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Glutamatergic CYLD deletion leads to aberrant excitatory activity in the basolateral amygdala:association with enhanced cued fear expression

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Neural Regeneration Research 2025年第11期20卷 3259-3272页

作者： Huidong Li Faqin Li Zhaoyi Chen Erwen Wu Xiaoxi Dai Danni Li haojie an Shiyi Zeng Chunyan Wang Li Yang Cheng Long School of Life Sciences South China Normal UniversityGuangzhouGuangdong ProvinceChina School of Life Sciences Guangzhou UniversityGuangzhouGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Major Obstetric Diseases The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Panyu Central HospitalGuangzhouGuangdong ProvinceChina

Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear ***(CYLD)is a deubiquitinase that negatively regulates the nuclear factor kappa-B *** is well studied in non-neuronal cells,yet underinvestigated in the brain,where it is highly *** studies have shown involvement of CYLD in the remodeling of glutamatergic synapses,neuroinflammation,fear memory,and anxiety-and autism-like ***,the precise role of CYLD in glutamatergic neurons is largely ***,we first proposed involvement of CYLD in cued fear *** next constructed transgenic model mice with specific deletion of Cyld from glutamatergic *** results show that glutamatergic CYLD deficiency exaggerated the expression of cued fear in only male ***,loss of CYLD in glutamatergic neurons resulted in enhanced neuronal activation,impaired excitatory synaptic transmission,and altered levels of glutamate receptors accompanied by over-activation of microglia in the basolateral amygdala of male ***,our study suggests a critical role of glutamatergic CYLD in maintaining normal neuronal,synaptic,and microglial *** may contribute,at least in part,to cued fear expression.

关键词： basolateral amygdala cued fear expression cylindromatosis deubiquitinase glutamate receptor 1 glutamatergic neuron microglial activation N-methyl-D-aspartate receptor 1 neuronal activation synaptic transmission

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四履带式甘蔗收割机越障性能仿真与试验

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农机化研究 2025年第1期47卷 226-233页

作者：李维兴刘庆庭张豪杰华南农业大学南方农业机械与装备关键技术教育部重点实验室广州510642 广东工程职业技术学院广州510650

目前,甘蔗主产地有广西、云南等地区,甘蔗主产区以丘陵山地为主。轮式底盘甘蔗收割机通过性差而无法在狭窄、连绵起伏等复杂坡面作业,需要一种能够适应丘陵山区的甘蔗收割机。为此,设计了一款三角履带式甘蔗收割机,底盘是由前三角履带... 详细信息

目前,甘蔗主产地有广西、云南等地区,甘蔗主产区以丘陵山地为主。轮式底盘甘蔗收割机通过性差而无法在狭窄、连绵起伏等复杂坡面作业,需要一种能够适应丘陵山区的甘蔗收割机。为此,设计了一款三角履带式甘蔗收割机,底盘是由前三角履带轮和后平履带轮构成的4履带行走系统,后履带偏摆转向。同时,对该机的结构参数、履带底盘在翻越垂直壁和跨越壕沟过程中的越障性能进行分析,得出4履带式甘蔗收割机履带底盘越障性能与其结构参数的内在联系;建立了该机的多体动力学模型,在RecurDyn软件中模拟了该机在不同的参数下的动力学性能,并对样机进行越障试验验证。验证试验表明:车辆能够跨越高为18 cm的固体垂直障碍,与仿真数据相比,实际测得的俯仰角、横摆角和翻滚角的幅值变化符合预期,车辆俯仰角波动幅值超过5°,甘蔗收割机的俯仰现象明显;翻滚角变化幅值达到3°,车辆通过障碍时,需要考虑其他因素导致车辆的俯仰角变化;跨越宽为50 cm、高18 cm壕沟时,安全通过壕沟;车辆的翻滚角变化明显,幅值最大相差2°,说明此时车辆左右两边履带的颠簸较为严重,但车辆总体越障稳定性较好。研究成果可为甘蔗收割机结构设计与改进、增强作业安全性提供关键技术支持,具有重要的参考价值。

关键词：甘蔗收割机 RecurDyn动力学底盘参数车辆建模及仿真

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A lumped mass Chebyshev spectral element method and its application to structural dynamic problems

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Earthquake Engineering and Engineering Vibration 2022年第3期21卷 843-859页

作者： Wang Jingxiong Li Hongjing Xing haojie Engineering Mechanics Institute Nanjing Tech UniversityNanjing 211816China Institute of Geophysics China Earthquake AdministrationBeijing 100081China

A diagonal or lumped mass matrix is of great value for time-domain analysis of structural dynamic and wave propagation problems,as the computational efforts can be greatly reduced in the process of mass matrix *** this study,the nodal quadrature method is employed to construct a lumped mass matrix for the Chebyshev spectral element method(CSEM).A Gauss-Lobatto type quadrature,based on Gauss-Lobatto-Chebyshev points with a weighting function of unity,is thus *** the aid of this quadrature,the CSEM can take advantage of explicit time-marching schemes and provide an efficient new tool for solving structural dynamic *** types of lumped mass Chebyshev spectral elements are designed,including rod,beam and plate *** performance of the developed method is examined via some numerical examples of natural vibration and elastic wave propagation,accompanied by their comparison to that of traditional consistent-mass CSEM or the classical finite element method(FEM).Numerical results indicate that the proposed method displays comparable accuracy as its consistent-mass counterpart,and is more accurate than classical *** the simulation of elastic wave propagation in structures induced by high-frequency loading,this method achieves satisfactory performance in accuracy and efficiency.

