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Bullous pemphigoid associated with acquired hemophilia A: A case report

World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-Ye Hu Meng-Can Li Zi-Jia hao Xu-ya Chai Pei-Sai Li yang Liu Li-Xia Liu Ying Xu Pan-Pan yang Ling-E Li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (< 1.0%). Furthermore, the FⅧ inhibitor titer had greatlyincreased (59.2 Bethesda units). Therefore, the patient was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 *** AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

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Gas breakdown in radio-frequency field within MHz range:a review of the state of the art

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Plasma Science and Technology 2022年第12期24卷 200-211页

作者： Wei jiang hao WU Zhijiang WANG Lin YI ya ZHANG School of Physics Huazhong University of Science and TechnologyWuhan 430074People's Republic of China International Joint Research Laboratory of Magnetic Confinement Fusion and Plasma Physics State Key Laboratory of Advanced Electromagnetic Engineering and TechnologySchool of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074People's Republic of China School of Electronics and Information Engineering Hubei University of Science and TechnologyXianning 437100People's Republic of China Department of Physics Wuhan University of TechnologyWuhan 430070People's Republic of China

Low-temperature plasmas(LTPs) driven by 1-100 MHz radio-frequency(MRF) are essential for many industrial applications,and their breakdown characteristics are different to that of direct current(DC) *** review seeks to understand the state of the art of electric breakdown in the MRF field and provide references for related basic and applied *** have given a brief history of research into MRF-driven breakdown,including Paschen curves,the corresponding discharge modes and parameter spaces,and the evolution of the parameters during the breakdown *** is shown that the focus has been transferred from the breakdown voltage and V-I characteristics to the evolution of plasma parameters during the breakdown,both in experiments and *** is shown that many fundamental and applied problems still need to be investigated,especially with the new global model and the incorporation of the external circuit model.

关键词： gas breakdown RF plasma Paschen curve

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GO/HTPB composite liner for anti-migration of small molecules

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Defence Technology（防务技术） 2023年第4期22卷 156-165页

作者： hao Li Jie Wei ya-nan Zhang Yu-bing Hu Wei jiang Teng-yue Zhang College of Materials Science and Engineering Nanjing Tech UniversityNanjing211816China National Special Superfine Powder Engineering Research Center of China Nanjing University of Science and TechnologyNanjing210014China Key Laboratory of Special Energy Materials Nanjing University of Science and TechnologyMinistry of EducationNanjing210094China China Research and Development Academy of Machinery Equipment Beijing100089China

Hydroxyl-terminated polybutadiene/toluene diisocyanate(HTPB/TDI)system is widely used in composite solid *** migrations of plasticizers and water molecules from solid propellants and surrounding environment to the inhibitor have always been the important *** study focuses on the preparation,characterization and anti-migration behavior of graphene oxide(GO)/HTPB nanocomposite *** GO/HTPB(GH)composite liners affect the migration of small molecules through a tighter cross-linked structure and weakening function of small molecule *** anti-migration performance of the liner at different temperatures was analyzed,and the influence of the added amount of GO on the anti-migration performance and adhesion performance was also systematically *** overall performance of the liner is optimized when the amount of GO filler is 0.3 wt%.After adding 0.3 wt%GO,the concentration of dioctyl sebacate(DOS)migrated into the liner is decreased by 23.28%,and the concentration of water molecules is decreased by 51.89%,indicating that the introduction of GO can significantly improve the anti-migration performance of the *** addition,the bond strength is greatly increased from 0.25 MPa to 0.95 MPa,which meets the application requirements of the current propellant *** research provides an important way for the preparation of structure-function synergistic anti-migration composite liners.

关键词： Graphene oxide Liner Structure-function Anti-migration Bonding

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Comprehensive recovery of lead, zinc, and iron from hazardous jarosite residues using direct reduction followed by magnetic separation

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International Journal of Minerals,Metallurgy and Materials 2018年第2期25卷 123-130页

作者： ya-yun Wang Hui-fen yang Bo jiang Rong-long Song Wei-hao Zhang Key Laboratory for High-Efficient Mining and Safety of Metal Mines of Ministry of Education University of Science and Technology Beijing School of Civil and Resource Engineering University of Science and Technology Beijing

