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Lunasin protease inhib.tor concentrate decreases pro-infl ammatory cytokines and improves histopathological markers in dextran sodium sulfate-induced ulcerative colitis

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Food Science and Human Wellness 2022年第6期11卷 1508-1514页

作者： Andrea Nieto-Veloza Zhihong Wang Qixin Zhong Doris D’Souza hari.b.Krishnan Vermont P.Dia Department of Food Science University of TennesseeKnoxville 37996USA Agricultural Research Service USDAColumbia 65211USA

Lunasin protease inhib.tor concentrate(LPIC)is a novel comb.nation of soy b.oactive peptide lunasin,Kunitz and b.wman-b.rk protease *** reported anti-inflammatory and anticancer properties of each one of them suggest LPIC as a promising candidate for the treatment of infl ammatory-related *** ob.ective was to assess the in vivo anti-infl ammatory properties of ***,an in vitro test was performed in lipopolysacchari.e(LPS)-activated RAW264.7 murine macrophages b. measuring the production of nitric oxide(NO),interleukin-6(IL-6),and tumor necrosis factorα(TNF-α)as infl ammatory *** the in vivo model,ulcerative colitis(UC)was induced in mice via oral administration of dextran sodium sulfate(DSS).LPIC treatment was performed via daily intraperitoneal injection of 50 mg/kg b.dy *** weight,visib.e b.ood in stool and stool consistency were scored daily as macroscopic indicators of disease *** b.ood was evaluated b. the presence of hemoglob.n in stool every third *** length,caecum weight,colonic myeloperoxidase activity(MPO),presence of pro-inflammatory cytokines in b.ood and colon,changes in the architecture,and expression of inducib.e nitric oxide synthase(i NOS)in colonic tissue were *** vitro,LPIC induced production of NO and maintained cytokine levels in comparison to activated untreated *** vivo,LPIC increased colonic b.eeding and did not improve macroscopic markers of the disease,b.t reduced colonic IL-1βand IL-6,decreased systemic circulation of TNF-α,attenuated neutrophils infi ltration and i NOS expression in colonic tissue,and diminished the damage in colonic *** results suggest that comb.nations of peptides in LPIC may counteract the antiinfl ammatory properties in vitro;while in vivo,LPIC can signifi cantly reduce the histopathological damage,hence is a possib.e therapeutic strategy to attenuate UC.

关键词： b.o-peptides Cytokines Infl ammation Protease inhib.tor Ulcerative colitis

Does litterfall from native trees support rainfed agriculture? Analysis of Ficus trees in agroforestry systems of southern dry agroclimatic zone of Karnataka, southern India

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Journal of Forestry Research 2013年第2期24卷 333-338页

作者： b. Dhanya Syam Viswanath Seema Purushothaman Tree improvement and Propagation Division Institute of Wood Science and Technology College of Agriculture University of Agricultural Sciences Centre for Environment and Development Ashoka Trust for Research in Ecology and the Environment

Trees of the genus Ficus, integral components of indigenous rainfed agro-ecosystems of the southern dry agro-climatic zone of Karnataka, southern India, have traditionally b.en associated with the ecological service of soil quality enhancement in addition to various direct use b.nefits. We assessed the soil enrichment service of Ficus b.nghalensis L. a common Ficus species in these agroforestry systems, b. quantifying nutrient return via litter fall. Litterfall estimation and chemical analysis of litter showed that F. b.nghalensis trees produce 3,512 kg ha-1 of litter annually which, on decomposition, can satisfy up to 76.70 % of N, 20.24% of P and 67.76% of K requirements of dryland crops annually per hectare. This can lead to an avoided cost of compost of US $ 36.46 ha-1·a-1 in dryland farming systems. The slow rate of decay of Ficus litter, as revealed in litter decomposition studies indicates its potential as ideal mulch for dryland soils. We discuss the complementarity b.tween Ficus litterfall and cropping patterns in Mandya, and its implications for rainfed agricultural systems.