关键词： mass lumping Chebyshev spectral element method Gauss-Lobatto-Chebyshev points Gauss-Lobatto type quadrature structural dynamic analysis elastic wave propagation

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Numerical Aspects of Isogeometric Boundary Element Methods:(Nearly)Singular Quadrature,Trimmed NURBS and Surface Crack Modeling

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Computer Modeling in Engineering & Sciences 2022年第1期130卷 513-542页

作者： Xuan Peng haojie Lian Department of Mechanical Engineering Suzhou University of Science and TechnologySuzhou215009China Key Laboratory of In-situ Property-improving Mining of Ministry of Education Taiyuan University of TechnologyTaiyuan030024China

This work presents some numerical aspects of isogeometric boundary element methods(IGABEM).The behavior of hyper-singular and nearly-singular integration is first explored on the distorted NURBS *** numerical treatments are proposed to enhance the quadrature in the framework of isogeometric *** a numerical implementation of IGABEM on the trimmed NURBS is *** on this idea,the surface crack problem is modeled incorporation with the phantom element *** proposed method allows the crack to intersect with the boundary of the body while preserving the original parametrization of the NURBS-based CAD geometry.

关键词： Isogeometric analysis trimmed NURBS singular integration boundary element method surface crack

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Scaffold attachment factor B 1： an intrinsic inhibitor ot androgen receptor downregulated in prostate cancer

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Asian Journal of Andrology 2013年第6期15卷 703-704页

作者： haojie Huang Department of Biochemistry and Molecular Biology Mayo Clinic College of Medicine Rochester MN 55905 USA Department of Urology Mayo Clinic College of Medicine Rochester MN 55905 USA Mayo Clinic Cancer Center Mayo Clinic College of Medicine. Rochester. MN 55905. USA

The androgen receptor （AR） is a pleio-trophic transcription factor that regu-lates expression of a large number of genes involved in many diverse cellular processes. The AR activation pathways have been studied extensively. However, the molecular mechanism and biological significance of AR inhibitory signals remain poorly understoo＆ Mukhopadhyay et aL have now identified the nuclear matrix protein scaffold attachmenl factor B1 （SAFB1） as a novel AR corepressor. The authors found that SAFB1 physically associates with AR protein and inhibits AR transcriptional activity and androgen-sens- itive gene expression. SAFB1 had no effect on chromatin occupancy of AR, but silencin of SAFB1 abolished recruitment MST1, known AR repressor, at AR target loci. The also showed that SAFB1 interacts with EZH2 SUZ12 and EED, three core components o the Polycomb repressive complex 2 （PRC2）, which catalyzes the gene repression histone modification H3 lysine 27 trimethylation （H3K27me3）. The authors further showed that forced expression of SAFB1 increases H3K27me3 at AR target loci and this effec requires EZH2. Finally, the authors demon strated that expression of SAFB1 is downre-guiated in human prostate cancer （PCa） specimens and SAFB1 knockdown results in an aggressive phenotype of PCa. These find-ings identify SAFB1 as an important node for integration of multiple inhibitory signals ot AR, which represents a viable pathway fol therapeutic intervention of PCa.

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Chern-Ricci curvatures, holomorphic sectional curvature and Hermitian metrics

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Science China Mathematics 2021年第4期64卷 763-780页

作者： haojie Chen Lingling Chen Xiaolan Nie Department of Mathematics Zhejiang Normal UniversityJinhua 321004China

We present some formulae related to the Chern-Ricci curvatures and scalar curvatures of special Hermitian *** prove that a compact locally conformal Kähler manifold with the constant nonpositive holomorphic sectional curvature is K?*** also give examples of complete non-Kähler metrics with pointwise negative constant but not globally constant holomorphic sectional curvature,and complete non-Kähler metrics with zero holomorphic sectional curvature and nonvanishing curvature tensors.