Lead, zinc, and iron were recovered from jarosite residues using direct reduction followed by magnetic separation. The influence of the coal dosage, reduction temperature, and reduction time on the volatilization rates of lead and zinc and the metallization rate of iron were investigated. The results show that the volatilization rates of lead and zinc were 96.97% and 99.89%, respectively, and the iron metallization rate was 91.97% under the optimal reduction roasting conditions of a coal dosage of 25.0 wt% and reduction roasting at 1250°C for 60 min. The magnetic concentrate with an iron content of 90.59 wt% and an iron recovery rate of 50.87% was obtained under the optimum conditions in which 96.56% of the reduction product particles were smaller than 37 μm and the magnetic field strength was 24 k A/m. Therefore, the results of this study demonstrate that recovering valuable metals such as lead, zinc, and iron from jarosite residues is feasible using the developed approach.

关键词： jarosite residues recovery direct reduction magnetic separation valuable metals

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Real-time label-free analysis of the thermostability of DNA structures using GelRed

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Nuclear Science and Techniques 2018年第10期29卷 148-154页

作者： ya-ya hao Lei Liu Lu-hao Zhang Qiu-Ling Huang Fei Wang jiang Li Jia-Qiang Xu Li-Hua Wang NEST Lab Department of ChemistryCollege of ScienceShanghai UniversityShanghai 200444China Division of Physical Biology and Bioimaging Center CAS Key Laboratory of Interfacial Physics and TechnologyShanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 10049China

In biological systems, conformational transformations of nucleic acids play critical roles in genetic regulation. However, it remains a tricky task to design and optimize specific labeling strategies to track these *** this study, we exploited an intercalating fluorescent dye,GelRed, to characterize different DNA structures. We studied the correlation between fluorescence intensity and DNA structural properties. We showed that single-stranded DNAs with predicted self-folded secondary structures show much stronger fluorescence than those without such structures. For double-stranded DNAs, we observed that fluorescence intensity is positively correlated to their GCcontent. We also demonstrated that GelRed can be used to monitor DNA conformational changes upon temperature variations in real time. Based on these findings, we concluded that the fluorescence intensity of a GelRed-stained DNA structure has a good correlation with its thermostability in the form of a change in Gibbs free energy.

关键词： GelRed Secondary structure GC content Conformational transformation

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供应链韧性研究进展及其测度方法研究

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南宁师范大学学报（自然科学版） 2025年第1期42卷 48-58页

作者：马小雅徐浩彭俊豪南宁师范大学物流管理与工程学院广西南宁530100

通过文献计量和知识图谱方法,以“供应链韧性”为主题,分别从Web of Science和CNKI数据库中筛选出相关度较高的期刊文献,以“供应链韧性”测度为主题,从Web of Science数据库中筛选相关度较高的期刊文献。通过分析2010年以来国内外相关... 详细信息

通过文献计量和知识图谱方法,以“供应链韧性”为主题,分别从Web of Science和CNKI数据库中筛选出相关度较高的期刊文献,以“供应链韧性”测度为主题,从Web of Science数据库中筛选相关度较高的期刊文献。通过分析2010年以来国内外相关研究,探讨供应链韧性的热点问题、核心领域以及测度方法。研究发现:供应链韧性的热点问题主要聚焦供应链韧性的特性、测度方法、评价指标和影响因素,供应链韧性研究的核心领域则在供应链韧性特性研究、供应链韧性的优化设计以及供应链风险管理;供应链韧性测度的研究热点聚焦供应链韧性测度方法、指标体系、影响因素和供应链特性方面;供应链韧性及其测度的研究均呈现明显的时期特征。通过对测度方法的深入研究分析发现:供应链韧性测度方法包括定性分析、定量分析和综合评价分析,常用的综合评价法涵盖主观和客观权重法,旨在全面评估供应链的抵抗、恢复和适应能力。最后从供应链韧性理论深化和整合方向、供应链韧性测度指标体系构建和方法创新等方面对未来的研究方向进行探讨,以期对后续研究提供一定的指导。

关键词：供应链韧性测度方法评价指标影响因素文献计量知识图谱

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Numerical investigation of separation-induced transition in a lowpressure turbine cascade in a low-disturbance environment

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Science China(Physics,Mechanics & Astronomy) 2020年第6期63卷 66-82页

作者： Si-ya jiang Song Fu School of Aerospace Engineering Tsinghua UniversityBeijing 100084China

