检索结果-南通市图书馆

右美托咪定镇静下七氟烷用于颈椎手术患者抑制喉罩反应的ED50测定

在线全文

学校读者我要写书评

暂无评论

中国临床药学杂志 2020年第1期29卷 24-29页

作者：李浩文田龙义林丽包晓芳毛程远方韬叶志坚浙江省金华市人民医院麻醉科

目的测定在右美托咪定镇静下,七氟烷用于颈椎手术患者抑制喉罩反应的ED(50)值。方法选择择期全麻颈椎手术患者,随机分为3组:C组(对照组)23例,生理盐水;D1组24例,10 min泵注负荷量0.5μg·kg^-1右美托咪定;D2组27例,10 min泵注负荷量1.0... 详细信息

目的测定在右美托咪定镇静下,七氟烷用于颈椎手术患者抑制喉罩反应的ED(50)值。方法选择择期全麻颈椎手术患者,随机分为3组:C组(对照组)23例,生理盐水;D1组24例,10 min泵注负荷量0.5μg·kg^-1右美托咪定;D2组27例,10 min泵注负荷量1.0μg·kg^-1右美托咪定,随后予以0.2μg·kg^-1·h^-1的速度维持。负荷量输注完毕后七氟烷吸入诱导,预定的七氟烷呼气末浓度为5%,6 L·min^-1氧流量吸入1 min,然后通过调节氧流量的大小达到七氟醚呼气末浓度的目标值,测得的呼气末浓度与目标呼气末浓度的比值维持在0.9到1.0之间,以确保肺泡气张力、动脉血和脑组织之间的平衡。目标呼气末浓度稳定5 min后成功置入喉罩,行可视软镜引导下从喉罩进入气管内插管。七氟烷呼气末预定浓度根据序贯法确定,相邻浓度间隔比值为1.1,采用改良Dixon序贯公式计算出七氟烷的ED(50)值及95%CI。结果喉罩置入呼气末七氟烷ED(50)(95%CI),C组为2.50%(2.36%~2.65%),D1组为2.26%(2.13%~2.40%),D2组为2.18%(2.04%~2.32%)。结论右美托咪定镇静下,七氟烷吸入诱导适合颈椎手术患者保留自主呼吸下行喉罩引导气管插管,且右美托咪定可剂量依赖性减少七氟烷呼气末浓度。

关键词：右美托咪定七氟烷颈椎手术 ED(50)测定

A Novel Bidirectional LSTM and Attention Mechanism Based Neural Network for Answer Selection in Community Question Answering

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2020年第3期62卷 1273-1288页

作者： Bo Zhang haowen Wang Longquan Jiang Shuhan Yuan Meizi li College of Information Mechanical and Electrical EngineeringShanghai Normal UniversityShanghai200234China The Computer Science and Computer Engineering Department University of ArkansasFayettevilleAR72703USA

Deep learning models have been shown to have great advantages in answer selection *** existing models,which employ encoder-decoder recurrent neural network(RNN),have been demonstrated to be ***,the traditional RNN-based models still suffer from limitations such as 1)high-dimensional data representation in natural language processing and 2)biased attentive weights for subsequent words in traditional time series *** this study,a new answer selection model is proposed based on the Bidirectional Long Short-Term Memory(Bi-LSTM)and attention *** proposed model is able to generate the more effective question-answer pair *** on a question answering dataset that includes information from multiple fields show the great advantages of our proposed ***,we achieve a maximum improvement of 3.8%over the classical LSTM model in terms of mean average precision.

关键词： Question answering answer selection deep learning Bi-LSTM attention mechanisms

Unraveling the complex roles of macrophages in obese adipose tissue:an overview

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Medicine 2024年第2期18卷 205-236页

作者： Chang Peng Jun Chen Rui Wu haowen Jiang Jia li Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou310000China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China University of Chinese Academy of Sciences Beijing100049China Department of Prosthodontics Shanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyNational Clinical Research Center for Oral DiseasesShanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghai200011China

Macrophages,a heterogeneous population of innate immune cells,exhibit remarkable plasticity and play pivotal roles in coordinating immune responses and maintaining tissue homeostasis within the context of metabolic *** activation of inflammatory macrophages in obese adipose tissue leads to detrimental effects,inducing insulin resistance through increased inflammation,impaired thermogenesis,and adipose tissue ***,adipose tissue macrophages also play a beneficial role in maintaining adipose tissue homeostasis by regulating angiogenesis,facilitating the clearance of dead adipocytes,and promoting mitochondrial *** the heterogeneity of macrophages in obese adipose tissue is crucial for unraveling the pathogenesis of obesity and holds significant potential for targeted therapeutic ***,the dual effects and some potential regulatory mechanisms of macrophages in adipose tissue have been elucidated using single-cell *** this review,we present a comprehensive overview of the intricate activation mechanisms and diverse functions of macrophages in adipose tissue during obesity,as well as explore the potential of drug delivery systems targeting macrophages,aiming to enhance the understanding of current regulatory mechanisms that may be potentially targeted for treating obesity or metabolic diseases.

