检索结果-南通市图书馆

Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2022年第2期7卷 502-518页

作者： Zhen Wang Fan-lian Zeng Ya-wen Hu Xiao-yan Wang Fu-lei Zhao Pei zhou Jing Hu Yuan-yuan Xiao Zhong-lan Hu Ming-feng Guo Xiao-qiong Wei Xiao Liu Nong-yu Huang Jun zhang Shu-wen Chen Juan Cheng Hua-ping Zheng Hong zhou Qi-xiang Zhao Chen zhang Yan hao Song Zou Yi-yue Gui Jia-dong Yu Lin-na Gu Cheng-cheng Yue hao-zhou zhang Wen-ling Wu Yi-fan zhou Xi-kun zhou Guo-bo Shen Xiu Teng Jiong Li State Key Laboratory of Biotherapy and Cancer Center West China HospitalWest China Medical SchoolSichuan University and Collaborative Innovation Center for BiotherapyChengduSichuan 610041China Department of Liver Surgery&Liver Transplantation West China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengduSichuan 610041China Laboratory of Liver Surgery West China HospitalSichuan UniversityChengduSichuan 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children Ministry of EducationSichuan UniversityChengdu 610041China Department of Cardiovascular Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Laboratory of Human Disease and Immunotherapies West China HospitalSichuan UniversityChengduSichuan 610041China

Interleukin-37b(hereafter called IL-37)was identified as fundamental inhibitor of natural and acquired *** molecular mechanism and function of IL-37 in colorectal cancer(CRC)has been ***,we found that IL-37 transgenic(IL-37tg)mice were highly susceptible to colitis-associated colorectal cancer(CAC)and suffered from dramatically increased tumor burdens in ***,IL-37 is dispensable for intestinal mutagenesis,and CRC cell proliferation,apoptosis,and ***,IL-37 dampened protective cytotoxic T cell-mediated immunity in CAC and B16-OVA ***8^(+)T cell dysfunction is defined by reduced retention and activation as well as failure to proliferate and produce cytotoxic cytokines in IL-37tg mice,enabling tumor evasion of immune *** dysfunction led by IL-37 antagonizes IL-18–induced proliferation and effector function of CD8+T cells,which was dependent on SIGIRR(single immunoglobulin interleukin-1 receptor-related protein).Finally,we observed that IL-37 levels were significantly increased in CRC patients,and positively correlated with serum CRC biomarker CEA levels,but negatively correlated with the CD8+T cell infiltration in CRC *** findings highlight the role of IL-37 in harnessing antitumor immunity by inactivation of cytotoxic T cells and establish a new defined inhibitory factor IL-37/SIGIRR in cancerimmunity cycle as therapeutic targets in CRC.

关键词： immunity cytotoxic Interleukin

Fiber Laser Based Multiplexed Sensing System

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Electronic Science and Technology of China 2008年第4期6卷 396-398页

作者： Jian-Hua Luo Bo Liu Hai-Bin zhou hao zhang Shao-Lin Yan College of Information Technical Science University of Nankai of China Tianjin 300071 China

A laser sensing system based on beat frequency demodulation is proposed. The sensor uses a single-longitudinal-mode distributed Bragg reflector （DBR） fiber laser as a sensing element. This laser sensor has great multiplexing capability due to its wide free spectral range. Wavelength-division-multiplex （WDM） and frequency-division-multiplex （FDM） techniques are studied. The sensing system has high sensitivity and multiplexing channels.

关键词： Distributed Bragg reflector (DBR) multiplexed sensing system single-longitudinal-mode,orthogonal polarization.

Transforming waste particles into valuable adsorbents via amyloid-mediated molecular engineering

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第01期 317-328页

作者： Qingmin Yang Jian Zhao Yujia zhang Xingyu zhou hao Ren Bowen Hu Zhongli Lei Lixin Chen Peng Yang School of Material and Chemical Engineering Bengbu University Anhui Provincial Engineering Laboratory of Silicon-Based Materials School of Chemistry and Chemical Engineering Northwestern Polytechnical University Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education School of Chemistry and Chemical EngineeringShaanxi Normal University Xi'an Key Laboratory of Polymeric Soft Matter School of Chemistry and Chemical Engineering Shaanxi Normal University International Joint Research Center on Functional Fiber and Soft Smart Textile School of Chemistry and Chemical EngineeringShaanxi Normal University

The high-value utilization of industrial solid waste using a facile and eco-friendly process is of great interest and significance in reducing environmental pollution and developing a green circular economy. Herein, we propose an amyloid-mediated molecular engineering strategy to transform particulate waste into valuable adsorbents for metal ions. Our method has the advantage of aqueous solution fabrication under mild conditions without the use of high-temperature hydrothermal methods and toxic chemical reagents. Amyloid-mediated molecular engineering manipulates the phase transition of bovine serum albumin(BSA)on particulate waste surfaces, resulting in a remarkable ～3.1 times improvement in the adsorption capacity of fly ash, a typical industrial solid waste for gold ions after modification with the phase-transitioned BSA(PTB). The resultant adsorption ability was 69–1,980 times higher than those of conventional and emerging adsorbent materials such as ion exchange resins, activated carbon(AC), covalent organic frameworks(COFs), and metal-organic frameworks(MOFs). We further demonstrated the application of our PTB-modified materials in the recovery of precious metals from low-grade gold ore and electronic waste leachates. Consequently, this strategy could increase the value of waste materials nearly 27 times. In addition, this method is generally extendable to other conventional industrial adsorbents such as resin, clay, and Al2O3, and enhances their adsorption capabilities at least twofold. Overall, this work provides a simple and green approach for improving the adsorption performance of solid particles, and is expected to develop into a universal strategy for transforming waste particles into high-value-added products.