In this paper,the separation-induced transition in an LPT(low-pressure turbine)cascade is investigated at low Reynolds number with DNS(direct numerical simulation).The transition process is accurately predicted giving good agreements between the DNS and experimental *** illustrate the secondary instability of separation-induced transition in a low-disturbance environment,the results are comprehensively analyzed in both Fourier space and physical *** is illustrated that the effect of hyperbolic instability dominates around the saddle point of hyperbolic *** instability mechanism is responsible for the emergence of the streamwise vortices in the braid *** and intensified because of the“stretching”effect of the background flow,these vortices become the most noticeable characteristic of the flow *** modes of small spanwise wavelength are excited in the braid region,so as some low-frequency *** elliptical instability plays a minor role than hyperbolic *** is also observed that the fundamental mode with a larger spanwise wavelength is unstable in the vortex core which is associated with the deformation of the vortex core via elliptical *** is no convincing evidence for the existence of subharmonic instability.

关键词： separation direct numerical simulation transition to turbulence

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Influence of shock attenuation on tailored operation in free piston shock tunnels

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Chinese Journal of Aeronautics 2021年第2期34卷 279-287页

作者： hao ZHU Hainan jiang China Academy of Aerospace Aerodynamics Beijing 100074China

The free piston shock tunnel is a type of shock tunnel with high performance. For this type of tunnel, the influence mechanism of shock wave attenuation on tailored operation is explored by numerical simulation and theoretical analysis. By introducing the normalized velocity, the simple constraint equation for shock wave under the tailored operation is deduced. Moreover, the real gas effect is also taken into account in this equation. Based on the equation, the tailored operation of shock tunnels can be predicted with very few calculations. The present study shows that the change rate of the thermodynamic state of the gas behind the shock wave is inconsistent with the attenuation rate of the shock wave, which is the fundamental reason why the wind tunnel achieves tailored operation at a lower Mach number of shock waves. This lower Mach number of shock waves differs from the corresponding ideal value by a factor, which is about the square root of shock attenuation rate.

关键词： Attenuation Constraint equation Free piston shock tunnel Real gas effect Shock wave Tailored operation

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Granulation of m A-modified mRNAs protects their functionality through cellular stress

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Journal of Molecular Cell Biology 2020年第11期12卷 821-822页

作者： hao jiang Department of Biochemistry and Molecular Genetics University of Virginia School of MedicineCharlottesvilleVA 22908USA

To cope with various stress conditions,cells turn off house-keeping processes and turn on stress-protective pathways(Rabouille and Alberti,2017).A successful strategy would also require cells to efficiently reactivate the essential cellular processes once the stress is *** addition to activation of signaling events,recent studies have shown that formation of certain membraneless assemblies plays a role in stress adaptation(Rabouille and Alberti,2017).

关键词： stress protective activation

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A newly unraveled 13.6-year oscillation from GPS displacements and its potential implications for the dynamic reference frame

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Science China Earth Sciences 2024年第10期67卷 3204-3212页

作者： hao DING Weiping jiang School of Geodesy and Geomatics Hubei Luojia LaboratoryWuhan UniversityWuhan 430079China GNSS Research Center Wuhan UniversityWuhan 430079China

Numerous practical geodetic and geophysical applications necessitate precise measurements of GNSS displacements at the millimeter or sub-millimeter level. To attain such precision, it is imperative to identify and analyze the unidentified decadal signals inherent in the GPS displacements. In this research, we employ the optimal sequence estimation method to effectively detect an about 13.6-year oscillational signal with an excited amplitude of 3.6±1.2 mm in the U-components of the GPS displacements. It is noteworthy that this signal demonstrates a consistent spatial pattern characterized by the spherical harmonic Y_(2,-2). We conduct a comparative analysis with the 13.6-year oscillation observed in length-of-day variations(and geomagnetic records), finding that they are in reverse phase. After eliminating the Earth's external excitation sources through the utilization of two distinct in-situ hydrological records, we suggest that the 13.6-year GPS signal may come from the internal motions within the Earth. However, the specific excitation source and the detailed physical mechanism remain uncertain. Additionally, we develop a mathematical displacement model to explain the 13.6-year signal. Our findings indicate that this signal can result in displacements of up to 1.37 mm and velocity effects of 0.63 mm/yr(for U-component) at maximum. These results underscore the necessity of incorporating this 13.6-year signal into the construction and maintenance of a dynamic reference frame at the millimeter level.

关键词： GPS displacements Decadal changes 13.6-year oscillation Displacement model Dynamic reference frame

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