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Neuroscience Bulletin 2024年第7期40卷 1025-1027页

作者： Yaxin Ye Boxing Jin hao W.Zhang Nengyin sheng State Key Laboratory of Genetic Resources and Evolution Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan ProvinceKunming Institute of ZoologyChinese Academy of SciencesKunming 650201China Kunming College of Life Science University of Chinese Academy of SciencesKunming 650201China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650201China

With the efforts in developmental biology and neuroscience during the past several decades,our knowledge has been significantly advanced about the genetic,cellular,and molecular mechanisms underlying brain development and ***,we should keep in mind that the human brain is the product of complex evolutionary processes,and there is a trade-off between brain evolution and neurological disorders[1].

关键词： function. neurological knowledge

Non-monotonic behavior of jam probability and stretchedexponential distribution in pedestrian counterflow

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Chinese Physics B 2024年第9期33卷 259-266页

作者： Ze-hao Chen Zhi-Xi Wu jian-Yue Guan College of Physical Science and Technology Guangxi Normal UniversityGuilin 541004China Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Provinceand Key Laboratory for Quantum Theory and Applications of the Ministry of EducationLanzhou UniversityLanzhou 730000China

We adopt a floor field cellular automata model to study the statistical properties of bidirectional pedestrian flow movingin a straight corridor. We introduce a game-theoretic framework to deal with the conflict of multiple pedestrians tryingto move to the same target location. By means of computer simulations, we show that the complementary cumulative distributionof the time interval between two consecutive pedestrians leaving the corridor can be fitted by a stretched exponentialdistribution, and surprisingly, the statistical properties of the two types of pedestrian flows are affected differently by theflow ratio, i.e., the ratio of the pedestrians walking toward different directions. We also find that the jam probability exhibitsa non-monotonic behavior with the flow ratio, where the worst performance arises at an intermediate flow ratio of around0.2. Our simulation results are consistent with some empirical observations, which suggest that the peculiar characteristicsof the pedestrians may attributed to the anticipation mechanism of collision avoidance.

关键词： traffic and crowd dynamics evolutionary game theory

Hydrodynamic characteristics and particle tracking of 90° lateral intakes at an inclined river slope

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Water Science and Engineering 2024年第2期17卷 197-208页

作者： Wei He Si-yuan Feng jian Zhang Hong-wu Tang Yang Xiao sheng Chen Chun-sheng Liu College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China State Key Laboratory of Hydrology Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210098China Collaborative Innovation Center on Water Safety and Water Science Hohai UniversityNanjing 210098China

Lateral intakes are common in *** pump effciency and sediment deposition are determined by the local hydrodynamic characteristics and mainstream division *** hydraulic characteristics of lateral withdrawal from inclined river slopes at different intake elevations should be ***,the division width exhibits significant vertical non-uniformity at an inclined river slope,which should be ***,a three-dimensional(3-D)hydrodynamic and particle-tracking model was developed with the Open Source Field Operation and Manipulation(Open FOAM),and the model was validated with physical model tests for 90°lateral withdrawal from an inclined side *** flow fields,withdrawal sources,and division widths were investigated with different intake bottom elevations,withdrawal discharges,and main channel *** study showed that under inclined side bank conditions,water entered the intake at an oblique angle,causing significant 3-D spiral flows in the intake rather than two-dimensional closed recirculation.A lower withdrawal discharge,a lower bottom elevation of the intake,or a higher main channel velocity could further strengthen this *** average division width and turbulent kinetic energy were smaller under inclined side bank conditions than under vertical bank *** a low intake bottom elevation,a low withdrawal discharge,or a high main channel velocity,the sources of lateral withdrawal were in similar ranges near the local inclined bank in the vertical *** inclined slope conditions,sediment deposition near the intake entrance could be reduced,compared to that under vertical slope *** results provide hydrodynamic and sediment references for engineering designs for natural rivers with inclined terrains.

关键词： Lateral withdrawal Hydrodynamic characteristics Particle tracking Inclined river slope Bottom elevation of intake OpenFOAM

Tiered clustering-based management architecture in mega-satellite networks

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Science China(Information Sciences) 2024年第5期67卷 215-227页

作者： Qi hao Di ZHOU Min sheng Yan SHI jiandong LI State Key Laboratory of Integrated Service Networks Xidian University

Hybrid orbital networking and the proliferation of satellites raise explosive management complexity in mega-satellite networks(MSNs) and prompt the management architecture to the hierarchy. In this regard, we propose a tiered clustering-based management architecture(TCMA) to realize the high-efficient and low-cost management performance. Specifically, based on the constrained satellite coverage, we derive an expression of the mapping relationship between the required control overhead of the controller interaction,the average path length of the proposed TCMA, and the corresponding number of management tiers and cluster size. The expression can determine the optimal number of tiers of the TCMA by minimizing the required flow table size between controllers, while ensuring high transmission efficiency. We then exhibit the elasticity of the hierarchical TCMA by adding the peer connections at the second-highest management tier to reduce maximum redundant paths. Simulation results verify the effectiveness of the proposed TCMA and illustrate that a 3-tier TCMA is sufficient for thousands of satellites.

