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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 621-629页

作者： Liwei wang Yingyun Sun haotian wang Pengfei Zhao Muhammad Safwan Jaffar School of Electrical and Electronic Engineering North China Electric Power UniversityBeijing 102206China

To reduce the difficulty and enhance the enthusiasm of private-owned electric vehicles(EVs) in participating in frequency regulation ancillary service market(FRASM), a decision aid model(DAM) is proposed. This paper presents three options for EV participating in FRASM, i. e., the base mode(BM), unidirectional charging mode(UCM), and bidirectional charging/discharging mode(BCDM), based on a reasonable simplification of users' participating willingness. In BM, individual EVs will not be involved in FRASM, and DAM will assist users to set the optimal charging schemes based on travel plans under the time-of-use(TOU) price. UCM and BCDM are two modes in which EVs can take part in FRASM. DAM can assist EV users to create their quotation plan, which includes hourly upper and lower reserve capabilities and regulation market mileage prices. In UCM and BCDM, the difference is that only the charging rate can be adjusted in the UCM, and the EVs in BCDM can not only charge but also discharge if necessary. DAM can estimate the expected revenue of all three modes, and EV users can make the final decision based on their preferences. Simulation results indicate that all the three modes of DAM can reduce the cost, while BCDM can get the maximum expected revenue.

关键词： Electric vehicle(EV) frequency regulation decision aid model(DAM) utility maximization battery wear cost

Functional characterization,structural basis,and protein engineering of a rare flavonoid 2′-O-glycosyltransferase from Scutellaria baicalensis

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3746-3759页

作者： Zilong wang Xueqing Du Guo Ye haotian wang Yizhan Liu Chenrui Liu Fudong Li HansÅgren Yang Zhou Junhao Li Chao He De-An Guo Min Ye State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Anhui Key Laboratory of Modern Biomanufacturing and School of Life Sciences Anhui UniversityHefei 230601China National Science Center for Physical Sciences at Microscale Division of Molecular&Cell Biophysics and School of Life Sciences University of Science and Technology of ChinaHefei 230026China Department of Physics and Astronomy Uppsala UniversityUppsala SE-75120Sweden School of Pharmacy Jinan UniversityGuangzhou 510632China Shanghai Research Center for Modernization of Traditional Chinese Medicine Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Glycosylation is an important post-modification reaction in plant secondary metabolism,and contributes to structural diversity of bioactive natural *** plants,glycosylation is usually catalyzed by *** 2′-O-glycosides are rare ***,no UGTs have been reported,thus far,to specifically catalyze 2′-O-glycosylation of *** this work,UGT71AP2 was identified from the medicinal plant Scutellaria baicalensis as the first flavonoid 2′-*** could preferentially transfer a glycosyl moiety to 2′-hydroxy of at least nine flavonoids to yield six new *** of the 2′-O-glycosides showed noticeable inhibitory activities against cyclooxygenase *** crystal structure of UGT71AP2(2.15Å)was solved,and mechanisms of its regio-selectivity was interpreted by pKa calculations,molecular docking,MD simulation,MM/GBSA binding free energy,QM/MM,and hydrogen‒deuterium exchange mass spectrometry *** structure-guided rational design,we obtained the L138T/V179D/M180T mutant with remarkably enhanced regio-selectivity(the ratio of 7-O-glycosylation byproducts decreased from 48%to 4%)and catalytic efficiency of 2′-O-glycosylation(kcat/Km,0.23 L/(s·μmol),12-fold higher than the native).Moreover,UGT71AP2 also possesses moderate UDP-dependent de-glycosylation activity,and is a dual function *** work provides an efficient biocatalyst and sets a good example for protein engineering to optimize enzyme catalytic features through rational design.

关键词： Glycosyltransferase Regio-selectivity Crystal structure De-glycosylation Catalytic mechanisms

Hydrogen Peroxide Electrosynthesis in a Strong Acidic Environment Using Cationic Surfactants

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Precision Chemistry 2024年第4期2卷 129-137页

作者： Zachary Adler Xiao Zhang Guangxia Feng Yaping Shi Peng Zhu Yang Xia Xiaonan Shan haotian wang Rice University Department of Chemical and Biomolecular EngineeringHoustonTexas 77005United States University of Houston Department of Electrical and Computer EngineeringHoustonTexas 77004United States

