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Changes of paired-pulse evoked responses during the development of epileptic activity in the hippocampus

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第9期12卷 704-711页

作者： Zhou-yan FENG Xiao-jing ZHENG Cong TIAN Yang WANG hao-yu xing Ministry of Education Key Lab of Biomedical Engineering College of Biomedical Engineering & Instrument ScienceZhejiang UniversityHangzhou 310027China

Dysfunction of inhibitory synaptic transmission can destroy the balance between excitatory and inhibitory synaptic inputs in neurons,thereby inducing epileptic *** aim of the paper is to investigate the effects of successive excitatory inputs on the epileptic activity induced in the absence of ***-pulse orthodromic and antidromic stimulations were used to test the changes in the evoked responses in the ***(PTX),γ-aminobutyric acid(GABA) type A(GABA A) receptor antagonist,was added to block the inhibitory synaptic transmission and to establish the epileptic *** evoked population spike(PS) was recorded in the CA1 region of the *** results showed that the application of PTX induced a biphasic change in the paired-pulse ratio of PS amplitude.A short latency increase of the second PS(PS2) was later followed by a reappearance of PS2 *** type of depression was observed in both orthodromic and antidromic paired-pulse responses,whereas the GABAergic PS2 depression [called paired-pulse depression(PPD)] during baseline recordings only appeared in orthodromic-evoked *** addition,the depression duration at approximately 100 ms was consistent with a relative silent period observed within spontaneous burst discharges induced by prolonged application of *** conclusion,the neurons may ignore the excitatory inputs and intrinsically generate bursts during epileptic *** depolarization block could be the mechanisms underlying the PPD in the absence of GABA A *** distinct neuronal responses to stimulations during different epileptic stages may implicate the different antiepileptic effects of electrical stimulation.

关键词： Epilepsy Paired-pulse depression γ-Aminobutyric acid(GABA) Picrotoxin(PTX) CA1 region In-vivo

Transcriptome response of wheat Norin 10 to long-term elevated CO_2 under high yield field condition

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Journal of Integrative Agriculture 2016年第9期15卷 2142-2152页

作者： LIN yue-bing SHEN Cheng-guo LIN Er-da hao xing-yu HAN Xue Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural Sciences/Key Laboratory of Agricultural Environment Ministry of Agriculture Bioinformatics Unit Source Bio Science College of Agronomy Shanxi Agricultural University

The increasing atmospheric carbon dioxide concentration, caused by fossil fuel combustion and deforestation, plays an important role in plant growth and development. Wheat, as a major staple crop, adapts to climate change by tuning its inherent molecular mechanism, which is not well understood. The present study employed the RNA-Seq method to generate transcriptome profiles of the wheat Norin 10 in response to elevated CO_2 in comparison with ambient CO_2. The 10 895 787 high-quality clean reads of Norin 10 were assembled de novo using Trinity（without a reference genome） resulting in a total of 18 206 candidate transcripts with significant BLAST matches. GO enrichment analysis of Norin 10 at different CO_2 concentrations showed that some functional genes related to plastids, precursor metabolites, and energy, thylakoid and photosynthesis were apparently enriched at elevated CO_2（550 μmol mol^–1） in contrast to that at ambient CO_2（400 μmol mol^–1）; these findings were further confirmed by RT-PCR analysis. The findings demonstrated the specific effects of elevated CO_2 during long-term period in free air CO_2 enrichment（FACE） on transcriptome response of the high yielding wheat variety, Norin 10, which has a large spike.

关键词： Norin 10 transcriptome response wheat long term elevated carbon dioxide GO enrichment

Leaf photosynthesis and yield components of mung bean under fully open-air elevated[CO_2]

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Journal of Integrative Agriculture 2015年第5期14卷 977-983页

作者： GAO Ji HAN Xue Saman Seneweera LI Ping ZONG yu-zheng DONG Qi LIN Er-da hao xing-yu Key Laboratory of Ministry of Agriculture on Agro-Environment and Climate Change Institute of Environment and Sustainable Development in Agriculture(IEDA)Chinese Academy of Agricultural Sciences College of Agriculture Shanxi Agricultural University Centre for Systems Biology University of Southern Queensland