关键词： Chern-Ricci curvatures holomorphic sectional curvature locally conformal Kähler metric kGauduchon metric

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Modeling pipe-soil interaction under vertical downward relative offset using B-spline material point method

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第6期15卷 1520-1534页

作者： Chunxin Zhang Honghu Zhu haojie Li School of Earth Sciences and Engineering Nanjing UniversityNanjing210023China Institute of Earth Exploration and Sensing Nanjing UniversityNanjing210023China

To analyze the pipeline response under permanent ground deformation,the evolution of resistance acting on the pipe during the vertical downward offset is an essential ***,the efficient simulation of pipe penetration into soil is challenging for the conventional finite element(FE)method due to the large deformation of the surrounding *** this study,the B-spline material point method(MPM)is employed to investigate the pipe-soil interaction during the downward movement of rigid pipes buried in medium and dense *** describe the density-and stress-dependent behaviors of sand,the J2-deformation type model with state-dependent dilatancy is *** effectiveness of the model is demonstrated by element tests and biaxial compression ***,the pipe penetration process is simulated,and the numerical outcomes are compared with the physical model *** effects of pipe size and burial depth are investigated with an emphasis on the mobilization of the soil resistance and the failure *** simulation results indicate that the bearing capacity formulas given in the guidelines can provide essentially reasonable estimates for the ultimate force acting on buried pipes,and the recommended value of yield displacement may be underestimated to a certain extent.

关键词： Pipe-soil interaction Material point method(MPM) Large ground deformation Failure mechanism Downward movement

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Defect Analysis and Innovation Design of Synchronizer for Clutchless Automatic Mechanical Transmission

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Chinese Journal of Mechanical Engineering 2022年第1期35卷 238-254页

作者： Lipeng Zhang Yunao Peng haojie Yang Shaohua Li Hebei Key Laboratory of Special Delivery Equipment Yanshan UniversityQinhuangdao 066004China State Key Laboratory of Mechanical Behavior and System Safety of Traffic Engineering Structures Shijiazhuang Tiedao UniversityShijiazhuang 050043China

The synchronizer is a key component of automatic mechanical transmission(AMT)equipped in electric vehicles,but the inertial lock-ring synchronizer(ILRS)commonly used there is not suitable especially for pure electric vehicles without a clutch because of big shift *** make the shifting process rapid and smooth,a new synchronizer named pressure-controllable friction ring synchronizer(PCFRS)was ***,the inevitable shortcoming of ILRS was verified by simulation and ***,the mechanical characteristics and advantages of the new synchronizer over ILRS were ***,the formulations describing the dynamic transmission based on the working mechanism of the PCFRS were ***,the shifting simulation results with PCFRS and ILRS based on the same operating conditions were compared and *** research shows that the PCFRS can meet the main shifting evaluation index of an AMT without complex control methods,as well as it takes only 0.2406 s to finish the comfortable and zero-speed-difference *** shifting quality of PCFRS is better than that of the *** lays a foundation for using the new synchronizer as a part of clutchless AMTs equipped in pure electric vehicles.

关键词： Electric vehicle Clutchless automatic mechanical transmission Inertial lock-ring synchronizer Pressure-controllable friction ring synchronizer Mechanical characteristics Shifting quality

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Lineage plasticity-mediated therapy resistance in prostate cancer

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Asian Journal of Andrology 2019年第3期21卷 241-248页

作者： Alexandra M Blee haojie Huang Department of Biochemistry and Molecular Biology Mayo Clinic College of Medicine Rochester MN 55905 USA Biochemistry and Molecular Biology Graduate Program Mayo Clinic Graduate School of Biomedical Sciences Rochester MN 55905 USA Department of Urology Mayo Clinic College of Medicine Rochester MN 55905 USA Mayo Clinic Cancer Center Mayo Clinic College of Medicine Rochester MN 55905 USA

Therapy resistance is a significant challenge for prostate cancer treatment in clinic. Although targeted therapies such as androgen deprivation and androgen receptor (AR) inhibition are effective initially, tumor cells eventually evade these strategies through multiple mechanisms. Lineage reprogramming in response to hormone therapy represents a key mechanism that is increasingly observed. The studies in this area have revealed specific combinations of alterations present in adenocarcinomas that provide cells with the ability to transdifferentiate and perpetuate AR-independent tumor growth after androgen-based therapies. Interestingly, several master regulators have been identified that drive plasticity, some of which also play key roles during development and differentiation of the cell lineages in the normal prostate. Thus, further study of each AR-independent tumor type and understanding underlying mechanisms are warranted to develop combinational therapies that combat lineage plasticity in prostate cancer.

关键词： lineage plasticity neuroendocrine prostate cancer therapy resistance transdifferentiation

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Experimental and Theoretical Analysis of the Drag Torque in Wet Clutches

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Fluid Dynamics & Materials Processing 2019年第4期15卷 403-417页

作者： haojie Pan Xiaojun Zhou School of Mechanical Engineering Zhejiang UniversityHangzhou310000China

Traditional mathematical models cannot predict and explain the phenomenon by which the drag torque(DT)in wet clutches rises in the high-speed *** order to evaluate the DT in such conditions,a two-phase air-fluid mathematical model for a DT with grooves was *** mathematical model was based on the theory of viscous fluid flow.A two-phase volume of fluid model was also used to investigate the distribution and volume fraction of air and *** on three friction plates with different grooves were conducted to validate the resulting mathematical *** was found that the gap between plates decreased in the high-speed zone,thereby producing an increase of the DT in the high-speed *** results support the understanding of the physical phenomena relating to disengaged wet clutches,and provide a theoretical basis for the future improvement of drive systems.

关键词： Wet clutch drag torque two-phase fluid groove form

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