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Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： Qing Qiu Mengting Yang Danfeng Gong Haiying liang Tingting Chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

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On Sullivan's Conjecture on Cycles in 4-free and 5-free Digraphs

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数学学报(中文版) 2013年第2期 289-290页

作者： hao liang jun Ming XU

For a simple digraph G,let β(G) be the size of the smallest subset X■E(G) such that G - X has no directed cycles,and letγ(G) be the number of unordered pairs of nonadjacent vertices in G.A digraph G is called k-free if G has no directed cycles of length at most *** paper proves that β(G)≤0.38197(G) if G is a 4-free digraph,and β(G)≤0.2679 γ(G) if G is a 5-free *** improve the results of Sullivan in 2008.

关键词： free On Sullivan’s Conjecture on Cycles in 4-free and 5-free Digraphs

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经桡动脉行冠脉造影及介入中上肢径路异常时PTCA导丝的应用价值

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中国心血管病研究 2016年第8期14卷 703-705页

作者：许浩军于宗良朱建中顾明汪强谷惠敏江苏大学附属昆山市第一人民医院心血管内科江苏省昆山市215300

目的探讨经桡动脉途径行冠状动脉造影及介入术中,上肢血管异常时PTCA导丝的应用价值.方法我院近3年行桡动脉造影及介入治疗2000例,如果0.035”J型导丝和亲水超滑导丝在右上肢血管推送过程中遇到阻力,遂撤出导丝,进行上肢局部血管造影... 详细信息

目的探讨经桡动脉途径行冠状动脉造影及介入术中,上肢血管异常时PTCA导丝的应用价值.方法我院近3年行桡动脉造影及介入治疗2000例,如果0.035”J型导丝和亲水超滑导丝在右上肢血管推送过程中遇到阻力,遂撤出导丝,进行上肢局部血管造影.疑似桡动脉痉挛的,局部推注维拉帕米100～200μg后再次复查血管造影.结果仍有40例未能成功,其中桡动脉环9例、严重桡动脉狭窄18例、桡动脉发育细小8例、桡动脉痉挛5例,随机分成PTCA导丝组和改股动脉组.PTCA导丝组改用PTCA导丝,最终完成冠状动脉造影检查;改股动脉组直接经股动脉途径行冠状动脉造影术.比较两组手术成功率、操作时间、造影剂用量及局部出血、血肿并发症等情况.结果两组完成冠状动脉造影成功率比较未见统计学差异（95％比100％,P=0.746）.PTCA导丝组操作时间长于改股动脉组[（950.0±125.3）s比（710.0±98.3）s,P=0.032].两组造影剂用量比较未见统计学差异[（50.0±6.3）ml比（47.0±5.9）ml,P=0.18].改股动脉组出血、血肿并发症多于PTCA组（20％比0％,P=0.035）.结论经桡动脉途径行冠状动脉造影及介入治疗术中,当上肢血管发生异常,常规导丝不能完成时,换用PTCA导丝,操作轻柔,并发症发生率低,是安全有效的,特别对不适合经股动脉造影的患者尤为适合.

关键词：冠状动脉造影术桡动脉 PTCA导丝

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专利批量维权中恶意诉讼的认定标准与规制路径

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科技与法律（中英文） 2025年第1期 1-13页

作者：毛昊梁珂馨同济大学上海国际知识产权学院上海200082

目前,我国专利领域批量维权现象较为突出,“流水线”式的维权活动具有涉案专利权利基础相同、案情类似,对小规模终端销售主体批量公证取证后起诉等规律性特征。专利批量诉讼是权利人维护知识产权的合理手段,具备正当性,但批量维权行为... 详细信息

