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鸡对马立克氏病病毒免疫应答的转录组和蛋白质组研究

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中国家禽 2011年第18期33卷 5-11页

作者： K.haq J.T.Brisbin N.Thanthrige-Don M.Heidari s.sharif 钟雷加拿大圭尔夫大学安大略兽医学院美国农业部禽病和肿瘤学研究所

近年来兴起的病毒基因组或部分目的基因以及蛋白表达分析技术,为人们更好地认识宿主对马立克氏病病毒(MDV)的免疫应答机制提供了有利帮助。本文主要综述了从转录组学和蛋白质组学开展的有关MDV致病机理、宿主对MDV反应、MD遗传抗性或易... 详细信息

近年来兴起的病毒基因组或部分目的基因以及蛋白表达分析技术,为人们更好地认识宿主对马立克氏病病毒(MDV)的免疫应答机制提供了有利帮助。本文主要综述了从转录组学和蛋白质组学开展的有关MDV致病机理、宿主对MDV反应、MD遗传抗性或易感性以及疫苗诱导的免疫反应等方面的最新研究进展,并讨论了应用miRNA以及RNAi技术对基因、蛋白和信号通路在MDV与宿主相互作用中发挥重要作用的效应单位进行功能分析。

关键词：马立克氏病病毒遗传抗性免疫应答转录组学蛋白质组学

Bacterial spectrum and Antimicrobial Profile of Pediatric Blood stream Infection at a Tertiary Care Hospital in Pakistan

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Chinese Medical sciences Journal 2020年第4期35卷 315-322页

作者： Anees Muhammad sadiq Noor Khan Tahir Jamal Irshad Ul haq Abdul Jabbar Ihsan Ali Department of Medical Laboratory Technology University of HaripurHaripurKhyber Pathtunkhwa(KPK)22620Pakistan Rehman Medical Institute(RMI) PeshawarKPK 22620Pakistan Department of Microbiology University of HaripurHaripurKPK 22620Pakistan College of Medical Technology Bacha Khan Medical CollegeMardanKPK 23200Pakistan lnstitute of Paramedical sciences Khyber Medical UniversityPeshawarKPK 22620Pakistan

Objectives Blood stream infections(BsIs)are the main cause of morbidity and mortality in children *** present study was carried out to determine the prevalence of BsI with a focus on the identification of the causative agent of BsI,and to further evaluate the antibiotic susceptibility profile of the causing bacterial *** A cross-section study was carried out at the tertiary care hospital in Peshawar,Pakistan from January to December,*** samples were collected in BACTEC™botdes and standard microbiological protocols were applied for the isolation and identification of bacterial *** antibiotic susceptibility tests were performed using disc diffusion method as per the 2014 guideline of Clinical Laboratory standard Institute(CLsI).Results Of 567 blood cultures in total,111(19.6%)were positive for *** children were 64%(71/111)and female children were 36%(40/111).For the causative predominant group of microorganisms,Gramnegative bacteria were identified in 79(71.1%)isolates,and Gram-positive bacteria in 32(28.9%)*** common bacteria of isolates were ***(n=35,31.5%),***(n=19,17.1%),***(n=18,16.2%),***(n=12,10.8%),and Enterococcus species(n=7,6.3%).The 36.7%(29/79)isolates of Gram-negative bacteria were EsBL producers,and 61.1%(11/18)of *** isolates were methicillin ***,72.9%isolates were multidrug *** Gram-negative bacteria were the main cause of pediatric BsIs,where the predominant microorganism was s.卯***,majority of the *** isolates were resistant to ciprofloxacin.

关键词： antibiotic resistance blood stream infections pediatric Pakistan

The Challenges of Integrated Management of Mekong River Basin in Terms of People’s Livelihood

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Journal of Water Resource and Protection 2010年第1期2卷 61-68页

作者： Alebel Abebe BELAY shah Md. Atiqul haq Vuong Quoc CHIEN Badandi ARAFAT 不详

Mekong River Basin is a life for many people in six south East Asian countries. The river basin is very productive and has crucial activities like: fishing, agriculture, hydroelectric power, transportation, biodiversity and so on. However, due to mismanagement, political intentions and one way interest only for development, the river basin has already started experiencing complications. The major challenges found out were, huge hydroelectric dam constructions and other projects, high population pressure, lack of cooperation among riparian states (especially upper Mekong region and lower one), and lack of proper management system. This leads to inequitable resource use, impact on water quality, biodiversity loss, and disasters like flooding. It is a high time to make a joint venture among riparian countries for sustainable use of the resource. Multi lateral cooperation and commitment among user countries by consulting all stakeholders will benefit all to use this precious resource equitably without major ecological impacts on the river basin.

