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Rapid,simple and stability-indicating determination of polyhexamethylene biguanide in liquid and gel-like dosage forms by liquid chromatography with diode-array detection

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Journal of Pharmaceutical Analysis 2013年第6期3卷 408-414页

作者： Markus Küsters Soren Beyer Stephan Kutscher harald Schlesinger Michael Gerhartz Central Hospital of the German Federal Armed Forces Koblenz Pharmacy Section Central Institute of the German Federal Armed Forces Koblenz Laboratory Department of Food and Environmental Chemistry

A rapid and simple method for the determination of potyhexamethylene biguanide （polyhexanide, PHMB） in liquid and gel-like pharmaceutical formulations by means of high performance liquid chromatography coupled to diode-array detection （HPLC DAD） was devel- oped. Best separation was achieved using a cyanopropyl bonded phase （Agilent Zorbax Eclipse XDB-CN column 4.6mm x 75 mm with particle size of 3.5 μm） as well as gradient elution consisting of acetonitrile/deionized water at a flow rate of 1.0 mL/min. The optimized and applied chromatographic conditions permitted separation of polyhexanide from interacting raatrix with subsequent detection at a wavelength of 235 nm with good sensitivity. The method validation was carried out with regard to the guidelines for analytical procedures demanded by the International Conference on Harmonisation （ICH）. Mean recoveries of 102% and 101% for gel-like as well as liquid preparations were obtained. Suitable repeatability as well as intermediate precision could bc achieved with limits of detection ≤0.004 mg/mL for both formulations, equivalent to ≤0.004% PHMB concerning sample preparation. Determination of PHMB was accomplished without tedious sample preparation. Interacting matrix could be eliminated by the chromatographicprocedure with excellent performance of system suitability. All analytical requirements were fulfilled permitting a reliable and precise determination of PHMB in pharmaceuticals. Further- more, the developed method was applied to stability testing of pharmaceutical preparations containing PHMB.

关键词： Polyhexamethylene biguanide Polyhexanide Pharmaceuticals High performance liquid chromatography

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COVID-19:Masks do not influence neurocognitive performance during a shift at the emergency department

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World Journal of Emergency Medicine 2023年第4期14卷 317-321页

作者： Jürgen Grafeneder Verena Fuhrmann Katharina Tscherny Maximilian Niederer Wolfgang Schreiber harald Herkner Dominik Roth Calvin Lukas Kienbacher Department of Emergency Medicine Medical University of ViennaWien 1090Austria Department of Anaesthesiology and Intensive Care Hospital ScheibbsScheibbs 3270Austria

The COVID-19 pandemic has led to the widespread mandatory use of personal protective equipment(PPE),including filtering face pieces(FFP).Emergency medical care providers now commonly use this equipment.

关键词： COV Mask protective

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Golimumab in real-world practice in patients with ulcerative colitis:Twelve-month results

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World Journal of Gastroenterology 2020年第21期26卷 2852-2863页

作者： Niels Teich harald Grümmer Eric Jorgensen Thomas Liceni Frank Holtkamp-Endemann Tim Fischer Susanne Hohenberger Internistische Gemeinschaftspraxis für Verdauungs-und Stoffwechselkrankheiten Leipzig und Schkeuditz Leipzig 04105Germany Praxis für Innere Medizin/Gastroenterologie Potsdam 14471Germany Magen-Darm-Zentrum Remscheid Remscheid 42859Germany MVZ für Gastroenterologie am Bayerischen Platz Berlin 10825Germany Gastroenterologische Gemeinschaftspraxis am Germania-Campus Münster 48159Germany Medical Affairs MSD Sharp and Dohme GmbHHaar 85540Germany