目前,我国专利领域批量维权现象较为突出,“流水线”式的维权活动具有涉案专利权利基础相同、案情类似,对小规模终端销售主体批量公证取证后起诉等规律性特征。专利批量诉讼是权利人维护知识产权的合理手段,具备正当性,但批量维权行为可能因以谋利为目的、使用权利基础不稳定的专利等因素而存在恶意诉讼的隐忧。国内部分法院在处理涉及专利批量维权的恶意诉讼案件时,普遍存在着认定标准不统一、规制手段单一等突出问题。结合美国和欧洲对NPE(非专利实施主体)和PAE(专利主张实体)恶意诉讼的认定及规制的域外经验,我国应从主观和客观两方面完善专利批量维权中恶意诉讼的认定标准,利用大数据、人工智能等技术甄别手段,完善批量维权审查修正机制与完善诉讼程序,综合运用法律、行政、经济、技术等多重规制措施实施综合治理,破解批量维权中的恶意诉讼难题。

关键词：专利批量维权恶意诉讼认定标准规制路径

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Terahertz metadevices for silicon plasmonics

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Chip 2022年第4期1卷 37-65页

作者： Yuan liang hao Yu Hong Wang hao Chi Zhang Tie jun Cui Southern University of Science and Technology(SUSTech) and the Engineer-ing Research Center of Integrated Circuits for Next-Generation Communica-tionsMinistry of EducationSouthern University of Science and TechnologyShenzhen 518055China Department of Materials Science and Engineering&Shenzhen Engineering Research Center for Novel Electronic Information Ma-terials and Devices Southern University of Science and TechnologyShenzhenChina State Key Laboratory of Millimeter Waves and Institute of Electromag-netic Space Southeast UniversityNanjing 210096China

Metamaterial devices(metadevices)have been developed in progress aiming to generate extraordinary performance over traditional de-vices in the(sub-)terahertz(THz)domain,and their planar integra-tion with complementary-metal-oxide-semiconductor(CMOS)cir-cuits pave a new way to build miniature silicon plasmonics that over-comes existing challenges in chip-to-chip *** an effort towards low-power,crosstalk-tolerance,and high-speed data link for future exascale data centers,this article reviews the recent progress on two metamaterials,namely,the spoof surface plasmon polaritons(SPPs),and the split-ring resonator(SRR),as well as their imple-mentations in silicon,focusing primarily on their fundamental the-ories,design methods,and implementations for future THz *** to their respective dispersion characteristic at THz,these two metadevices are highly expected to play an important role in miniature integrated circuits and systems toward compact size,dense integration,and outstanding performance.A design example of a fully integrated sub-THz CMOS silicon plasmonic system integrating these two metadevices is provided to demonstrate a dual-channel crosstalk-tolerance and energy-efficient on-off keying(OOK)communication *** directions and potential applications for THz metade-vices are discussed.

关键词： CMOS I/O transceiver Channel crosstalk Metamaterial Metawaveguide Spoof surface plasmon polaritons Split-ring resonator Terahertz Transmission line Interconnect

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地应力对玻璃钢套管抗挤强度影响的分析

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洛阳理工学院学报（自然科学版） 2013年第2期23卷 10-15页

作者：邱桂林宋彦琦吕兆远夏凡郝亮钧中国矿业大学(北京)力学与建筑工程学院北京100083 中国矿业大学(北京)理学院北京100083

在煤层气开发活动(如注水、压裂)的过程中,当套管穿过复杂的地质构造时,任何一层地质结构发生变化,都会使得区域构造发生小范围变化,这些变化会引起局部构造应力场发生较大的改变,导致套管所受的应力发生变化。鉴于此,本文基于地应力作... 详细信息

在煤层气开发活动(如注水、压裂)的过程中,当套管穿过复杂的地质构造时,任何一层地质结构发生变化,都会使得区域构造发生小范围变化,这些变化会引起局部构造应力场发生较大的改变,导致套管所受的应力发生变化。鉴于此,本文基于地应力作用下套管的力学模型,利用有限元数值模拟软件,分析均匀地应力与非均匀地应力对玻璃钢套管强度的影响。分别研究这两种情况下套管失效的过程,重点分析均匀地应力下套管内部Mises应力分布规律,以及非均匀地应力对套管抗挤强度影响的规律。并编制了计算均匀地应力及非均匀地应力条件下套管抗挤强度计算的程序。

关键词：地应力玻璃钢套管 ABAOUS数值模拟软件抗挤强度

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Bioaccumulation and human health risk assessment of trace metals in the freshwater mussel Cristaria plicata in Dongting Lake, China

