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RapidET:a MEMS-based platform for label-free and rapid demarcation of tumors from normal breast biopsy tissues

Microsystems & Nanoengineering 2022年第1期8卷 123-138页

作者： Anil Vishnu G.K Gayatri Gogoi Bhagaban Behera Saeed Rila Annapoorni Rangarajan hardik j.pandya Center for BioSystems Science and Engineering Indian Institute of ScienceBangaloreKarnatakaIndia Department of Pathology Assam Medical CollegeDibrugarhAssamIndia Department of Electronic Systems Engineering Indian Institute of ScienceBangaloreKarnatakaIndia Department of Molecular Reproduction Developmentand GeneticsIndian Institute of ScienceBangaloreKarnatakaIndia Centre for Product Design and Manufacturing Indian Institute of ScienceBangaloreKarnatakaIndia

The rapid and label-free diagnosis of malignancies in ex vivo breast biopsy tissues has significant utility in pathology laboratories and operating *** report a MEMS-based platform integrated with microchips that performs phenotyping of breast biopsy tissues using electrothermal *** microchip,fabricated on a silicon substrate,incorporates a platinum microheater,interdigitated electrodes(IDEs),and resistance temperature detectors(RTDs)as on-chip sensing *** microchips are integrated onto the platform using a slide-fit contact enabling quick replacement for biological *** bulk resistivity(ρB),surface resistivity(ρS),and thermal conductivity(k)of deparaffinized and formalin-fixed paired tumor and adjacent normal breast biopsy samples from N=8 patients were *** formalin-fixed samples,the meanρB for tumors showed a statistically significant fold change of 4.42(P=0.014)when the tissue was heated from 25°C to 37°C compared to the adjacent normal tissue,which showed a fold change of *** meanρS measurements also showed a similar *** mean k of the formalinfixed tumor tissues was 0.309±0.02Wm^(-1)K^(-1)compared to a significantly higher k of 0.563±0.028 Wm^(-1)K^(-1)for the adjacent normal tissues.A similar trend was observed inρB,ρS,and k for the deparaffinized tissue *** analysis of a combination ofρ_(B,)ρ_(S,)and k using Fisher’s combined probability test and linear regression suggests the advantage of using all three parameters simultaneously for distinguishing tumors from adjacent normal tissues with higher statistical significance.

关键词： biopsy breast resistivity

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Oldest Asian Record of Snapping Shrimps(Malacostraca:Alpheidae)from the Kutch Basin,Western India and Associated Biota:Biostratigraphic,Paleoenvironmental and Paleoecological Significance

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Acta Geologica Sinica(English Edition) 2022年第6期96卷 1867-1883页

作者： Vivesh V.KAPUR Kamlesh KUMAR Pranav j.pandya Amit KGHOSH Arindam CHAKRABORTY Anupam SHARMA Gaurav CHAUHAN M.G.THAKKAR Birbal Sahni Institute of Palaeosciences 53University RoadLucknow 226007India Department of Biology Shri R.R.Lalan CollegeBhujKachchh DistrictGujaratIndia Institute of Earth Sciences Academia SinicaTaipeiTaiwan 11529China Department of Earth and Environmental Science K.S.K.V.Kachchh UniversityBhujKachchh DistrictGujaratIndia

The oldest Asian record of alpheid shrimps,assigned to genus Alpheus,based on snapping claw fingertips from the Miocene Khari Nadi Formation in the Kutch Basin,western India reported herein,extends the fossil record of the family Alpheidae from Asia by~22 million *** early Miocene(Aquitanian)age is estimated based on the associated assemblage of calcareous nannofossils,Sphenolithus disbelemnos,Cyclicargolithus floridanus,and Reticulofenestra *** co-occurring microbiota includes bony fish otolith remains,identified as“genus Gobiidarum”,isolated teeth of Dasyatis rays,Sphyrna sharks,and teleosts,ctenoid and placoid scales,ostracods,belonging to the genera Paractinocythereis,Alocopocythere,Ruggieria,Aglaiocypris,Bairdoppilata,and echinoid *** together,the microfossil assemblage and data from chemical analyses using Energy Dispersive Spectroscopy,X-Ray Diffraction and Wavelength Dispersive X-Ray Fluorescence of host and associated lithologies suggests prevalence of a shallow(neritic)to coastal marine(intertidal)depositional *** present investigation also provides the oldest fossil evidence on the co-occurrence of Alpheus and gobiids(based on otoliths)that strongly advocates that the mutualistic association between these animal groups had developed by the Aquitanian.