BACKGROUND The introduction of biologics has revolutionized the management of the chronic inflammatory bowel disease,ulcerative colitis(UC),with many patients experiencing significant improvements not only in their symptoms but in other outcomes relevant to individuals and society as a *** Germany,there are no prospective data>3 mo that assess the work productivity,daily activities and quality of life(QoL)of patients with moderate-to-severe UC treated with *** To assess change in work productivity,capacity for daily activities and QoL in UC patients treated with golimumab in *** The validated Work Productivity Activity Impairment(WPAI)Questionnaire was used to analyze the change in work productivity,the capacity for daily activities after three months(primary endpoint)and disease specific and health related QoL(HRQoL)up to 1 year(secondary endpoints).The changes in work productivity and activity impairment were evaluated every three months until month twelve compared to ***-specific and health-related QoL were assessed with the inflammatory bowel disease questionnaire and with the short-form 12 health survey questionnaire(SF-12).RESULTS This prospective non-interventional study included 287 *** analysis population was comprised of 282 patients who had completed at least two *** baseline,61%of patients had moderate UC and 18%had severe ***,75%of patients worked full-time or part-time at baseline.A total of 212 patients who were employed at the start of the study(employed population)were evaluated for the primary *** significantly reduced all WPAI sub-scores compared to baseline after three,six,nine and twelve months after the start of treatment(P<0.0001).In addition,disease-specific QoL and HRQoL,as measured by the SF-12 questionnaire,improved significantly with golimumab at all evaluation times(P<0.0001 in each case vs baseline).CONCLUSION Treatment of moderate-to-severe UC with golimum

关键词： Ulcerative colitis Quality of life Work productivity Non-interventional study Golimumab Work Productivity Activity Impairment(WPAI)Questionnaire

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Abnormal Savda Syndrome:Long-Term Consequences of Emotional and Physical Stress on Endocrine and Immune Activities in An Animal Model

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Chinese Journal of Integrative Medicine 2013年第8期19卷 603-609页

作者：阿地里江.阿布力米提 harald Khnel Alois Strasser 哈木拉提.吾甫 Xinjiang Medical University Department of Biomedical Sciences Institute of PhysiologyUniversity of Veterinary Medicine Vienna

Objective： To investigate the relationship between emotional status, cold-dry environment and long-term immune responses to the stressors, and the potential pathological mechanisms between causative factors of abnormal Savda syndrome （ASS） and the susceptibility to disease; thus to clarify the ASS, and secondly to identify the optimal ASS animal model for further studies on traditional Uighur therapeutical formulations. Methods： Sixty mice were randomly and equally divided into 4 groups： control and 3 stress groups. The cold-dry environment was applied by keeping the mice in a climatic chamber. The emotional stress was induced by the application of the repeated electric foot-shocks in the electric foot-shock apparatus. The mice of the combined stress group underwent the repeated electric foot-shock treatment before being housed in the climatic chamber. The experimental routine was repeated for 21 days. In order to look into endocrine and immune stress responses, ELISA was used to determine the serum levels of the hormones corticotropin- releasing hormone （CRH）, adrenocorticotropic hormone （ACTH）, Beta-endorphin （13-END） and corticosterone （CORT）, of the cytokines interleukin 2 （IL-2）, interleukin 6 （IL-6）, interferon-gamma （INF- ~/） and tumor necrosis factor-alpha （TNF-or）, and of the immunoglobulins immunoglobulin A （IgA）, immunoglobulin M （IgM） and immunoglobulin G （IgG）. Lymphocyte subsets were analyzed in duplicate in order to determine differences in the T cell ratio. Results： In the cold-dry environment group, the serum levels of CRH, ACTH and CORT were significantly higher than those of the control group, whereas serum 13 -END was not found significantly different. In both the repeated electric foot-shock group as well as in the combined stress group the serum levels of CRH, ACTH, 13 -END and CORT were significantly higher. Compared to the control animals, the serum concentration of INF-,y was significantly lower in all three different stress groups. The seru

关键词： abnormal Savda syndrome endocrine and immune activites traditional uighur medicine

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Different typologies of workplace conflict and their connections with post traumatic embitterment disorder (PTED)

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Health 2010年第3期2卷 234-236页

作者： harald Ege Università Politecnica delle Marche Ancona Italy

Reported is an empirical study which shows that Post-Traumatic Embitterment Disorder (PTED) is the most appropriate psychological diagnosis for victims of workplace conflicts, particularly bullying. A group of 118 people all reporting conflict at work were evaluated with the LIPT questionnaire, the PTED self-rating scale and a guided psychological interview. 91.5% proved to be affected by a PTED, the slight majority males, aged between 31 and 40 years and subjected to bullying. The evidence suggests that some workplace conflict victims who are presently diagnosed and treated as depression or phobia can be in fact cases of PTED. The treatment may be adjusted and the PTED scale may be used as a screening in-strument similar to scales for anxiety and depressive disorders.

