检索结果-南通市图书馆

Strategic regulation of nitrogen-containing intermediates for enhanced nitrate reduction over Co_(3)O_(4)/SiC catalyst having multiple active centers

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第9期96卷 291-299页

作者： Ming-hao guan hao-Nan Xu Jin Liu Tao Wu An-Hui Lu State Key Laboratory of Fine Chemicals Liaoning Key Laboratory for Catalytic Conversion of Carbon ResourcesSchool of Chemical EngineeringDalian University of TechnologyDalian 116024LiaoningChina

Regulating the intermediates involved in the electrocatalytic nitrate reduction reaction(NO_(3)RR)is crucial for the enhancement of reaction ***,it remains a great challenge to regulate the reaction intermediates through active site manipulation on the surface of the ***,a family of n%-Co_(3)O_(4)/SiC(n=5,8,12,20)catalysts with a delicate percentage of Co^(2+)and Co^(3+)were prepared for NO_(3)*** found that Co^(3+)primarily acts as the active site for NO_(3)^(−)reduction to NO_(2)^(−),while Co^(2+)is responsible for the conversion of NO_(2)^(−)to NH_(3).Moreover,the conversion of these intermediates over the active sites is autonomous and separately *** processes synergistically accomplish the reduction of nitrate ions to synthesize *** the experimental studies and density functional theory(DFT)calculations,it is discovered the pathway(^(*)NHO→^(*)NHOH→^(*)NH_(2)OH→^(*)NH_(2)→^(*)NH_(3))is more favorable due to the lowerΔG value(0.25 eV)for the rate-limiting step(^(*)NO→^(*)NHO).The NH_(3)yield rate of 8%-Co_(3)O_(4)/SiC reached 1.08 mmol/(cm^(2)h)with a Faradaic efficiency of 96.4%at−0.89 V versus the reversible hydrogen electrode(RHE),surpassing those of most reported non-noble NO_(3)RR *** strategy not only provides an efficient catalyst for NO_(3)RR but also serves as an illustrative model for the regulation of multi-step reaction intermediates through the design of distinct active sites,thereby presenting a new approach to enhance the efficiency of intricate reactions.

关键词： Electrocatalysis Nitratereduction Co_(3)O_(4)/SiC catalysts Intermediates control

Circulating RNA ZFR promotes hepatocellular carcinoma cell proliferation and epithelial-mesenchymal transition process through miR-624-3p/WEE1 axis

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 52-63页

作者： Li Zhang Sai He hao guan Yao Zhao Di Zhang Department of General Surgery the Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004China Department of Breast Cancer Shaanxi Provincial Cancer HospitalXi’an 710000China

Background:Hepatocellular carcinoma(HCC),the most common type of primary liver cancer,is the fourth leading cause of cancer-related deaths *** evidence shows that the expression of circulating RNA ZFR(circZFR)is upregulated in HCC ***,the molecular mechanism of circZFR in HCC is ***:Quantitative reverse transcriptase polymerase chain reaction(qRT-PCR)was employed to detect the expression of circZFR,microRNA-624-3p(miR-624-3p)and WEE1 in HCC tissues and *** R assay and actinomycin D treatment assay were used to analyze the characteristics of *** functional analysis,the capacities of colony formation,cell proliferation,cell apoptosis,migration and invasion were assessed by colony formation assay,5-ethynyl-2-deoxyuridine(EdU)assay,flow cytometry assay and transwell *** blot was used to examine the protein levels of WEE1 and epithelial-mesenchymal transition(EMT)-related *** interactions between miR-624-3p and circZFR or WEE1 were validated by dual-luciferase reporter assay and RNA immunoprecipitation(RIP)*** models were established to determine the role of circZFR in ***:circZFR and WEE1 were upregulated,while miR-624-3p expression was reduced in HCC tissues and *** could sponge miR-624-3p,and WEE1 was a downstream gene of *** of circZFR significantly reduced the malignant behaviors of HCC and that co-transfection with miR624-3p inhibitor restored this *** of WEE1 abolished the inhibitory effect of miR624-3p mimic on HCC ***,circZFR acted as a competitive endogenous RNA(ceRNA)to regulate WEE1 expression by targeting ***,in vivo studies have illustrated that circZFR knockdown inhibited tumor ***:circZFR knockdown reduced HCC cell proliferation,migration and invasion and promoted apoptosis by regulating the miR-624-3p/WEE1 axis,suggesting that the circZFR/miR-624-3p/WEE1 axis might

