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Contributors to tidal duration asymmetry with varied coastline configurations on western shelf of Yellow Sea

Water Science and Engineering 2024年第1期17卷 1-12页

作者： Xi Feng Zheng li Hui Feng Jia-yan Yang Shou-peng Xie Wei-bing Feng College of Harbor.Coastal and Offshore Engineering Hohai UniversityNanjing 210098China China Harbour Engineering Co. LtdBeijing 100027China Key Laboratory of Port Waterway and Sedimentation Engineering of the Ministry of CommunicationsNanjing 210029China China South-to-North Water Diversion Corporation limited Beijing 100036China

Coastal management in China is confronted with an urgent choice between natural restoration and maintenance of existing seawalls and reclaimed land for economic development.A key criterion for making this decision is the resilience to coastal flooding,which depends on the ability to predict tidal *** duration asymmetry(TDA)is a key parameter in determination of the arrival and duration of flood *** study selected the western inner shelf of the Yellow Sea(WYS)as the study area and investigated the responses of TDA to different shoreline configurations and relative sea level *** responses of TDA to shoreline reconstruction yielded spatial variability locally and *** the nearshore area,the responses of TDA to the complex ocean environment mainly originated from the combined functions of reflection,bottom friction,and advection,which controlled the energy transfer from M2 or S2 constituents to their overtides or compound *** sensitivity of TDA to coastline typologies was not limited to coastal waters but could stretch over the entire inner *** vulnerability of tidal responses was due to the displacement of the M2 amphidrome of the Kelvin wave on the WYS,which in turn changed tidal energy fluxes over the *** relative sea level rise could intensify the feedback of TDA to seawalls and land reclamation.

关键词： Tidal duration asymmetry Western inner shelf of Yellow Sea Natural restoration Relative sea level rise Tidal amphidrome

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Composition analysis of Compound Shenhua Tablet,a seven-herb Chinese medicine for IgA nephropathy:evaluation of analyte-capacity of the assays

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Chinese Journal of Natural Medicines 2024年第2期22卷 178-192页

作者： ZHANG Haiyan WANG Qiuyue WANG Jianan ZHANG Sichao JIA Weiwei HE Ning XIA Xiaoyan WANG Ting LAI liyu li Jiaying DU Jing OLALEYE Olajide E CHEN Xiangmei YANG Junling li Chuan Graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmacy University of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100049China Department of Nephrology First Medical Center of Chinese PLA General HospitalNephrology Institute of the Chinese People’s Liberation ArmyNational Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney Disease ResearchBeijing 100853China Zhongshan Institute for Drug Discovery Zhongshan 528400China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China

Compound Shenhua Tablet,a medicine comprising seven herbs,is employed in treating IgA *** study aimed to meticulously analyze its chemical *** on a list of candidate compounds,identified through extensive literature review pertinent to the tablet’s herbal components,the composition analysis entailed the systematic identification,characterization,and quantification of the *** analyte-capacity of LC/ESI-MS-based and GC/EI-MS-based assays was *** identified and characterized constituents were quantified to determine their content levels and were ranked based on the constituents’daily doses.A total of 283 constituents,classified into 12 distinct categories,were identified and characterized in the Compound Shenhua *** constituents exhibited content levels of 1−10982μg·g^(−1),with daily doses of 0.01−395μmol·d^(−1).The predominant constituents,with daily doses of≥10μmol·d^(−1),include nine organic acids(citric acid,quinic acid,chlorogenic acid,cryptochlorogenic acid,gallic acid,neochlorogenic acid,isochlorogenic acid C,isochlorogenic acid B,and linoleic acid),five iridoids(specnuezhenide,nuezhenoside G13,nuezhenidic acid,secoxyloganin,and secologanoside),two monoterpene glycosides(paeoniflorin and albiflorin),a sesquiterpenoid(curzerenone),a triterpenoid(oleanolic acid),and a phenylethanoid(salidroside).Additionally,there were 83,126,and 55 constituents detected in the medicine with daily doses of 1–10,0.1–1,and 0.01–0.1μmol·d^(−1),*** combination of the LC/ESI-MS-based and GC/EI-MS-based assays demonstrated a complementary relationship in their analyte-capacity for detecting the constituents present in the *** comprehensive composition analysis establishes a solid foundation for further pharmacological research on Compound Shenhua Tablet and facilitates the quality evaluation of this complex herbal medicine.