关键词： obesity inflammation adipose tissue macrophages adipose tissue homeostasis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

龙卷风作用下双拱屋面风荷载特性研究

低温建筑技术 2024年第9期46卷 147-151页

作者：赵方锐李方慧朱志峰张舒涵白宇李灏文黑龙江大学建筑工程学院哈尔滨150086

为研究龙卷风对连续双拱屋面的风荷载影响,研究利用Ward型龙卷风模拟发生装置,并选用Realizable k-ε湍流模型,对龙卷风作用下的连续双拱屋面风荷载进行了详细的数值模拟分析。基于0.5的涡流比,针对三种不同的前跨矢跨比(1/4、1/5、1/6)... 详细信息

为研究龙卷风对连续双拱屋面的风荷载影响,研究利用Ward型龙卷风模拟发生装置,并选用Realizable k-ε湍流模型,对龙卷风作用下的连续双拱屋面风荷载进行了详细的数值模拟分析。基于0.5的涡流比,针对三种不同的前跨矢跨比(1/4、1/5、1/6),分析连续双拱屋面的风压系数和周围迹线。结果表明当屋面位于龙卷风核心时,连续双拱屋面的风压系数呈现出负压特征,而且屋檐两侧的风压变化更加显著,而屋顶中部的风压则相对稳定。当矢跨比增加时,连续双拱屋面的最大负压会略微升高,由0.54增加至0.552,增大了2.2%。研究可为龙卷风对低矮建筑的数值模拟提供不同矢跨比模型的参考。

关键词：双拱屋面涡流比矢跨比风压系数

Recent advances in molecular and nanoparticle probes for fluorescent bioanalysis

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第7期17卷 6443-6474页

作者： haowen Luo Lejie Tian Yaoming Zhang Yang Wu Bin li Jianxi liu State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsSchool of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Yantai Zhongke Research Institute of Advanced Materials and Green Chemical Engineering Shandong Laboratory of Advanced Materials and Green ManufacturingYantai 264006China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

With the increasing emphasis on ecological safety and physical health,the detection and treatment of harmful substances and diseases are becoming more and more ***,efficiently monitoring these biological behaviors with high accuracy and sensitivity in real-time has shown prominent research *** use of fluorescent probes to analyze organisms has gained momentum in recent years,especially in the field of organ imaging and assisted cancer therapy,where fluorescent bioanalysis demonstrates significant *** this review,we explored the latest advancements in fluorescent molecular probes(e.g.,small-molecule,macro-molecule,supramolecule)and fluorescent nanoparticle probes(e.g.,quantum dots or nanoclusters,metal-organic frameworks,polymers,complexes)used as bioanalytical tools in various assays over the last three *** also delved into their detective mechanisms,specific application areas,and characterization tools for responsive *** review aims to showcase the most recent and comprehensive research progress in fluorescent bioanalysis based on molecular and nanoparticle probes,offering guidance for future developments in the design and fabrication of fluorescent probes and their potential applications.

关键词： fluorescent biosensing bioimaging disease diagnosis tumor detection and treatment

Application of topology-based structure features for machine learning in materials science

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Structural Chemistry 2023年第7期42卷 47-53页

作者： Shisheng Zheng haowen Ding Shunning li Dong Chen Feng Pan School of Advanced Materials Peking University Shenzhen Graduate SchoolShenzhenGuangdong518055PR China Department of Mathematics Michigan State UniversityEast Lansing MIUSA

Structure features play an important role in machine learning models for the materials ***,two topology-based features for the representation of material structure,specifically structure graph and algebraic topology,are *** present the fundamental mathematical concepts underlying these techniques and how they encode material ***,we discuss the practical applications and enhancements of these features made in specific material predicting *** review may provide suggestions on the selection of suitable structural features and inspire creativity in developing robust descriptors for diverse applications.

关键词： Machine learning Structure feature Structure graph Algebraic topology

西藏色东普沟2024年两期冰川泥石流堵江灾害发育特征研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国地质灾害与防治学报 2024年第6期35卷 24-32页

作者：万佳威高浩源高杨肖金城李军李江山李浩文中国地质科学院地质力学研究所北京100081 自然资源部活动构造与地质安全重点实验室北京100081 中测新图(北京)遥感技术有限责任公司北京100039

色东普沟位于西藏雅鲁藏布大峡谷,是特大堵江链式灾害的频发区,严重威胁着边疆建设的地质安全。文章主要针对2024年4月15日和5月14日两次堵江灾害事件开展详细研究,全面分析了灾害形成过程、主要成因和发展趋势。通过水位监测、地震动... 详细信息