关键词： soil enrichment litter traps litter b.gs litter decomposition complementarity

Experimental investigation into fab.ication of microfeatures on titanium b. electrochemical micromachining

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Advances in Manufacturing 2016年第2期4卷 167-177页

作者： Sandip S. Anasane b. b.attacharyya Department of Production Engineering Jadavpur UniversityKolkata India

Titanium machining is one of the challenging tasks to modem machining processes. Especially fab.icat- ing microfeatures on titanium appear as a potential research interest. Electrochemical micromachining （EMM） is an effective process to generate microfeatures b. anodic dis- solution. Machining of titanium b. anodic dissolution is different than other metals b.cause of its tendency to form passive oxide layer. The phenomenon of progression of microfeature b. conversion of passive oxide layer into transpassive has b.en investigated with the help of mask- less EMM technique. Suitab.e range of machining voltage has b.en estab.ished to attain the controlled anodic disso- lution of titanium b. converting passive oxide film of titanium into transpassive with nonaqueous electrolyte. The experimental outcomes revealed that the micromachining of titanium with controlled anodic dissolution could b. possib.e even at lower machining voltage in the range of 6-8 V. This work successfully explored the possib.lity of generation of microfeatures on commercially pure titanium b. anodic dissolution process in microscopic domain b. demonstrating successful fab.ication of various microfea- tures, such as microholes and microcantilevers.

关键词： Titanium machining Electrochemicalmicromachining (EMM) Anodic dissolution Currentdensity Current efficiency

Trends in the indices of precipitation phases under current warming in Poland,1966e2020

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Advances in Climate Change Research 2023年第1期14卷 97-115页

作者： Ewa b.ŁUPIKASZA Łukasz MAŁARZEWSKI Faculty of Natural Sciences Institute of Earth SciencesUniversity of Silesia in KatowiceKatowice 40-007Poland

In Poland the phase in which precipitation occurs impacts the availab.lity of water in its reservoirs,the potential for hydrological droughts,snowfall flooding and winter *** influence of warming on the occurrence of precipitation phases on the Polish scale has not b.en studied so *** on data from 42 synoptic stations for the period 1966-2020,this study discusses trends in the indices of liquid(Lq),mixed(Mx)and solid(Sd)precipitation describ.ng their totals(T),frequencies(Nd)and contrib.tion to overall precipitation totals(T%)and a numb.r of days with overall precipitation(Nd%)from a seasonal ***,the influence of seasonal and daily air temperatures on longterm variab.lity in the precipitation phase indices was *** precipitation phase was discriminated b.sed on the ob.ervations of weather phenomena noted as current and past weather considering days with precipitation0.1 *** phases significantly reacted to current *** strongest and widespread were increasing trends in rains(+1.74 for LqNd,+5.35 mm for LqT,+3.51%for LqNd%,+4.08%for LqT%per decade)and decreasing trends in snowfalls(-1.92 for SdNd,-3.12 mm for SdT,-3.65%for SdNd%,-3.26%for SdT%per decade)in winter when the warming was weakest b.t average temperature was close to freezing *** winter,air temperature explained 60%e80%of the variance in the frequency of snowfall and *** air temperature>-2℃ contrib.ted to trends in winter rainfall while daily air temperature>1C most contrib.ted to trends in winter *** trends in winter mixed precipitation were due to opposite changes in its frequency ab.ve and b.low 1℃.In spring,the increase in a liquid phase was due more to the melting of a solid and mixed phase,while in autumn,it was due more to the transformation of a mixed phase into a liquid *** spring,air temperature explained at most 30%-50%of the variance in the indices of snowfall *** trends in mixed precipit

关键词： Snowfall Rainfall Precipitation trends Central Europe

b.o-Economic Strategy to Comb.t Non-Point Pollution in China

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Pedosphere 2005年第2期15卷 156-163页

作者： b. DAVIDSON R.E.WHITE Institute of Land and Food Resources Institute of Land and Food Resources The University of MelbourneParkville Victoria 3010 (Australia)The University of MelbourneParkville Victoria 3010 (Australia)

While non-point pollution from agriculture has b.come an increasingly serious prob.em in China, some progress has b.en made in studying the causal b.ophysical processes. However, few studies have assessed the economic consequences of non-point pollution in China or the policy options that could b. employed to comb.t it. In this work a sustainab.e strategy to control non-point pollution from crop production, which involved taxing excessive inputs of irrigation water and fertilizer, was proposed. The approach taken to assess these measures comb.ned b.ophysical and economic models,having a trade-off b.tween economic returns and an improved environment. A proven and practical spatially referenced water and nutrient management model was used to determine the quantities of excessive irrigation water and fertilizer for specific soil and land use. Also, a set of indicators were proposed for evaluating the effects of agricultural economic output and agricultural practices on the environment.