关键词： Workplace Conflict PTED Bullying Straining

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Earth orientation parameters from VLBI determined with a Kalman filter

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Geodesy and Geodynamics 2017年第6期8卷 396-407页

作者： Maria Karbon Benedikt Soja Tobias Nilsson Zhiguo Deng Robert Heinkelmann harald Schuh GFZ German Research Centre for Geosciences Telegrafenherg A 17 Potsdam Germany Jet Propulsion Laboratory California Institute of Technology Pasadena CA USA Technical University of Berlin Strafe des 17. Juni 135 Berlin Germany

This paper introduces the reader to our Kalman filter developed for geodetic VLBI（very long baseline interferometry） data analysis. The focus lies on the EOP（Earth Orientation Parameter） determination based on the Continuous VLBI Campaign 2014（CONT14） data, but also earlier CONT campaigns are analyzed. For validation and comparison purposes we use EOP determined with the classical LSM（least squares method） estimated from the same VLBI data set as the Kalman solution with a daily resolution. To gain higher resolved EOP from LSM we run solutions which yield hourly estimates for polar motion and dUTl = Universal Time（UT1）-Coordinated Universal Time（UTC）. As an external validation data set we use a GPS（Global Positioning System） solution providing hourly polar motion ***, we describe our approach for determining the noise driving the Kalman filter. It has to be chosen carefully, since it can lead to a significant degradation of the results. We illustrate this issue in context with the de-correlation of polar motion and ***, we find that the agreement with respect to GPS can be improved by up to 50% using our filter compared to the LSM approach, reaching a similar precision than the GPS solution. Especially the power of erroneous high-frequency signals can be reduced dramatically, opening up new possibilities for highfrequency EOP studies and investigations of the models involved in VLBI data *** prove that the Kalman filter is more than on par with the classical least squares method and that it is a valuable alternative, especially on the advent of the VLBI2010 Global Observing System and within the GGOS frame work.

关键词： VLBI Earth rotation CONT14 Kalman filter Data analysis Least squares GPS

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JPEG2000在空间太阳望远镜中的改进应用(英文)

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北京大学学报（自然科学版） 2006年第3期42卷 366-370页

作者：谢华 harald MICHALIK 金声震艾国祥北京大学天文系中科院国家天文台北京100012 德国布伦瑞克技术大学计算机通信网络工程研究所布伦瑞克38106

对JPEG2000算法提出了一种新的改进,以提高它的编码效率。通过修改编码顺序,使得在每个Tile中,数据按照其重要性降序编码。从而,码流截断方法也随之简化,并可以提前终止编码,而率失真效果仍接近最优。最后,给出一个可行的并行化方案,可... 详细信息

对JPEG2000算法提出了一种新的改进,以提高它的编码效率。通过修改编码顺序,使得在每个Tile中,数据按照其重要性降序编码。从而,码流截断方法也随之简化,并可以提前终止编码,而率失真效果仍接近最优。最后,给出一个可行的并行化方案,可大大缩短运行时间。改进后的JPEG2000更适用于计算资源有限的星上系统,满足了空间太阳望远镜的压缩需求。

关键词：天文图像压缩信噪比率控制并行

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Remote sensing ionospheric variations due to total solar eclipse, using GNSS observations

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Geodesy and Geodynamics 2020年第3期11卷 202-210页

作者： Mohamad Mahdi Alizadeh harald Schuh Saeed Zare Sahar Sobhkhiz-Miandehi Lung-Chih Tsai Dept.of Geodesy and Geomatics Eng. K.N.Toosi University of TechnologyTehranIran Inst.of Geodesy and Geoinformation Science Technical University of BerlinBerlinGermany Dept.1:Geodesy GFZ German Research Center for GeosciencesPotsdamGermany Center for Space and Remote Sensing Research National Central UniversityChung-LiTaiwanChina GPS Application and Research Center National Central UniversityChung-LiTaiwanChina