色东普沟位于西藏雅鲁藏布大峡谷,是特大堵江链式灾害的频发区,严重威胁着边疆建设的地质安全。文章主要针对2024年4月15日和5月14日两次堵江灾害事件开展详细研究,全面分析了灾害形成过程、主要成因和发展趋势。通过水位监测、地震动监测、直升机调查、高原无人机航测等方法,识别和分析了两次堵江灾害的形成发展过程,发现灾害运动时间可达8 min,堵江成坝时间大于10 h,第二次灾害相对更为严重,形成的堰塞湖未完全溃决,严重加剧了雅鲁藏布江干流河道的淤堵。从地形和地质条件、地震因素、气候因素等方面对灾害成因进行了分析,发现色东普沟地形高差大、岩体结构破碎、沟道内巨厚层松散堆积体物源丰富,为灾害形成提供了有利条件,而春夏交替过程中的气温上升导致冰川消融加快和水动力作用增强,触发了堵江灾害链的发生。通过综合遥感数据解译,发现色东普沟已进入堵江灾害链活跃期,2018年特大堵江灾害造成了雅鲁藏布江河流地貌发生巨大改变,而之后至今的大规模堵江事件导致河道淤积更加严重,形成巨型堰塞坝体的风险不断增大。最后,文章针对色东普沟高位远程灾害堵江溃决、监测预警、减灾措施等方面提出了建议。

关键词：色东普沟冰川泥石流形成过程灾害成因发展趋势

维普期刊数据库博看期刊

Monte Carlo Simulation of Fractures Using Isogeometric Boundary Element Methods Based on POD-RBF

在线全文

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2021年第7期128卷 1-20页

作者： Haojie lian Zhongwang Wang haowen Hu Shengze li Xuan Peng Leilei Chen Key Laboratory of In-Situ Property-Improving Mining of Ministry of Education Taiyuan University of TechnologyTaiyuan030024China School of Architecture and Civil Engineering Huanghuai UniversityZhumadian463003China College of Architecture and Civil Engineering Xinyang Normal UniversityXinyang464000China Artificial Intelligence Research Center National Innovation Institute of Defense TechnologyBeijing100071China Department of Mechanical Engineering Suzhou University of Science and TechnologySuzhou215009China

This paper presents a novel framework for stochastic analysis of linear elastic fracture *** Carlo simulation(MCs)is adopted to address the multi-dimensional uncertainties,whose computation cost is reduced by combination of Proper Orthogonal Decomposition(POD)and the Radial Basis Function(RBF).In order to avoid re-meshing and retain the geometric exactness,isogeometric boundary element method(IGABEM)is employed for simulation,in which the Non-Uniform Rational B-splines(NURBS)are employed for representing the crack surfaces and discretizing dual boundary integral *** stress intensity factors(SIFs)are extracted by M integral *** numerical examples simulate several cracked structures with various uncertain parameters such as load effects,materials,geometric dimensions,and the results are verified by comparison with the analytical solutions.

关键词： Monte Carlo simulation POD RBF isogeometric boundary element method fracture

Importance of V^(4)and optimal acid environment in the hydroxylation of inert benzene via activation of C_(sp2)-H bond

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2024年第10期74卷 216-226页

作者： Peng Dong Yang Xin Yanwei li Xiaohui Zhang Xiaorui Wang Yu Zhao Dongqiang Zhang haowen Ma Guixian li School of Petrochemical Engineering Lanzhou University of TechnologyLanzhou 730050China Key Laboratory of Low Carbon Energy and Chemical Engineering of Gansu Province Lanzhou 730050China Lanzhou Petrochemical University of Vocational Technology Lanzhou 730060China Lanzhou Petrochemical Research Center Petrochemical Research InstitutePetroChina Company LimitedLanzhou 730060China

Hydroxylation of inert benzene through the activation of the C_(sp2)-H bond is a representative reaction about the transformation of C-H bonds to C-O bonds,which has far-reaching guiding significance but remains a challenging scientific *** overcome this problem,a series of VOx-Ga_(2)O_(3)/SiO_(2)-Al_(2)O_(3)were prepared to achieve an efficient and economical hydroxylation path of benzene to *** results showed that the phenol yield was 72.89%(selectivity>98.1%)under the optimum *** reason is that the C-H bond in the benzene ring is activated by heterolysis over a VOx-Ga_(2)O_(3)/SiO_(2)-Al_(2)O_(3)***,the introduction of aluminum(Al)and gallium(Ga)made a qualitative change in the catalyst,enhancing the electron motion and spin motion of vanadium species,resulting in the increase of V4^(+)/V5^(+)*** addition,the catalyst can provide an optimal acidic environment and a threedimensional cross-linked surface structure that facilitates product diffusion.

关键词： C_(sp2)-H activation V4^(+)/V5^(+)ratio Acid microenvironment Catalysis Support Catalyst activation