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Design and implementation of precise position controller of active probe of atomic force microscopy for nanomanipulation

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Chinese Science Bulletin 2008年第13期53卷 2090-2096页

作者： hao lina ZHANG JiangBo XI Ning School of Mechanical Engineering & Automation Northeastern University Shenyang 110004 China Department of Electrical and Computer Engineering Michigan State University East Lansing MI 48824 USA

Efficiency and accuracy of AFM-based nanomanipulation are still major problems to be solved,due to the nonlinearities and uncertainties,such as drift,creep,hysteresis,etc. The deformation of cantilevers caused by manipulation force is also one of the most major factors of nonlinearities and uncertainties. It causes difficulties in precise control of the tip position and causes the tip to miss the position of the object. In order to solve this problem,the traditional approach is to use a rigid cantilever. However,this will significantly reduce the sensitivity of force sensing during manipulation,which is essential for achieving an efficient and reliable nanomanipulation. In this paper,a kind of active AFM probe has been used to solve this problem by directly controlling the cantilever’s flexibility or rigidity during manipu-lation. Based on Euller-Bernoulli Model,a kind of controller of the active probe employing Peri-odic-Output-Feedback(POF)law is implemented. The results of simulation and experiments have demonstrated that this theoretical model and POF controller are suitable for precise position control of nanomanipulation.

关键词：活化探针原子显微镜周期输出反馈控制原子力

Simulation and Experiment Based on FSMLC Method with EUPI Hysteresis Compensation for a Piezo-Driven Micro Position Stage

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Journal of Systems Science & Complexity 2019年第5期32卷 1340-1357页

作者： GAO Jinhai hao lina CHENG Hongtai CAO Ruimin SUN Zhiyong School of Mechanical Engineering&Automation Northeastern UniversityShenyang 110819China Department of Industrial and Manufacturing Systems Engineering The University of Hong KongHong KongChina.

Micro/nano positioning technologies have been attractive for decades in industrial and scientific applications fields. The actuators have inherent hysteresis that can cause system unexpected behave in some extend. In this research, the authors used extented unparallel Prandtl-Ishlinshii(EUPI)models to represent the input-output relationship of a piezo-driven micro position stage. Integral inverse(I-I) compensator is used for compensating the hysteresis characteristics of the micro positioning stage and compared with direct inverse(D-I) compensator and inverse model(I-M) compensator. However,the accuracy and the robustness of the I-I compensator are worse when there is noisy in the system,a novel sliding-mode-like-control with EUPI(SMLC-EUPI) method was proposed and analyzed by different trajectory tracking experiments in Matlab environment. Though the above strategies can alleviate most deviation, the adjustment of the SMLC’s parameters is very complex. So the fuzzy method is used to adjust these parameters and be verified by trajectory tracking experiments. Finally,for validating the proposed control method, the paper did the corresponding experiment in microscope with CMOS and obtained convincing results.

关键词： EUPI fuzzy hysteresis compensation micro position stage sliding-mode-like-control

Cropping pattern optimization considering uncertainty of water availability and water saving potential

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International Journal of Agricultural and Biological Engineering 2018年第1期11卷 178-186页

作者： lina hao Xiaoling Su Vijay P.Singh College of Water Resources and Architectural Engineering Northwest A&F UniversityYangling 712100ShaanxiChina Department of Biological&Agricultural Engineering and Zachry Department of Civil Engineering Texas A&M UniversityCollege StationTX 77843-2117USA

In arid and semi-arid areas,the profitability of irrigated agriculture mainly depends on the availability of water resources and optimal cropping patterns of irrigation *** this study,an integrated agricultural cropping pattern optimization model was developed with considering the uncertainty of water availability and water saving potential in the future,aiming to maximize agricultural net benefit per unit of irrigation *** available water which was based on the uncertainty of runoff was divided into five *** irrigation water-saving potential in the future was quantified by assuming an increase in the rate irrigation water-saving of 10% and 20%.The model was applied to the middle reaches of Heihe River basin,in Gansu Province,*** showed that if the irrigation water-saving rate was assumed to increase by 10%,then the net water-saving quantity would increase by 21.5-22.5 million m3 and the gross water-saving quantity would increase by 275.7-303.0 million ***,if the irrigation water-saving rate increased by 20%,then the net water-saving quantity would increase by 43.0-45.1 million m3 and the gross water-saving quantity would increase by 331.7-383.2 million *** the agricultural cropping pattern was optimized,the optimal water and cultivated area allocation for maize would be greater than those for other *** the premise that similar volume of irrigation water quantity was available in different scenarios,results showed differences in system benefit and net benefit per unit of irrigation water,for the distribution of available irrigation water was diverse in different irrigation districts.

关键词： cropping pattern optimization irrigation water-saving potential different scenarios water availability water use efficiency particle swarm optimization(PSO)

Modelling and analysis of hybrid stochastic timed Petri net

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Journal of Control and Decision 2019年第2期6卷 90-110页

作者： Ruimin Cao lina hao Fengli Wang Qiang Gao School of Mechanical Engineering&Automation Northeastern UniversityShenyangChina Key Laboratory of Manufacturing Industrial Integrated Automation Shenyang UniversityShenyangChina

In this paper,an interesting Hybrid Stochastic Timed Petri Net(HSTPN)is proposed for a class of hybrid *** proposed HSTPN can be adopted to represent hybrid systems with discrete,continuous,conflicting,time-delay and stochastic characteristics *** proposed HSTPN outperforms conventional hybrid Petri net models in terms of describing the scalability and immediacy of hybrid *** of the HSTPN on describing hybrid system are verified by establishing some equivalent models of HPN and its derived models.

