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Preparing cyclic polymers at high concentrations via self-folding cyclization technique by adjusting the contents of hydrophilic units in linear precursors

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Chinese Chemical Letters 2024年第2期35卷 283-288页

作者： hao zha Zuowei Wang Chao Liu Chunyan Hong Department of Polymer Science and Engineering University of Science and Technology of ChinaHefei 230026China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China

Cyclic polymers are a class of polymers that feature endless topology,and the synthesis of cyclic polymers has attracted the attention of many ***,cyclic polymers were efficiently constructed by self-folding cyclization technique at high *** poly((oligo(ethylene glycol)acrylate)-co-(dodecyl acrylate))(P(OEgA-co-DDA))precursors with different ratios of hydrophilic and hydrophobic moieties were synthesized by reversible addition-fragmentation chain transfer(RAFT)polymerization using a bifunctional chain transfer agent with two anthryl end *** amphiphilic linear precursors underwent the self-folding process to generate polymeric nanoparticles in *** irradiating the aqueous solution of the nanoparticles with 365 nm UV light,cyclic polymers were synthesized successfully via coupling of anthryl *** effects of the ratios of hydrophilic and hydrophobic moieties in linear P(OEgA-co-DDA)copolymers and polymer concentration on the purity of the obtained cyclic polymers were explored in detail via ^(1)H nuclear magnetic resonance(^(1)H NMR),dynamic light scattering(DLS),UV‒visible(vis)analysis,three-detection size exclusion chromatography(TD-SEC)and transmission electron microscopy(TEM).It was found that by adjusting the content of the hydrophilic segments in linear precursors,single chain polymeric nanoparticles(SCPNs)can be generated at high polymer ***,cyclic polymers with high purity can be constructed *** method overcomes the limitation of traditional ring-closure method,which is typically conducted in highly dilute conditions,providing an efficient method for the scalable preparation of cyclic polymers.

关键词： Cyclic polymers Self-folding cyclization technique Single chain polymeric nanoparticles RAFT polymerization Direct visualization

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Efficient synthesis of bottle-brush polymers enabled by selective photoactivation strategy in NIR-induced PET-RAFT polymerization

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Science China Chemistry 2024年第7期67卷 2353-2361页

作者： hao zha Lin Cheng Zuowei Wang Chao Liu Chunyan Hong Department of Polymer Science and Engineering University of Science and Technology of ChinaHefei 230026China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China

Bottle-brush polymers possessing densely grafted side chains have special properties that are distinct from linear ***,an efficient method for preparing bottle-brush polymers based on a selective photoactivation strategy in the photoinduced electron/energy transfer reversible addition-fragmentation chain transfer(PET-RAFT)polymerization was developed.A methacrylate monomer 2-(2-(dodecylthiocarbonothioylthio)propionate)ethyl methacrylate(DTPEMA)containing a 2-(dodecylthiocarbonothioylthio)propionate(DTP)unit with a secondary R group was *** the unique selectivity of metal naphthalocyanine photocatalyst zinc 2,11,20,29-tetra-tert-butyl-2,3-naphthalocyanine(ZnTtBNc)toward trithiocarbonate with tertiary R group,the PET-RAFT polymerization of DTPEMA catalyzed by ZnTtBNc was performed under near infrared(NIR)light(λ_(max)=760 nm)irradiation at room temperature,using 4-cyano-4-[(dodecylsulfanylthiocarbonyl)-sulfanyl]pentanoic acid(CDTPA)with a tertiary R group as a chain transfer agent(CTA).Proton nuclear magnetic resonance(1H NMR)and gel permeation chromatography(gPC)results demonstrated that the DTP units in the side chains were inert during the *** grafting poly(methyl acrylate)(PMA)from PDTPEMA via thermal-initiated RAFT polymerization,welldefined P(DTPEMA-g-PMA)bottle-brush polymers could be ***,the film prepared from the bottle-brush polymer exhibited excellent scratch self-healing property due to the interlocking of side chains.