关键词： Compound Shenhua Tablet Composition analysis Analyte-capacity

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An improved installation of 2-hydroxy-4-methoxybenzyl(iHmb)method for chemical protein synthesis

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Chinese Chemical Letters 2024年第5期35卷 145-150页

作者： Ying li Long-Jie Wang Yong-Kang Zhou Jun liang Bin Xiao Ji-Shen Zheng The First Affiliated Hospital of USTC MOE Key Laboratory for Membraneless Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Chemistry University of Science and Technology of ChinaHefei 230027China

The 2-hydroxy-4-methoxybenzyl(Hmb)backbone modification can prevent amide bond-mediated sidereactions(e.g.,aspartimide formation,peptide aggregation)by installing the removable Hmb group into a peptide bond,thus improving the synthesis of long and challenging peptides and ***,its use is largely precluded by the limited Hmb’s installation *** this report,an improved installation of Hmb(iHmb)method was developed to achieve the flexible installation and the convenient removal of *** iHmb method involves two critical steps:(1)oxidative diazotization of the readily installed 2-hydroxy-4-methoxy-5-amino-benzyl(Hmab)to give 2-hydroxy-4-methoxy-5-diazonium-benzyl(Hmdab)by combining soamyl nitrite(IAN)/HBF_(4),and(2)reductive elimination of Hmdab to give the desired Hmb by 1,2-ethanedithiol(EDT).The iHmb method enables the installation of Hmb at any primary amino acid including the highly sterically hindered amino acids(e.g.,valine and isoleucine).The practicality and utility of the iHmb method was demonstrated by one-shot solid-phase synthesis of a challenging aspartimide-prone peptide,the mirror-image version of a hydrophobic peptide and a long-chain peptide up to ***,the iHmb method can be utilized to facilitate chemical protein ligation,as exemplified by the synthesis of the single-spanning membrane protein *** iHmb method expands the toolkit for peptide synthesis and ligation and facilitates the preparation of peptides/proteins.

关键词： Chemical protein synthesis Solid-phase peptide synthesis Removable backbone modification 2-Hydroxy-4-methoxybenzyl(Hmb)group Aspartimide-prone peptides Difficult peptides Membrane proteins

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Morphological Classification of Infrared Galaxies Based on WISE

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Research in Astronomy and Astrophysics 2024年第4期24卷 222-236页

作者： Zhi-Ren Pan Bo Qiu Cui-Xiang liu A-li Luo Xia Jiang Xiao-Yu Guo School of Electronic and Information Engineering Hebei University of TechnologyTianjin 300401China Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China

This study introduces a novel convolutional neural network,the WISE Galaxy Classification Network(WGC),for classifying spiral and elliptical galaxies using Wide-field Infrared Survey Explorer(WISE)*** attains an accuracy of 89.03%,surpassing the combined use of K-means or SVM with the Color-Color method in more accurately identifying galaxy *** enhanced variant,WGC_mag,integrates magnitude parameters with image features,further boosting the accuracy to 89.89%.The research also delves into the criteria for galaxy classification,discovering that WGC primarily categorizes dust-rich images as elliptical galaxies,corresponding to their lower star formation rates,and classifies less dusty images as spiral *** paper explores the consistency and complementarity of WISE infrared images with SDSS optical images in galaxy morphology *** SDSS Galaxy Classification Network(SGC),trained on SDSS images,achieved an accuracy of 94.64%.The accuracy reached 99.30% when predictions from SGC and WGC were *** the complementarity of features in WISE and SDSS images,a novel variant of a classifier,namely the Multi-band Galaxy Morphology Integrated Classifier,has been *** classifier elevates the overall prediction accuracy to 95.39%.Lastly,the versatility of WGC was validated in other data *** the HyperLEDA data set,the distinction between elliptical galaxies and Sc,Scd and Sd spiral galaxies was most pronounced,achieving an accuracy of 90%,surpassing the classification results of the Galaxy Zoo 2 labeled WISE data *** research not only demonstrates the effectiveness of WISE images in galaxy morphology classification but also represents an attempt to integrate multi-band astronomical data to enhance understanding of galaxy structures and evolution.

