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A deep kernel method for lithofacies identification using conventional well logs

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Petroleum Science 2023年第3期20卷 1411-1428页

作者： Shao-Qun Dong Zhao-Hui Zhong Xue-Hui Cui Lian-Bo Zeng Xu Yang Jian-jun Liu Yan-Ming Sun jing-ru hao State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China Collge of Science China University of PetroleumBeijing102249China College of Geoscience China University of PetroleumBeijing102249China

How to fit a properly nonlinear classification model from conventional well logs to lithofacies is a key problem for machine learning *** methods(e.g.,KFD,SVM,MSVM)are effective attempts to solve this issue due to abilities of handling nonlinear features by kernel *** mining of log features indicating lithofacies still needs to be improved for kernel ***,this work employs deep neural networks to enhance the kernel principal component analysis(KPCA)method and proposes a deep kernel method(DKM)for lithofacies identification using well *** includes a feature extractor and a *** feature extractor consists of a series of KPCA models arranged according to residual network structure.A gradient-free optimization method is introduced to automatically optimize parameters and structure in DKM,which can avoid complex tuning of parameters in *** test the validation of the proposed DKM for lithofacies identification,an open-sourced dataset with seven con-ventional logs(GR,CAL,AC,DEN,CNL,LLD,and LLS)and lithofacies labels from the Daniudi Gas Field in China is *** are eight lithofacies,namely clastic rocks(pebbly,coarse,medium,and fine sand-stone,siltstone,mudstone),coal,and carbonate *** comparisons between DKM and three commonly used kernel methods(KFD,SVM,MSVM)show that(1)DKM(85.7%)outperforms SVM(77%),KFD(79.5%),and MSVM(82.8%)in accuracy of lithofacies identification;(2)DKM is about twice faster than the multi-kernel method(MSVM)with good *** blind well test in Well D13 indicates that compared with the other three methods DKM improves about 24%in accuracy,35%in precision,41%in recall,and 40%in F1 score,*** general,DKM is an effective method for complex lithofacies *** work also discussed the optimal structure and classifier for *** re-sults show that(m_(1),m_(2),O)is the optimal model structure and linear svM is the optimal classifier.(m_(1),m_(2),O)means there

关键词： Lithofacies identification Deepkernel method Well logs Residual unit Kernel principal component analysis Gradient-free optimization

Long-term Di-(2-ethylhexyl) phthalate Exposure Disturbs the Lipid Metabolism Profiles and Hepatic Enzymes in Male Rats:A UPLC-MS-based Serum Metabolomics Analysis

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Biomedical and Environmental Sciences 2021年第11期34卷 920-925页

作者： DONG Xin Wen WU Wei Dong YAO san Qiao ZHANG Yun Bo WANG Cheng WU hao Yu NA Xiao Lin Department of Environmental and Occupational Health School of Public HealthXinxiang Medical UniversityXinxiang 453003HenanChina Department of Environmental Hygiene Public Health CollegeHarbin Medical UniversityHarbin 150086HeilongjiangChina

In recent years,many investigations have indicated that environmental endocrine disruptors(EEDs)may accelerate the development of obesity[1].One kind of EEDs,di-(2-ethylhexyl)phthalate(DEHP),is ubiquitous in natural e... 详细信息

关键词： Lipid Metab Serum

Design, fabrication, and testing of low-group-velocity S-band traveling-wave accelerating structure

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Nuclear Science and Techniques 2022年第11期33卷 133-143页

作者： Xian-Cai Lin hao Zha Jia-ru Shi Liu-Yuan Zhou Yi-Fan Liang Jian Gao Qiang Gao Huai-Bi Chen Chuan-Xiang Tang Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle and Radiation Imaging(Tsinghua University) Ministry of EducationBeijing 100084China

To implement the Tsinghua Thomson Scattering X-ray Source upgrade plan and the Very Compact Inverse Compton Scattering Gamma-ray Source (VIGAS) program, a new 1.5-m traveling-wave accelerating structure was designed to replace the old 3-m SLAC-type structure with the aim of increasing the accelerating gradient from15 to 30 MV/m. The new type of structure works in the 3π/4 mode with a comparatively low group velocity varying from 0.007c to 0.003c to increase the accelerating gradient at a given power. An elliptical iris was employed to reduce the surface field enhancement. The filling process of the low-group-velocity structure was analyzed using a circuit model. After fabrication, the structure was precisely tuned using the non-contact tuning method, followed by detailed low-power radiofrequency measurements. The structure was first installed and utilized at a beamline for the terahertz experiment at Tsinghua University. After 120 h of conditioning, it is now operating at a gradient of 24.2 MV/m and a 20.7-MW input power, with the klystron operating at its full power. It is expected to generate an accelerating gradient of 30 MV/m when the klystron power is upgraded to 30 MW in the near future.