关键词： bottle-brush polymers PET-RAFT polymerization selective photoactivation scratch self-healing

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Mechanisms underlying the role of endoplasmic reticulum stress in the placental injury and fetal growth restriction in an ovine gestation model

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Journal of Animal Science and Biotechnology 2024年第1期15卷 201-217页

作者： hao zha.g Xia zha Yi Zheng Xiaoyun Liu Mabrouk Elsabagh Hongrong Wang Honghua Jiang Mengzhi Wang Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition College of Animal Science and TechnologyYangzhou UniversityYangzhou 225009P.R.China Joint International Research Laboratory of Agriculture and Agri‑Product Safety Ministry of Education of ChinaYangzhou UniversityYangzhou 225009P.R.China Department of Animal Production and Technology Faculty of Agricultural Sciences and TechnologiesNiğde Omer Halisdemir UniversityNigde 51240Turkey Department of Nutrition and Clinical Nutrition Faculty of Veterinary MedicineKafrelsheikh UniversityKafrelSheikhEgypt Department of Pediatrics Northern Jiangsu People’s HospitalClinical Medical CollegeYangzhou UniversityYangzhou 225001China State Key Laboratory of Sheep genetic Improvement and Healthy Production Xinjiang Academy of Agricultural Reclamation ScienceShihezi 832000China

Background Exposure to bisphenol A(BPA),an environmental pollutant known for its endocrine-disrupting properties,during gestation has been reported to increase the risk of fetal growth restriction(FgR)in an ovine model of *** hypothesized that the FgR results from the BPA-induced insufficiency and barrier dysfunction of the placenta,oxidative stress,inflammatory responses,autophagy and endoplasmic reticulum stress(ERS).However,precise mechanisms underlying the BPA-induced placental dysfunction,and subsequently,FgR,as well as the potential involvement of placental ERS in these complications,remain to be *** In vivo experiment,16 twin-pregnant(from d 40 to 130 of gestation)Hu ewes were randomly distributed into two groups(8 ewes each).One group served as a control and received corn oil once a day,whereas the other group received BPA(5 mg/kg/d as a subcutaneous injection).In vitro study,ovine trophoblast cells(OTCs)were exposed to 4 treatments,6 replicates *** OTCs were treated with 400μmol/L BPA,400μmol/L BPA+0.5μg/m L tunicamycin(Tm;ERS activator),400μmol/L BPA+1μmol/L 4-phenyl butyric acid(4-PBA;ERS antagonist)and DMEM/F12 complete medium(control),for 24 *** In vivo experiments,pregnant Hu ewes receiving the BPA from 40 to 130 days of pregnancy experienced a decrease in placental efficiency,progesterone(P4)level and fetal weight,and an increase in placental estrogen(E2)level,together with barrier dysfunctions,OS,inflammatory responses,autophagy and ERS in type A *** vitro experiment,the OTCs exposed to BPA for 24 h showed an increase in the E2 level and related protein and gene expressions of autophagy,ERS,pro-apoptosis and inflammatory response,and a decrease in the P4 level and the related protein and gene expressions of antioxidant,anti-apoptosis and barrier ***,treating the OTCs with Tm aggravated BPA-induced dysfunction of barrier and endocrine(the increased E2 level and decreased P4 level),OS,inflamm

关键词： Autophagy Bisphenol A Endoplasmic reticulum stress Fetal growth restriction Inflammatory responses Sheep

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A compact X-band backward traveling-wave accelerating structure

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Nuclear Science and Techniques 2024年第5期35卷 13-29页

作者： Xian-Cai Lin hao zha Jia-Ru Shi Qiang gao Fang-Jun Hu Qing-Zhu Li Huai-Bi Chen Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle and Radiation Imaging(Tsinghua University) Ministry of EducationBeijing 100084China

Very high-energy electrons(VHEEs)are potential candidates for FLASH radiotherapy for deep-seated *** proposed a compact VHEE facility based on an X-band high-gradient high-power *** this study,we investigated and realized the first X-band backward traveling-wave(BTW)accelerating structure as the buncher for a VHEE facility.A method for calculating the parameters of single cell from the field distribution was introduced to simplify the design of the BTW ***-domain circuit equations were applied to calculate the transient beam parameters of the buncher in the unsteady state.A prototype of the BTW structure with a thermionic cathode-diode electron gun was designed,fabricated,and tested at high power at the Tsinghua X-band high-power test *** structure successfully operated with 5-MW microwave pulses from the pulse compressor and outputted electron bunches with an energy of 8 MeV and a pulsed current of 108 mA.