关键词： Hybrid stochastic timed Petri net hybrid dynamic system structural equivalence equivalence rules scalability

Apoptosis-linked antifungal effect of ambroxol hydrochloride by cystolic calcium concentration disturbance in resistant Candida albicans

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Science China(Life Sciences) 2019年第12期62卷 1601-1604页

作者： Xiuyun Li Xuexin Wu Yan Gao lina hao Shujuan Sun Pharmaceutical Department Qilu Childrens Hospital of Shandong UniversityJinan 250022China Pharmaceutical Department Shandong Provincial Qianfoshan Hospitalthe First Hospital Affiliated with Shandong First Medical UniversityJinan 250014China

Dear Editor,Since the early 1980s,the incidence of fungal infections has significantly increased in immunocompromised individuals(WisplinghofF et al.,2004;Pfaller and Diekema,2007).However,due to the extensive and indiscriminate use of available antifungal agents,an increasing number of antifungal-resistant pathogens have been isolated over the past few decades(Sanglard and Odds,2002).***,an important opportunistic fxingal pathogen,is becoming increasingly resistant to several antifungal agents,particularly triazole *** resistance in *** has emerged as an important public health concern(Sanglard and Odds,2002).Although ambroxol hydrochloride(ABH)has recently been found to display antifungal activity against susceptible ***,its antifungal effect and mechanism against resistant *** have not yet been thoroughly *** aim of this study was to elucidate the antifungal effects(in vitro and in vivo)and mechanisms of ABH against resistant ***.

关键词： antifungal effect thoroughly

Cholecystokinin octapeptide antagonizes apoptosis in human retinal pigment epithelial cells

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Neural Regeneration Research 2014年第14期9卷 1402-1408页

作者： Yuan Liu Yueling Zhang Zhaohui Gu lina hao Juan Du Qian Yang Suping Li Liying Wang Shilei Gong Department of Ophthalmology First Central Hospital of Baoding Department of Ophthalmology Hebei Province People’s Hospital Department of Endoscope Room First Central Hospital of Baoding

Although cholecystokinin octapeptide-8 is important for neurological function, its neuroprotective properties remain unclear. We speculated that cholecystokinin octapeptide-8 can protect human retinal pigment epithelial cells against oxidative injury. In this study, retinal pigment epithelial cells were treated with peroxynitrite to induce oxidative stress. Peroxynitrite triggered apoptosis in these cells, and increased the expression of Fas-associated death domain, Bax, caspase-8 and Bcl-2. These changes were suppressed by treatment with cholecystokinin octapeptide-8. These results suggest that cholecystokinin octapeptide-8 can protect human retinal pigment epithelial cells against apoptosis induced by peroxynitrite.

关键词： nerve regeneration retinal pigment epithelial cells peroxynitrite cholecystokininoctapeptide apoptosis Fas-associated death domain Bax Caspase-8 Bcl-2 neural regeneration

Study of Enterprise Equipment Maintenance Management Integrated Information System Based on B/S

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International Journal of Plant Engineering and Management 2000年第4期5卷 154-160页

作者： hao lina XU Xinhe The College of Mechanical Engineering&Automation Northeastern UniversityShenyang110004P.R.China Control&Simulation Research Center Northeastern UniversityShenyang110004P.R.China

Equipment maintenance management integrated information system is an important constituent part of enterprise IMS (Intelligent Manufacture System). The system should make the best of all kinds of information sources around the enterprise, and meet the demand for agile production. This paper presents an implementation scheme of Integrated Equipment Maintenance Management Information System Based on Internet/Intranet and gives component division scheme of each tier. This scheme adopts a three-tiers mode of B/S (Browser/Server) and software programming module based on software reusing technology. This makes the system integrated and open, makes maintenance and updating convenient, and largely increases software safety and reusability.

关键词： equipment maintenance management integrated information system component Internet/Intranet Browser/Server?

Puerarin antagonizes peroxyntrite-induced injury in retinal pigment epithelial cells

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Neural Regeneration Research 2012年第9期7卷 669-674页

作者： lina hao Xudong Zhang Tao Yang Junling Ma Ophthalmology Department Hebei Province People＇s Hospital Shijiazhuang 050051 Hebei Province China Pharmaceutical Department Hebei Province People＇s Hospital Shijiazhuang 050051 Hebei Province China Internal Department the First Hospital Hebei Medical University Shijiazhuang 050031 Hebei Province China

A rat model of diabetes mellitus was established by intraperitoneal injection of streptozotocin. Three days later, the rats were intraperitoneally administered 140 mg puerarin/kg daily, for a total of 60 successive days. DNA ladder results showed increased apoptosis over time in retinal pigment epithelial cells from rats with streptozotocin-induced diabetes mellitus. Western blot analysis, Reverse transcription-PCR, immunohistochemistry, and flow cytometry results showed increased expression of 3-nitrotyrosine, a peroxyntrite marker, as well as inducible nitric synthase and Fas/FasL, in retinal pigment epithelial cells. Puerarin reversed these changes, and results demonstrated that puerarin inhibited Fas/FasL expression and alleviated peroxyntrite injury to retinal pigment epithelial cells. These results suggested that puerarin inhibited production of inducible nitric oxide synthase and directly antagonized peroxyntrite injury in retinal pigment epithelial cells.

关键词： apoptosis Fas/FasL inducible nitric oxide synthase oxidative stress puerarin retinal pigment epithelial cells

Characteristic Analysis of Hybrid Stochastic Timed Petri Net

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Characteristic Analysis of Hybrid Stochastic Timed Petri Net