The two-electron oxygen reduction reaction(2e^(−)-ORR)can be exploited for green production of hydrogen peroxide(H_(2)O_(2)),but it still suffers from low selectivity in an acidic electrolyte when using non-noble metal ***,inspired by biology,we demonstrate a strategy that exploits the micellization of surfactant molecules to promote the H_(2)O_(2)selectivity of a low-cost carbon black catalyst in strong acid *** surfactants near the electrode surface increase the oxygen solubility and transportation,and they provide a shielding effect that displaces protons from the electric double layer(EDL).Compared with the case of a pure acidic electrolyte,we find that,when a small number of surfactant molecules were added to the acid,the H_(2)O_(2)Faradaic efficiency(FE)was improved from 12%to 95%H_(2)O_(2)under 200 mA cm^(−2),suggesting an 8-fold *** in situ surface enhanced Raman spectroscopy(SERS)and optical microscopy(OM)studies suggest that,while the added surfactant reduces the electrode’s hydrophobicity,its micelle formation could promote the O_(2) gas transport and its hydrophobic tail could displace local protons under applied negative potentials during catalysis,which are responsible for the improved H_(2)O_(2)selectivity in strong acids.

关键词： electrocatalysis hydrogen peroxide electrosynthesis oxygen reduction reaction interfacial engineering surfactant CTAB

基于CFD的具有首翼的新型飞翔形式AUV升力和阻力估计:对阻力极曲线和推力估计的见解

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哈尔滨工程大学学报（英文版） 2024年第2期23卷 352-365页

作者： Faheem Ahmed Xianbo Xiang haotian wang Gong Xiang Shaolong Yang School of Naval Architecture and Ocean Engineering Huazhong University of Science and Technology1037Luoyu RoadWuhan 430074China State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and Technology1037Luoyu RoadWuhan 430074China

To achieve hydrodynamic design excellence in Autonomous Underwater Vehicles(AUVs)largely depends on the accurate prediction of lift and drag *** study presents Computational Fluid Dynamics(CFD)-based lift and drag estimations of a novel torpedo-shaped flight-style AUV with *** horizontal bow-wings are provided to accommodate the electromagnetic arrays used to perform the cable detection and tracking operations near the *** hydrodynamic performance of the AUV due to addition of these horizontal bow-wings is required to be investigated,particularly at the initial design ***,CFD techniques are employed to compute the lift and drag forces observed by the flight-style AUV,maneuvering underwater at different angles of attack and varying *** Reynolds-Averaged Navier-Stokes Equations(RANSE)closure is achieved by employing the modified k-ϵ model and Two-Scale Wall Function(2-SWF)approach is used for boundary layer ***,the study also highlights the unique mesh refinement and solution-adaptive meshing techniques to perform the CFD simulations in Solidworks Flow Simulation(SWFS)*** drag polar curve for flight-style AUV with and without bow-wings is generated using the computed lift and drag *** curve provided essential insights for achieving hydrodynamically efficient and optimized AUV *** the drag polar curve,it is revealed that due to horizontal bow-wings,the flight-style AUV is capable to generate higher lift with less drag and thus,it gives better lift-to-drag ratio compared to the AUV without ***,simulated results of axial drag observed by the AUV have also been compared with free-running experimental results and are found in good agreement.

关键词： Autonomous underwater vehicle(AUV) Computational fluid dynamics(CFD) Solidworks flow simulation(SWFS) Drag polar curve Free-running experiments

Tumor-derived DEFB1 induces immune tolerance by inhibiting maturation of dendritic cell and impairing CD8+ T cell function in esophageal squamous cell carcinoma

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Chinese Journal of Cancer Research 2024年第4期36卷 351-375页

作者： Jingjing Duan haotian wang Minglu Liu Yin Chen Ning Li Jieqiong Liu Lingxiong wang Lin Li Yaru Liu Pengfei Dong Xiuxuan wang Zhongyi Fan Shunchang Jiao Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer Tianjin Key Laboratory of Digestive Cancer Key Laboratory of Cancer Prevention and Therapy Department of Oncology the Fifth Medical Center of Chinese PLA General Hospital Beijing DCTY Biotech CO. LTD. Department of Biotherapy Center Shenzhen Third People's Hospital Second Hospital Affiliated to Southern University of Science and Technology

