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Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy

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Bioactive Materials 2022年第2期7卷 309-324页

作者： Meng li Jiaxiang Bai Huaqiang Tao li hao Weiling Yin Xiaoxue Ren Ang Gao Ning li miao Wang Shiyuan Fang Yaozeng Xu liang Chen Huilin Yang Huaiyu Wang Guoqing Pan Dechun Geng Department of Orthopaedics The First Affiliated Hospital of Soochow University188 Shizi StreetSuzhou215006JiangsuChina Institute for Advanced Materials School of Materials Science and EngineeringJiangsu University301 Xuefu RoadZhenjiang212013JiangsuChina Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055GuangdongChina Department of Orthopaedics The First Affiliated Hospital of USTCUniversity of Science and Technology of China17 Lujiang RoadHefei230001AnhuiChina Department of Oncology The First Affiliated Hospital of USTCUniversity of Science and Technology of China17 Lujiang RoadHefei230001AnhuiChina

Polyetheretherketone(PEEK)has been widely used as orthopedic and dental materials due to excellent mechanical and physicochemical ***,its biological inertness,poor osteoinduction,and weak antibacterial activity make the clinical applications in a *** by the mussel adhesion mechanism,here we reported a biomimetic surface strategy for rational integration and optimization of anti-infectivity and osteo-inductivity onto PEEK surfaces using a mussel foot proteins(Mfps)-mimic peptide with clickable azido *** peptide enables mussel-like adhesion on PEEK biomaterial surfaces,leaving azido groups for the further steps of *** this study,antimicrobial peptide(AMP)and osteogenic growth peptide(OGP)were bioorthogonally clicked on the azido-modified PEEK biomaterials to obtain a dual-effect of host defense and tissue *** bioorthogonal clicking allows precise collocation between AMP and OGP through changing their feeding molar ratios,an optimal PEEK surface was finally obtained in this research,which could long-term inhibit bacterial growth,stabilize bone homeostasis and facilitate interfacial bone *** a word,this upgraded mussel surface strategy proposed in this study is promising for the surface bioengineering of inert medical implants,in particular,achieving rational integration of multiple biofunctions to match clinical requirements.

关键词： Surface biomodification Polyetheretherketone Anti-infectivity and osteo-inductivity Mussel adhesion Bioorthogonal chemistry

基于PB-MWCNTs-GNPs修饰的电化学免疫传感器检测流产布鲁氏菌

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陆军军医大学学报 2024年第17期46卷 1969-1975页

作者：迟宇曹宇程浩曹静文敖建玥李海波马雷刘明佳木斯大学临床医学院黑龙江佳木斯154007 陆军军医大学(第三军医大学)药学与检验医学系重庆400038 重庆医科大学附属巴南医院检验科重庆401320 重庆市沙坪坝区陈家桥医院检验科重庆401331

目的构建一种高性能的电化学免疫传感器用于检测流产布鲁氏菌。方法制备普鲁士蓝(prussian blue,PB)-多壁碳纳米管(multi walled carbon nanotubes,MWCNTs)-纳米金粒子(gold nanoparticles,GNPs)纳米复合物,以流产布鲁氏菌作为待测样本... 详细信息

目的构建一种高性能的电化学免疫传感器用于检测流产布鲁氏菌。方法制备普鲁士蓝(prussian blue,PB)-多壁碳纳米管(multi walled carbon nanotubes,MWCNTs)-纳米金粒子(gold nanoparticles,GNPs)纳米复合物,以流产布鲁氏菌作为待测样本,选择合适的抗体构建电化学免疫传感器,通过对传感器构建关键因素的考察确定最优条件,最后对传感器进行性能评价。结果明确传感器最优构建条件为:MWCNTs-PB混合比例为1∶5,材料干燥温度为37℃,缓冲体系最佳pH=7.5,抗体孵育时间为1 h,样本孵育时间为30 min;流产布鲁氏菌在10~1×10^(5) CFU/mL范围内呈良好的线性关系,传感器抗干扰能力、检测重复性与稳定性好,准确度高。结论基于PB-MWCNTs-GNPs纳米材料所修饰的用于检测流产布鲁氏菌的电化学免疫传感器构建简便,性能良好,可为布鲁氏病的临床早期诊断提供参考。

关键词：电化学免疫传感器 PB-MWCNTs-GNPs 流产布鲁氏菌

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基于CKL风电容量预测的可信度评估

电气自动化 2024年第5期46卷 4-7页

作者：李天宇马刚李豪李伟康孟宇翔南京师范大学电气与自动化工程学院江苏南京210046

由于风力发电受风速以及其他天气因素的影响极大,从而导致新能源发电产生波动性,因此,对风力发电容量可信度评估研究成为提高风力发电可靠性的重要内容之一。首先建立了CEEMD-KPCA-LSTM(CKL)预测模型,用CKL模型对考虑多环境变量情况下... 详细信息