关键词： mega-satellite networks hierarchical architecture average hop tiered structure clustering

Design,Simulation and Kinematic Validation of a Hip Prosthetic Mechanism with a Multimotor Function

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Journal of Bionic Engineering 2024年第3期21卷 1321-1333页

作者： Majun Song Zhongyi Li Jingjing jiang Weihai Chen sheng Guo hao Zheng Lianzheng Niu Hangzhou Innovation Institute Beihang UniversityHangzhou310051China Hangzhou Huacheng Software Technology Co.Ltd. Hangzhou310051China School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing100044China

We previously developed a powered hip prosthetic mechanism with kinematic functions of hip flexion-extension and abduction-adduction,and its theoretical and simulation-based kinematics were *** internal-external hip rotation has a positive effect on the movements of human lower limbs according to medical research,we developed a novel hip prosthetic mechanism based on a previous hip prosthesis that possesses motion characteristics similar to those of a human bionic hip,and the motion characteristics of multiple Degrees-of-Freedom(DoFs)were analyzed after kinematic ***,a walking model of the human‒machine model was established,and the walking stability of an amputee,which reflects the rehabilitation effect,was explored while the hip prosthetic mechanism considered the internal-external rotation of the ***,a prototype and its verification platform were built,and kinematic validation of the hip prosthetic mechanism was carried *** results showed that the designed Parallel Mechanism(PM)possesses human-like motion characteristics similar to those of a human bionic hip and can be used as a hip ***,the existing motion characteristic of internal-external hip rotation can enhance the walking stability of an amputee via this hip prosthetic mechanism.

关键词： Hip prosthetic mechanism Parallel mechanism Walking stability Kinematic validation

Review on dietary supplements as an effective improvement of Alzheimer's disease:focus on structures and mechanisms

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Food Science and Human Wellness 2024年第4期13卷 1787-1805页

作者： sheng Li Yinling Wei Zhenzhen Liang Lingli Guo Xiaojiang hao Yu Zhang State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China College of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China

Alzheimer’s disease(AD),the major form of neurodegenerative diseases that can severely impede normal cognitive function,makes it one of the most common fatal *** are currently over 50 million AD patients *** neuropathology of AD is perplexing and there is a scarcity of disease-modifying ***,early diagnosis of AD has been made possible with the discovery of biological markers associated with pathology,providing strong support for the improvement of the disease *** search for inhibitors of AD markers from dietary supplements(DSs)has become a major hot *** with the widespread use of DSs,DSs containing polyphenols,alkaloids,terpenes,polysaccharides and other bioactive components can prevent AD by reducing Aβdeposition,inhibiting tau protein hyperphosphorylation,reconstructing synaptic dysfunction,weakening cholinesterase activity,regulating mitochondrial oxidative stress,neuronal inflammation and *** review summarizes the anti-AD effects of the main DSs and their bioactive constituents,as well as the potential molecular mechanisms covers from 2017 to ***,we discussed the opportunities and challenges faced by DSs in the process of AD prevention and treatment,aiming to further provide new perspectives for functional food development.

关键词： Dietary supplements Bioactive ingredients Alzheimer’s disease Mechanism of action

Atomic force microscopy-based nanoscale infrared techniques for liquid environments

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Science Bulletin 2024年第2期69卷 151-153页

作者： jian Li Jing Liang Mu-hao Lan Xing-Hua Xia State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Infrared(IR)light energy matches well with the vibration and rotation of chemical bonds in molecules,hence IR spectroscopy is commonly used for accurate molecular identification[1].Conventional IR analysis involves bulk samples,providing averaged information of the entire *** spatially-resolved investigation of heterogeneous sample properties is constrained by the micrometer-level spatial resolution of optical IR microscopy.