关键词： biostratigraphy Crustacea Caridea Elasmobranchs Gobiidae invertebrate and vertebrate paleontology nannofossils Oligocene-Miocene Indian subcontinent

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Radiofrequency ablation of pancreatic ductal adenocarcinoma:The past,the present and the future

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World journal of Gastrointestinal Oncology 2015年第2期7卷 6-11页

作者： Garvi j.pandya Vishal G Shelat Medicine Ministry of Health Holdings Pte LtdSingapore 308433 Singapore Division of Hepato-pancreatico-biliary Surgery Tan Tock Seng HospitalSingapore 308433Singapore

Pancreatic ductal adenocarcinoma(PDAC)is one of the most aggressive cancers with a grim overall 5-year survival rate of 5%.Advances in surgical techniques,critical care,molecular diagnosis,diagnostic imaging,endosonology and adjuvant therapy have improved outcomes;but still more needs to be *** is an urgent need to discover new avenues that may impact *** ablation(RFA)has attracted attention as an adjunctive treatment in PDAC.A review of English literature in Pub Med was done using the MESH terms for PDAC and *** the articles were reviewed and core information was tabulated for *** a comprehensive review of all articles the data was evaluated to discover the role of RFA in PDAC ***,contraindications,feasibility,success rate,safety,complications and impact on survival were reviewed and are discussed *** appears to be an attractive option for nonmetastatic locally advanced *** is feasible but has a significant *** the present time the integration of RFA into the management of pancreatic ductal adenocarcinoma is *** should be considered as having a complimentary role to current standard therapy in the multimodal management care *** is likely that indications and patient selection for pancreatic RFA will expand.

关键词： Pancreatic cancer Radiofrequency ablation

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An efficient technique for solving fractional-order diffusion equations arising in oil pollution

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journal of Ocean Engineering and Science 2023年第3期8卷 217-225页

作者： hardik Patel Trushit Patel Dhiren Pandit Department of Mathematics Uka Tarsadia UniversityBardoliGujaratIndia Computer Science University of the PeoplePasadenaCA 91101United States Department of Mathematics and Humanities Nirma UniversityAhmedabadIndia

In this article,non-linear time-fractional diffusion equations are considered to describe oil pollution in the *** latest technique,fractional reduced differential transform method(FRDTM),is used to ac-quire approximate solutions of the time fractional-order diffusion equation and two cases of Allen-Cahn *** acquired results are collated with the exact solutions and other results from literature for integer-orderα,which reveal that the proposed method is ***,FRDTM can be employed to obtain solutions for different types of nonlinear fractional-order IVPs arising in engineering and science.

关键词： FRDTM Time-fractional nonlinear partial differential equation Diffusion equation Allen-Cahn(AC)equation Parabolic equations

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Tsunami wave propagation model:A fractional approach

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journal of Ocean Engineering and Science 2022年第6期7卷 509-520页

作者： Priti Tandel hardik Patel Trushit Patel Department of Mathematics Veer Narmad South Gujarat UniversitySuratGujaratIndia Department of Mathematics Uka Tarsadia UniversityBardoliGujaratIndia Department of Mathematics Veermata Jijabai Technological InstituteMumbaiIndia

This paper presents a fractional approach to study the mathematical model of tsunami wave propagation along a coastline of an *** Reduced Differential Transform Method(FRDTM)is used to analyze this *** present model has been studied on the shallow-water *** is represented by a time-fractional coupled system of non-linear partial differential *** to the proposed model for different coastal slopes and ocean depths have been *** of coast slope and sea depth variations on tsunami wave velocity and wave amplification have been demonstrated at different time levels and different ordersα.The obtained results are compared with Elzaki Adomian Decomposition Method(EADM)to validate the proposed method for an orderα=1.

关键词： Tsunami wave Shallow water Time-fractional coupled system of partial differential equations Fractional reduced differential transform method(FRDTM)

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Analytical study of atmospheric internal waves model with fractional approach

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journal of Ocean Engineering and Science 2024年第4期9卷 326-337页

作者： Trushit Patel hardik Patel Ramakanta Meher Computer Science University of the PeoplePasadenaCA 91101United States Department of Mathematics Uka Tarsadia UniversityBardoliGujaratIndia Mathematics and Humanities Department Sardar Vallabhbhai National Institute of TechnologySuratGujaratIndia

This study looks at the mathematical model of internal atmospheric waves,often known as gravity waves,occurring inside a fluid rather than on the *** the shallow-fluid assumption,internal atmospheric waves may be described by a nonlinear partial differential equation *** shallow flow model’s primary concept is that the waves are spread out across a large horizontal area before rising *** Fractional Reduced Differential Transform Method(FRDTM)is applied to provide approximate solutions for any given *** aids in the modelling of the global atmosphere,which has applications in weather and climate *** the integer-order value(α=1),the FRDTM solution is compared to the precise solution,EADM,and HAM to assess the correctness and efficacy of the proposed technique.

