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Tabernaesine J,a Novel Vincamine-Type Indole Alkaloid with 6/5/6/6/6/5/5 Heptacyclic-Ring System Scaffold from Tabernaemontana pachysiphon

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Chinese Journal of Chemistry 2022年第4期40卷 475-479页

作者： Wen-Fang yi Tiwalade A.Adelakun Xue Bai yu Zhang Xiao-Jiang hao State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China

Comprehensive Summary Tabernaesine J(1),an unprecedented vincamine-type indole alkaloid with 6/5/6/6/6/5/5 heptacyclic-ring system,as well as one new biogenetically related vincamine-type indole alkaloid(2),were isolated from leaves of Tabernaemontana *** structures were established by a combination of HRESIMS,NMR,single crystal X-ray diffraction,and ECD *** unprecedented pen-ta-lactone ring in tabernaesine J(1)was postulated to be derived from acetyl-CoA enolate *** 2 combined with fluconazole has the potential to overcome fluconazole resistance in Candida albicans.

关键词： Natural products Alkaloids Structure elucidation Tabernaemontana pachysiphon Tabernaesine J

Transient Damping of Virtual Synchronous Generator for Enhancing Synchronization Stability during Voltage Dips

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CES Transactions on Electrical Machines and Systems 2024年第2期8卷 143-151页

作者： Shitao Sun yu Lei Guowen hao yi Lu Jindong Liu Zhaoxin Song Jie Zhang North China Electric Power Research Institute Co. Ltd.Beijing 100045China State Grid Xinyuan Co. Ltd.Beijing 100761China Hebei Fengning Pumped Storage Energy Co.Ltd. Chengde 068350China

Virtual synchronous generators(VSGs)are widely introduced to the renewable power generation,the variablespeed pumped storage units,and so on,as a promising gridforming *** is noted that VSGs can provide virtual inertia for frequency support,but the larger inertia would worsen the synchronization stability,referring to keeping synchronization with the grid during voltage ***,this paper presents a transient damping method of VSGs for enhancing the synchronization stability during voltage *** is revealed that the loss of synchronization(LOS)of VSGs always accompanies with the positive frequency deviation and the damping is the key factor to remove LOS when the equilibrium point *** order to enhance synchronization stability during voltage dips,the transient damping is proposed,which is generated by the frequency deviation in active power ***,the proposed method can realize seamless switching between normal state and grid ***,detailed control design for transient damping gain is given to ensure the synchronization stability under different inertia requirements during voltage ***,the experimental results are presented to validate the analysis and the effectiveness of the improved transient damping method.

关键词： Virtual synchronous generator(VSG) Transient damping Synchronization stability Voltage dips

Role of triggering receptor expressed on myeloid cells 1/2 in secondary injury after cerebral hemorrhage

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World Journal of Clinical Cases 2025年第9期13卷 1-12页

作者： Fan yi hao Wu Hai-Kang Zhao Xi’an Medical University Xi’an 710021Shaanxi ProvinceChina Department of Neurosurgery The Second Affiliated Hospital of Xi’an Medical UniversityXi’an 710038Shaanxi ProvinceChina

Intracerebral hemorrhage(ICH)is a common severe emergency in neurosurgery,causing tremendous economic pressure on families and society and devastating effects on patients both physically and psychologically,especially among patients with poor functional *** is often accompanied by decreased consciousness and limb *** seriously affects patients’ability to live *** rapid advances in neurosurgery have greatly improved patient survival,there remains insufficient evidence that surgical treatment significantly improves long-term *** in-depth pathophysiological studies after ICH,increasing evidence has shown that secondary injury after ICH is related to long-term prognosis and that the key to secondary injury is various immune-mediated neuroinflammatory reactions after *** basic and clinical studies of various systemic inflammatory diseases,triggering receptor expressed on myeloid cells 1/2(TREM-1/2),and the TREM receptor family is closely related to the inflammatory *** inflammatory diseases can be upregulated and downregulated through receptor *** the TREM receptor functions after ICH,the types of results from intervention,and whether the outcomes can improve secondary brain injury and the long-term prognosis of patients are *** analysis of relevant research results from basic and clinical trials revealed that the inhibition of TREM-1 and the activation of TREM-2 can alleviate the neuroinflammatory immune response,significantly improve the long-term prognosis of neurological function in patients with cerebral hemorrhage,and thus improve the ability of patients to live independently.