关键词： spatially hence rotation

Uncertainty and sensitivity analysis of in-vessel phenomena under severe accident mitigation strategy based on ISAA-SAUP program

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Nuclear Science and Techniques 2024年第1期35卷 108-123页

作者： hao Yang Ji-Shen Li Zhi-Ran Zhang Bin Zhang jian-Qiang Shan School of Nuclear Science and Technology Xi’an Jiaotong UniversityXi’an 710049China State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an 710049China

The phenomenology involved in severe accidents in nuclear reactors is highly ***,integrated analysis programs used for severe accident analysis heavily rely on custom empirical parameters,which introduce considerable ***,in recent years,the field of severe accidents has shifted its focus toward applying uncertainty analysis methods to quantify uncertainty in safety assessment programs,known as“best estimate plus uncertainty(BEPU).”This approach aids in enhancing our comprehension of these programs and their further development and *** study concentrates on a third-generation pressurized water reactor equipped with advanced active and passive mitigation *** an Integrated Severe Accident Analysis Program(ISAA),numerical modeling and uncertainty analysis were conducted on severe accidents resulting from large break loss of coolant *** uncertainty parameters of the ISAA program were meticulously *** Wilks'formula,the developed uncertainty program code,SAUP,was employed to carry out Latin hypercube sampling,while ISAA was employed to execute batch *** analysis was then conducted on two figures of merit,namely hydrogen generation and the release of fission products within the pressure *** calculations revealed that hydrogen production and the fraction of fission product released exhibited a normal distribution,ranging from 182.784 to 330.664 kg and from 15.6 to 84.3%,*** ratio of hydrogen production to reactor thermal power fell within the range of 0.0578–0.105.A sensitivity analysis was performed for uncertain input parameters,revealing significant correlations between the failure temperature of the cladding oxide layer,maximum melt flow rate,size of the particulate debris,and porosity of the debris with both hydrogen generation and the release of fission products.

关键词： Gen-III PWR Severe accident mitigation Wilks’formula Hydrogen Fission products Uncertainty and sensitivity analysis

Essential oils improve nursery pigs'performance and appetite via modulation of intestinal health and microbiota

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Animal Nutrition 2024年第1期16卷 174-188页

作者： Bi-Chen Zhao Tian-hao Wang jian Chen Bai-hao Qiu Ya-Ru Xu Jin-Long Li College of Veterinary Medicine Northeast Agricultural UniversityHarbin150030China Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine Northeast Agricultural UniversityHarbin150030China Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment Northeast Agricultural UniversityHarbin150030China

Optimal intestinal health and functionality are essential for animal health and performance,and simultaneously intestinal nutrient transporters and intestinal peptides are also involved in appetite and feed intake control *** the potential of essential oil(EO)in improving animal performance and improving feed palatability,we hypothesized that dietary supplementation of cinnamaldehyde and carvacrol could improve performance and appetite of nursery pigs by modulating intestinal health and ***(100 mg/kg),carvacrol(100 mg/kg),and their mixtures(including 50 mg/kg cinnamaldehyde and 50 mg/kg carvacrol)were supplemented into the diets of 240 nursery pigs for 42 d,and data related to performance were ***,the influence of EO on intestinal health,appetite and gut microbiota and their correlations were *** supplementation increased(P<0.05)the body weight,average daily gain(ADG)and average daily feed intake(ADFI)of piglets,and reduced(P<0.05)diarrhea rates in nursery ***,EO increased(P<0.05)the intestinal absorption area and the abundance of tight junction proteins,and decreased(P<0.05)intestinal permeability and local *** terms of intestinal development and the mucus barrier,EO promoted intestinal development and increased(P<0.05)the number of goblet ***,we found that piglets in the EO-supplemented group had upregulated(P<0.05)levels of transporters and digestive enzymes in the intestine,which were significantly associated with daily gain and feed *** addition,EO supplementation somewhat improved appetite in nursery pigs,increased the diversity of the gut microbiome and the abundance of beneficial bacteria,and there was a correlation between altered bacterial structure and appetite-related *** findings indicate that EO is effective in promoting growth performance and nutrient absorption as well as in regulating appetite by improving intestinal health and ba

关键词： Nursery pig Essential oil Intestinal health Appetite Microbiota

Postoperative pneumocranium after endoscopic transnasal optic canal decompression

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 973-975页

作者： sheng-jian Lu Bo Yu Wen-Can Wu The Eye Hospital School of Ophthalmology&OptometryWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

Dear Editor,We present the first time,a case of a patient developed cerebrospinal fluid(CSF)leak and pneumocranium following optic canal decompression(OCD).INTRODUCTION Indirect traumatic optic neuropathy(ITON)impairs visual functions and quality of *** transnasal optic canal decompression(ETOCD)is one of the standard treatment strategies for the *** the ETOCD,the optic nerve sheath are usually incised for sufficient decompression of optic nerve after removal of optic canal,which is associated with complications like CSF leakage,ophthalmic artery injury,and optic nerve injury[1].Generally,the mild CSF leak is common and can heal spontaneously using conventional treatment,the severe CSF leak requires surgical repair[2].

关键词： decompression nasal traumatic