关键词： Backward traveling-wave accelerating structure Equivalent circuit model High-power test Very high-energy electron radiotherapy

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Tet methylcytosine dioxygenase 2(TET2)deficiency elicits EgFR-TKI(tyrosine kinase inhibitors)resistance in non-small cell lung cancer

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1706-1720页

作者： Jian zha.g Kejia Zhao Wenjing Zhou Ran Kang Shiyou Wei Yueli Shu Cheng Yu Yin Ku Yonghong Mao hao Luo Juqin Yang Jiandong Mei Qiang Pu Senyi Deng Zhengyu zha.gang Yuan Shensi Shen Yaohui Chen Lunxu Liu Department of Thoracic Surgery and Institute of Thoracic Oncology West China Hospital of Sichuan UniversityChengdu 610097China Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer Sichuan UniversityChengdu 610097China Biobank of West China Hospital Sichuan UniversityChengdu 610041China

Despite epidermal growth factor receptor(EgFR)tyrosine kinase inhibitors(TKl)have shown remarkable efficacy in patients with EgFR-mutant non-small cell lung cancer(NSCLC),acquired resistance inevitably develops,limiting clinical *** found that TET2 was poly-ubiquitinated by E3 ligase CUL7^(FBXW11) and degraded in EgFR-TKI resistant NSCLC *** perturbationof TET2 rendered parental cells more tolerant to TKI ***2 was stabilized by MEK1 phosphorylation at Ser 1107,while MEK1 inactivation promoted its proteasome degradation by enhancing the recruitment of CUL7^(FBXW11),Loss of TET2 resulted in the upregulation of TNF/NF-kB signaling that confers the EgFR-TKI *** or pharmacological inhibition of NF-kB attenuate the TKI resistance both in vitro and in *** findings exemplified how a cell growth controlling kinase MEK1 leveraged the epigenetic homeostasis by regulating TET2,and demonstrated an alternative path of non-mutational acquired EgFR-TKI resistance modulated by TET2 ***,combined strategy exploiting EgFR-TKI and inhibitors of TET2/NF-κB axis holds therapeutic potential for treating NSCLC patients who suffered from this resistance.

关键词： TET2 TKI resistance

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genetic Polymorphisms of 22 Novel Autosomal Short Tandem Repeat Loci in Sierra Leone Population

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Journal of Forensic Science and Medicine 2024年第3期10卷 209-213,I0001-I0008页

作者： Yi Liu Chudong Wang Dan Wen Weifeng Qu hao Xing Hongtao Jia Ruyi Xu Xuan Tang Siqi Chen Jienan Li guanlin Li Lagabaiyila zha Yong Wang Department of Forensic Medicine School of Basic Medical SciencesCentral South UniversityChangshaChina Department of Clinical Laboratory First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina China-Africa Research Center of Infectious Diseases Central South UniversityChangshaChina

Background:Exploring and identifying novel alleles of noncombined DNAIndex System(CODIS)short tandem repeat(STR)loci in different ethnic groups is important for the establishment of forensic reference databases and study of population ***:This study is aimed to explore the genetic polymorphism of 22 non-CODIS autosomal STR loci(D6S477,D18S535,D19S253,D15S659,D11S2368,D20S470,D1S1656,D22-gATA198B05,D8S1132,D4S2366,D21S1270,D13S325,D9S925,D3S3045,D14S608,D10S1435,D12S391,D7S3048,D17S1290,D5S2500,D2S1338,and D16S539)in Sierra Leone population and analyze the population genetic relationships in comparison with *** ethods:The amples of a total of 495 unrelated individuals(274 females and 221 males)from Sierra Leonewere examined by the Microreader^(TM)23SPID System,and their genetic polymorphisms and associated forensic parameters were *** genetic relationships between Sierra Leonepopulation and other populations were evaluated as ***:Atotal of 287 alleles were observed with allelic frequencies ranging from 0.001 to *** cumulative power of discrimination(CPD)of the 22 autosomal STR loci was *** cumulative probability of exclusion(CPE)of the 22 autosomal STR loci was 0.9999998514(CPEdous)and 0.9999999999826(CPEtrios).All of the STR loci reached the Hardy–Weinberg equilibrium after Bonferroni *** population genetics analysis results demonstrated that Sierra Leone population exhibited distinctive genetic characteristics compared to those of East Asian populations and it had relatively close genetic distances to the Uygur ***:The results of this study could enrich the forensic databases with Sierra Leone *** 22 STR loci are highly polymorphic and could be used for forensic practice and population genetics studies.