关键词： Cerebral hemorrhage Secondary injury Triggering receptor expressed on myeloid cells 1/2 Neurosurgery Inflammatory response

皮肤毛母细胞瘤与基底细胞癌的临床病理鉴别诊断

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诊断病理学杂志 2018年第3期25卷 201-204页

作者：吴雪梅王小明郭少峰颜浩余梦懿肖柳眉山市人民医院病理科四川眉山620010

目的探讨皮肤毛母细胞瘤与基底细胞癌的临床病理及免疫组化、鉴别诊断要点。方法对已确诊的6例毛母细胞瘤和20例基底细胞癌的石蜡标本行HE染色及CK7、bcl-2、AR、CD10、Ki-67免疫组化染色,观察形态学和免疫组化表达特点。结果毛母细胞... 详细信息

目的探讨皮肤毛母细胞瘤与基底细胞癌的临床病理及免疫组化、鉴别诊断要点。方法对已确诊的6例毛母细胞瘤和20例基底细胞癌的石蜡标本行HE染色及CK7、bcl-2、AR、CD10、Ki-67免疫组化染色,观察形态学和免疫组化表达特点。结果毛母细胞瘤来源于基底样生发细胞,肿瘤位于真皮及皮下组织内,不与表皮相连,境界清楚,由分布均匀的伴有毛囊分化的毛母细胞团构成;免疫组化:5例CK7(-),1例弱(+);3例bcl-2(-),3例弱(+);6例AR(-),6例CD10(-),而瘤周间质(+);Ki-67阳性指数10%~20%。基底细胞癌来源于基底样生发细胞,癌细胞与表皮基底部相连,呈浸润性生长,周边癌细胞呈栅栏状排列,周围间质疏松,癌巢和间质之间形成收缩裂隙;免疫组化14例CK7(+),6例弱(+);17例bcl-2(+),3例弱(+);16例AR(+),4例弱(+);20例为癌细胞CD10(+),癌周间质(-);Ki-67阳性指数20%~30%。结论结合镜下组织学特点及免疫表型,有助于两种肿瘤的鉴别诊断。

关键词：毛母细胞瘤基底细胞癌临床病理特点免疫组化

Variations of the hilar biliary confluence from postoperative cholangiography in Chinese population

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Hepatobiliary & Pancreatic Diseases International 2021年第3期20卷 301-303页

作者： yu Li Wei Zhang hao Sun Xue-Min Liu yi Lv Department of Hepatobiliary Surgery the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China National Local Joint Engineering Research Center for Precision Surgery&Regenerative Medicine Xi’an 710061China Shaanxi Province Center for Regenerative Medicine and Surgery Engineering Research Xi’an 710061China

To the Editor: Treatment of the bile ducts at the porta hepatis is a critical step for avoiding post-surgical bile leakage and atrophy of the residual liver and/or the graft during hepatobiliary surgeries, such as hemihepatectomy, surgeries for cholangiocarcinoma or procurement of graft. Precise knowledge of the bile duct anatomy in individual cases has great importance in avoiding these kinds of complications. According to the Couinaud nomenclature.

关键词： anatomy biliary bile

Destroying a Peldan Electrostatic Solution Black Hole

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Chinese Physics Letters 2017年第4期34卷 9-12页

作者： hao Tang yu Song Rui-Hong yue Cheng-yi Sun Institute of Modern Physics and Shaanxi Key Laboratory for Theoretical Physics Frontiers Northwest University Xi＇an 710069 College of Physical and Technology Yangzhou University Yangzhou 225009

By throwing a particle with electric charge and angular momentum into the black holes, much evidence shows that the naked singularity of some （3＋1）-dimensional black holes might be seen, which is not allowed in the weak cosmic censorship conjecture. In this study, we consider a （2＋1）-dimensional Peldan black hole and find that it could be destroyed under certain conditions in both extreme and near-extreme cases.