Mung bean（Vigna radiata L.） has the potential to establish symbiosis with rhizobia,and symbiotic association of soil micro flora may facilitate the photosynthesis and plant growth response to elevated[CO2].Mung bean was grown at either ambient CO2 400 μmol mol^（-1） or[CO2]（（550＋17） μmol mol^（-1）） under free air carbon dioxide enrichment（FACE） experimental facility in North ***[CO2]increased net photosynthetic rate（Pn）,water use efficiency（WUE） and the non-photochemical quenching（NPQ） of upper most fully-expanded leaves,but decreased stomatal conductance（Gs）,intrinsic efficiency of PSII（Fv ＇/Fm＇）,quantum yield of PSII（φ（PSll）） and proportion of open PSII reaction centers（qp）.At elevated[CO2],the decrease of Fv＇/Fm＇,φ（PSII）,qp at the bloom stage were smaller than that at the pod *** the other hand,Pn was increased at elevated[CO2]by 18.7 and 7.4%at full bloom（R2） and pod maturity stages（R4）,*** these findings,we concluded that as a legume despite greater nutrient supply to the carbon assimilation at elevated[CO2],photosynthetic capacity of mung bean was still suppressed under elevated[CO2]particularly at pod maturity stage but plant biomass and yield was increased by 11.6 and 14.2%,***,these findings suggest that even under higher nutrient acquisition systems such as legumes,nutrient assimilation does not match carbon assimilation under elevated[CO2]and leads photosynthesis down-regulation to elevated[CO2].

关键词： photosynthesis photosynthetic elevated stomatal PSII maturity nutrient assimilation ambient facility

Low‑Temperature Fabrication of Stable Black‑Phase CsPbI_(3) Perovskite Flexible Photodetectors Toward Wearable Health Monitoring

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Nano-Micro Letters 2025年第3期17卷 232-245页

作者： Yingjie Zhao Yicheng Sun Chaoxin Pei xing Yin Xinyi Li Yi hao Mengru Zhang Meng yuan Jinglin Zhou yu Chen Yanlin Song College of Chemistry and Pingyuan Laboratory Zhengzhou UniversityZhengzhou 450001People’s Republic of China Key Laboratory of Green Printing Institute of ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Key Laboratory of Bio‑Inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049People’s Republic of China

Flexible wearable optoelectronic devices fabricated fromorganic–inorganic hybrid perovskites significantly accelerate the developmentof portable energy,biomedicine,and sensing fields,but their poor thermal stabilityhinders further ***,all-inorganic perovskites possessexcellent thermal stability,but black-phase all-inorganic perovskite filmusually requires high-temperature annealing steps,which increases energy consumptionand is not conducive to the fabrication of flexible wearable *** this work,an unprecedented low-temperature fabrication of stable blackphaseCsPbI3perovskite films is demonstrated by the in situ hydrolysis reactionof diphenylphosphinic chloride *** released diphenyl phosphateand chloride ions during the hydrolysis reaction significantly lower the phasetransition temperature and effectively passivate the defects in the perovskitefilms,yielding high-performance photodetectors with a responsivity of 42.1 AW−1 and a detectivity of 1.3×10^(14)***,high-fidelity imageand photoplethysmography sensors are demonstrated based on the fabricated flexible wearable *** work provides a newperspective for the low-temperature fabrication of large-area all-inorganic perovskite flexible optoelectronic devices.

关键词： In situ hydrolyzation Low-temperature processing All-inorganic perovskite Flexible photodetectors Health monitoring

Low-concentration atropine(0.01%)on quantitative contrast sensitivity function in Chinese children with myopia

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 117-124页

作者： yu-hao Ye Yi-Yong Xian Fang Liu Zhong-Lin Lyu xing-Tao Zhou Jing Zhao Department of Ophthalmology and Optometry Eye&ENT Hospital of Fudan UniversityShanghai 200031China NHC Key Laboratory of Myopia(Fudan University) Key Laboratory of MyopiaChinese Academy of Medical SciencesShanghai 200000China Shanghai Research Center of Ophthalmology and Optometry Shanghai 200000China Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care(20DZ2255000).Shanghai 200030 China Division of Arts and Sciences NYU ShanghaiShanghai 200000China Center for Neural Science and Department of Psychology New York UniversityNew York 10012USA Nyu-ECNU Institute of Brain and Cognitive Science NYU ShanghaiShanghai 200000China