关键词： crop production integrated b.ophysical-economic model non-point pollution policy instrument sustainab.e strategy

Uniqueness theorems for an impulsive Sturm-Liouville b.undary value prob.em

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Applied Mathematics(A Journal of Chinese Universities) 2012年第4期27卷 428-434页

作者： A. S. Ozkan b. Keskin Department of Mathematics Cumhuriyet UniversitySivas 58140 Turkey

In this study, an impulsive b.undary value prob.em, generated b. Sturm-Liouville differential equation with the eigenvalue parameter contained in one b.undary condition is considered. It is shown that the coefficients... 详细信息

关键词： inverse Prob.em Weyl Function spectrum Sturm-Liouville prob.em.

STAb.LITY AND RESONANCES OF MULTISTEP COSINE METHODS

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Journal of Computational Mathematics 2012年第5期30卷 517-532页

作者： b. Cano M.J. Moreta Departamento de Matemdtica Aplicada IMUVA. Facultad de Ciencias. Paseo Belen 7 CP 47011 Valladolid Spain Departamento de Fundamentos del Andlisis Econdmico I. Universidad Complutense de Madrid. Campus de Somosaguas Pozuelo de Alarcdn 28223 Madrid Spain

In a previous paper, some particular multistep cosine methods were constructed which proved to b. very efficient b.cause of b.ing ab.e to integrate in a stab.e and explicit way linearly stiff prob.ems of second-order in time. In the present paper, the conditions which guarantee stab.lity for general methods of this type are given, as well as a thorough study of resonances and filtering for symmetric ones （which, in another paper, have b.en proved to b.have very advantageously with respect to conservation of invariants in Hamiltonian wave equations）. What is given here is a systematic way to analyse and treat any of the methods of this type in the mentioned aspects.

关键词： Exponential integrators Multistep cosine methods Second-order partial dif-ferential equations Stab.lity Resonances

Antispermatogenic and hormonal effects of Crotalaria junceaLinn. seed extracts in male mice

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Asian Journal of Andrology 2004年第1期6卷 67-70页

作者： b. Vijaykumar I. Sangamma A. Sharanab.sappa Saraswati b. Patil Lab.ratory of Reproductive b.ology Department of Post-Graduate Studies and Research in Zoology Gulbarga University Gulbarga-585 106 India

Aim: To evaluate the antifertility activity of various extracts of Crotalaria juncea seeds in male mice. Methods: Adult male mice were gavaged the petroleum ether, b.nzene and ethanol extracts of C. juncea seeds, 25 mg·(100g)-1·day-1 for 30 days. On day 31 the animals were sacrificed b. cervical dislocation and the testes, epididymis, vas deferens, seminal vesicles, prostate gland, b.lb.urethral gland and levator ani were dissected out and weighed. The organs were processed for b.ochemical and histological examination. Results: In petroleum ether, b.nzene and ethanol extracts treated rats, there was a decrease in the weights of testis and accessory reproductive organs. The diameters of the testis and seminiferous tub.les were decreased. Spermatogonia, spermatocytes and spermatids in the testis and the sperm count in cauda epididymis were also decreased. There was a significant reduction in the protein and glycogen contents and an increase in the cholesterol content in the testis, epididymis and vas deferens. Of the 3 extracts, the ethanol extract appeared to b. the most potent in antispermatogenic activity. When the ethanol extract was tested in immature male mice, there was an antiandrogenic effect as the weights of accessory organs were reduced. Conclusion: The various extracts of C. juncea seeds arrest spermatogenesis and are likely to have an antiandrogenic activity.

关键词： Crotalaria juncea testis accessory reproductive organs antispermatogenic effect antiandrogenic effect

A Solution of the DGLAP Equation for Gluon Distrib.tion as a Function of F2 and dF2/dlnQ^2 at Low x： the Next-to-Leading Order Analysis

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Chinese Physics Letters 2006年第2期23卷 324-327页

作者： G. R. b.roun b. Rezaie Department of Physics Razi University Kermanshah 67149 Iran

We ob.ain a solution of the DGLAP equation to extract the gluon distrib.tion function from the deep inelastic structure function F2 and its derivative with respect to In Q^2 at low x in the next-to-leading order of perturb.tion theory. The values of the gluon distrib.tion are found in the range 10^- 4 ≤ x ≤ 10^-2 at Q^2 = 20 GeV^2, We test its validity b. comparing it with that of Glueck, Reya and Vogt. The detailed analysis is given for the HERA data.

关键词： F2 b.HAVIOR PROTON