Objective: CD8+ T cells are the key effector cells in the anti-tumor immune response. The mechanism underlying the infiltration of CD8+ T cells in esophageal squamous cell carcinoma(ESCC) has not been clearly ***: Fresh ESCC tissues were collected and grouped according to the infiltration density of CD8+ T *** the transcriptome sequencing on these samples and the combined analyses with The Cancer Genome Atlas(TCGA) ESCC data, a secreted protein DEFB1 was selected to explore its potential role in the infiltration of CD8+T cells. Bioinformatics analyses, histological verification and in vitro experiments were then ***: DEFB1 was highly expressed in ESCC, and the high expression of DEFB1 was an independent risk factor for overall survival. Since the up-regulation or down-regulation of DEFB1 did not affect the proliferation,migration and apoptosis of ESCC cells, we speculated that the oncogenic effect of DEFB1 was achieved by regulating microenvironmental characteristics. Bioinformatics analyses suggested that DEFB1 might play a major role in the inflammatory response and anti-tumor immune response, and correlate to the infiltration of immature dendritic cell(im DC) in ESCC. Histological analyses further confirmed that there were less CD8+ T cells infiltrated, less CD83+ mature DC(m DC) infiltrated and more CD1a+ im DC infiltrated in those ESCC samples with high expression of DEFB1. After the treatment with recombinant DEFB1 protein, the maturation of DC was hindered significantly, followed by the impairment of the killing effects of T cells in both 2D and 3D culture in ***: Tumor-derived DEFB1 can inhibit the maturation of DC and weaken the function of CD8+ T cells, accounting for the immune tolerance in ESCC. The role of DEFB1 in ESCC deserves further exploration.

关键词： CD8+ T cells DEFB1 dendritic cells esophageal squamous cell carcinoma tumor immune microenvironment

基于前景理论的电动汽车用户日前调频决策模型

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现代电力 2024年第3期41卷 574-583页

作者：汪丽伟王昊天孙英云华北电力大学电气与电子工程学院北京市昌平区102206

为降低电动汽车(electric vehicle,EV)用户参与日前调频辅助服务市场的难度,提高其参与积极性,将EV完成充电离网时所获得的净收益和电池电量对用户心理的影响引入前景理论的价值函数中,建立有限理性下的EV用户参与调频辅助服务市场的日... 详细信息

为降低电动汽车(electric vehicle,EV)用户参与日前调频辅助服务市场的难度,提高其参与积极性,将EV完成充电离网时所获得的净收益和电池电量对用户心理的影响引入前景理论的价值函数中,建立有限理性下的EV用户参与调频辅助服务市场的日前决策模型。该模型考虑EV参与调频辅助服务的电池老化成本,研究EV备用容量的优化策略及调频辅助服务市场的报价策略,并给出3种可行的简化EV调频辅助服务参与模式供用户选择。通过算例分析,验证了基于前景理论的EV用户日前调频决策模型的有效性及可行性,并更符合实际EV用户的决策行为。

关键词：前景理论日前调频决策模型用户行为电池电量

基于CDEM的天然气水合物沉积物水力压裂裂纹扩展数值模拟

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Acta Mechanica Sinica 2024年第2期40卷 28-38页

作者：黄宇东王天驹王蕊王昊天鲁晓兵张旭辉 Institutes of Mechanics Chinese Academy of SciencesBeijing100190China School of Engineering Science University of Chinese Academy of SciencesBeijing100049China CPOE Research Institute of Engineering Technology Tianjin300450China CNPC Offshore Engineering Company Limited Beijing100176China

目前,天然气水合物开采存在储层渗透率低和热传导导致生产效率低等问题.作为一种常规油气勘探中有效提高储层渗透率的技术,水力压裂有望用于改善天然气水合物储层的渗透率,提高采收效率.然而,有关含天然气水合物沉积物(GHBS)水力压裂应... 详细信息

目前,天然气水合物开采存在储层渗透率低和热传导导致生产效率低等问题.作为一种常规油气勘探中有效提高储层渗透率的技术,水力压裂有望用于改善天然气水合物储层的渗透率,提高采收效率.然而,有关含天然气水合物沉积物(GHBS)水力压裂应用的研究却很少.本文采用有限元和离散元耦合的连续离散元法(CDEM),对不同地层性质的天然气水合物沉积物(GHBS)的水力压裂过程进行了二维的数值模拟,研究了储层性质和压裂参数对GHBS中裂缝生成的影响.主要结论是,在本研究考虑的压裂参数和沉积物性质中,内摩擦角越小、注入流量越大对产生裂缝越有利;当饱和度和黏聚力处于适当范围时,最有利于产生裂缝;当各方向的地应力相等时,最有利于压裂产生裂缝,但最不利于主要裂缝向更远的方向延伸.