AIM:To investigate the effect of 0.01%low-concentration atropine(LA)on quantitative contrast sensitivity function(qCSF)in children with ***:This paired case-control study included 90 eyes of 58 children who were sex-,age-,and refractionmatched and equally divided into two groups:the 0.01%LA group had undergone 6mo use of daily 0.01%atropine and control group was naïve to *** ophthalmic examinations and qCSF test without refractive correction were *** groups were compared in monocular and binocular qCSF parameters,including the area under logCSF,CSF acuity,and contrast sensitivity(CS)at 1.0-18.0 cycle per degree(cpd).RESULTS:In the monocular comparison,the CSF acuity of the LA group was significantly higher than that of the control group(7.58±5.51 vs 6.37±4.22 cpd,P<0.05).The subgroup analysis showed that in the 6-9y group,CSF acuity was significantly higher in the LA group than the control group(8.76±6.19 vs 6.54±4.25 cpd,P<0.05),and in the Female group,low refraction sphere group,and high refraction cylinder group,the CS at high spatial frequencies(12.0 and 18.0 cpd)were significantly higher in the LA group than in the control group(all P<0.05).In the binocular test,CSF acuity and CS at 12.0 cpd were significantly higher in the LA group than in the control group(10.95±7.00 vs 8.65±5.12 cpd;0.17±0.33 vs 0.06±0.16,respectively;both P<0.05).CONCLUSION:Use of LA may result in improved CS in children with early onset myopia.

关键词： low-concentration atropine myopia quantitative contrast sensitivity function Chinese children

Physics-informed battery degradation prediction:Forecasting charging curves using one-cycle data

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Journal of Energy Chemistry 2025年第2期101卷 825-836页

作者： Aihua Tang yuchen Xu Jinpeng Tian xing Shu Quanqing yu Key Laboratory of Advanced Manufacturing Technology for Automobile Parts Ministry of Education Chongqing University of Technology Department of Electrical and Electronic Engineering and Research Centre for Grid Modernization The Hong Kong Polytechnic University School of Automotive Engineering Harbin Institute of Technology

Accurately predicting battery degradation is crucial for battery system ***,due to the complexities of aging mechanisms and limitations of historical data,comprehensively indicating battery degradation solely through maximum capacity loss assessment is *** machine learning offers promising solutions,it often overlooks domain knowledge,resulting in reduced accu racy,increased computational burden and decreased ***,this study proposes a method to predict the voltage-capacity（V-Q） curve during battery degradation with limited historical *** process is achieved through two physically interpretable components:a lightweight interpretable physical model and a physics-informed neural *** components incorporate domain knowledge into machine learning to improve V-Q curve prediction performance and enhance *** validation was conducted on 52 batteries of different types under different testing *** proposed method can accurately predict future *** for hundreds of cycles using only one-present-cycle V-Q curve,with root mean square error and mean absolute error basically less than 0.035 Ah and R2basically less than 98.5%.This means that incremental capacity curves can be extracted from the predicted results for a more comprehensive and accurate battery degradation ***,the method can flexibly adjust prediction length and density to cater to the practical needs of long-cycle prediction and data *** study provides a viable method for rapid degradation prediction and is expected to be generalized to in-vehicle implementations.

关键词： Degradation prediction Lightweight interpretable physical model Lithium-ion battery Physics-informed neural network Voltage-capacity curve

Unraveling the therapeutic potential of Calculus Bovis in liver cancer:A novel step for targeted cancer treatment

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World Journal of Gastroenterology 2025年第3期31卷 127-129页

作者： xing-yu Chen Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

Hepatocellular carcinoma is one of the leading causes of cancer-related deaths globally,and effective treatments are urgently *** present study aimed to investigate the inhibitory effect of Calculus Bovis(CB)on liver cancer and the underlying *** inhibited M2 tumor-associated macrophage polarization and modulated the Wnt/β-catenin signaling pathway,thereby suppressing the proliferation of liver cancer *** inhibitory effect on liver cancer growth was confirmed by both in vivo and in vitro experiments(detailed by Huang et al).The present study provides a theoretical basis for the application of CB for the treatment of liver cancer,providing new avenues for liver cancer treatment.