关键词： Challenges Ecology IWRM Livelihood Mekong River sustainability

Investigation of stingray spines by Fourier transform infrared spectroscopy analysis to recognize functional groups

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Journal of Coastal Life Medicine 2013年第3期 169-174页

作者： Muthuramalingam Uthaya siva Mohideen Abdul Badhul haq Deivasigamani selvam Ganesan Dinesh Babu Rathinam Bakyaraj Centre of Advanced study in Marine Biology Faculty of Marine SciencesAnnamalai UniversityParangipettai-608502TamilnaduIndia

Objective:To investigate functional groups of toxic spines in stingray by Fourier transform infrared spectroscopic ***:sephen were centrifuged at 6000 r/min for 10 *** supernatant was collected and preserved separately in methanol,ethanol,chloroform,acetone(1:2)and then soaked in the mentioned solvents for 48 *** extracts were filtered and used for Fourier transform infrared spectroscopic ***:The venom extract of Himantura gerrardi,Himantura imbricata and Pastinachus and random coiled secondary *** presence of O-H stretch,C=O stretch,C-H stretch,N-H deformation,O-H deformation and C-O stretch in the sample aligned with standard bovine serum *** influence of functional groups within the molecule was because of the impact of preferred spatial orientation,chemical and physical interaction on the *** conclusion,compared to bovine serum albumin,Himantura imbricata consists of two C=O stretch,are involved in the hydrogen bonding that takes place between the different elements of secondary ***:The results identified that the presence of free amino acids and protein having β-sheet medicine not available for treatment against injuries causing ***,it's the baseline study,to motivate further process and produce effective *** venom of poisonous animals has been extensively studied,since standard.

关键词： FTIR Himantura gerrardi Himantura imbricata Pastinachus sephen stingray spines Polypeptides Toxic spines

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环丁砜活化甲基二乙醇胺对天然气脱硫的研究

环丁砜活化甲基二乙醇胺对天然气脱硫的研究

作者：一杰（Ijaz UI haq）西北师范大学

学位级别：硕士

人们对天然气日益增长的需求,促使了现有的脱硫工艺的改善、能源的有效利用及有害排放的有效控制,最终目的是造福人民群众。长庆油田天然气厂位于中国的西北部,该厂处理天然气的关键设备是吸收塔和再生塔,单套设备的设计和处理规模为375... 详细信息

人们对天然气日益增长的需求,促使了现有的脱硫工艺的改善、能源的有效利用及有害排放的有效控制,最终目的是造福人民群众。长庆油田天然气厂位于中国的西北部,该厂处理天然气的关键设备是吸收塔和再生塔,单套设备的设计和处理规模为375×104 m3/天。该工厂正在使用40%(wt)的MDEA,但加工后的天然气中的H2s浓度仍然不符合GB-17820-2018的要求。本文是将HO-CO-环丁砜活化的MDEA-Hs合并到Aspen HYsYs V9中的酸性气体化学溶剂中进行的一项研究。采用严格的动力学模型对该装置进行了模拟和验证。结果表明,5%的环丁砜活化的35%MDEA分别提高了H2s(mg/m3),CO2(mol%)的吸收能力99.71%,56.79%,并使再沸器负荷(Mw)降低了10.84%。环丁砜活化的MDEA降低了吸收塔的内部温度。对活化MDEA溶液浓度、活化精益MDEA溶液循环速率、精益活化MDEA溶液温度、吸收塔塔盘进行敏感性分析。随着MDEA活性浓度的增加,吸收塔的效率明显降低。研究表明,环丁砜活化的精益MDEA溶液循环速率提高了H2s/CO2的吸收。随着活化MDEA温度的升高,H2s/CO2的溶解度显著降低。随着精益活化MDEA温度的升高,环丁砜活化MDEA的损失较低。研究发现,随着塔板数量的增加,烟气中H2s和CO2的浓度都会降低。提高再生塔压力可使再沸器的温度最大化,从而降低再沸器的负荷,蓄热塔进料温度对回流比和再沸器负荷均有影响。提高再生塔进料温度会降低回流比和再沸器负荷。实验结果表明,增加再生塔板可以提高H2s/CO2的解吸能力,可以再生出质量较好的清洁活性MDEA。