关键词： methods:data analysis infrared:galaxies galaxies:spiral galaxies:elliptical and lenticular cD

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The influence of proxy selection on global annual mean temperature reconstructions during the Common Era

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Science China Earth Sciences 2024年第8期67卷 2522-2534页

作者： Bao YANG Xia li Minhui HE Feng WANG Yesi ZHAO Peng ZHANG Jianglin WANG Frontiers Science Center for Critical Earth Material Cycling School of Geography and Ocean ScienceNanjing UniversityNanjing 210023China Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Centre Eau Terre Environnement Institut National de la Recherche ScientifiqueQuébecQCG1K 9A9Canada GEOTOP Research Centre in the Dynamics of the Earth System MontréalQC H2X 3Y7Canada

The reconstruction of global annual mean temperatures made by the PAGES 2k Consortium in 2019 represents one of the most influential sequences of global climate variability over the Common ***,it is still not clear how the reconstruction can be influenced by the selection of reconstruction methods and the selection of proxy records with different temporal resolutions over different *** adopt a widely used Composite-Plus-Scale method to elucidate the effects of the selection of the proxy records on temperature *** ensure the uniformity of data,different types of proxy records spanning the past~2000 years from the PAGES 2k proxy network were used to investigate the potential effects of proxy selection in hemispheric and global temperature reconstructions during the past two *** long-term trends,spectral characteristics,and volcanic responses of the annual temperatures were studied based on the *** results reveal a significant cooling trend in the global annual mean temperature using both tree-ring and non-tree-ring records during the 1–1850CE period,and show that the cooling exhibits a stronger trend in the Southern Hemisphere(SH)than that in the Northern Hemisphere(NH).Yet,the long-term trends vary according to different combinations of proxy *** reconstructions based on different types of proxies also exhibit different features in terms of volcanic responses and spectral ***-ring-based temperature reconstructions show stronger cooling responses to tropical volcanic eruptions,while non-tree-ring-based reconstructions suggest less robust volcanic responses,which may be related to dating uncertainties and low temporal resolution of the ***-ring width records tend to preserve a substantial proportion of high-frequency(lity,whereas non-tree-ring proxies tend to capture a larger fraction of low-frequency(>200 years)*** are needed to reduce uncertainti

关键词： Millennial cooling trend Global climate change Proxy records Volcanic eruptions Spectral properties Common Era

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The role of snapin in regulation of brain homeostasis

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Neural Regeneration Research 2024年第8期19卷 1696-1701页

作者： Jiawen li Xinqi Huang Yumei An Xueshi Chen Yiyang Chen Mingyuan Xu Haiyan Shan Mingyang Zhang Shanghai Key Lab of Forensic Medicine Key Lab of Forensic ScienceMinistry of JusticeChina(Academy of Forensic Science)ShanghaiChina Institute of Forensic Sciences Suzhou Medical CollegeSoochow UniversitySuzhouJiangsu ProvinceChina Department of Obstetrics and Gynecology The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhouJiangsu ProvinceChina

Brain homeostasis refe rs to the normal working state of the brain in a certain period,which is impo rtant for overall health and normal life ***,there is a lack of effective treatment methods for the adverse consequences caused by brain homeostasis *** is a protein that assists in the formation of neuronal synapses and plays a crucial role in the normal growth and development of ***,many researchers have reported the association between snapin and neurologic and psychiatric disorders,demonstrating that snapin can improve brain *** manifestations of brain disease often involve imbalances in brain homeostasis and may lead to neurological and behavioral *** article aims to explo re the role of snapin in restoring brain homeostasis after injury or diseases,highlighting its significance in maintaining brain homeostasis and treating brain ***,it comprehensively discusses the implications of snapin in other extracerebral diseases such as diabetes and viral infections,with the objective of determining the clinical potential of snapin in maintaining brain homeostasis.