关键词： Shallow-fluid equations Atmospheric internal waves Time-fractional partial differential equations Fractional reduced differential transform method(FRDTM) Climate prediction

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Integration of evacuated solar collectors with an adsorptive ice maker for hot climate region

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Energy and Built Environment 2022年第2期3卷 181-189页

作者： Nishant Modi Bhargav pandya College of Sciences and Engineering University of TasmaniaTasmaniaAustralia School of Chemical Engineering University of BirminghamBirminghamUnited Kingdom

This research study compares the steady-state and dynamic behaviour of a solar-powered activated carbon-35(AC35)/methanol-based vapour adsorption refrigeration system for production of ice at hot climate ***-modynamic comparisons are made with the coefficient of performance(COP),system COP(SCOP),specific refrig-eration capacity(SRC)and critical parameters such as cycle time and ice production rate are ***,the sustainability of the proposed ice maker has proven by integrating economic and environmental *** minimum solar flux required to ensure continuous ice production was found 800 W/m^(2).Moreover,the max-imum ice production rate and COP were decreased by 32.36%and 37.63%respectively when the system was operated under real ambient *** proposed solar adsorptive ice maker achieved maximum SRC of 61.6 g m^(−2)during April month and reduced the CO_(2)emissions by 12.82 ton annually.

关键词： Solar cooling system Adsorption refrigeration cycle Ice production rate Activated carbon-35(AC35)/Methanol GHG emissions Simple payback period

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Decay rates and electromagnetic transitions of heavy quarkonia

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Chinese Physics C 2015年第12期39卷 19-24页

作者： j.N.pandya N.R.Soni N.Devlani A.K.Rai Applied Physics Department Faculty of Technology & Engineeringthe M S University of Baroda Applied Physics Department Polytechnicthe M S University of Baroda Department of Applied Physics Sardar Vallabhbhai National Institute of Technology

The electromagnetic radiative transition widths for heavy quarkonia, as well as digamma and digluon decay widths, are computed in the framework of the extended harmonic confinement model （ERHM） and Coulomb plus power potential （CPP,） with varying potential index v. The outcome is compared with the values obtained from other theoretical models and experimental results. While the mass spectra, digamma and digluon widths from ERHM as well as CPP v=1 are in good agreement with experimental data, the electromagnetic transition widths span over a wide range for the potential models considered here making it difficult to prefer a particular model over the others because of the lack of experimental data for most transition widths.

关键词： heavy quarkonia radiative decays electromagnetic transitions

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Is myopia a protective factor against central serous chorioretinopathy?

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International journal of Ophthalmology(English edition) 2016年第2期9卷 266-270页

作者： George j.Manayath Saurabh Arora hardik Parikh Parag K.Shah Sarvesh Tiwari Venkatapathy Narendran Department of Retina and Ocular Oncology Aravind Eye Hospital

AIM： To evaluate if any association exists between central serous chorioretinopathy （CSCR） and the refractive status of the eye. METHODS： This retrospective, institutional, case control study included 499 patients, wherein 262 patients diagnosed as acute CSCR, were compared with an age and gender matched control group of 237 patients. All patients were evaluated with a detailed systemic and ocular history, objective and subjective refractions for both eyes and complete ocular examination by a retina specialist, at all visits. Optical coherence tomography confirmed the diagnosis of CSCR. ~ RESULTS： The mean age was found to be 40.7y in the study group （Group 1） compared to 38 10y in the control group （Group 2）. Most common refractive status in the study group, was emmetropia seen in 191 patients （72.9%）, followed by hypermetropia seen in 47 patients （17.9%） and astigmatism seen in 21 patients （8.0%）. Only 3 subjects （1.1%） had myopia, which was less than or equal to 1.0 D, compared to 70 subjects （29.5%） in the control group, suggesting a statistically significant lower incidence of CSCR among the myopic patients （P〈 0.0001）. With respect to the systemic factors, 26 （9.9%） patients were using systemic steroids in the study group （Group 1） compared to none in the control group （Group 2） suggesting a statistically significant association of CSCR with systemic steroid use （P〈0.05）. No other significant systemic risk factors were noted. CONCLUSION： Though CSCR is a multifactorial disease, myopia serves as a protective factor for CSCR. Thus, myopic eyes are less likely to develop CSCR. Since both retinal pigment epithelium （RPE） and choriocapillaris are postulated in the pathogenesis of CSCR, chorio-retinal thinning and atrophy seen in myopic eyes are less likely to cause CSCR.

关键词： central serous chorioretinopathy refractivestatus myopia

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PS-TBD triggered general protocol for the synthesis of 4H-chromene,pyrano[4,3-b]pyran and pyrano[3,2-c]chromene derivatives of 1H-pyrazole and their biological activities

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Chinese Chemical Letters 2016年第1期27卷 168-172页

作者： Nileshkumar D.Vala hardik H.jardosh Manish P.Patel Department of Chemistrty Sardar Patel University Vallabh Vidyanagar 388120 India

A general protocol has been developed for the facile construction of titled derivatives via three component reaction between 3-substituted phenyl-1H-pyrazole-4-carbaldehyde, malononitrile and various Michael donors in presence of 5 mol% polystyrene supported 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene（PS-TBD）. PS-TBD was reused for at least five runs with nearly constant catalytic activity. All compounds were screened for antimicrobial and antioxidant activities.

关键词： PS-TBD 1H-Pyrazole Antimicrobial activity Antioxidant activity

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