关键词：酸性气体脱除天然气再沸器热负荷活化MDEA 硫化氢二氧化碳 GB-17820-2018

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世界上第一条短信售出

英语画刊(高中版) 2022年第1期 9-10页

作者： sana Noor haq

近日,世界上第一条短信在法国巴黎被拍卖,以近15万美元的价格作为非同质化代币售出。这条开启人类短信时代的信息在近3 0年前发出。参考译文:据法国奥古特拍卖行称,世界上第一条短信在巴黎的拍卖会以149,729美元的价格作为非同质化代币(...

近日,世界上第一条短信在法国巴黎被拍卖,以近15万美元的价格作为非同质化代币售出。这条开启人类短信时代的信息在近3 0年前发出。参考译文:据法国奥古特拍卖行称,世界上第一条短信在巴黎的拍卖会以149,729美元的价格作为非同质化代币(NFT)售出。1992年12月3日,英国程序员尼尔·帕普沃思在电脑上向时任英国电信公司沃达丰总监的理查德·贾维斯发送了一条“圣诞快乐”的短信。

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Human leukocyte antigen B polymorphism and association between HLA-B27 and endoplasmic reticulum aminopeptidase 1 rs30187 sNP in patients with ankylosing spondylitis in Bangladesh

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Rheumatology & Autoimmunity 2022年第1期2卷 15-21页

作者： Md Kamrul H.sajib shamim Ahmed syed A.haq Minhaj R.Choudhury Mohammed Uddin Furkan Uddin Muhammad s.A.Khan Mohammad M.Zaman Department of Rheumatology Dhaka Medical College HospitalDhakaBangladesh Department of Rheumatology Bangabandhu Sheikh Mujib Medical UnivesityDhakaBangladesh Department of Human Genetics Mohammed Bin Rashid University of Medicine and Health SciencesCollege of MedicineDubaiUAE Genetics and Genomic Department NeuroGen HealthcareDhakaBangladesh Department of Medicine Sheikh Hasina Institute of Burn and Plastic SurgeryDhakaBangladesh Advisor(Research and Publication) World Health OrganizationDhakaBangladesh

Objectives:To determine the association of Human leukocyte antigen B(HLA‑B)alleles with ankylosing spondylitis and the allelic association of HLAB27 with endoplasmic reticulum aminopeptidase 1(ERAP1)single-nucleotide polymorphism(sNP)rs30187 in patients with ankylosing spondylitis(As).Methods:We studied 48 consecutively enrolled well-defined As patients and 48 healthy controls recruited from the outpatient clinic of the rheumatology department of Bangabandhu sheikh Mujib Medical University(BsMMU),Dhaka,*** genotype HLA-B alleles from peripheral blood DNA,we designed sequence-specific primers for polymerase chain ***'s sequencing method was used to detect the ERAP1 rs30187 *** HLA-B allele distributions were compared between cases and *** infer an allelic association between HLA-B27 and ERAP1,allele distributions from both loci were compared using ***-squared test or Fisher's exact test was used to quantify the association,and their strength of association was tested by odds ratio(OR)with 95%confidence interval(CI).Results:The frequency of HLA-B27 was found to be higher in As patients(60.4%)than in healthy controls(8.3%).HLA-B27 allele had an OR of 16.8(95%CI=5.2–54.4)for the development of ***,4%of As patients had both HLA-B27 and *** significant association was found between ERAP1 rs30187 sNP and HLA-B27 in patients with As(OR=1.7,95%CI=0.5–5.6).Conclusions:HLA-B27 was significantly associated with As in patients in ***,no association between ERAP1 rs30187 sNP and HLA-B27 was observed.