关键词： brain homeostasis diabetes neurological diseases snapin traumatic brain injury vesicle fusion

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Thermoelectric transport properties of p-type Bi2Se3-Sb2Se3-In2Se3 high entropy compounds

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Rare Metals 2024年第7期43卷 3415-3421页

作者： Feng Jiang Cheng-liang Xia Yong-Bin Zhu Jun li Yue Chen Wei-Shu liu Department of Materials Science and Engineering Southern University of Science and Technology Department of Mechanical Engineering The University of Hong Kong Guangdong Provincial Key Laboratory of Functional Oxide Materials and Devices Southern University of Science and Technology

The introduction of entropy concept into thermoelectric materials recently has attracted broad ***,we showed the phase diagram of the ternary systems of *** the high entropy compounds （HECs）,we have identified an in... 详细信息

关键词： Selenium compounds

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Chidamide plus prednisone,cyclophosphamide,and thalidomide for relapsed or refractory peripheral T-cell lymphoma:A multicenter phase II trial

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Chinese Medical Journal 2024年第13期137卷 1576-1582页

作者： Jinhua liang li Wang Xiaodong Wang Guohui Cui Jianfeng Zhou Tongyao Xing Kaixin Du Jingyan Xu Luqun Wang Rong liang Biyun Chen Jian Cheng Haorui Shen Jianyong li Wei Xu Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Key Laboratory of Hematology of Nanjing Medical University NanjingJiangsu 210029China Collaborative Innovation Center for Cancer Personalized Medicine NanjingJiangsu 210029China Department of Hematology Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalSchool of Medicine of University of Electronic Science and Technology of ChinaChengduSichuan 610000China Department of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Hematology Nanjing Drum Tower HospitalNanjing University Medical SchoolNanjingJiangsu 210008China Department of Hematology Qilu Hospital of Shandong UniversityJinanShandong 250000China Department of Hematology Xijing HospitalThe Fourth Military Medical UniversityXi’anShaanxi 710032China Department of Hematology Fujian Provincial HospitalFuzhouFujian 350001China Department of Hematology Zhongda HospitalMedical School of Southeast UniversityNanjingJiangsu 210009China

Background:Although the treatment of peripheral T-cell lymphoma(PTCL)has undergone advancements during the past several years,the response rate and long-term effects with respect to patients with PTCL remain unsatisfactory—particularly for relapsed or refractory(R/R)*** phase II trial was designed to explore the efficacy and safety of an all-oral regimen of chidamide plus prednisone,cyclophosphamide,and thalidomide(CPCT)for R/R PTCL patients who could not tolerate the standard chemotherapy for a variety of ***:We conducted a multicenter phase II clinical trial in which we combined chidamide(30 mg twice weekly)with prednisone(20 mg daily after breakfast),cyclophosphamide(50 mg daily after lunch),and thalidomide(100 mg daily at bedtime)(the CPCT regimen)for a total of fewer than 12 cycles as an induction-combined treatment period,and then applied chidamide as single-drug ***-five patients were ultimately enrolled from August 2016 to April 2021 with respect to Chinese patients at nine *** primary objective was to assess the overall response rate(ORR)after the treatment with ***:Of the 45 enrolled patients,the optimal ORR and complete response(CR)/CR unconfirmed(CRu)were 71.1%(32/45)and 28.9%(13/45),respectively,and after a median follow-up period of 56 months,the median progression-free survival(PFS)and overall survival(OS)were 8.5 months and 17.2 months,*** five-year PFS and OS rates were 21.2%(95%confidence interval[CI],7.9-34.5%)and 43.8%(95%CI,28.3-59.3%),*** most common adverse event was neutropenia(20/45,44.4%),but we observed no treatment-related ***:The all-oral CPCT regimen was an effective and safe regimen for R/R PTCL patients who could not tolerate standard chemotherapy for various *** Registration:***,NCT02879526.