关键词： Traveling-wave accelerating structure Cavity optimization Tuning method High-power test

C-terminal tensin-like (CTEN) knockin alleviates cystic kidney defects in Tensin-1 knockout mice

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Genes & Diseases 2023年第3期10卷 643-646页

作者： Chun-Lung Chiu Shiao-Ya Hong Ying Tan Yuh-ru Julie Lee Yi-Ping Shih Clifford GTepper Su hao Lo Department of Biochemistry and Molecular Medicine University of California-DavisSacramentoCA 95817USA Department of Plant Biology University of California-DavisDavisCA 95616USA

Tensin-1(TNS1)is a 220 kD focal adhesion protein that binds to actin filaments,integrin receptors,small GTPases,tyrosine-phosphorylated proteins,and lipids.1 These binding activities enable TNS1 to link the actin cytoskeleton to integrins and transduce outside-in and inside-out signals at focal adhesion sites,thereby regulating cell attachment,migration,proliferation,and mechanical sensing.1 Lack of TNS1 in kidney epithelial cells results in multiple lumen,instead of single lumen,phenotypes in the three-dimensional(3D)culture.

关键词： kidney Tensin thereby

Long non-coding RNA MEG3 regulates autophagy after cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2022年第4期17卷 824-831页

作者： Tian-hao Li Hong-Wei Sun Lai-Jun Song Bo Yang Peng Zhang Dong-Ming Yan Xian-Zhi Liu Yu-ru Luo Department of Neurosurgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina

Severe cerebral ischemia/reperfusion injury has been shown to induce high-level autophagy and neuronal ***,it is extremely important to search for a target that inhibits autophagy *** non-coding RNA MEG3 participates in ***,it remains unclear whether it can be targeted to regulate cerebral ischemia/reperfusion *** results revealed that in oxygen and glucose deprivation/reoxygenation-treated HT22 cells,MEG3 expression was obviously upregulated,and autophagy was increased,while knockdown of MEG3 expression greatly reduced ***,MEG3 bound mi R-181 c-5 p and inhibited its expression,while mi R-181 c-5 p bound to autophagy-related gene ATG7 and inhibited its *** experiments revealed that mir-181 c-5 p overexpression reversed the effect of MEG3 on autophagy and ATG7 expression in HT22 cells subjected to oxygen and glucose deprivation/*** vivo experiments revealed that MEG3 knockdown suppressed autophagy,infarct volume and behavioral deficits in cerebral ischemia/reperfusion *** findings suggest that MEG3 knockdown inhibited autophagy and alleviated cerebral ischemia/reperfusion injury through the mi R-181 c-5 p/ATG7 signaling ***,MEG3 can be considered as an intervention target for the treatment of cerebral ischemia/reperfusion *** study was approved by the Animal Ethics Committee of the First Affiliated Hospital of Zhengzhou University,China(approval ***20190538)on January 4,2019.

关键词： ATG7 autophagy cerebral infarction cerebral ischemia/reperfusion injury long non-coding RNA miR-181c-5p neuron oxygen and glucose deprivation/reoxygenation

Surrogate production of genome-edited sperm from a different subfamily by spermatogonial stem cell transplantation

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Science China(Life Sciences) 2022年第5期65卷 969-987页

作者： Fenghua Zhang Yongkang hao Xianmei Li Yi Li Ding Ye ru Zhang Xiaosi Wang Mudan He Houpeng Wang Zuoyan Zhu Yonghua Sun State Key Laboratory of Freshwater Ecology and Biotechnology Hongshan LaboratoryInstitute of HydrobiologyInnovation Academy for Seed DesignChinese Academy of SciencesWuhan 430072China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China

The surrogate reproduction technique,such as inter-specific spermatogonial stem cells(SSCs)transplantation(SSCT),provides a powerful tool for production of gametes derived from endangered species or those with desirable ***,generation of genome-edited gametes from a different species or production of gametes from a phylogenetically distant species such as from a different subfamily,by SSCT,has not ***,using two small cyprinid fishes from different subfamilies,Chinese rare minnow(gobiocypris rarus,for brief:Gr)and zebrafish(danio rerio),we successfully obtained Gr-derived genome-edited sperm in zebrafish by an optimized SSCT *** transplanted Gr SSCs supported the host gonadal development and underwent normal spermatogenesis,resulting in a reconstructed fertile testis containing Gr spermatids and zebrafish testicular somatic ***,the surrogate spermatozoa resembled those of host zebrafish but not donor Gr in morphology and swimming *** pou5f3 and chd knockout Gr SSCs were transplanted,Gr-derived genome-edited sperm was successfully produced in *** is the first report demonstrating surrogate production of gametes from a different subfamily by SSCT,and surrogate production of genome-edited gametes from another species as *** method is feasible to be applied to future breeding of commercial fish and livestock.