关键词： Hepatocellular carcinoma circZFR miR-624-3p WEE1 Liver cancer

New perspectives in prognostication of hepatocellular carcinoma:The role and clinical implications of transient receptor potential family genes

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2862-2864页

作者： Shi-hao guan Wen-Jing Hu Xin-Yu Wang Yue-Xia Gu De-Hua Zhou Department of Plastic Surgery Qingpu Branch of Zhongshan Hospital Affiliated to Fudan UniversityShanghai 201700China Department of Nursing Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of Thyroid Breast and Vascular SurgeryShanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of Gastrointestinal Surgery Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China

The study titled“Transient receptor potential-related risk model predicts prognosis of hepatocellular carcinoma patients”is a significant contribution to hepatocellular carcinoma(HCC)research,highlighting the role of transient receptor potential(TRP)family genes in the disease’s progression and *** data from The Cancer Genome Atlas database,it establishes a new risk assessment model,emphasizing the interaction of TRP genes with tumor proliferation pathways,key metabolic reactions like retinol metabolism,and the tumor immune ***,the overexpression of the TRPC1 gene in HCC correlates with poorer patient survival outcomes,suggesting its potential as a prognostic biomarker and a target for personalized therapy,particularly in strategies combining immunotherapy and anti-TRP agents.

关键词： Hepatocellular carcinoma Transient receptor potential channels TRPC1 gene Tumor immune microenvironment Cancer prognosis Bioinformatics in cancer research

重视胸骨切开术后胸骨深部伤口感染的预防和处理

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华烧伤与创面修复杂志 2024年第2期40卷 125-130页

作者：官浩陈阳空军军医大学第一附属医院全军烧伤中心烧伤与皮肤外科西安710032

胸骨深部伤口感染(DSWI)是心脏手术后潜在且灾难性的并发症之一。尽管临床上采用了更小的切口、常规预防性使用抗生素和优化血糖管理等措施,但DSWI的发病率依然在1%~5%波动。DSWI在发生初期的症状和体征均不明显,致使临床医师的干预介... 详细信息

胸骨深部伤口感染(DSWI)是心脏手术后潜在且灾难性的并发症之一。尽管临床上采用了更小的切口、常规预防性使用抗生素和优化血糖管理等措施,但DSWI的发病率依然在1%~5%波动。DSWI在发生初期的症状和体征均不明显,致使临床医师的干预介入偏晚。DSWI一旦未被及时处理,患者病死率极高。因此,及早预防、诊断和适当处理对于防止DSWI进一步发展至致命的结局非常重要。鉴于DSWI的临床危害性和治疗的复杂性,故本文重点探讨和分享在各个环节中预防DSWI发生的经验、发生后的重建修复策略,以引起广大同行对DSWI的重视。

关键词：胸骨切开术外科伤口感染纵隔炎手术后并发症胸骨深部伤口感染预防和治疗创面修复

Photoionisation detection of a single Er3+ ion with sub-100-ns time resolution

在线全文

学校读者我要写书评

暂无评论

National Science Review 2024年第4期11卷 38-45页

作者： Yangbo Zhang Wenda Fan Jiliang Yang hao guan Qi Zhang Xi Qin Changkui Duan Gabriele G.de Boo Brett C.Johnson Jeffrey C.Mc Callum Matthew J.Sellars Sven Rogge Chunming Yin Jiangfeng Du CAS Key Laboratory of Microscale Magnetic Resonance and School of Physical Sciences University of Science and Technology of China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of China Hefei National Laboratory University of Science and Technology of China Centre of Excellence for Quantum Computation and Communication Technology School of Physics University of New South Wales Centre of Excellence for Quantum Computation and Communication Technology School of Engineering RMIT University Centre of Excellence for Quantum Computation and Communication Technology School of Physics University of Melbourne Centre of Excellence for Quantum Computation and Communication Technology Research School of Physics and Engineering Australian National University