关键词： Destroying a Peldan Electrostatic Solution Black Hole

Emergent quantum phenomena in atomically engineered iridate heterostructures

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Fundamental Research 2023年第3期3卷 313-321页

作者： Lin hao Di yi Meng Wang Jian Liu Pu yu Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field LaboratoryHFIPSChinese Academy of SciencesHefeiAnhui 230031China State Key Lab of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China RIKEN Center for Emergent Matter Science(CEMS) Wako 351-0198Japan Department of Physics and Astronomy University of TennesseeKnoxvilleTennessee 37996USA State Key Laboratory of Low Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing 100084China Frontier Science Center for Quantum Information Beijing 100084China

Over the last few years,researches in iridates have developed into an exciting field with the discovery of numerous emergent phenomena,interesting physics,and intriguing *** the studies,iridate-based artificial structures play a crucial role owing to their extreme flexibility and tunability in lattice symmetry,chemical composition,and crystal *** this article,we present an overview of the recent progress regarding iridate-based artificial *** first explicitly introduce several essential concepts in ***,we illustrate important findings on representative SrIrO_(3)/SrTiO_(3) superlattices,heterostructures comprised of SrIrO3 and magnetic oxides,and their response to external electric-field ***,we comment on existing problems and promising future directions in this exciting field.

关键词： Iridate Spin-orbit coupling Many-body physics Artificial crystalline structure Magnetism Magnetotransport property Ionic liquid gating

Astrocyte polarization in glaucoma: a new opportunity

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Neural Regeneration Research 2022年第12期17卷 2582-2588页

作者： yi-Xin Liu hao Sun Wen-yi Guo Department of Ophthalmology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology ShanghaiChina

Astrocyte polarization is a new concept which is similar to microglia polarization and in which astrocytes are classified as A1(neurotoxic)and A2(neuroprotective).Several studies on astrocyte polarization have focused mainly on neurodegenerative diseases,trauma,and ***,the role of astrocyte polarization in glaucoma,a neurodegenerative disease,has not been fully *** this review,we first describe the characteristics of astrocyte astrogliosis in glaucoma,including morphological,molecular,proliferative and functional *** then summarize understanding of astrocyte polarization in other diseases,and show that A1 astrocytes are involved in the death of retinal ganglion cells in glaucoma,and that their neurotoxins kill only damaged retinal ganglion *** on this,we propose new interesting conjecture on astrocyte polarization in glaucoma:(1)That the neurotoxin from A1 astrocytes is a product of the complement system(membrane-attacking complex),since this system is known to mediate synaptic elimination and the C3 expression is clearly increased in A1 astrocytes;(2)that reactive scar-forming astrocytes in the optic nerve head may be classified as A2 astrocytes since their ablation leads to a worse prognosis in ***,current therapeutic research progress on astrocyte polarization in other diseases is also *** of astrocyte polarization can be achieved by extracellular microglia-related and intracellular *** A1 or increased A2 astrocytes can rescue the *** example,glucagon-like peptide-1 receptor agonist rescues retinal ganglion cells by reducing A1 astrocytes via the extracellular microglia-related pathway in an ocular hypertension model,suggesting that regulation of astrocyte polarization as a therapeutic target in glaucoma is feasible.

关键词： astrocytes glaucoma heterogeneity microglia neurodegenerative disease neuroinflammation neuroprotection optic nerve retina therapy

Direct constraint on cosmic neutrino mass using observational Hubble parameter data

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Research in Astronomy and Astrophysics 2018年第10期18卷 75-84页

作者： hao-yi Wan Shu-Lei Cao Huan-yu Teng yu Liu Jian-Chen Zhang Tong-Jie Zhang Department of Astronomy Beijing Normal UniversityBeijing 100875China Dezhou University Dezhou 253023China

In order to explore the properties of cosmic neutrinos, i.e. sum of the neutrino mass （∑mv） and the effective number of neutrino species （Neff）, which affects the Hubble expansion rate H（z） and the power of observational Hubble parameter data （OHD） in constraining cosmological parameters under the ACDM model, we utilize OHD to constrain the properties of cosmic neutrinos and apply an accurate H（z） function with ∑ mv, and Neff. First, we simulate new OHD beyond the existing 43 OHD. According to the predictions of measurements of Ho （the current H（z） value）, baryon acoustic oscillations （BAO） peaks, Sandage-Loeb （SL） test and cosmic microwave background （CMB）, we as-sume observational accuracy up to 2% and redshift 0 〈 z ~〈 5. With simulated H（z） data obtained from the fiducial model, we constrain the parameters including ∑ mv, and Neff. When all parameters are set free, ∑mv 〈 0.196eV （95%） and Neff = 2.984 ± 0.826 （68%） are obtained, and when fixing Neff as the standard baseline 3.046, we attain ∑ mv 〈 0.240 eV （95%）. These constrained results are much tighter than the ones obtained by the current OHD, which makes the prospect of OHD in constraining cosmological parameters more promising as its accuracy and quantity grow.

关键词： cosmological parameters - cosmology miscellaneous - methods data analysis