screening method was cheap and easy to perform with similar results to broth microdilution ***:All the evaluation methods for colistin resistance showed similar *** the laboratories can choose any method for detection of colistin ***,we recommend colistin disk elution screening method because,it is easy and cheap and can be performed in limited resources.

关键词： Multi-drug resistant organism Colisitin resistance mcr gene Broth micro dilution Disk elution method

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Evaluation of reusing alum sludge for the coagulation of industrial wastewater containing mixed anionic surfactants

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Journal of Environmental Sciences 2011年第4期23卷 587-594页

作者： Siriprapha Jangkorn Sinchai Kuhakaew Suwapee Theantanoo harit Klinla-or Tongchai Sriwiriyarat Environmental Science Program Faculty of Science Burapha University Department of Chemical Engineering Faculty of Engineering Burapha University

A coagulation-flocculation process is typically employed to treat the industrial wastewater generated by the consumer products industry manufacturing detergents, soaps, and others. The expenditure of chemicals including coagulants and chemicals for pH adjustment is costly for treating this wastewater. The objective of this study was to evaluate the feasibility of reusing the aluminum sulfate (alum) sludge as a coagulant or as a coagulation aid so that the fresh alum dosage can be minimized or the removal efficiency can be enhanced. The experiments were conducted in a jar-test apparatus simulating the coagulation-flocculation process for simultaneous removals of organic matters, anionic surfactants, suspended solids, and turbidity. At the optimum initial pH value of 10 and the fresh alum concentration of 400 mg/L, the total suspended solids (TSS), total chemical oxygen demand (TCOD), total anionic surfactants, and turbidity removal efficiencies were 71.5%, 76.4%, 95.4%, and 98.2%, respectively. The addition of alum sludge as a coagulant alone without any fresh alum addition could significantly remove the turbidity, TCOD, and anionic surfactants. The TSS was left in the supernatants after the settling period, but would subsequently be removed by adding the fresh alum. The TSS, TCOD, and turbidity removal efficiencies were also enhanced when both the alum sludge and the fresh alum were employed. The TCOD removal efficiency over 80% has been accomplished, which has never fulfilled by using the fresh alum alone. It is concluded that the alum sludge could be reused for the treatment of industrial wastewater generated by the consumer products industry.

关键词： alum sludge coagulation anionic surfactants consumer products

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Management of isolated zygomaticomaxillary complex fractures with an individualized approach: a retrospective study

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Plastic and Aesthetic Research 2014年第1期1卷 51-53页

作者： Rahul Datta Kanwar harit Yasmin Grewal Department of Oral and Maxillofacial Surgery Rayat Bahra Dental College and HospitalMohali 140104PunjabIndia Department of Public Health Dentistry Rayat Bahra Dental College and HospitalMohali 140104PunjabIndia

Aim:Fractures of the zygomatico maxillary complex(ZMC)are commonly seen after traumatic injuries to the facial *** aim of the study was to review the outcome of individualized treatment approach in the management of isolated ZMC ***:A retrospective analysis of 25 patients was conducted to assess the outcomes of isolated ZMC(iZMC)fracture treatment at a multi specialty hospital(Punjab,India)over a 3–year ***:Out of the 25 patients reviewed,4 patients required no surgical intervention and 21 patients underwent surgical reduction via the buccal sulcus *** individualized treatment plan was formulated for each patient to decide mini plate fixation at one–two–or three–point with or without orbital rim *** patients required removal of mini plates from the buttress area on postoperative follow ***:Our review shows that an individualized treatment approach produces the most favorable results in the management of iZMC fractures.

关键词： Fixation fractures reduction zygomatic complex

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Nimotuzumab with Concurrent Chemoradiation in Inoperable Locally Advanced Squamous Cell Carcinoma of Head and Neck: An Indian Experience

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Journal of Cancer Therapy 2018年第1期9卷 89-100页

作者： Ankur Bahl Komal Singh Pragati Choudhary A. K. Anand Amal Roy Chaoudhoory harit Chaturvedi Biswajyoti Hazarika Dilip Pawar Medical Oncology Max Super Specialty Hospital Saket New Delhi India Radiation Oncology Max Super Specialty Hospital Saket New Delhi India Surgical Oncology Max Super Specialty Hospital Saket New Delhi India Medical Affairs & Clinical Development Biocon Banglore India

Background: The prognosis of patients with Epidermal Growth Factor Receptor (EGFR) overexpression in inoperable Locally Advanced Squamous Cell Carcinoma of Head and Neck (LASCCHN) remains poor. Nimotuzumab is an Anti EGFR humanized monoclonal antibody approved for treatment of LASCCHN, with concurrent chemoradiation. Objective: To assess the efficacy and safety of nimotuzumab with concurrent chemoradiation in inoperable LASCCHN patients. Methodology: This is a single-centre, single arm, retrospective study evaluating 35 patients with histologically confirmed inoperable LASCCHN (stages III-IV). The patients were administered IV cisplatin 50 mg/m2 and IV nimotuzumab 200 mg for 6 - 7 weeks, along with radiotherapy of 6600 - 7000 cGy over 35 fractions. Patients were evaluated over response evaluation criteria in solid tumors (RECIST) criteria 12 weeks after the last cycle of chemotherapy. They were also followed up for overall survival and relapse free survival. Results: The median duration of follow-up was 20 months. The most common site of cancer was oropharynx (68.6%). One patient was lost to follow up. Objective Response Rate (ORR) was observed in 97% of the patients with 17 patients (48.6%) achieving complete response (CR) and 17 patients (48.6%) achieving partial response (PR). The median overall survival was 22.7 months (95% CI: 21.30, 34.27). The median relapse free survival was 16.7 months (95% CI: 9.80, 24.50). Nimotuzumab was safe and well tolerated with few mild, self-limiting adverse events. Conclusion: Nimotuzumab with chemoradiation is a safe and efficacious option in patients with LASCCHN. Larger studies are needed to verify the same.

关键词： Epidermal Growth Factor Receptor Chemoradiation Locally Advanced Squamous Cell Carcinoma of Head and Neck Humanised Monoclonal Antibody Nimotuzumab

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