关键词：

同方期刊数据库

Laser-Induced Highly Stable Conductive Hydrogels for Robust Bioelectronics

在线全文

学校读者我要写书评

暂无评论

NANO-MICRO LETTERS 2025年第1期17卷 1-4页

作者： Li, Yibo zhou, hao Yang, Huayong Xu, Kaichen Zhejiang Univ Sch Mech Engn State Key Lab Fluid Power & Mechatron Syst Hangzhou 310058 Peoples R China

Despite the promising progress in conductive hydrogels made with pure conducting polymer, great challenges remain in the interface adhesion and robustness in long-term monitoring. To address these challenges, Prof. Seung Hwan Ko and Taek-Soo Kim's team introduced a laser-induced phase separation and adhesion method for fabricating conductive hydrogels consisting of pure poly(3,4-ethylenedioxythiophene):polystyrene sulfonate on polymer substrates. The laser-induced phase separation and adhesion treated conducting polymers can be selectively transformed into conductive hydrogels that exhibit wet conductivities of 101.4 S cm-1 with a spatial resolution down to 5 mu m. Moreover, they maintain impedance and charge-storage capacity even after 1 h of sonication. The micropatterned electrode arrays demonstrate their potential in long-term in vivo signal recordings, highlighting their promising role in the field of bioelectronics.

关键词： Laser processing Conductive hydrogels Stable interface Bio-interfacing electrodes Bioelectronic application

连续激光供能单结GaAs光电池输出特性仿真

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

红外与激光工程 2017年第10期46卷 31-38页

作者：孙浩周大勇张宏超陆健南京理工大学理学院江苏南京210094 上海空间电源研究所上海200245

为了研究808 nm连续激光供能对单结GaAs光电池输出性能的影响,利用COMSOL和MATLAB软件构建了相应物理模型,通过数值仿真研究了激光功率密度、等效串并联电阻和减反膜对热稳态时光电池伏安特性、开路电压、短路电流、光电转换效率、填充... 详细信息

为了研究808 nm连续激光供能对单结GaAs光电池输出性能的影响,利用COMSOL和MATLAB软件构建了相应物理模型,通过数值仿真研究了激光功率密度、等效串并联电阻和减反膜对热稳态时光电池伏安特性、开路电压、短路电流、光电转换效率、填充因子和稳态工作温度的影响。结果表明:随着激光功率密度增大,开路电压和短路电流不断增大,且转换效率和填充因子都具有最大值;减小等效串联电阻和增大等效并联电阻是提高光电池输出性能的有效方法;减反膜结构对提高光电池转换效率非常重要,但也使光电池热稳态工作温度较高。当入射功率密度为62.4 mW/cm^2时,光电池热稳态输出效率达到最高为50.13%。该数值模拟结果与相关实验结果基本相符,对连续激光供能光电池输出特性研究提供一定的理论依据。

关键词：连续激光数值模拟输出特性

Electrode/Electrolyte Optimization-Induced Double-Layered Architecture for High-Performance Aqueous Zinc-(Dual) Halogen Batteries

在线全文

学校读者我要写书评

暂无评论

NANO-MICRO LETTERS 2025年第1期17卷 1-17页

作者： zhou, Chengwang Ding, Zhezheng Ying, Shengzhe Jiang, hao Wang, Yan Fang, Timing zhang, You Sun, Bing Tang, Xiao Liu, Xiaomin Qingdao Univ Sch Text & Clothing Sch Chem & Chem Engn Qingdao 266071 Shandong Peoples R China Univ Technol Sydney Fac Sci Ctr Clean Energy Technol Sch Math & Phys Sci Ultimo NSW 2007 Australia Henan Normal Univ Sch Chem & Chem Engn Xinxiang 453007 Henan Peoples R China