关键词：含天然气水合物沉积物水力压裂离散元法地层性质水合物储层天然气水合物开采内摩擦角裂纹扩展

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基于有机电极材料的低温电池研究进展

储能科学与技术 2024年第7期13卷 2259-2269页

作者：王浩天王永刚董晓丽复旦大学上海200433

基于无机嵌入化合物电极材料的锂离子电池在低温(<-20℃)下会失去大部分容量,限制了其在电动汽车、航空航天和国防等关键领域的应用。与传统的无机嵌入化合物电极材料相比,具有氧化还原活性基团的有机电极材料通常表现出较快的电极反应... 详细信息

基于无机嵌入化合物电极材料的锂离子电池在低温(<-20℃)下会失去大部分容量,限制了其在电动汽车、航空航天和国防等关键领域的应用。与传统的无机嵌入化合物电极材料相比,具有氧化还原活性基团的有机电极材料通常表现出较快的电极反应动力学、较强的载流子适应性和优异的低温性能。同时,有机电极材料具有结构可设计性强、资源丰富、环境友好等优点,近年来在二次电池研究领域中受到了广泛关注。本文主要介绍了基于有机电极材料的低温电池体系的研究进展,根据不同氧化还原反应机理对有机电极材料进行了分类,阐述了有机电极材料的储能机制及其特点,结合近几年国内外研究介绍了有机物金属(离子)、非金属离子电池,有机物双离子电池等几类典型的低温有机物电池体系,分析了不同工作机理的有机电极材料在低温下的电化学行为,最后总结了有机电极材料在低温电池中的应用前景和挑战,旨在为未来低温有机物电池中有机电极材料的设计及其与电解液的适配性提供指导。

关键词：有机电极材料储能机制低温电池双离子电池

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MoS_(2)-g-C_(3)N_(4)纳米基气凝胶制备及其光热协同光催化净化染料废水

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中国科学：化学 2024年第6期54卷 924-934页

作者：王皓天王家铭杨牧青熊子龙李檬华北电力大学环境科学与工程系保定071003

将界面太阳能水蒸发技术与光催化降解过程耦合被视为解决能源和环境问题的有效策略,但开发具有光热与催化协同效应的双功能蒸发器仍然具有挑战性.本文构建了MoS_(2)-g-C_(3)N_(4)(MG)异质结并将其负载于气凝胶上制备了一系列双功能的MoS... 详细信息

将界面太阳能水蒸发技术与光催化降解过程耦合被视为解决能源和环境问题的有效策略,但开发具有光热与催化协同效应的双功能蒸发器仍然具有挑战性.本文构建了MoS_(2)-g-C_(3)N_(4)(MG)异质结并将其负载于气凝胶上制备了一系列双功能的MoS_(2)-g-C_(3)N_(4)(MG)气凝胶蒸发器.这些MG气凝胶具有高比表面积、有效光吸收和高光催化活性,表现出优异的光热转换性能和光催化降解能力.MG气凝胶大的比表面积和丰富的孔隙结构不仅有利于水的渗透和蒸发焓的降低,还有利于有机污染物的吸附降解.其中,基于MG-0.4构筑的蒸发器具有1.72 kg m^(-2)h^(-1)的高水蒸发效率,同时表现出显著的罗丹明B降解效率(90.1%).这项工作为解决淡水短缺和水污染控制问题提供了一个新方法.

关键词：太阳能水蒸发光催化协同效应 MoS_(2)-g-C_(3)N_(4) 罗丹明B

大学生自我领导力与课堂参与度的关系:自我控制的中介作用和感知有用性的调节作用

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心理学探新 2024年第1期44卷 44-51页

作者：徐广路王皓天吴崇南京信息工程大学商学院南京210044 武汉大学经济与管理学院武汉430072

为探讨大学生自我领导力与课堂参与度的关系及作用机制,对410名在校大学生进行调查。结果发现:(1)自我领导力对自我控制和课堂参与度均有显著正向影响;(2)自我控制在自我领导力对课堂参与度的影响中起中介作用;(3)感知有用性在自我控制... 详细信息

为探讨大学生自我领导力与课堂参与度的关系及作用机制,对410名在校大学生进行调查。结果发现:(1)自我领导力对自我控制和课堂参与度均有显著正向影响;(2)自我控制在自我领导力对课堂参与度的影响中起中介作用;(3)感知有用性在自我控制对课堂参与度的影响中起正向调节作用;(4)自我领导力通过自我控制对课堂参与度的间接影响受到了感知有用性的正向调节。研究结果揭示了大学生自我领导力对课堂参与度的影响机制,对提高大学生课堂参与度具有重要的实践启示。

关键词：大学生自我领导力自我控制感知有用性课堂参与度