由于风力发电受风速以及其他天气因素的影响极大,从而导致新能源发电产生波动性,因此,对风力发电容量可信度评估研究成为提高风力发电可靠性的重要内容之一。首先建立了CEEMD-KPCA-LSTM(CKL)预测模型,用CKL模型对考虑多环境变量情况下的风电容量进行预测;进而提出风电场可靠运行时的可信度评估方法;最后在IEEE-RTS97基础上进行仿真试验,将预测值进行可信度分析,得出未来断面的容量可信度,并研究可信度的影响因素。算例分析表明,CKL预测模型和可信度模型结合,可以实现风电场未来的可信度分析,并且验证了储能设备对容量预测可信度的影响,最终使得风电系统具备较为准确的容量预测功能。

关键词：完全集成经验模态分解核主成分分析长短期预测神经网络蒙特卡洛模拟法预测容量可信度

基于机器视觉的纱线非接触张力控制方法与试验验证

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南京航空航天大学学报 2024年第2期56卷 334-340页

作者：李昊昊单忠德孙启利孙正王尧尧郭子桐黄浩刘越南京航空航天大学机电学院南京210016 南京航空航天大学航空航天结构力学及控制全国重点实验室南京210016 北京理工大学机械与车辆学院北京100081 南京长江工业技术研究院南京211500

为避免传统接触式测量方法导致检测设备与纱线直接接触带来的摩擦损耗,提出了纱线张力非接触式测量方法,设计了基于机器视觉的纱线张力非接触测量系统。使用双目相机检测纱线末端的消耗速度,调控纱线另一端的主动式携纱器的收放速度,使... 详细信息

为避免传统接触式测量方法导致检测设备与纱线直接接触带来的摩擦损耗,提出了纱线张力非接触式测量方法,设计了基于机器视觉的纱线张力非接触测量系统。使用双目相机检测纱线末端的消耗速度,调控纱线另一端的主动式携纱器的收放速度,使纱线平稳运行,维持纱线张力稳定。研究表明,所设计基于机器视觉的纱线张力非接触式测量系统较常规接触式张力控制方法,控制纱线张力变化幅度降低到25%左右,具有较高的精度和可靠性,能实现三维编织纱线张力的主动控制,具有较强的应用潜力。

关键词：三维织造非接触式检测机器视觉张力控制复合材料

Base-Promoted Formylation and N-Difluoromethylation of Azaindoles with Ethyl Bromodifluoroacetate as a Carbon Source

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Chinese Journal of Chemistry 2021年第6期39卷 1477-1482页

作者： Yang li Ning Sun Cai-lin Zhang Meng hao Xi'an Key Laboratory of Textile Chemical Engineering Auxiliaries School of Environmental and Chemical EngineeringXi'an Polytechnic UniversityXi'anShaanxi 710048China

We reported for the first time that ethyl bromodifluoroacetate directly reacts with azaindole without transition metal catalysis to produce a difluoromethyl protected 5-aldehyde group product in one *** is worth mentioning that the reacted aldehyde group is only formed at the 5 *** addition,this method has good substrate applicability and functional group ***,we also carried out some mechanism auxiliary experiments,which confirmed that the aldehyde-based carbon comes from ethyl bromodifluoroacetate.

关键词： Azaindoles C1 building blocks Difluoromethylene Hydrolysis Synthetic methods

Silicon-based on-chip hybrid(de)multiplexers

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Science China(Information Sciences) 2018年第8期61卷 90-103页

作者： Chenlei li hao WU Ying TAN Shipeng WANG Daoxin DAI Centre for Optical and Electromagnetic Research State Key Laboratory for Modern Optical InstrumentationCollege of Optical Science and Engineering Zhejiang University

A review is given on the recent progress of silicon-based on-chip hybrid multiplexers, which are the key elements to enable more than one(de)multiplexing techniques simultaneously, including wavelengthdivision-multiplexing(WDM), polarization-division-multiplexing(PDM), and mode-division-multiplexing(MDM). This helps enhance the link capacity of optical interconnects multiplexed with many *** first part gives a review on the recent developed silicon-based hybrid WDM-PDM(de)multiplexers enabling WDM and PDM simultaneously, which helps achieve 2 N channels by introducing N wavelengths and dual polarizations. The recent progress of silicon-based hybrid WDM-MDM(de)multiplexers developed is reviewed in the second part. With the hybrid WDM-MDM(de)multiplexers, one can achieve N × M channels by using N wavelengths and M guided-modes. Finally, the silicon-based hybrid MDM-PDM(de)multiplexers are presented as the key to enhance the link capacity for a single wavelength carrier.