关键词： Peripheral T-cell lymphoma Chidamide Prednisone Cyclophosphamide Thalidomide All-oral regimen

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Analysis of Epidemiological and Issues Encountered in Case Reports on Echinococcosis—China,2022

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China CDC weekly 2024年第6期6卷 100-104页

作者： Yan Kui Shuai Han Xiaojuan Zhang Guangzhong Shi Yale Yu Ruirui li Peizheng Zhan Hongju Duan Wenbo Luo Benfu li Shaoqi Ning Yalan Zhang Aiya Zhu Jingbo Xue National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)National Health Commission Key Laboratory of Parasite and Vector BiologyWorld Health Organization Collaborating Center for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghaiChina Gansu Provincial Center for Disease Control and Prevention Lanzhou CityGansu ProvinceChina The Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region Urumuqi CityXinjiang Uygur Autonomous RegionChina Xinjiang Production and Construction Corps Center for Disease Control and Prevention Urumuqi CityXinjiang Uygur Autonomous RegionChina Sichuan Provincial Center for Disease Control and Prevention Chengdu CitySichuan ProvinceChina Qinhai Institute for Endemic Disease Control and Prevention Xining CityQinghai ProvinceChina Ningxia Center for Disease Control and Prevention Yinchuan CityNingxia Hui Autonomous RegionChina Inner Mongolia Autonomous Region Center for Comprehensive Disease Control and Prevention Hohhot CityInner Mongolia AutonomousChina Yunnan Institute of Parasitic Diseases Puer CityYunnan ProvinceChina Shaanxi Provincial Center for Disease Control and Prevention Xi'an CityShaanxi ProvinceChina Henan Provincial Center for Disease Control and Prevention Zhengzhou CityHenan ProvinceChina Guizhou Provincial Center for Disease Control and Prevention Guiyang CityGuizhou ProvinceChina

Summary What is already known about this topic?Echinococcosis is classified as a Class C infectious disease in *** is endemic in 370 counties located in the agricultural and pastoral regions of western *** is added by this report?This report provides a comprehensive overview of the cases of echinococcosis reported in China in *** a thorough evaluation conducted by provincial CDCs.

关键词： China Ech counties

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Antibacterial mechanism of kojic acid and tea polyphenols against Escherichia coli O157:H7 through transcriptomic analysis

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Food Science and Human Wellness 2024年第2期13卷 736-747页

作者： Yilin lin Ruifei Wang Xiaoqing li Keren Agyekumwaa Addo Meimei Fang Yehui Zhang Yigang Yu School of Food Sciences and Engineering South China University of TechnologyGuangzhou 510640China Sericulture&Agri-food Research Institute Guangdong Academy of Agricultural Sciences Key Laboratory of Functional FoodsMinistry of Agriculture and Rural AffairsGuangdong Key Laboratory of Agricultural Products ProcessingGuangzhou 510610China Research Center of Food Safety and Detection College of Food Science and EngineeringSouth China University of TechnologyGuangzhou 510640China

Escherichia coli O157:H7 is one of the major foodborne pathogenic bacterial that cause infectious diseases in *** previous found that a combination of kojic acid and tea polyphenols exhibited better activity against *** O157:H7 than using either *** study aimed to explore responses underlying the antibacterial mechanisms of kojic acid and tea polyphenols from the gene *** functional enrichment analysis by comparing kojic acid and tea polyphenols individually or synergistically against *** O157:H7 found that acid resistance systems in kojic acid were activated,and the cell membrane and genomic DNA were destructed in the cells,resulting in“oxygen starvation”.The oxidative stress response triggered by tea polyphenols inhibited both sulfur uptake and the synthesis of ATP,which affected the bacteria's life metabolic ***,we found that kojic acid combined with tea polyphenols hindered the uptake of iron that played an essential role in the synthesis of DNA,respiration,tricarboxylic acid *** results suggested that the iron uptake pathways may represent a novel approach for kojic acid and tea polyphenols synergistically against *** O157:H7 and provided a theoretical basis for bacterial pathogen control in the food industry.

关键词： Kojic acid Tea polyphenols Antibacterial mechanism Escherichia coli O157:H7 RNA-seq

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