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The Experimental Study of Hyperoxygenated Solution on Acute Hemorrhagic Shock

麻醉与监护论坛 2011年第5期18卷 332-336页

作者： hao xu.md. Lichun Han, md. Rui Lu, md. Jin Zhang, md. Hui Zhang,md. Lixian xu, md. Department of Anesthesiology School of Stomatology Fourth Military Medical University Xi＇anShaanxi Province China Department ofAnesthesiology Shaanxi province tumor hospital Xi＇anShaanxi Province China

Background: The aim of this study was to explore the impact of hyperoxygenated solution(HOS) on mean arterial pressure (MAP), blood viscosity, blood gas and related biochemical indicators during acute hemorrhagic shock in rabbits. Materials and Methods: Thirty three male rabbits were randomly divided into three groups: Ringer's solution group (RS Group), HOSI group and HOS2 group. Acute hemorrhagic shock models that 45 percent systemic blood volume was released from femoral artery within 5 min were prepared. At 60min after the shock, HOS 1 group and HOS2 group received 10 ml/Kg and 20 ml/Kg intravenous infusion of hyperoxygenated Ringer's solution, and RS group received 10ml / Kg intravenous infusion of Ringer's solution. MAP, blood viscosity, blood gas, blood lactate (BL) and malondialdehyde (mdA) content were recorded and determined in plasma before shock, shock 60 min, after the transfusion 30 and 60 min, and MAP was recorded after the transfusion 5 and 10min. Results: After shock MAP reduced from 12.69±0.78 kPa to 5.78±0.98 kPa, buffer excess (BE) reduced from 1.92±1.62 mmol / L to -9.91±4.92 mmol/L. BL content in plasma, BV, PV, AI showed a marked increase at Acute hemorrhagic shock 60 min. The blood pressure increased quickly in groups that RS was infusion, and then decreased significantly after 30 min, but the blood pressure in HOS1 and HOS2 groups dropped slowly than that of in RS group. Blood pressure in HOS2 group was significantly higher than that of in HOSI group. At 30 and 60 min after HOS infusion, buffer excess (BE), PaO2 and SaO2 in HOSI and HOS2 groups were significantly higher than those of in RS Group. BE and BL in HOS1, HOS2 these two groups had no significant difference, and content of BL were both lower than that of in RS group. PaO2, SaO2 in HOS2 group were significantly higher than those of in HOSI group. At 60 min after HOS infusion, BV, AI in HOS1 group and BV, PV, AI in HOS2 group were significantly lower than that of in RS Group. There is

关键词：摘要编辑部编辑工作读者

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Discovery of Partial Differential Equations from Highly Noisy and Sparse Data with Physics-Informed Information Criterion

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Research 2024年第1期2023卷 247-259页

作者： hao xu Junsheng Zeng Dongxiao Zhang BIC-ESAT EREand SKLTCSCollege of EngineeringPeking UniversityBeijing 100871P.R.China Institute of Applied Physics and Computational Mathematics Beijing 100088P.R.China Eastern Institute for Advanced Study Eastern Institute of TechnologyNingbo 315200ZhejiangP.R.China National Center for Applied Mathematics Shenzhen(NCAMS) Southern University of Science and TechnologyShenzhen 518055GuangdongP.R.China Department of Mathematics and Theories Peng Cheng LaboratoryShenzhen 518000GuangdongP.R.China

Data-driven discovery of partial differential equations(PDEs)has recently made tremendous progress,and many canonical PDEs have been discovered successfully for proof of ***,determining the most proper PDE without prior references remains challenging in terms of practical *** this work,a physics-informed information criterion(PIC)is proposed to measure the parsimony and precision of the discovered PDE *** proposed PIC achieves satisfactory robustness to highly noisy and sparse data on 7 canonical PDEs from different physical scenes,which confirms its ability to handle difficult *** PIC is also employed to discover unrevealed macroscale governing equations from microscopic simulation data in an actual physical *** results show that the discovered macroscale PDE is precise and parsimonious and satisfies underlying symmetries,which facilitates understanding and simulation of the physical *** proposition of the PIC enables practical applications of PDE discovery in discovering unrevealed governing equations in broader physical scenes.