关键词： silicon photonics (de)multiplexing wavelength mode polarization waveguide

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基于改进YOLOv5s的花生仁检测系统

信息技术 2024年第9期48卷 168-175,185页

作者：刘居林李德豪张振豪员玉良青岛市即墨区第一职业中等专业学校山东青岛266200 青岛农业大学机电工程学院山东青岛266109

为提升对花生仁的检测水平,文中设计了基于改进YOLOv5s的花生仁检测系统。在YOLOv5s神经网络模型引入MobileNet V2模块和CBAM注意力机制后,将其部署到检测系统中。由实验结果可知,部署改进后的神经网络检测系统,检测精度达到98.26%,检... 详细信息

为提升对花生仁的检测水平,文中设计了基于改进YOLOv5s的花生仁检测系统。在YOLOv5s神经网络模型引入MobileNet V2模块和CBAM注意力机制后,将其部署到检测系统中。由实验结果可知,部署改进后的神经网络检测系统,检测精度达到98.26%,检测速度提升至改进前的4倍,且权重文件减小了10.5 MB。由此可见,该花生仁检测系统能实现对花生仁的快速、准确检测。

关键词：花生仁检测模型改进花生仁数据集模型训练最优模型

Use of glycated albumin for the identification of diabetes in subjects from northeast China

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World Journal of Diabetes 2021年第2期12卷 149-157页

作者： Guo-Yan li hao-Yu li Qiang li Department of Endocrinology and Metabolism The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150080Heilongjiang ProvinceChina Faculty of Population Health Sciences University College LondonLondon WC1E 6BTUnited Kingdom

BACKGROUND Metabolic memory is important for the diagnosis and treatment of diabetes in the early stage,and in maintaining blood glucose concentrations within the normal *** clinical diagnosis of diabetes mellitus is currently made using fasting plasma glucose,2 h-plasma glucose(2h-PG)during a 75 g oral glucose tolerance test,and hemoglobin A1c(HbA1c)***,the fasting plasma glucose test requires fasting,which is a barrier to screening,and reproducibility of the 2h-PG level is ***1c is affected by a shortened red blood cell *** patients with anemia and hemoglobinopathies,the measured HbA1c levels may be *** with HbA1c,glycated albumin(GA)is characterized by more rapid and greater changes,and can be used to diagnose new-onset diabetes especially if urgent early treatment is required,for example in gestational *** this study,we provided cutoff values for GA and evaluated its utility as a screening and diagnostic tool for diabetes in a large high-risk group *** To evaluate the utility of GA in identifying subjects with diabetes in northeast China,and to assess the diagnostic accuracy of the proposed GA cutoff in the diagnosis of diabetes *** This cross-sectional study included 1935 subjects,with suspected diabetes or in high-risk groups,from 2014 to 2015 in the Second Affiliated Hospital of Harbin Medical University(Harbin,China).The use of GA to identify diabetes was investigated using the area under the receiver operating characteristic curve(AUC).The GA cutoffs were derived from different 2h-PG values with hemoglobin A1c cutoffs used as a calibration *** The GA cutoff for the diagnosis of diabetes mellitus was 15.15%from the receiver operating characteristic(ROC)*** analysis demonstrated that GA was an efficient marker for detecting diabetes,with an AUC of 90.3%.CONCLUSION Our study supports the use of GA as a biomarker for the diagnosis of diabetes.

关键词： Glycated albumin Receiver operating characteristic Cut-off Hemoglobin A1c Diagnosis Diabetes mellitus

High-loading Co-doped NiO nanosheets on carbon-welded carbon nanotube framework enabling rapid charge kinetic for enhanced supercapacitor performance

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Journal of Energy Chemistry 2020年第11期29卷 240-247页

作者： hao Xu Yufang Cao Yong li Pei Cao Dandan liu Yongyi Zhang Qing wen li School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026AnhuiChina Key Laboratory of Multifunctional Nanomaterials and Smart Systems Advanced Materials DivisionSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123JiangsuChina Division of Nanomaterials and Jiangxi Key Lab of Carbonene Materials Suzhou Institute of Nano-Tech and Nano-BionicsNanchangChinese Academy of SciencesNanchang 330200JiangxiChina School of Materials Science and Engineering Nanchang UniversityNanchang 330031JiangxiChina

Developing high power and energy supercapacitors(SCs)is a long-pursued goal for the application in transportation and energy storage ***,a rationally-designed Co-doped nickel oxide nanosheets@carbon-welded carbon nanotube foam(Co-doped NiO@WCNTF)as freestanding electrode is successfully prepared for high power and energy *** WCNTF framework with high specific surface area provides three dimensional highly conductive network for fast charge transport and ensures high loading of active materials(9.2 mg/cm2).Moreover,porous Co-doped NiO nanosheets uniformly anchored on the WCNTF framework enable rapid charge kinetics due to the high intrinsic conductivity of Co-doped Ni O nanosheets and their good contact with conductive WCNTF *** a result,the unique integrated electrode with 3D architecture exhibits an ultrahigh specific capacitance of 11.45 F/cm2 at 5 mA/cm2,outstanding rate capability(11.45 F/cm2 at 5 mA/cm2 and a capacitance retention of 86.2%at 30 mA/cm2)and good cycling stability,suggesting great potential for high performance supercapacitor.

关键词： Carbon nanotube foam Pseudocapacitors Co-doped NiO nanosheets Freestanding electrode