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Journal of Environmental Sciences 2021年第6期33卷 335-350页

作者： Dianbao Li Baozhu Pan liang Chen Yuzhu Wang Taoyi Wang jun Wang hao Wang State Key Laboratory of Eco-hydraulic in Northwest Arid Region of China Xi’an University of TechnologyXi’an 710048ShaanxiChina

Trace metal contamination in water and bioaccumulation in aquatic organisms are human health risks of increasing concern. However, the bioaccumulation of trace metals in the organs of the mussel Cristaria plicata in Dongting Lake, China and the human health risks of mussel consumption are largely unknown. We investigated the concentrations of 15 trace metals and metalloids in surface water, sediments, and C. plicata organs(foot, gill, mantle, and visceral mass) and quantified the bioaccumulation and human health risk of these trace metals in specimens collected from Dongting Lake. The concentrations of most metals in surface water exceeded previously published background values. In contrast, the concentrations of most metals in sediments showed a decreasing trend. Overall, the metal concentrations in the gill and visceral masses of C. plicata were higher than those in the foot and mantle, and higher bioaccumulation capacities were observed for essential metals than for nonessential metals. The mean concentrations of the trace elements Zn, Pb, Cd, As, Cu, and Cr in C. plicata foot samples were lower than the threshold values established by international and Chinese organizations. The estimated daily intake(EDI) values of the essential metal Mn in C. plicata foot was higher than the recommended tolerable daily intake(TDI) values for juveniles. Only Mn for juveniles and As for both juveniles and adults may pose noncarcinogenic health risks through foot consumption. The hazard index(HI) values for adults and juveniles were higher than 1, suggesting significant risks of noncarcinogenic effects to humans by exposure to multiple metals.

关键词： Trace metals Bioaccumulation Health risks Cristaria plicata Dongting lake

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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan junling Lü Chunchi Zhang Dong liang Lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

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宝鸡某冶炼厂周边土壤铅镉总量及形态空间分布特征

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干旱地区农业研究 2014年第4期32卷 202-207,268页

作者：许绍娥郝军亮孟昭福王瑶李璐彭鸽白昭杨淑英李彬李忠强西北农林科技大学资源与环境学院陕西杨凌712100 陕西省固体废物管理中心陕西西安710054 农业部西北植物营养与农业环境重点实验室陕西杨凌712100 陕西省环境监测中心站陕西西安710054 西北农林科技大学理学院陕西杨凌712100

采用克里金插值法对宝鸡某冶炼厂周边农田土壤中铅镉含量及形态空间分布特征进行了研究,并分析了土壤中铅镉总量及各形态含量与小麦中铅镉含量的相关性,目的在于为冶炼厂周边土壤重金属污染的表征提供依据。结果表明,土壤中Pb形态的高... 详细信息

采用克里金插值法对宝鸡某冶炼厂周边农田土壤中铅镉含量及形态空间分布特征进行了研究,并分析了土壤中铅镉总量及各形态含量与小麦中铅镉含量的相关性,目的在于为冶炼厂周边土壤重金属污染的表征提供依据。结果表明,土壤中Pb形态的高低顺序为:残渣态>有机硫结合态>铁锰氧化态>可交换态,Cd形态为:可交换态>残渣态>有机硫结合态>铁锰氧化态。土壤中Pb总量及Pb、Cd铁锰氧化态在距离冶炼厂500 m处含量均显著高于1 500 m和2 500 m处,后两者之间无差异;而Cd总量及Pb、Cd可交换态、有机硫结合态和残渣态在三个采样距离并没有表现出显著性差异。克里金插值分析表明,除Pb可交换态外,Pb和Cd其余形态在一定程度上均显示出与风向的一致性。相关分析表明,土壤中Pb、Cd可交换态、铁锰氧化态与小麦Pb和Cd含量均有显著的相关性,表明冶炼厂周边旱地土壤中,Pb、Cd可交换态和铁锰氧化态都可能作为土壤重金属污染空间分布和有效性表征的指标。

关键词：土壤重金属形态空间分布小麦

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