A double-layered protective film based on zinc-based coordination compound and ZnF2-rich solid electrolyte interphase layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic *** double-layered architecture can effectively modulate Zn2+ flux and suppress the zinc dendrite growth, thus facilitating the uniform zinc *** as-developed zinc-(dual) halogen batteries based on double-layered protective film can present high areal capacity and satisfactory cycling stability. Aqueous zinc-halogen batteries are promising candidates for large-scale energy storage due to their abundant resources, intrinsic safety, and high theoretical capacity. Nevertheless, the uncontrollable zinc dendrite growth and spontaneous shuttle effect of active species have prohibited their practical implementation. Herein, a double-layered protective film based on zinc-ethylenediamine tetramethylene phosphonic acid (ZEA) artificial film and ZnF2-rich solid electrolyte interphase (SEI) layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic optimization. The ZEA-based artificial film shows strong affinity for the ZnF2-rich SEI layer, therefore effectively suppressing the SEI breakage and facilitating the construction of double-layered protective film on the zinc metal anode. Such double-layered architecture not only modulates Zn2+ flux and suppresses the zinc dendrite growth, but also blocks the direct contact between the metal anode and electrolyte, thus mitigating the corrosion from the active species. When employing optimized metal anodes and electrolytes, the as-developed zinc-(dual) halogen batteries present high areal capacity and satisfactory cycling stability. This work provides a new avenue for developing aqueous zinc-(dual) halogen batteries.

关键词： Zn metal anodes Double-layered protective film Electrode/electrolyte optimization Aqueous zinc-(dual) halogen batteries

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong zhang Zhiying Chen Yinyi Xiong Qin zhou Ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

Low-Temperature Fabrication of Stable Black-Phase CsPbI₃ Perovskite Flexible Photodetectors Toward Wearable Health Monitoring

在线全文

学校读者我要写书评

暂无评论

NANO-MICRO LETTERS 2025年第1期17卷 1-14页

作者： Zhao, Yingjie Sun, Yicheng Pei, Chaoxin Yin, Xing Li, Xinyi hao, Yi zhang, Mengru Yuan, Meng zhou, Jinglin Chen, Yu Song, Yanlin Zhengzhou Univ Coll Chem Zhengzhou 450001 Peoples R China Zhengzhou Univ Pingyuan Lab Zhengzhou 450001 Peoples R China Chinese Acad Sci Inst Chem Key Lab Green Printing Beijing 100190 Peoples R China Chinese Acad Sci Tech Inst Phys & Chem Key Lab Bioinspired Mat & Interfacial Sci Beijing 100190 Peoples R China Chinese Acad Sci Inst High Energy Phys Beijing 100049 Peoples R China

Low-temperature fabrication of black-phase CsPbI3 perovskite films is first demonstrated by using diphenylphosphinic chloride additive under 30-50 degrees C, arising from the steric effect and chloride insertion ***-area high-quality all-inorganic perovskite films with fewer defects enhanced crystallographic orientation, and excellent environmental stability is *** record performances are demonstrated for flexible wearable photodetectors with a responsivity of 42.1 A W-1, a detectivity of 1.3 x 1014 Jones, high-fidelity image, photoplethysmography sensor functions, and high mechanical stability. Flexible wearable optoelectronic devices fabricated from organic-inorganic hybrid perovskites significantly accelerate the development of portable energy, biomedicine, and sensing fields, but their poor thermal stability hinders further applications. Conversely, all-inorganic perovskites possess excellent thermal stability, but black-phase all-inorganic perovskite film usually requires high-temperature annealing steps, which increases energy consumption and is not conducive to the fabrication of flexible wearable devices. In this work, an unprecedented low-temperature fabrication of stable black-phase CsPbI3 perovskite films is demonstrated by the in situ hydrolysis reaction of diphenylphosphinic chloride additive. The released diphenyl phosphate and chloride ions during the hydrolysis reaction significantly lower the phase transition temperature and effectively passivate the defects in the perovskite films, yielding high-performance photodetectors with a responsivity of 42.1 A W-1 and a detectivity of 1.3 x 1014 Jones. Furthermore, high-fidelity image and photoplethysmography sensors are demonstrated based on the fabricated flexible wearable photodetectors. This work provides a new perspective for the low-temperature fabrication of large-area all-inorganic perovskite flexible optoelectronic devices.

关键词： In situ hydrolyzation Low-temperature processing All-inorganic perovskite Flexible photodetectors Health monitoring

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

城市中爆炸波的传播

四川建材 2009年第2期35卷 128-130,132页

作者：周浩璋中国建筑西南设计研究院有限公司四川成都610081

本文利用LS-DYNA软件,采用ALE(Arbi-trary Lagrange-Euler)方法,对城市复杂环境中爆炸波的传播规律与超压荷载进行了数值计算和分析。通过对两建筑物模型的数值模拟,以及其与单建筑物模型的对比分析,论证了在计算爆炸波超压荷载时考虑... 详细信息

本文利用LS-DYNA软件,采用ALE(Arbi-trary Lagrange-Euler)方法,对城市复杂环境中爆炸波的传播规律与超压荷载进行了数值计算和分析。通过对两建筑物模型的数值模拟,以及其与单建筑物模型的对比分析,论证了在计算爆炸波超压荷载时考虑相邻建筑物的重要性;通过对一个典型的T型街道的数值模拟,以及其与简单环境的对比分析,揭示了爆炸波在城市复杂环境中的传播规律,并揭示了爆炸波的超压荷载在城市复杂环境中的变化规律和分布特征。

关键词： LS-DYNA软件 ALE方法爆炸波城市复杂环境超压荷载传播规律