关键词： process canonical proof

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pH- and near-infrared light-responsive,biomimetic hydrogels from aqueous dispersions of carbon nanotubes

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Nano Research 2024年第4期17卷 3120-3129页

作者： Lulin Hu Xinxin Yu Jingcheng hao Lu xu Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing Yantai 264000China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Yantai Center for Food and Drug Control Yantai 264000China Key Laboratory of Colloid and Interface Chemistry&Key Laboratory of Special Aggregated Materials Shandong UniversityJinan 250100China

Owing to their low flexibility,poor processability and a lack of responsiveness,inorganic materials are usually non-ideal for constructing a living ***,to date,lifelike materials with structural hierarchies and adaptive properties usually rely on light and soft organic molecules,although few exceptions have been acquired using two-dimensional(2D)inorganic ***,with a systematic study on the gelation behavior of carbon-based 0D quantum dots,1D nanotubes,and 3D fullerenes,we find that acidified 1D carbon nanotubes(CNTs)can serve as an alternative building block for fabricating purely inorganic biomimetic soft *** as-prepared CNT gels exhibit not only a pH-or photothermal-triggered mechanical and tribological adaptivity,which allows them to simulate the behavior of sea cucumbers,peacock mantis shrimps,and mammalian muscles or cortical bones,but also a unique damping property that is similar to spider’s cuticular *** high elasticity,effective lubrication,excellent biocompatibility,and controllable friction and wear also allow them to function as a new type of smart lubricants,whose tribological properties can be regulated either by its internal pH changes or spatiotemporally by near-infrared(NIR)light irradiations,free of any toxic and flammable base oils or additives.

关键词： biomimetic hydrogels carbon nanotubes(CNTs) mechanical and tribological adaptivity pH-and near-infrared(NIR)light responsiveness switchable lubrication

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Persymmetric adaptive polarimetric detection of subspace range-spread targets in compound Gaussian sea clutter

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Journal of Systems Engineering and Electronics 2024年第1期35卷 31-42页

作者： xu Shuwen hao Yifan WANG Zhuo xuE Jian National Key Laboratory of Radar Signal Processing Xidian UniversityXi’an 710071China Xi’an Electronic Engineering Research Institute Xi’an 710100China Beijing Institute of Radio Measurement Beijing 100039China School of Communications and Information Engineering Xi’an University of Posts and TelecommunicationsXi’an 710121China

This paper focuses on the adaptive detection of range and Doppler dual-spread targets in non-homogeneous and nonGaussian sea *** sea clutter from two polarimetric channels is modeled as a compound-Gaussian model with different parameters,and the target is modeled as a subspace rangespread target *** persymmetric structure is used to model the clutter covariance matrix,in order to reduce the reliance on secondary data of the designed *** adaptive polarimetric persymmetric detectors are designed based on the generalized likelihood ratio test(GLRT),Rao test,and Wald *** the proposed detectors have constant falsealarm rate property with respect to the clutter texture,the speckle covariance *** results on simulated and measured data show that three adaptive detectors outperform the competitors in different clutter environments,and the proposed GLRT detector has the best detection performance under different parameters.

关键词： sea clutter adaptive polarimetric detection compound Gaussian model subspace range-spread target persymmetric structure

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MODIFIED SPLIT-STEP THETA METHOD FOR STOCHASTIC DIFFERENTIAL EQUATIONS DRIVEN BY FRACTIONAL BROWNIAN MOTION

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Journal of Computational Mathematics 2024年第5期42卷 1226-1245页

作者： Jingjun Zhao hao Zhou Yang xu School of Mathematics Harbin Institute of TechnologyHarbin 150001China

For solving the stochastic differential equations driven by fractional Brownian motion,we present the modified split-step theta method by combining truncated Euler-Maruyama method with split-step theta *** the problem under a locally Lipschitz condition and a linear growth condition,we analyze the strong convergence and the exponential stability of the proposed ***,for the stochastic delay differential equations with locally Lipschitz drift condition and globally Lipschitz diffusion condition,we give the order of ***,numerical experiments are done to confirm the theoretical conclusions.