关键词： surrogate reproduction genome editing spermatogonial stem cell transplantation zebrafish Gobiocypris rarus

Efficacy of endoscopic treatment on patients with severe dysplasia/carcinoma in situ of esophageal squamous cell carcinoma: A prospective cohort study

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Chinese Journal of Cancer Research 2019年第2期31卷 357-365页

作者： Meng Wang Changqing hao Shuanghua Xie Shanrui Ma Qing Ma Rongshou Zheng ru Chen Xinqing Li Wenqiang Wei Office of Cancer Registry National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Endoscopy Linzhou Cancer Hospital

Objective: To explore the natural history of severe dysplasia/carcinoma in situ(SD/CIS) patients and to evaluate the efficacy of endoscopic treatment to SD/CIS ***: Between January 2005 and December 2009, a population-based prospective screening program on esophageal squamous cell carcinoma(ESCC) was performed in Linzhou, China, with endoscopic screening plus iodine staining. All the eligible histologically confirmed SD/CIS patients were followed up through the door-todoor follow-up and local cancer registry. The endpoint was diagnosed as ESCC or the December 31 st, ***-Meier survival analysis and Log-rank test were used to compare the survival rates among treated and untreated ***: A total of 175 SD/CIS patients were enrolled and grouped by whether they received endoscopic treatment. Eleven-year cumulative incidence rates for untreated and treated SD/CIS patients were 10.7% [95%confidence interval(95% CI): 6.9-16.1] and 3.2%(95% CI: 1.4-7.0), respectively. The ESCC incidence free survival rate, and all-cause incidence and mortality free survival rates were all significantly higher in the treated patients vs. untreated patients(P=0.043, P=0.008 and P=0.015, respectively). The ESCC mortality free survival rate showed no significant differences between the two groups(P=0.847).Conclusions: The cumulative incidence rate of SD/CIS patients to ESCC was much lower than previously reported. The Kaplan-Meier survival analysis showed that endoscopic treatment could increase the ESCC and allcause disease-free survival rates of SD/CIS patients significantly.

关键词： Endoscopy esophageal squamous cell carcinoma precancerous lesions management mass screening

Fabrication,tuning,and high-gradient testing of an X-band traveling-wave accelerating structure for VIGAS

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Nuclear Science and Techniques 2022年第8期33卷 77-88页

作者： Xian-Cai Lin hao Zha Jia-ru Shi Qiang Gao Jia-Yang Liu Liu-Yuan Zhou Jian Gao Huai-Bi Chen Chuan-Xiang Tang Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle and Radiation Imaging(Tsinghua University) Ministry of EducationBeijing 100084China

X-band high-gradient linear accelerators are a challenging and attractive technology for compact electron linear-accelerator *** Very Compact Inverse Compton Scattering Gamma-ray Source(VIGAS)program at Tsinghua University will utilize X-band high-gradient accelerating structures to boost the electron beam from 50 to 350 MeV over a short distance.A constant-impedance traveling-wave structure consisting of 72 cells working in the 2π/3 mode was designed and fabricated for this *** tuning and detailed measurements were successfully applied to the *** 180 h of conditioning in the Tsinghua high-power test stand,the structure reached a target gradient of 80 MV/*** breakdown rate versus gradient of this structure was measured and analyzed.

关键词： Traveling-wave accelerating structure X-band high gradient Tuning method High-power test

Hydrogen bonding-induced oxygen clusters and long-lived room temperature phosphorescence from amorphous polyols

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Chinese Chemical Letters 2023年第1期34卷 187-191页

作者： Ya-Ling Wang Kang Chen Hai-ru Li Bo Chu Zishan Yan hao-Ke Zhang Bin Liu Shengliang Hu Yongzhen Yang School of Energy and Power Engineering North University of ChinaTaiyuan 030051China MOE Key Laboratory of Interface Science and Engineering in Advanced Materials Taiyuan University of TechnologyTaiyuan 030024China Department of Polymer Science and Engineering MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationZhejiang UniversityHangzhou 310027China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032China

Developing non-conjugated luminescent polymers(NCLPs)with fluorescence and long-lived roomtemperature phosphorescence is of great significance for revealing the essence of NCLPs luminescence,which has gradually attracted the attention of researchers in recent ***,polymethylol(PMO)and poly(3-butene-1,2-diol)(PBD)with polyhydroxy structures were prepared and their luminescence behaviors were investigated to reveal the clusteroluminescence(CL)*** with polyvinyl alcohol with non-luminescent behavior,PMO and PBD exhibit cyan-blue fluorescence with quantum yields of ca.12%and green room-temperature phosphorescence with lifetimes of ca.89 ms in the solid *** fluorescence and phosphorescence exhibit typical excitation-dependent CL *** and theoretical analyses show that the strong hydrogen-bonding interaction of PMO and PBD greatly promotes the formation of oxygen clusters and the through-space n-n interaction of oxygen atoms,enabling fluorescence and phosphorescence *** results have enormous implications for understanding the CL mechanism of NCLPs and provide a new polymer design strategy for the rational design of novel NCLPs materials.

关键词： Clusteroluminescence Through-space interactions Polymethylol Poly(3-butene-1,2-diol) Hydrogen bonding Polymerization