关键词： genetic polymorphisms Microreader™23SP ID System short tandem repeat Sierra Leone

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高速动车组齿轮箱轴承载荷特性研究

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机械工程学报 2024年第15期60卷 173-184页

作者：曹杰任尊松查浩徐宁杨超北京交通大学机械与电子控制工程学院北京100044 株洲中车时代电气股份有限公司株洲412001

齿轮箱是高速动车组的重要部件之一,通过多种类型轴承分别与车轴和联轴器联结,这些轴承对齿轮箱实现动力传递和确保列车的运行安全和稳定性具有重要作用。由于工程测试难度,目前难以直接测试这些轴承承受的载荷。基于轴承动力学理论和... 详细信息

齿轮箱是高速动车组的重要部件之一,通过多种类型轴承分别与车轴和联轴器联结,这些轴承对齿轮箱实现动力传递和确保列车的运行安全和稳定性具有重要作用。由于工程测试难度,目前难以直接测试这些轴承承受的载荷。基于轴承动力学理论和齿轮传动动力学理论,建立了包含三类轴承、齿轮啮合及齿轮箱箱体的耦合动力学模型,结合线路实测激励,采用数值方法,获取了齿轮箱轴承滚子滚道接触载荷。在验证轴承滚子滚道载荷分布特性的基础上,分析了多种工况下齿轮箱轴承的滚子滚道接触载荷。结果表明,齿轮箱小齿轮轴圆柱滚子轴承滚子滚道接触载荷均值主要受牵引力矩影响,牵引力亦会影响受载滚子数量。齿轮啮合力影响滚子滚道接触载荷局部波动幅值,在外部激励作用下,NU214轴承滚子滚道接触载荷最大值最高增大35.0%。列车上下行工况改变滚子滚道接触载荷分布区域以及载荷均值,但接触区位置不受列车速度等级的影响。建立的齿轮箱耦合模型,详细考虑了齿轮箱各轴承的受载特点,对深入研究齿轮箱轴承受载特性具有重要作用。

关键词：高速动车组齿轮箱传动系统动力学模型轴承载荷

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基于多光谱图像分割算法的冷冻猪肉色泽无损表征技术

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中国食品学报 2024年第8期24卷 414-421页

作者：葛玲查靖耿浩陈光刘紫琪马飞合肥工业大学食品与生物工程学院合肥230009 皖南特色农产品加工技术研究与应用中心安徽宣城242000 宣州区农业农村局安徽宣城242000

色泽是冻藏肉质评价第一感官指标,构建原位评价冻肉色泽方法对稳定消费市场十分关键。本文提出一种以图像阈值分割算法为核心的冷冻肉色实时检测方法,即:利用典型判别分析和全局阈值分割两种算法对120个冻肉多光谱图像进行分割处理,并... 详细信息

色泽是冻藏肉质评价第一感官指标,构建原位评价冻肉色泽方法对稳定消费市场十分关键。本文提出一种以图像阈值分割算法为核心的冷冻肉色实时检测方法,即:利用典型判别分析和全局阈值分割两种算法对120个冻肉多光谱图像进行分割处理,并提取两类像素光谱,随后采用连续投影、偏最小二乘等算法建立光谱与肉色(L*、a*和b*)之间的关联性模型。结果显示:全局阈值分割算法结合连续投影和偏最小二乘3种计量学方法建立最佳L*、a*和b*值的预测模型,其决定系数(R2)分别为0.9563,0.9593和0.9570,相应的剩余预测偏差(RPD)分别为4.7745,4.6265和4.2126,表现出较好的精度与鲁棒性。研究结果为冷冻肉色无损、快速检测的工业实践提供了理论基础。

关键词：多光谱成像图像分割算法冷冻猪肉无损检测色泽

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Adenylate kinase phosphate energy shuttle underlies energetic communication in flagellar axonemes

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Science China(Life Sciences) 2024年第8期67卷 1697-1714页