关键词： Stochastic differential equation Fractional Brownian motion Split-step theta method Strong convergence Exponential stability

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Impact of initial fluctuations and nuclear deformations in isobar collisions

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Nuclear Science and Techniques 2024年第6期35卷 155-162页

作者： Jian-Fei Wang hao-Jie xu Fu-Qiang Wang Department of Modern Physics University of Science and Technology of ChinaHefei 230026China School of Science Huzhou UniversityHuzhou 313000China Strong-Coupling Physics International Research Laboratory(SPiRL) Huzhou UniversityHuzhou 313000China Department of Physics and Astronomy Purdue UniversityWest LafayetteIN 47907USA

Relativistic isobar^(96)_(44)Ru+^(96)_(44)Ru and^(96)_(40)Zr+^(96)_(40)Zrcollisions have revealed intricate differences in their nuclear size and shape,inspiring unconventional studies of nuclear structure using relativistic heavy ion *** this study,we investigate the relative differences in the mean multiplicityR_()and the secondR_(ε2)and third-order eccentricityR_(ε3)between isobar collisions using initial state Glauber *** is found that initial fluctuations and nuclear deformations have negligible effects on R_()in most central collisions,while both are important for the R_(ε2)and R_(ε3),the degree of which is sensitive to the underlying nucleonic or sub-nucleonic degree of *** features,compared to real data,may probe the particle production mechanism and the physics underlying nuclear structure.

关键词： Relativistic isobar collisions Initial fluctuations Nuclear deformation

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Fe-Zn alloy, a new biodegradable material capable of reducing RoS and inhibiting oxidative stress

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Regenerative Biomaterials 2024年第2期3卷 114-122页

作者： Shuaikang Yang Weiqiang Wang Yanan xu Yonghui Yuan Shengzhi hao School of Materials Science and Engineering Dalian University of TechnologyDalian 116024PR China Clinical Research Center for Malignant Tumor of Liaoning Province Cancer Hospital of Dalian University of TechnologyShenyang 110042PR China

Fe-based biodegradable materials have attracted significant attention due to their exceptional mechanical properties and favorable ***,research on Fe-based materials mainly focuses on regulating the degradation ***,excessive release of Fe ions during material degrada-tion will induce the generation of reactive oxygen species(ROS),leading to oxidative stress and ***,the con-trol of RoS release and the improvement of biocompatibility for Fe-based materials are very *** this study,new Fe-Zn alloys were prepared by electrodeposition with the intention of using Zn as an antioxidant to reduce oxidative damage during alloy ***,the impact of three potential degra-dation ions(Fe^(2+),Fe^(3+),Zn^(2+))from the Fe-Zn alloy on human endothelial cell(EC)activity and migration ability was ***,cell adhesion,cell activity,ROs production and DNA damage were assessed at various locations surrounding the ***,the influence of different concentrations of Zn^(2+) in the medium on cell viability and ROS production was *** levels of ROS exhibited evident toxic effects on ECs and promoted DNA *** an antioxidant,Zn?+effectively reduced ROS production around Fe and improved the cell viability on its surface at a concentration of 0.04 mmol/*** findings demonstrate that Fe-Zn alloy can attenuate the ROS generated from Fe degradation therebyenhancingcytocompatibility.

关键词： biodegradable iron Fe-Zn alloys reactive oxygen species oxidative stress cytocompatibility

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Strategic regulation of nitrogen-containing intermediates for enhanced nitrate reduction over Co_(3)O_(4)/SiC catalyst having multiple active centers

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Journal of Energy Chemistry 2024年第9期96卷 291-299页

作者： Ming-hao Guan hao-Nan xu Jin Liu Tao Wu An-Hui Lu State Key Laboratory of Fine Chemicals Liaoning Key Laboratory for Catalytic Conversion of Carbon ResourcesSchool of Chemical EngineeringDalian University of TechnologyDalian 116024LiaoningChina