关键词： Calculus Bovis Liver cancer M2 tumor-associated macrophage polarization Wnt/β-catenin Pathway Tumor microenvironment

CoPSe nanoparticles confined in nitrogen-doped dual carbon network towards high-performance lithium/potassium ion batteries

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Chinese Chemical Letters 2025年第1期36卷 568-573页

作者： Zhong-Hui Sun yu-Qi Zhang Zhen-Yi Gu Dong-Yang Qu Hong-yu Guan xing-Long Wu Guangdong Engineering Technology Research Center for Photoelectric Sensing Materials and Devices c/o School of Chemistry and Chemical EngineeringGuangzhou UniversityGuangzhou 510006China MOE Key Laboratory for UV Light-Emitting Materials and Technology Northeast Normal UniversityChangchun 130024China

The metal ion batteries have gained widespread attention for wearable electronics due to their competitive energy density and long cycling *** the advanced anode materials is significant for next generation energy storage ***,severe electrode volume changes and sluggish redox kinetics are the critical problems for lithium/potassium ion batteries(LIBs/PIBs)towards large-scale ***,we prepare a novel anode material,which consists of reduced graphene oxide wrapping one-dimensional(1D)N-doped porous carbon nanotube with cobalt phosphoselenide(CoPSe)nanoparticles embedded inside them(r GO@Co PSe/NC).Benefited from the dual carbon decorations and ultrafine nanoparticles structure,it achieves a reversible capacity of 245 mAh/g at 5 A/g after 2000 cycles for LIBs and 215 mAh/g at 1 A/g after 500 cycles for *** pseudocapacitance and GITT measurements are used to investigate the electrochemical kinetics of r GO@Co PSe/NC for *** addition,the lithium ion full cell also shows good electrochemical performance when paired with high capacity LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) *** work provides a feasible electrode design strategy for high-efficiency metal ion batteries based on multidimensional nanoarchitecture engineering and composition tailoring.

关键词： Cobalt phosphoselenide Lithium-ion batteries Potassium-ion batteries Reduced graphene oxide Structural stability Full cell

Dark energy effects on surface gravitational redshift and Keplerian frequency of neutron stars

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Communications in Theoretical Physics 2025年第1期77卷 122-129页

作者： Jia-Jing He Yan Xu Yi-Bo Wang Xiu-Lin Huang xing-xing Hu yu-Fu Shen Changchun Observatory National Astronomical ObservatoriesChinese Academy of SciencesChangchun 130117China School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China

Research on the properties of neutron stars with dark energy is a particularly interesting yet unresolved problem in *** analyze the influence of dark energy on the equation of state,the maximum mass,the surface gravitational redshift and the Keplerian frequency for the traditional neutron star and the hyperon star matter within the relativistic mean field theory,using the GM1 and TM1 parameter sets by considering the two flavor symmetries of SU(6)and SU(3)combined with the observations of PSR J1614-2230,PSR J0348+0432,PSR J0030+0451,RX J0720.4-3125,and 1E *** is found that the existence of dark energy leads to the softened equations of the state of the traditional neutron star and the hyperon *** radius of a fixed-mass traditional neutron star(or hyperon star)with dark energy becomes smaller,which leads to increased *** existence of dark energy can also enhance the surface gravitational redshift and the Keplerian frequency of traditional neutron stars and hyperon *** growth of the Keplerian frequency may cause the spin rate to speed up,which may provide a possible way to understand and explain the pulsar glitch ***,we infer that the mass and the surface gravitational redshift of PSR J1748-2446ad without dark energy for the GM1(TM1)parameter set are 1.141 M_(☉)(1.309 M_(☉))and 0.095(0.105),*** corresponding values for the GM1(TM1)parameter set are 0.901 M_(☉)(1.072M_(☉))and 0.079(0.091)if PSR J1748-2446ad contains dark energy withα=*** J1748-2446ad may be a low-mass pulsar with a lower surface gravitational redshift under our selected models.

关键词： dark energy neutron stars gravitational redshift Keplerian frequency