Efficient detection of single optical centres in solids is essential for quantum information processing, sensing and single-photon generation *** this work,we use radio-frequency（RF） reflectometry to electrically detect the photoionisation induced by a single Er3+ion in *** high bandwidth and sensitivity of the RF reflectometry provide sub-100-ns time resolution for the photoionisation *** this technique,the optically excited state lifetime of a single Er3+ion in a Si nano-transistor is measured for the first time to be 0.49±0.04μ*** results demonstrate an efficient approach for detecting a charge state change induced by Er excitation and *** approach could be used for fast readout of other single optical centres in solids and is attractive for large-scale integrated optical quantum systems thanks to the multi-channel RF reflectometry demonstrated with frequency multiplexing techniques.

关键词： single optical centres erbium ions RF reflectometry photoionisation detection

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

以制度创新推动新质生产力发展

南京大学学报（哲学．人文科学．社会科学） 2024年第2期61卷 5-14页

作者：张兴祥曾冠豪厦门大学新质生产力研究发展中心福建省厦门市361005 厦门大学经济学院经济学系福建省厦门市361005

作为人类社会进步的决定性力量,生产力处在不断新质化的运动中,而新质生产力则代表了生产力“跃迁”的最新质态。发展新质生产力需要进一步全面深化改革,而这有赖于制度创新。回顾历史可以看到,1984年的一封“松绑”放权呼吁信掀起了国... 详细信息

作为人类社会进步的决定性力量,生产力处在不断新质化的运动中,而新质生产力则代表了生产力“跃迁”的最新质态。发展新质生产力需要进一步全面深化改革,而这有赖于制度创新。回顾历史可以看到,1984年的一封“松绑”放权呼吁信掀起了国有企业改革的热潮,40年来,从“松绑”放权到“放管服”改革,我国行政体制改革已历经四个发展阶段,破解了政府与市场关系的世界性难题,形成了简政放权、放管结合、优化服务三位一体,有效市场与有为政府有机耦合,市场活力与政府治理能力双向提升的新格局。新时代为加快发展新质生产力,需要深化“放管服”,以制度创新破除深层次体制机制障碍。

关键词： “松绑”放权 “放管服”改革新质生产力新型生产关系

融合机器视觉与区间仿射算法的桥梁结构影响线实测研究

在线全文

学校读者我要写书评

暂无评论

中国公路学报 2024年第2期37卷 142-151页

作者：周云张路遥胡锦楠郝官旺湖南大学工程结构损伤诊断湖南省重点实验室湖南长沙410082 湖南大学土木工程学院湖南长沙410082

影响线是桥梁结构状态评估的重要指标。传统影响线实测方法依赖车辆称重系统(WIM)和接触式传感器,存在使用成本高、效率低、风险大、阻碍交通等问题。为实现“无需接触式传感”、“无需封闭交通”、“无需车辆称重系统”的智能桥梁检测... 详细信息

影响线是桥梁结构状态评估的重要指标。传统影响线实测方法依赖车辆称重系统(WIM)和接触式传感器,存在使用成本高、效率低、风险大、阻碍交通等问题。为实现“无需接触式传感”、“无需封闭交通”、“无需车辆称重系统”的智能桥梁检测,提出了一种融合机器视觉与区间仿射算法的桥梁结构影响线实测方法。该方法首先利用机器视觉技术获取多工况的桥梁测点动态位移响应;其次,根据车辆出厂信息建立其轴重区间矩阵并通过区间仿射算法计算多工况的影响线区间;最后,采用支持向量机(SVM)从影响线区间中识别桥梁真实影响线。将该方法应用于野外实际桥梁试验,通过控制标定车辆的载重和行驶速度获取多工况的位移响应数据以评估该方法的性能。结果表明:该方法能够有效地从影响线区间中识别桥梁真实影响线,混合工况下影响线的识别相对误差为8.48%;影响线的识别相对误差随车速的增大而增大,在车速分别10、20、30 km·h^(-1)工况下,影响线的识别相对误差分别为9.22%、10.23%、12.38%。提出的桥梁影响线实测方法具有非接触、高精度、经济灵活等优势,可有效突破现有接触式桥梁影响线实测方法的技术局限,具有较好的工程应用前景。