Regulating the intermediates involved in the electrocatalytic nitrate reduction reaction(NO_(3)RR)is crucial for the enhancement of reaction ***,it remains a great challenge to regulate the reaction intermediates through active site manipulation on the surface of the ***,a family of n%-Co_(3)O_(4)/SiC(n=5,8,12,20)catalysts with a delicate percentage of Co^(2+)and Co^(3+)were prepared for NO_(3)*** found that Co^(3+)primarily acts as the active site for NO_(3)^(−)reduction to NO_(2)^(−),while Co^(2+)is responsible for the conversion of NO_(2)^(−)to NH_(3).Moreover,the conversion of these intermediates over the active sites is autonomous and separately *** processes synergistically accomplish the reduction of nitrate ions to synthesize *** the experimental studies and density functional theory(DFT)calculations,it is discovered the pathway(^(*)NHO→^(*)NHOH→^(*)NH_(2)OH→^(*)NH_(2)→^(*)NH_(3))is more favorable due to the lowerΔG value(0.25 eV)for the rate-limiting step(^(*)NO→^(*)NHO).The NH_(3)yield rate of 8%-Co_(3)O_(4)/SiC reached 1.08 mmol/(cm^(2)h)with a Faradaic efficiency of 96.4%at−0.89 V versus the reversible hydrogen electrode(RHE),surpassing those of most reported non-noble NO_(3)RR *** strategy not only provides an efficient catalyst for NO_(3)RR but also serves as an illustrative model for the regulation of multi-step reaction intermediates through the design of distinct active sites,thereby presenting a new approach to enhance the efficiency of intricate reactions.

关键词： Electrocatalysis Nitratereduction Co_(3)O_(4)/SiC catalysts Intermediates control

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Advances in understanding and managing celiac disease:Pathophysiology and treatment strategies

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World Journal of Gastroenterology 2024年第35期30卷 3932-3941页

作者： hao-Jie Ge xu-Lin Chen Department of Burns The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina

In this editorial,we comment on an article published in the recent issue of the World Journal of *** disease(CeD)is a disease occurring in genetically susceptible individuals,which is mainly characterized by gluten intolerance in the small intestine and clinical symptoms such as abdominal pain,diarrhea,and ***,patients often need a lifelong gluten-free diet,which greatly affects the quality of life and expenses of *** gold standard for diagnosis is intestinal mucosal biopsy,combined with serological and genetic *** present,the lack of safe,effective,and satisfactory drugs for CeD is mainly due to the complexity of its pathogenesis,and it is difficult to find a perfect target to solve the multi-level needs of *** this editorial,we mainly review the pathological mechanism of CeD and describe the current experimental and improved drugs for various pathological aspects.

关键词： Celiac disease Gluten-free diet Pathology Human leukocyte antigen Immunotherapy Treatment Aspergillus niger prolyl endoprotease

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Prognostic analysis of related factors of adverse reactions to immunotherapy in advanced gastric cancer and establishment of a nomogram model

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1268-1280页

作者： xu-xu He Bang Du Tao Wu hao Shen Department of Surgery Fudan University Affiliated Zhongshan Hospital(Qingpu Branch)Shanghai 201700China Department of Surgery Anhui Provincial Red Cross Society HospitalHefei 230031Anhui ProvinceChina Department of General Surgery West China Hospital of Sichuan UniversityChengdu 610044Sichuan ProvinceChina

BACKGROUND Immunotherapy for advanced gastric cancer has attracted widespread attention in recent ***,the adverse reactions of immunotherapy and its relationship with patient prognosis still need further *** order to determine the association between adverse reaction factors and prognosis,the aim of this study was to conduct a systematic prognostic *** comprehensively evaluating the clinical data of patients with advanced gastric cancer treated by immunotherapy,a nomogram model will be established to predict the survival status of patients more *** To explore the characteristics and predictors of immune-related adverse reactions(irAEs)in advanced gastric cancer patients receiving immunotherapy with programmed death protein-1(PD-1)inhibitors and to analyze the correlation between irAEs and patient *** A total of 140 patients with advanced gastric cancer who were treated with PD-1 inhibitors in our hospital from June 2021 to October 2023 were *** were divided into the irAEs group and the non-irAEs group according to whether or not irAEs *** features,manifestations,and prognosis of irAEs in the two groups were collected and analyzed.A multivariate logistic regression model was used to analyze the related factors affecting the occurrence of irAEs,and the prediction model of irAEs was *** receiver operating characteristic(ROC)curve was used to evaluate the ability of different indicators to predict irAEs.A Kaplan-Meier survival curve was used to analyze the correlation between irAEs and *** Cox proportional risk model was used to analyze the related factors affecting the prognosis of *** A total of 132 patients were followed up,of whom 63(47.7%)developed *** looked at the two groups’clinical features and found that the two groups were statistically different in age≥65 years,Ki-67 index,white blood cell count,neutrophil count,and regulatory T cell(Treg)count

关键词： Advanced gastric cancer Prognostic analysis Immunotherapy Nomogram model

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