For years great interest has been taken in the effects of physical phenomena on ionosphere structure. A total solar eclipse was visible in North America on August 21 st, 2017. This event offered a great opportunity for remote sensing the ionospheric behavior under the eclipse condition. In this study we investigated the effects of total solar eclipse on variations of Total Electron Content(TEC), and consequently deviations on regional models of Vertical TEC(VTEC), as well as variations in ionospheric scintillation occurrence. Although variations of TEC due to total solar eclipse are studied thoroughly by many authors, but the effect of solar eclipse on ionospheric scintillation has never been considered before. Our study is based on measurements from a high-rate GPS network over North America on the day of eclipse, a day before and after its occurrence, on the other hand, GPS measurements from groundbased stations on similar days were used to model TEC on the day of event, and also one day before and after it. The results of this study demonstrate that solar eclipse reduced scintillation occurrence at the totality region up to 28 percent and TEC values showed a decrease of maximum 7 TECU. Considering TEC models, our study showed apparent variations in the regional models, which confirms previous studies on ionospheric responses to eclipse as well as theoretical assumptions.

关键词： Ionosphere Solar eclipse Remote sensing Ionospheric scintillation Total electron content GPS measurements

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欧共体反倾销制度的突出特点

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国际经贸探索 2008年第4期24卷 80-84页

作者： harald Wenig 吕航欧委会贸易总司贸易救济服务司吉林大学经济学院吉林长春130012

译文首先从制度控制层面的角度介绍欧共体反倾销制度,认为欧同体反倾销措施受到了反倾销委员会、欧洲初审法院和欧洲法院以及WTO争端解决机制三个层面有效控制;其次专门介绍了公共利益评估和从低征税这两个"超WTO"规则;最后介绍了欧同... 详细信息

译文首先从制度控制层面的角度介绍欧共体反倾销制度,认为欧同体反倾销措施受到了反倾销委员会、欧洲初审法院和欧洲法院以及WTO争端解决机制三个层面有效控制;其次专门介绍了公共利益评估和从低征税这两个"超WTO"规则;最后介绍了欧同体对非市场经济和转型经济的实践。欧共体反倾销制度有效地平衡当事方利益,是较为成功的制度。

关键词：欧共体反倾销突出特点

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Organic photovoltaics for simultaneous energy harvesting and high-speed MIMO optical wireless communications

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Light(Science & Applications) 2021年第3期10卷 379-389页

作者： Iman Tavakkolnia Lethy K.Jagadamma Rui Bian Pavlos P.Manousiadis Stefan Videv Graham A.Turnbull Ifor D.W.Samuel harald Haas LiFi Research and Development Centre Department of Elearonic&Electrical EngineeringThe University of StrathclydeTechnology&Innovation Centre99 George StreetGlasgow G11RDUK Organic Semiconductor Centre SUPASchool of Physics and AstronomyUniversity of St AndrewsSt Andrews KY169SSUK pureLiFi Rosebery House9 Haymarket TerraceEdinburgh EH125EZUK

We show that organic photovoltaics(OPVs)are suitable for high-speed optical wireless data receivers that can also harvest *** addition,these OPVs are of particular interest for indoor applications,as their bandgap is larger than that of silicon,leading to better matching to the spectrum of artificial *** selecting a suitable combination of a narrow bandgap donor polymer and a nonfullerene acceptor,stable OPVs are fabricated with a power conversion efficiency of 8.8%under 1 Sun and 14%under indoor lighting *** an optical wireless communication experiment,a data rate of 363 Mb/s and a simultaneous harvested power of 10.9 mW are achieved in a 4-by-4 multipleinput multiple-output(MIMO)setup that consists of four laser diodes,each transmitting 56 mW optical power and four OPV cells on a single panel as receivers at a distance of 40 *** result is the highest reported data rate using OPVs as data receivers and energy *** finding may be relevant to future mobile communication applications because it enables enhanced wireless data communication performance while prolonging the battery life in a mobile device.

关键词： MIMO simultaneous lighting

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