关键词：桥梁工程桥梁影响线机器视觉区间仿射算法车桥耦合

(定量)构效关系评估帕瑞昔布钠有关物质遗传毒性

在线全文

学校读者我要写书评

暂无评论

中国新药杂志 2024年第15期33卷 1586-1594页

作者：胡钖牛剑钊关皓月中国食品药品检定研究院北京102629

目的:基于合成工艺梳理帕瑞昔布钠原料药生产过程中可能产生的有关物质,评估其致突变性和致癌性,确定杂质类别,为药物生产工艺的优化以及终产品的质量控制提供依据。方法:帕瑞昔布钠中51个有关物质的遗传毒性通过数据库及2种(定量)构效... 详细信息

目的:基于合成工艺梳理帕瑞昔布钠原料药生产过程中可能产生的有关物质,评估其致突变性和致癌性,确定杂质类别,为药物生产工艺的优化以及终产品的质量控制提供依据。方法:帕瑞昔布钠中51个有关物质的遗传毒性通过数据库及2种(定量)构效关系[(quantitative) structure-activity relationship,(Q)SAR]预测软件进行评估,根据风险评估结果对有关物质的遗传毒性进行分类,并根据ICH M7指导原则制定相应的可接受限度。结果:梳理出的51个有关物质中,综合评估结果为阳性有9个,需要按遗传毒性杂质控制;综合评估结果为阴性的有37个,按非遗传毒性杂质控制;还有5个预测结果模棱两可,不确定是否为遗传毒性物质。结论:为了保证药物质量与安全,经(Q)SAR评估为阳性的有关物质其最高限度不得超过18 ppm,同时提示应针对帕瑞昔布钠中具有警示结构的9个潜在遗传毒性杂质建立科学、合理的质量控制方法。

关键词：遗传毒性有关物质帕瑞昔布钠 (定量)构效关系警示结构

Physicochemical characterization of Dendrobium officinale polysaccharides and regulation of immunometabolic homeostasis in Sub-health mice based on the CD4-Th17/Treg immunity axis

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Bo Li Ze-Hua Zhang hao-Ru guan Xing-Li-Shang He Ning Wang Ying-Jie Dong Mei Rong Jiu-Jie Jia Ting-Ting Chen Zhi-Yuan Li Gui-Yuan Lv Lin-Nan Zhang Su-Hong Chen Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals， Zhejiang University of Technology Zhejiang Provincial Key Laboratory of TCM for Innovative R & D and Digital Intelligent Manufacturing of TCM Great Health Products.Huzhou College of Pharmaceutical Science， Zhejiang Chinese Medical University

The aim of this study was to investigate the role of DOPS and DOPS100 in attenuating immune dysfunction in subfertile mice. The results of the study revealed several noteworthy findings. First， DOPS and DOPS100 treatments led to significant improvement in weight gain and reversal of fatigue-related behaviors compared to the normal group. Second， both DOPS and DOPS100 showed effectiveness in reducing immune organ swelling， modulating immunoglobulin （IgA and IgM） levels， and restoring complement （C3c and C4） levels. In addition， they demonstrated a significant ability to enhance the integrity of the intestinal mechanical barrier by differentially upregulating the tight junction proteins Occludin and ZO-1. In addition， it was found that DOPS100 specifically enhanced the CD4+-Th17/Treg immune axis in the gut， as evidenced by increased expression of Foxp3 as well as decreased expression of RORγt， and further modulation of IL-10， IL-22， and IL-17A expression levels of inflammatory factors. These findings collectively suggest that DOPS100 holds significant potential in improving sub-healthy status by repairing the intestinal barrier， restoring local immune homeostasis， and activating the intestinal immune regulatory network. The study's outcomes provide valuable insights into the therapeutic implications of DOPS and DOPS100 in addressing immune dysfunction in sub-healthy conditions.

关键词：