关键词： As Bangladesh ERAP1 rs30187 sNP HLA-B HLA-B27

HLA-DQ and-DR alleles in patients with sLE:A tertiary hospital-based case–control study in Bangladesh

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Rheumatology & Autoimmunity 2023年第1期3卷 43-49页

作者： Muhammad s.A.Khan shamim Ahmed Iftekhar H.Bandhan Farhana Zaman MdKamrul H.sajib shirin Tarafder Minhaj R.Choudhury syed A.haq Mohammad M.Zaman sheikh Hasina National Institute of Burn and Plastic surgery DhakaBangladesh Department of Rheumatology Bangabandhu Sheikh Mujib Medical UniversityDhakaBangladesh Upazilla Health Complex BancharampurB-BariaBangladesh Department of Community Medicine Universal Medical CollegeDhakaBangladesh Department of Rheumatology Dhaka Medical College HospitalDhakaBangladesh Green Life Center for Rheumatic Care and Research DhakaBangladesh World Health Organization DhakaBangladesh

Background:systemic lupus erythematosus(sLE)is a systemic autoimmune disease characterized by the involvement of multiple organs and autoantibody *** study aimed to determine the association of human leukocyte antigen(HLA)-DQ and-DR alleles with sLE at a tertiary hospital in ***:This case-control study was conducted in the Department of Rheumatology,Bangabandhu sheikh Mujib Medical University(BsMMU),Dhaka,*** patients who fulfilled the 1997 revised American College of Rheumatology classification criteria for sLE were considered cases(n=41).The controls(n=32)were selected from the hospital staff of BsMMU,including doctors and nurses who did not suffer from any known rheumatic diseases,and there was no such disease in their first-degree *** chain reaction using a sequence-specific primer(PCRssP)in a low-resolution typing method was carried out on blood samples collected for HLA-DQ and-DR allele ***:The cases and controls had comparable mean ages(31 vs.32 years),and most cases were female(95.1%vs.34.4%).The most frequent clinical manifestations were mucocutaneous(85.4%),followed by musculoskeletal(70.7%)and constitutional symptoms(58.5%).The cases had a significantly higher frequency of HLA-DR2 allele compared with healthy controls(70.7%vs.43.8%;odds ratio:3.1;95%confidence interval:1.2-8.2).In addition,HLADQ6 allele was found to have a significant association with mucocutaneous manifestations of the cases(88.9%,P=0.03).Conclusions:Bangladeshi adults having HLA-DR2 may be more susceptible to ***-DQ6 allele might be associated with mucocutaneous manifestations of sLE.

关键词： alleles Bangladesh HLA-DQ HLA-DR systemic lupus erythematosus

Does Cash Incentive Effect TB Case Notification by Public Private Mix-General Practitioners Model in Pakistan?

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Journal of Tuberculosis Research 2018年第2期6卷 166-174页

作者： Robina Ashraf Farah Naureen Arif Noor Jafer Ilyas Razia Fatima Aashifa Yaqoob Ahmad Wali Mahboob Ul haq Abdullah Latif sumaira Hussain Islamabad Medical and Dental College Islamabad Pakistan Mercy Corps Islamabad Pakistan National Tuberculosis Control Program Pakistan Islamabad Pakistan Provincial TB Control Program Balochistan Quetta Pakistan

setting: Private healthcare providers including solo practitioners and laboratories enrolled with Public Private Mix General Practitioners model in Pakistan who were enrolled with the program and maintained participation during 2014 to 2016. Objective: To assess the change in case notification by private healthcare providers as well as effect on sputum smear positivity rate at private laboratories after introduction of incentives. Design: A comparative cross-sectional study based on routinely maintained National TB Control Program data collected before and after the introduction of incentives (2014 and 2016). Results: In 2016, TB case notification increased by 71% after cash incentives was introduced. Among the 618 private healthcare providers who enrolled and maintained participation in the Public Private Mix program, only 1% of the GPs contributed to 19% increase in case notification, whereas 27% GPs had reported a reduced number of cases compared to the pre-intervention period. After incentives, slide positivity rate for diagnostic declined by 1.9% and follow-up increased by 0.6%. Number of slides for diagnostic and follow-up testing increased by 82% and 72% respectively. Conclusion: Engaging the private healthcare sector, by providing cash incentives to private health care Provider’s is an effective strategy for providing a substantial increase in National TB case notification.

关键词： Public Private Mix Cash Incentive Tuberculosis General Practitioner Pakistan