作者： Huan Wu Yanman zha.g Yuqian Li Shuya Sun Jintao zha.g Qingsong Xie Yue Dong Shushu Zhou Xuan Sha Kuokuo Li Jinyi Chen Xin zha.g Yang gao Qunshan Shen guanxiong Wang Xiaomin zha Zongliu Duan Dongdong Tang Chuan Xu hao geng Mingrong Lv Yuping Xu Ping Zhou Zhaolian Wei Rong Hua Yunxia Cao Mingxi Liu Xiaojin He Reproductive Medicine Center Department of Obstetrics and GynecologyThe First Affiliated Hospital of Anhui Medical UniversityHefei 230022China State Key Laboratory of Reproductive Medicine and Offspring Health Department of Histology and EmbryologySchool of Basic Medical SciencesNanjing Medical UniversityNanjing 210029China State Key Laboratory of Reproductive Medicine and Offspring Health The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityTaizhou School of Clinical MedicineNanjing Medical UniversityNanjing 211166China Reproductive Medicine Center Department of Obstetrics and GynecologyShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China State Key Laboratory of Reproductive Medicine and Offspring Health Clinical Center of Reproductive MedicineThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China NHC Key Laboratory of Study on Abnormal gametes and Reproductive Tract(Anhui Medical University) Hefei 230032China Key Laboratory of Population Health Across Life Cycle(Anhui Medical University) Ministry of Education of the People’s Republic of ChinaHefei 230032China Anhui Province Key Laboratory of Reproductive Health and genetics Hefei 230032China Biopreservation and Artificial Organs Anhui Provincial Engineering Research CenterAnhui Medical UniversityHefei 230032China

The complexities of energy transfer mechanisms in the flagella of mammalian sperm flagella have been intensively investigated and demonstrate significant diversity across *** shuttles,particularly adenylate kinase(AK)and creatine kinase(CK),are pivotal in the efficient transfer of intracellular ATP,showing distinct tissue-and ***,the expression profiles of AK and CK were investigated in mice and found to fall into four subgroups,of which Subgroup III AKs were observed to be unique to the male reproductive system and conserved across *** AK8 and AK9 were found to be indispensable to male reproduction after analysis of an infertile male *** mouse models showed that AK8 and AK9 were central to promoting sperm *** combined with mass spectrometry revealed that AK8 and AK9 interact with the radial spoke(RS)of the *** of various human and mouse sperm samples with substructural damage,including the presence of multiple RS subunits,showed that the head of radial spoke 3 acts as an adapter for AK9 in the flagellar *** an ATP probe together with metabolomic analysis,it was found that AK8 and AK9 cooperatively regulated ATP transfer in the axoneme,and were concentrated at sites associated with energy consumption in the *** findings indicate a novel function for RS beyond its structural role,namely,the regulation of ATP *** conclusion,the results expand the functional spectrum of AK proteins and suggest a fresh model regarding ATP transfer within mammalian flagella.

关键词： adenylate kinase Subgroup III AKs AK8 AK9 male infertility ATP transfer radial spoke

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Hg_(0.72)Cd_(0.28)Te扫描隧道谱的模型解释

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红外与毫米波学报 2024年第3期43卷 300-304页

作者：肖正琼戴昊光刘欣扬陈平平查访星上海大学理学院物理系上海200444 中国科学院上海技术物理研究所红外物理国家重点实验室上海200083

本工作利用截面扫描隧道显微镜(XSTM)研究了分子束外延生长的Hg_(0.72)Cd_(0.28)Te薄膜。扫描隧道谱(STS)测量表明,此碲镉汞材料的电流-电压(I/V)隧道谱呈现的零电流平台宽度(隧道谱表观带隙)比其实际材料带隙增大约130%,说明存在明显... 详细信息

本工作利用截面扫描隧道显微镜(XSTM)研究了分子束外延生长的Hg_(0.72)Cd_(0.28)Te薄膜。扫描隧道谱(STS)测量表明,此碲镉汞材料的电流-电压(I/V)隧道谱呈现的零电流平台宽度(隧道谱表观带隙)比其实际材料带隙增大约130%,说明存在明显的针尖诱导能带弯曲(TIBB)效应。扫描隧道谱三维TIBB模型计算发现低成像偏压测量时获取的I/V隧道谱数据与理论计算结果有令人满意的一致性。然而较大成像偏压时所计算的I/V谱与实验谱线在较大正偏压区域存在一定偏离。这是目前的TIBB模型未考虑带带隧穿、缺陷辅助隧穿等碲镉汞本身的输运机制对隧道电流的影响造成的。

关键词：扫描隧道显微镜扫描隧道谱 HgCdTe 针尖诱导能带弯曲

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